19962020

Research output per year

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Research Output

2020

Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding

Veninga, A., De Simone, I., Heemskerk, J. W. M., Ten Cate, H. & van der Meijden, P. E. J., 1 Aug 2020, In : Haematologica-the Hematology Journal. 105, 8, p. 2020-2031 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Comparison of the GPVI inhibitors losartan and honokiol

Onselaer, M-B., Nagy, M., Pallini, C., Pike, J. A., Perrella, G., Quintanilla, L. G., Eble, J. A., Poulter, N. S., Heemskerk, J. W. M. & Watson, S. P., 17 Feb 2020, In : Platelets. 31, 2, p. 187-197 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Crystal Clots as Therapeutic Target in Cholesterol Crystal Embolism

Shi, C., Kim, T., Steiger, S., Mulay, S. R., Klinkhammer, B. M., Baeuerle, T., Melica, M. E., Romagnani, P., Moeckel, D., Baues, M., Yang, L., Brouns, S. L. N., Heemskerk, J. W. M., Braun, A., Lammers, T., Boor, P. & Anders, H-J., 10 Apr 2020, In : Circulation Research. 126, 8, p. E37-E52 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Flow studies on human GPVI-deficient blood under coagulating and noncoagulating conditions

Nagy, M., Perrella, G., Dalby, A., Becerra, M. F., Quintanilla, L. G., Pike, J. A., Morgan, N., Gardiner, E. E., Heemskerk, J. W. M., Azocar, L., Miquel, J. F., Mezzano, D. & Watson, S. P., 14 Jul 2020, In : Blood advances. 4, 13, p. 2953-2961 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Clinical Protocol to Prevent Thrombogenic Effect of Liver-Derived Mesenchymal Cells for Cell-Based Therapies

Coppin, L., Najimi, M., Bodart, J., Rouchon, M-S., van der Smissen, P., Eeckhoudt, S., Dahlqvist, G., Castanares-Zapatero, D., Komuta, M., Brouns, S. L., Baaten, C. C., Heemskerk, J. W. M., Horman, S., Belmonte, N., Sokal, E. & Stephenne, X., Aug 2019, In : Cells. 8, 8, 16 p., 846.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

Nagy, M., van Geffen, J. P., Stegner, D., Adams, D. J., Braun, A., de Witt, S. M., Elvers, M., Geer, M. J., Kuijpers, M. J. E., Kunzelmann, K., Mori, J., Oury, C., Pircher, J., Pleines, I., Poole, A. W., Senis, Y. A., Verdoold, R., Weber, C., Nieswandt, B., Heemskerk, J. W. M. & 1 others, Baaten, C. C. F. M. J., 30 Jul 2019, In : Frontiers in cardiovascular medicine. 6, 15 p., 99.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Defective Zn2+ homeostasis in mouse and human platelets with alpha- and delta-storage pool diseases

Gotru, S. K., van Geffen, J. P., Nagy, M., Mammadova-Bach, E., Eilenberger, J., Volz, J., Manukjan, G., Schulze, H., Wagner, L., Eber, S., Schambeck, C., Deppermann, C., Brouns, S., Nurden, P., Greinacher, A., Sachs, U., Nieswandt, B., Hermanns, H. M., Heemskerk, J. W. M. & Braun, A., 6 Jun 2019, In : Scientific Reports. 9, 7 p., 8333.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

Slater, A., Perrella, G., Onselaer, M-B., Martin, E. M., Gauer, J. S., Xu, R-G., Heemskerk, J. W. M., Ariens, R. A. S. & Watson, S. P., 3 Apr 2019, In : Platelets. 30, 3, p. 281-289 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

van Geffen, A., Brouns, S., Batista, J., McKinney, H., Kempster, C., Nagy, M., Sivapalaratnam, S., Baaten, C., Bourry, N., Frontini, M., Jurk, K., Krause, M., Pilliteri, D., Swieringa, F., Verdoold, R., Cavill, R., Kuijpers, M., Ouwehand, W. H., Downes, K. & Heemskerk, J., 31 May 2019, In : Haematologica-the Hematology Journal. 104, 6, p. 1256-1267 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

Govers-Riemslag, J. W. P., Konings, J., Cosemans, J. M. E. M., van Geffen, J. P., de Laat, B., Heemskerk, J. W. M., Dargaud, Y. & Ten Cate, H., Jul 2019, In : TH open : companion journal to thrombosis and haemostasis. 3, 3, p. e273-e285 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelet biology and functions: new concepts and clinical perspectives

van der Meijden, P. E. J. & Heemskerk, J. W. M., Mar 2019, In : Nature Reviews Cardiology. 16, 3, p. 166-179 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Store-operated calcium entry in thrombosis and thrombo-inflammation

