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Research Output 2005 2019

  • 49 Article
  • 2 Review article
  • 1 Conference Abstract/Poster in journal
  • 1 Doctoral Thesis
2019

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

Muller, M., Hernandez, M. A. G., Goossens, G. H., Reijnders, D., Holst, J. J., Jocken, J. W. E., van Eijk, H., Canfora, E. E. & Blaak, E. E., 29 Aug 2019, In : Scientific Reports. 9, 9 p., 12515.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Plasma lipid profiling of tissue-specific insulin resistance in human obesity

May 2019, In : International Journal of Obesity. 43, 5, p. 989-998 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans

van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T. & Blaak, E. E., Dec 2019, In : Diabetes. 68, 12, p. 2247-2258 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity

Hernandez, M. A. G., Canfora, E. E., Jocken, J. W. E. & Blaak, E. E., Aug 2019, In : Nutrients. 11, 8, 32 p., 1943.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Vitamin D deficiency in the aetiology of obesity-related insulin resistance

Pramono, A., Jocken, J. W. E. & Blaak, E. E., Jul 2019, In : Diabetes-metabolism Research and Reviews. 35, 5, 10 p., 3146.

Research output: Contribution to journalReview articleAcademicpeer-review

2018

Abdominal subcutaneous adipose tissue gene expression in relation to tissue-specific insulin resistance in human obesity

Oct 2018, In : Diabetologia. 61, p. S110-S110 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Verboven, K., Wouters, K., Gaens, K., Hansen, D., Bijnen, M., Wetzels, S., Stehouwer, C. D., Goossens, G. H., Schalkwijk, C. G., Blaak, E. E. & Jocken, J. W., 16 Mar 2018, In : Scientific Reports. 8, 8 p., 4677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity

Xu, Q., Mariman, E. C. M., Roumans, N. J. T., Vink, R. G., Goossens, G. H., Blaak, E. E. & Jocken, J. W. E., 1 Jan 2018, In : Adipocyte. 7, 1, p. 12-19 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training

Verboven, K., Stinkens, R., Hansen, D., Wens, I., Frederix, I., Eijnde, B. O., Jocken, J. W. E., Goossens, G. H. & Blaak, E. E., 16 Aug 2018, In : Clinical Science. 132, 15, p. 1685-1698 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans

Vogel, M. A. A., Jocken, J. W. E., Sell, H., Hoebers, N., Essers, Y., Rouschop, K. M. A., Cajlakovic, M., Blaak, E. E. & Goossens, G. H., Oct 2018, In : Journal of Clinical Endocrinology & Metabolism. 103, 10, p. 3688-3697 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of diet-induced weight loss on angiopoietin-like protein 4 and adipose tissue lipid metabolism in overweight and obese humans

van der Kolk, B. W., Vink, R. G., Jocken, J. W. E., Roumans, N. J. T., Goossens, G. H., Mariman, E. C. M., van Baak, M. A. & Blaak, E. E., Jul 2018, In : Physiological Reports. 6, 13, 10 p., e13735.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of gut microbiota manipulation on ex vivo lipolysis in human abdominal subcutaneous adipocytes

Jocken, J. W. E., Reijnders, D., Canfora, E. E., Boekschoten, M. V., Plat, J., Goossens, G. H. & Blaak, E. E., 1 Jan 2018, In : Adipocyte. 7, 2, p. 106-112 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity

Stinkens, R., Brouwers, B., Jocken, J. W., Blaak, E. E., Teunissen-Beekman, M. F., Hesselink, M. K., van Baak, M. A., Schrauwen, P. & Goossens, G. H., Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1585-1593 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effects of angiotensin receptor neprilysin inhibition by sacubitril/valsartan on adipose tissue transcriptome and protein expression in obese hypertensive patients

Stinkens, R., van der Kolk, B. W., Jordan, J., Jax, T., Engeli, S., Heise, T., Jocken, J. W., May, M., Schindler, C., Havekes, B., Schaper, N., Albrecht, D., Kaiser, S., Hartmann, N., Letzkus, M., Langenickel, T. H., Goossens, G. H. & Blaak, E. E., 2 Mar 2018, In : Scientific Reports. 8, 7 p., 3933.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans

Most, J., Warnke, I., Boekschoten, M. V., Jocken, J. W. E., de Groot, P., Friedel, A., Bendik, I., Goossens, G. H. & Blaak, E. E., 1 Jan 2018, In : Adipocyte. 7, 3, p. 190-196 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Circulating classical monocytes are associated with CD11c(+) macrophages in human visceral adipose tissue

Wouters, K., Gaens, K., Bijnen, M., Verboven, K., Jocken, J., Wetzels, S., Wijnands, E., Hansen, D., van Greevenbroek, M., Duijvestijn, A. M., Biessen, E. A. L., Blaak, E. E., Stehouwer, C. D. A. & Schalkwijk, C. G., 15 Feb 2017, In : Scientific Reports. 7, 8 p., 42665.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