Mammadova-Bach, E., Nagy, M., Heemskerk, J. W. M., Nieswandt, B. & Braun, A., Jan 2019, In : Cell Calcium. 77, p. 39-48 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

Kiouptsi, K., Jaeckel, S., Pontarollo, G., Grill, A., Kuijpers, M. J. E., Wilms, E., Weber, C., Sommer, F., Nagy, M., Neideck, C., Jansen, Y., Ascher, S., Formes, H., Karwot, C., Bayer, F., Kollar, B., Subramaniam, S., Molitor, M., Wenzel, P., Rosenstiel, P. & 8 others, Todorov, H., Gerber, S., Walter, U., Jurk, K., Heemskerk, J. W. M., van der Vorst, E. P. C., Doering, Y. & Reinhardt, C., 2019, In : Mbio. 10, 5, 16 p., e02298-19.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation

Lepropre, S., Kautbally, S., Octave, M., Ginion, A., Onselaer, M-B., Steinberg, G. R., Kemp, B. E., Hego, A., Wera, O., Brouns, S., Swieringa, F., Giera, M., Darley-Usmar, V. M., Ambroise, J., Guigas, B., Heemskerk, J., Bertrand, L., Oury, C., Beauloye, C. & Horman, S., 13 Sep 2018, In : Blood. 132, 11, p. 1180-1192 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

Baaten, C. C. F. M. J., Meacham, S., de Witt, S. M., Feijge, M. A. H., Adams, D. J., Akkerman, J-W. N., Cosemans, J. M. E. M., Grassi, L., Jupe, S., Kostadima, M., Mattheij, N. J. A., Prins, M. H., Ramirez-Solis, R., Soehnlein, O., Swieringa, F., Weber, C., White, J. K., Ouwehand, W. H. & Heemskerk, J. W. M., 13 Dec 2018, In : Blood. 132, 24, p. E35-E46 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis

Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., Asquith, N. & 43 others, Heemskerk, J., Heinzmann, A., Moorlag, M., Mackman, N., van der Meijden, P., Meijers, J. C. M., Heestermans, M., Renne, T., Dolleman, S., Chayoua, W., Ariens, R. A. S., Baaten, C. C., Nagy, M., Kuliopulos, A., Posma, J. J., Harrison, P., Vries, M. J., Crijns, H. J. G. M., Dudink, E. A. M. P., Buller, H. R., Henskens, Y. M. C., Sjalander, A., Zwaveling, S., Erkuner, O., Eikelboom, J. W., Gulpen, A., Peeters, F. E. C. M., Douxfils, J., Olie, R. H., Baglin, T., Leader, A., Schotten, U., Scaf, B., van Beusekom, H. M. M., Mosnier, L. O., van der Vorm, L., Declerck, P., Visser, M., Dippel, D. W. J., Strijbis, V. J., Pertiwi, K., ten Cate-Hoek, A. J. & ten Cate, H., 1 Feb 2018, In : Thrombosis and Haemostasis. 118, 2, p. 229-250 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Hofmann, I., Geer, M. J., Vogtle, T., Crispin, A., Campagna, D. R., Barr, A., Calicchio, M. L., Heising, S., van Geffen, J. P., Kuijpers, M. J. E., Heemskerk, J. W. M., Eble, J. A., Schmitz-Abe, K., Obeng, E. A., Douglas, M., Freson, K., Pondarre, C., Favier, R., Jarvis, G. E., Markianos, K. & 5 others, Turro, E., Ouwehand, W. H., Mazharian, A., Fleming, M. D. & Senis, Y. A., 27 Sep 2018, In : Blood. 132, 13, p. 1399-1412 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

High-throughput measurement of human platelet aggregation under flow: application in hemostasis and beyond

Brouns, S. L. N., van Geffen, J. P. & Heemskerk, J. W. M., 1 Jan 2018, In : Platelets. 29, 7, p. 662-669 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy

Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M. & van der Meijden, P. E. J., 31 Aug 2018, In : Haematologica-the Hematology Journal. 103, 9, p. 1557-1567 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inhibitory mechanisms of very low-dose rivaroxaban in non-ST-elevation myocardial infarction

Borst, O., Munzer, P., Alnaggar, N., Geue, S., Tegtmeyer, R., Rath, D., Droppa, M., Seizer, P., Heitmeier, S., Heemskerk, J. W. M., Jennings, L. K., Storey, R. F., Angiolillo, D. J., Rocca, B., Spronk, H., Ten Cate, H., Gawaz, M. & Geisler, T., 27 Mar 2018, In : Blood advances. 2, 6, p. 715-730 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrating platelet and coagulation activation in fibrin clot formation