Verboven, K., Hansen, D., Jocken, J. W. E. & Blaak, E. E., Nov 2017, In : Obesity Reviews. 18, 11, p. 1243-1259 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals

Canfora, E. E., van der Beek, C. M., Hermes, G. D. A., Goossens, G. H., Jocken, J. W. E., Holst, J. J., van Eijk, H. M., Venema, K., Smidt, H., Zoetendal, E. G., Dejong, C. H. C., Lenaerts, K. & Blaak, E. E., Jul 2017, In : Gastroenterology. 153, 1, p. 87-97.e3 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016
1 Citation (Scopus)

Altered Skeletal Muscle Fatty Acid Handling in Subjects with Impaired Glucose Tolerance as Compared to Impaired Fasting Glucose

Goossens, G. H., Moors, C. C. M., Jocken, J. W. E., van der Zijl, N. J., Jans, A., Konings, E., Diamant, M. & Blaak, E. E., Mar 2016, In : Nutrients. 8, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Altered skeletal muscle fatty acid handling is associated with the degree of insulin resistance in overweight and obese humans

van der Kolk, B. W., Goossens, G. H., Jocken, J. W. & Blaak, E. E., Dec 2016, In : Diabetologia. 59, 12, p. 2686-2696

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics

van der Kolk, B. W., Goossens, G. H., Jocken, J. W., Kersten, S. & Blaak, E. E., Jun 2016, In : Journal of Clinical Endocrinology & Metabolism. 101, 6, p. 2332-2339

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

Verboven, K., Hansen, D., Moro, C., Eijnde, B. O., Hoebers, N., Knol, J., Bouckaert, W., Dams, A., Blaak, E. E. & Jocken, J. W. E., 1 Jul 2016, In : Clinical Science. 130, 13, p. 1105-1114

Research output: Contribution to journalArticleAcademicpeer-review

Combinations of bio-active dietary constituents affect human white adipocyte function in-vitro

Warnke, I., Jocken, J. W. E., Schoop, R., Toepfer, C., Goralczyk, R. & Schwager, J., 21 Nov 2016, In : Nutrition & Metabolism. 13, 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial

Most, J., Timmers, S., Warnke, I., Jocken, J. W. E., van Boekschoten, M., de Groot, P., Bendik, I., Schrauwen, P., Goossens, G. H. & Blaak, E. E., Jul 2016, In : American Journal of Clinical Nutrition. 104, 1, p. 215-227

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2015

A 3-day EGCG-supplementation reduces interstitial lactate concentration in skeletal muscle of overweight subjects

Most, J., van Can, J. G., van Dijk, J. W., Goossens, G., Jocken, J., Hospers, J. J., Bendik, I. & Blaak, E. E., 1 Jan 2015, In : Scientific Reports. 5, 17896.

Research output: Contribution to journalArticleAcademicpeer-review

96 Citations (Scopus)

Short-chain fatty acids in control of body weight and insulin sensitivity

Canfora, E. E., Jocken, J. & Blaak, E. E., Oct 2015, In : Nature Reviews Endocrinology. 11, 10, p. 577-591 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Targeting fatty acid metabolism to improve glucose metabolism

Stinkens, R. E., Goossens, G. H., Jocken, J. W. & Blaak, E. E., 1 Jan 2015, In : Obesity Reviews. 16, 9, p. 715-757

Research output: Contribution to journalArticleAcademicpeer-review

2014
17 Citations (Scopus)

Targeting Adipose Tissue Lipid Metabolism to Improve Glucose Metabolism in Cardiometabolic Disease

Jocken, J. W. E., Goossens, G. H. & Blaak, E. E., 1 Jan 2014, In : EMJ Diabetes. 2014, 2, p. 273-282

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men.

Konings, E., Timmers, S., Boekschoten, M. V., Goossens, G. H., Jocken, J. W., Afman, L. A., Muller, M., Schrauwen, P., Mariman, E. C. & Blaak, E. E., Mar 2014, In : International Journal of Obesity. 38, 3, p. 470-473 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
16 Citations (Scopus)

Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance.

Jocken, J. W., Goossens, G. H., Boon, H., Mason, R. R., Essers, Y., Havekes, B., Watt, M. J., van Loon, L. J. C. & Blaak, E. E., Oct 2013, In : Diabetologia. 56, 10, p. 2255-2265 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
4 Citations (Scopus)

Adipose triglyceride lipase and hormone-sensitive lipase protein expression in subcutaneous adipose tissue is decreased after an isoenergetic low-fat high-complex carbohydrate diet in the metabolic syndrome.

van Hees, A. M. J., Jocken, J. W., Essers, Y., Roche, H. M., Saris, W. H. & Blaak, E. E., Oct 2012, In : Metabolism-Clinical and Experimental. 61, 10, p. 1404-1412 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Resveratrol-Induced Changes of the Human Adipocyte Secretion Profile

Anja Rosenow, A. R., Noben, J. P., Jocken, J., Kallendrusch, S., Fischer Posovszky, P., Mariman, E. C. & Renes, J., 1 Jan 2012, In : Journal of Proteome Research. 11, 9, p. 4733-4743

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial

Goossens, G. H., Moors, C. C., van der Zijl, N. J., Venteclef, N., Alili, R., Jocken, J. W., Essers, Y., Cleutjens, J. P. M., Clement, K., Diamant, M. & Blaak, E. E., 29 Jun 2012, In : PLOS ONE. 7, 6, 10 p., 39930.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2011
115 Citations (Scopus)

Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation

Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P. M., Konings, E., Jocken, J. W., Cajlakovic, M., Ribitsch, V., Clement, K. & Blaak, E. E., 5 Jul 2011, In : Circulation. 124, 1, p. 67-76 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010
15 Citations (Scopus)

Skeletal muscle lipase content and activity in obesity and type 2 diabetes.

Jocken, J. W. E., Moro, C., Goossens, G. H., Hansen, D., Mairal, A., Hesselink, M. K. C., Langin, D., van Loon, L. J. C. & Blaak, E. E., 1 Jan 2010, In : Journal of Clinical Endocrinology & Metabolism. 95, 12, p. 5449-5453

Research output: Contribution to journalArticleAcademicpeer-review

2009
26 Citations (Scopus)

Activation of liver X receptor regulates substrate oxidation in white adipocytes

Stenson, B. M., Ryden, M., Steffensen, K. R., Wahlen, K., Pettersson, A. T., Jocken, J. W., Arner, P. & Laurencikiene, J., 1 Jan 2009, In : Endocrinology. 150, 9, p. 4104-13

Research output: Contribution to journalArticleAcademicpeer-review

110 Citations (Scopus)

Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes

Bezaire, V., Mairal, A., Ribet, C., Lefort, C., Girousse, A., Jocken, J., Laurencikiene, J., Anesia, R., Rodriguez, A. M., Ryden, M., Stenson, B. M., Dani, C., Ailhaud, G., Arner, P. & Langin, D., 1 Jan 2009, In : Journal of Biological Chemistry. 284, 27, p. 18282-91

Research output: Contribution to journalArticleAcademicpeer-review

2008
36 Citations (Scopus)

Adipose triglyceride lipase (ATGL) expression in human skeletal muscle is type I (oxidative) fiber specific

Jocken, J. W., Smit, E., Goossens, G. H., Essers, Y. P., van Baak, M. A., Mensink, M., Saris, W. H. & Blaak, E. E., 1 Jan 2008, In : Histochemistry and Cell Biology. 129, 4, p. 535-8

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Blunted beta-adrenoceptor-mediated fat oxidation in overweight subjects: a role for the hormone-sensitive lipase gene

Jocken, J. W., Blaak, E. E., van der Kallen, C. J. H., van Baak, M. A. & Saris, W. H., 1 Jan 2008, In : Metabolism-Clinical and Experimental. 57, 3, p. 326-32

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)

Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men.

Jocken, J. W., Goossens, G. H., van Hees, A. M. J., Frayn, K. N., van Baak, M. A., Stegen, J. H. C. H., Pakbiers, M. T., Saris, W. H. & Blaak, E. E., 1 Jan 2008, In : Diabetologia. 51, 2, p. 320-327

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation

Jocken, J. W., Roepstorff, C., Goossens, G. H., van der Baan, P., van Baak, M., Saris, W. H., Kiens, B. & Blaak, E. E., 1 Jan 2008, In : Diabetes. 57, 7, p. 1834-1841

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Short-term beta-adrenergic regulation of leptin, adiponectin and interleukin-6 secretion in vivo in lean and obese subjects.

Goossens, G. H., Jocken, J. W., van Baak, M. A., Jansen, E. H., Saris, W. H. & Blaak, E. E., 1 Jan 2008, In : Diabetes Obesity & Metabolism. 10, 11, p. 1029-1038

Research output: Contribution to journalArticleAcademicpeer-review

181 Downloads (Pure)

The lipolytic pathway in the obese insulin resistant state

Jocken, J. W. E., 1 Jan 2008, Maastricht: Datawyse / Universitaire Pers Maastricht. 192 p.

Research output: ThesisDoctoral ThesisInternal

Open Access
File
2007
109 Downloads (Pure)

Adipose TriGlyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL) protein expression is decreased in the obese insulin resistant state

Jocken, J. W., Langin, D., Smit, E., Saris, W. H., Valle, C., Hul, G. B. J., Holm, C., Arner, P. & Blaak, E. E., 1 Jan 2007, In : Journal of Clinical Endocrinology & Metabolism. 29, 6, p. 2292-2299

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
21 Citations (Scopus)
130 Downloads (Pure)

Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

Jocken, J. W., Blaak, E. E., Schiffelers, S. L. H., Arner, P., van Baak, M. A. & Saris, W. H., 1 Jan 2007, In : International Journal of Obesity. 31, 5, p. 813-819

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File