Swieringa, F., Spronk, H. M. H., Heemskerk, J. W. M. & van der Meijden, P. E. J., Jul 2018, In : Research and practice in thrombosis and haemostasis. 2, 3, p. 450-460 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets

Vajen, T., Heinzmann, A. C. A., Dickhout, A., Zhao, Z., Nagy, M., Heemskerk, J. W. M. & Koenen, R. R., 1 Apr 2018, In : Journal of visualized experiment. 134, 6 p., e57009.

Research output: Contribution to journalArticleAcademicpeer-review

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148

Mori, J., Nagy, Z., Di Nunzio, G., Smith, C. W., Geer, M. J., Al Ghaithi, R., van Geffen, J. P., Heising, S., Boothman, L., Tullemans, B. M. E., Correia, J. N., Tee, L., Kuijpers, M. J. E., Harrison, P., Heemskerk, J. W. M., Jarvis, G. E., Tarakhovsky, A., Weiss, A., Mazharian, A. & Senis, Y. A., 8 Mar 2018, In : Blood. 131, 10, p. 1122-1144 23 p.

Research output: Contribution to journalArticleAcademicpeer-review

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

Baaten, C. C. F. M. J., Swieringa, F., Misztal, T., Mastenbroek, T. G., Feijge, M. A. H., Bock, P. E., Donners, M. M. P. C., Collins, P. W., Li, R., van der Meijden, P. E. J. & Heemskerk, J. W. M., 25 Sep 2018, In : Blood advances. 2, 18, p. 2320-2331 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Platelet proteomics: from discovery to diagnosis

Loosse, C., Swieringa, F., Heemskerk, J. W. M., Sickmann, A. & Lorenz, C., 1 Jan 2018, In : Expert Review of Proteomics. 15, 6, p. 467-476 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Suppressive Role of Tissue Factor Pathway Inhibitor-alpha in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength

Thomassen, S., Mastenbroek, T. G., Swieringa, F., Winckers, K., Feijge, M. A. H., Schrijver, R., Cosemans, J. M. E. M., Maroney, S. A., Mast, A. E., Hackeng, T. M. & Heemskerk, J. W. M., 1 Mar 2018, In : Thrombosis and Haemostasis. 118, 3, p. 502-513 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

Farmery, J. H. R., Smith, M. L., Lynch, A. G., Huissoon, A., Furnell, A., Mead, A., Levine, A. P., Manzur, A., Thrasher, A., Greenhalgh, A., Parker, A., Sanchis-Juan, A., Richter, A., Gardham, A., Lawrie, A., Sohal, A., Creaser-Myers, A., Frary, A., Greinacher, A., Themistocleous, A. & 31 others, Peacock, A. J., Marshall, A., Mumford, A., Rice, A., Webster, A., Brady, A., Koziell, A., Manson, A., Chandra, A., Hensiek, A., in't Veld, A. H., Maw, A., Kelly, A. M., Moore, A., Noordegraaf, A. V., Attwood, A., Herwadkar, A., Ghofrani, A., Houweling, A. C., Girerd, B., Furie, B., Treacy, C. M., Millar, C. M., Sewell, C., Roughley, C., Titterton, C., Williamson, C., Hadinnapola, C., Deshpande, C., Heemskerk, J. W. M. & NIHR-BioResource Rare Dis, 3 Sep 2018, In : Scientific Reports. 8, 4 p., 1300.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Geer, M. J., van Geffen, J. P., Gopalasingam, P., Vogtle, T., Smith, C. W., Heising, S., Kuijpers, M. J. E., Tullemans, B. M. E., Jarvis, G. E., Eble, J. A., Jeeves, M., Overduin, M., Heemskerk, J. W. M., Mazharian, A. & Senis, Y. A., 27 Sep 2018, In : Blood. 132, 13, p. 1413-1425 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

Nagy, M., Mastenbroek, T. G., Mattheij, N. J. A., de Witt, S., Clemetson, K. J., Kirschner, J., Schulz, A. S., Vraetz, T., Speckmann, C., Braun, A., Cosemans, J. M. E. M., Zieger, B. & Heemskerk, J. W. M., 28 Feb 2018, In : Haematologica-the Hematology Journal. 103, 3, p. 540-549 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Benchmarking recent national practice in rectal cancer treatment with landmark randomized controlled trials

Borstlap, W. A. A., Deijen, C. L., den Dulk, M., Bonjer, H. J., van de Velde, C. J., Bemelman, W. A., Tanis, P. J., Aalbers, A., Acherman, Y., Algie, G. D., von Geu-sau, B. A., Amelung, F., Aukema, T. S., Bakker, I. S., Bartels, S. A., Basha, S., Bastiaansen, A. J. N. M., Belgers, E., Bleeker, W., Blok, J. & 31 others, Bosker, R. J. I., Bosmans, J. W., Boute, M. C., Bouvy, N. D., Bouwman, H., Brandt-Kerkhof, A., Brinkman, D. J., Bruin, S., Bruns, E. R. J., Burbach, J. P. M., Burger, J. W. A., Buskens, C. J., Clermonts, S., Coene, P. P. L. O., Compaan, C., Consten, E. C. J., Darbyshire, T., de Mik, S. M. L., de Groot, I., Heemskerk, J., Heijnen, B., Hoogland, P., Jongen, A. C., Kool, M. E., van Rossem, C. C., Rutten, H. J., Schouten, N., Simkens, G. A., Wetzel, M., Wouters, M. W. & Dutch Snapshot Res Grp, Jun 2017, In : Colorectal Disease. 19, 6, p. O219-O231 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., Nicolaes, G. A. F. & 8 others, Doering, Y., Soehnlein, O., Lutgens, E., Heemskerk, J. W. M., Koenen, R. R., Mayo, K. H., Hackeng, T. M. & Weber, C., 5 Apr 2017, In : Science Translational Medicine. 9, 384, 14 p., eaah6650.

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease

Carss, K. J., Arno, G., Erwood, M., Stephens, J., Sanchis-Juan, A., Hull, S., Megy, K., Grozeva, D., Dewhurst, E., Malka, S., Plagnol, V., Penkett, C., Stirrups, K., Rizzo, R., Wright, G., Josifova, D., Bitner-Glindzicz, M., Scott, R. H., Clement, E., Allen, L. & 20 others, Armstrong, R., Brady, A. F., Carmichael, J., Chitre, M., Henderson, R. H. H., Hurst, J., MacLaren, R. E., Murphy, E., Paterson, J., Rosser, E., Thompson, D. A., Wakeling, E., Ouwehand, W. H., Michaelides, M., Moore, A. T., Webster, A. R., NIHR-BioResource Rare Dis, Henskens, Y., Heemskerk, J. & Raymond, F. L., 5 Jan 2017, In : American Journal of Human Genetics. 100, 1, p. 75-90 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of platelet-derived beta-thromboglobulins on coagulation

Egan, K., van Geffen, J. P., ma, H., Kevane, B., Lennon, A., Allen, S., Neary, E., Parsons, M., Maguire, P., Wynne, K., Kennedy, R. O., Heemskerk, J. M. & Ainle, F. N., Jun 2017, In : Thrombosis Research. 154, p. 7-15 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension

BioResource-Rare Dis Consortium, UK Natl Cohort Study Idiopathic He, BRIDGE-BPD Consortium, Henskens, Y., Heemskerk, J. & Vries, M., 21 Nov 2017, In : Circulation. 136, 21, p. 2022-2033 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype

Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J. & Koenen, R. R., 16 May 2017, In : Journal of Extracellular Vesicles . 6, 1, 14 p., 1322454.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

Petersen, R., Lambourne, J. J., Javierre, B. M., Grassi, L., Kreuzhuber, R., Ruklisa, D., Rosa, I. M., Tome, A. R., Elding, H., van Geffen, J. P., Jiang, T., Farrow, S., Cairns, J., Al-Subaie, A. M., Ashford, S., Attwood, A., Batista, J., Bouman, H., Burden, F., Choudry, F. A. & 39 others, Clarke, L., Flicek, P., Garner, S. F., Haimel, M., Kempster, C., Ladopoulos, V., Lenaerts, A-S., Materek, P. M., McKinney, H., Meacham, S., Mead, D., Nagy, M., Penkett, C. J., Rendon, A., Seyres, D., Sun, B., Tuna, S., van der Weide, M-E., Wingett, S. W., Martens, J. H., Stegle, O., Richardson, S., Vallier, L., Roberts, D. J., Freson, K., Wernisch, L., Stunnenberg, H. G., Danesh, J., Fraser, P., Soranzo, N., Butterworth, A. S., Heemskerk, J. W., Turro, E., Spivakov, M., Ouwehand, W. H., Astle, W. J., Downes, K., Kostadima, M. & Frontini, M., 13 Jul 2017, In : Nature Communications. 8, 12 p., 16058.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Platelet populations and priming in hematological diseases

Baaten, C. C. F. M. J., ten Cate, H., van der Meijden, P. E. J. & Heemskerk, J. W. M., Nov 2017, In : Blood Reviews. 31, 6, p. 389-399 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

Beck, F., Geiger, J., Gambaryan, S., Solari, F. A., Dell'Aica, M., Loroch, S., Mattheij, N. J., Mindukshev, I., Poetz, O., Jurk, K., Burkhart, J. M., Fufezan, C., Heemskerk, J. W. M., Walter, U., Zahedi, R. P. & Sickmann, A., 12 Jan 2017, In : Blood. 129, 2, p. E1-E12 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Use of microfluidics to assess the platelet-based control of coagulation

Nagy, M., Heemskerk, J. W. M. & Swieringa, F., 2017, In : Platelets. 28, 5, p. 441-448 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2016

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies

BRIDGE-BPD Consortium, Collaborators, Heemskerk, J., Henskens, Y. & Ouwehand, W. H., 2 Mar 2016, In : Science Translational Medicine. 8, 328, 15 p., 328ra30.

Research output: Contribution to journalArticleAcademicpeer-review

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

Simeoni, I., Stephens, J. C., Hu, F., Deevi, S. V. V., Megy, K., Bariana, T. K., Lentaigne, C., Schulman, S., Sivapalaratnam, S., Vries, M. J. A., Westbury, S. K., Greene, D., Papadia, S., Alessi, M-C., Attwood, A. P., Ballmaier, M., Baynam, G., Bermejo, E., Bertoli, M., Bray, P. F. & 59 others, Bury, L., Cattaneo, M., Collins, P., Daugherty, L. C., Favier, R., French, D. L., Furie, B., Gattens, M., Germeshausen, M., Ghevaert, C., Goodeve, A. C., Guerrero, J. A., Hampshire, D. J., Hart, D. P., Heemskerk, J. W. M., Henskens, Y. M. C., Hill, M., Hogg, N., Jolley, J. D., Kahr, W. H., Kelly, A. M., Kerr, R., Kostadima, M., Kunishima, S., Lambert, M. P., Liesner, R., Lopez, J. A., Mapeta, R. P., Mathias, M., Millar, C. M., Nathwani, A., Neerman-Arbez, M., Nurden, A. T., Nurden, P., Othman, M., Peerlinck, K., Perry, D. J., Poudel, P., Reitsma, P., Rondina, M. T., Smethurst, P. A., Stevenson, W., Szkotak, A., Tuna, S., van Geet, C., Whitehorn, D., Wilcox, D. A., Zhang, B., Revel-Vilk, S., Gresele, P., Bellissimo, D. B., Penkett, C. J., Laffan, M. A., Mumford, A. D., Rendon, A., Gomez, K., Freson, K., Ouwehand, W. H. & Turro, E., 9 Jun 2016, In : Blood. 127, 23, p. 2791-2803

Research output: Contribution to journalArticleAcademicpeer-review

Coated platelets function in platelet-dependent fibrin formation via integrin alpha(IIb)beta(3) and transglutaminase factor XIII

Mattheij, N. J. A., Swieringa, F., Mastenbroek, T. G., Berny-Lang, M. A., May, F., Baaten, C. C. F. M. J., van der Meijden, P. E. J., Henskens, Y. M. C., Beckers, E. A. M., Suylen, D. P. L., Nolte, M. W., Hackeng, T. M., McCarty, O. J. T., Heemskerk, J. W. M. & Cosemans, J. M. E. M., Apr 2016, In : Haematologica-the Hematology Journal. 101, 4, p. 427-436

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome

Solari, F. A., Mattheij, N. J. A., Burkhart, J. M., Swieringa, F., Collins, P. W., Cosemans, J. M. E. M., Sickmann, A., Heemskerk, J. W. M. & Zahedi, R. P., Oct 2016, In : Molecular & Cellular Proteomics. 15, 10, p. 3154-3169

Research output: Contribution to journalArticleAcademicpeer-review

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes

Gerdes, N., Seijkens, T., Lievens, D., Kuijpers, M. J. E., Winkels, H., Projahn, D., Hartwig, H., Beckers, L., Megens, R. T. A., Boon, L., Noelle, R. J., Soehnlein, O., Heemskerk, J. W. M., Weber, C. & Lutgens, E., Mar 2016, In : Arteriosclerosis Thrombosis and Vascular Biology. 36, 3, p. 482-490

Research output: Contribution to journalArticleAcademicpeer-review