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Joannes Luiken

Dr.

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Research Output 2003 2019

2019

AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M. & Schroen, B., 1 Mar 2019, In : Molecular Therapy - Nucleic Acids. 14, p. 424-437 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop

Liu, Y., Rodriguez-Calvo, R., Wang, S., Zhu, X., Broers, J. L. V., Glatz, J. F. C., Luiken, J. J. F. P. & Neumann, D., 23 Jan 2019, In : PLOS ONE. 14, 1, 14 p., 0210704.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pivotal role of membrane substrate transporters on the metabolic alterations in the pressure-overloaded heart

Geraets, I. M. E., Glatz, J. F. C., Luiken, J. J. F. P. & Nabben, M., 1 May 2019, In : Cardiovascular Research. 115, 6, p. 1000-1012 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2018

Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism

Papur, O. S., Sun, A., Glatz, J. F. C., Luiken, J. J. F. P. & Nabben, M., 7 Jun 2018, In : Frontiers in cardiovascular medicine. 5, 9 p., 65.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Assessing fatty acid oxidation flux in rodent cardiomyocyte models

Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B. & Nabben, M., 24 Jan 2018, In : Scientific Reports. 8, 6 p., 1505.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of AMPK-Stimulated Cellular Long-Chain Fatty Acid and Glucose Uptake

Luiken, J., Neumann, D., Glatz, J., Coumans, W., Chanda, D. & Nabben, M., 2018, AMPK Methods and Protocols. Neumann, D. & Viollet, B. (eds.). Humana Press, Vol. 1732. p. 343-361 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization

Glatz, J. F. C. & Luiken, J. J. F. P., 1 Jul 2018, In : Journal of Lipid Research. 59, 7, p. 1084-1093 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Fatty Acids Prevent Hypoxia-InducibleFactor-1aSignaling Through DecreasedSuccinate in Diabetes

Dodd, M. S., Fialho, M. D. L. S., Montes Aparicio, C. N., Kerr, M., Timm, K. N., Griffin, J. L., Luiken, J., Glatz, J., Tyler, D. J. & Heather, L. C., 2018, In : JACC: Basic to Translational Science. 3, 4, p. 485-498

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance

Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P. & Nabben, M., 1 May 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 5, p. 1960-1967 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Metabolic remodelling in heart failure revisited

Nabben, M., Luiken, J. J. F. P. & Glatz, J. F. C., 2018, In : Nature Reviews Cardiology. 15, 12, p. 780-780 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction

Liu, Y., Neumann, D., Glatz, J. F. C. & Luiken, J. J. F. P., Sep 2018, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 136, p. 131-141 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes

Chanda, D., Oligschlaeger, Y., Geraets, I., Liu, Y., Zhu, X., Li, J., Nabben, M., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C. & Neumann, D., 28 Apr 2017, In : Journal of Biological Chemistry. 292, 17, p. 7105-7114 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

A new leptin-mediated mechanism for stimulating fatty acid oxidation: a pivotal role for sarcolemmal FAT/CD36

Momken, I., Chabowski, A., Dirkx, E., Nabben, M., Jain, S. S., McFarlan, J. T., Glatz, J. F. C., Luiken, J. J. F. P. & Bonen, A., 1 Jan 2017, In : Biochemical Journal. 474, 1, p. 149-162 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

A two dimensional electromechanical model of a cardiomyocyte to assess intra-cellular regional mechanical heterogeneities

Garcia-Canadilla, P., Rodriguez, J. F., Palazzi, M. J., Gonzalez-Tendero, A., Schonleitner, P., Balicevic, V., Loncaric, S., Luiken, J. J. F. P., Ceresa, M., Camara, O., Antoons, G., Crispi, F., Gratacos, E. & Bijnens, B., 24 Aug 2017, In : PLOS ONE. 12, 8, 20 p., 0182915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations

Abdurrachim, D., Nabben, M., Hoerr, V., Kuhlmann, M. T., Bovenkamp, P., Ciapaite, J., Geraets, I. M. E., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., Schaefers, M., Nicolay, K., Faber, C., Hermann, S. & Prompers, J. J., 1 Aug 2017, In : Cardiovascular Research. 113, 10, p. 1148-1160 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

From fat to FAT (CD36/SR-B2): Understanding the regulation of cellular fatty acid uptake

Glatz, J. F. C. & Luiken, J. J. F. P., May 2017, In : Biochimie. 136, p. 21-26 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation

Mansor, L. S., Fialho, M. D. L. S., Yea, G., Coumans, W. A., West, J. A., Kerr, M., Carr, C. A., Luiken, J. J. F. P., Glatz, J. F. C., Evans, R. D., Griffin, J. L., Tyler, D. J., Clarke, K. & Heather, L. C., 1 Jun 2017, In : Cardiovascular Research. 113, 7, p. 737-748 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction

Liu, Y., Steinbusch, L. K. M., Nabben, M., Kapsokalyvas, D., van Zandvoort, M., Schonleitner, P., Antoons, G., Simons, P. J., Coumans, W. A., Geomini, A., Chanda, D., Glatz, J. F. C., Neumann, D. & Luiken, J. J. F. P., 1 Jun 2017, In : Diabetes. 66, 6, p. 1521-1534 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes

Rodriguez-Calvo, R., Chanda, D., Oligschlaeger, Y., Miglianico, M., Coumans, W. A., Barroso, E., Tajes, M., Luiken, J. J. F. P., Glatz, J. F. C., Vazquez-Carrera, M. & Neumann, D., May 2017, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1862, 5, p. 541-551 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016
2 Citations (Scopus)
4 Citations (Scopus)

Regulation of the subcellular trafficking of CD36, a major determinant of cardiac fatty acid utilization

Glatz, J. F. C., Nabben, M., Heather, L. C., Bonen, A. & Luiken, J. J. F. P., Oct 2016, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1861, 10, p. 1461-1471

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Signaling pathways involved in cardiac energy metabolism

Chanda, D., Luiken, J. J. F. P. & Glatz, J. F. C., Aug 2016, In : Febs Letters. 590, 15, p. 2364-2374

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

The interaction between AMPK beta 2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content

Oligschläger, Y., Miglianico, M., Dahlmans, V. E., Rubio-Villena, C., Chanda, D., Adelaida Garcia-Gimeno, M., Coumans, W. A., Liu, Y., Voncken, J. W., Luiken, J. J. F. P., Glatz, J. F. C., Sanz, P. & Neumann, D., 1 Apr 2016, In : Biochemical Journal. 473, 7, p. 937-947

Research output: Contribution to journalArticleAcademicpeer-review

2015
4 Citations (Scopus)

Cardiac contraction-induced GLUT4 translocation requires dual signaling input

Luiken, J. J. F. P., Glatz, J. F. C. & Neumann, D., Aug 2015, In : Trends in Endocrinology and Metabolism. 26, 8, p. 404-410

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats

Bonen, A., Jain, S. S., Snook, L. A., Han, X-X., Yoshida, Y., Buddo, K. H., Lally, J. S., Pask, E. D., Paglialunga, S., Beaudoin, M-S., Glatz, J. F. C., Luiken, J. J. F. P., Harasim, E., Wright, D. C., Chabowski, A. & Holloway, G. P., Oct 2015, In : Diabetologia. 58, 10, p. 2381-2391

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Fatty acids in cell signaling: Historical perspective and future outlook

Glatz, J. F. C. & Luiken, J. J. F. P., Jan 2015, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 92, p. 57-62

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Fatty acid transport and transporters in muscle are critically regulated by Akt2

Jain, S. S., Luiken, J. J. F. P., Snook, L. A., Han, X. X., Holloway, G. P., Glatz, J. F. C. & Bonen, A., 14 Sep 2015, In : Febs Letters. 589, 19, p. 2769-2775

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models

Abdurrachim, D., Luiken, J. J. F. P., Nicolay, K., Glatz, J. F. C., Prompers, J. J. & Nabben, M., 1 May 2015, In : Cardiovascular Research. 106, 2, p. 194-205

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Marine omega-3 fatty acids prevent myocardial insulin resistance and metabolic remodeling as induced experimentally by high insulin exposure

Franekova, V., Angin, Y., Hoebers, N. T. H., Coumans, W. A., Simons, P. J., Glatz, J. F. C., Luiken, J. J. F. P. & Larsen, T. S., 15 Feb 2015, In : American Journal of Physiology-Cell Physiology. 308, 4, p. C297-C307

Research output: Contribution to journalArticleAcademicpeer-review

2014
6 Citations (Scopus)

Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake

Angin, Y., Schwenk, R. W., Nergiz-Unal, R., Hoebers, N., Heemskerk, J. W. M., Kuijpers, M. J., Coumans, W. A., van Zandvoort, M. A. M. J., Bonen, A., Neumann, D., Glatz, J. F. C. & Luiken, J., 15 Jul 2014, In : American Journal of Physiology : Endocrinology and Metabolism. 307, 2, p. E225-E236

Research output: Contribution to journalArticleAcademicpeer-review

Control of myocardial fatty acid uptake

Glatz, J. & Luiken, J., 2014, Cardiac energy metabolism in health and disease. Advances in biochemistry in health and disease. Lopaschuk, G. D. & Dhalla, N. S. (eds.). 11 ed. New York: Springer

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2013
11 Citations (Scopus)

CD36 as a target to prevent cardiac lipotoxicity and insulin resistance

Glatz, J. F. C., Angin, Y., Steinbusch, L. K. M., Schwenk, R. W. & Luiken, J. J. F. P., Jan 2013, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 88, 1, p. 71-77

Research output: Contribution to journalArticleAcademicpeer-review

Differential Translocation of the Fatty Acid Transporter, FAT/CD36, and the Glucose Transporter, GLUT4, Coordinates Changes in Cardiac Substrate Metabolism During Ischemia and Reperfusion

Heather, L. C., Pates, K. M., Atherton, H. J., Cole, M. A., Ball, D. R., Evans, R. D., Glatz, J. F., Luiken, J. J., Griffin, J. L. & Clarke, K., Sep 2013, In : Circulation-Heart Failure. 6, 5, p. 1058-1066

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes

Steinbusch, L. K. M., Dirkx, E., Hoebers, N. T. H., Roelants, V., Foretz, M., Viollet, B., Diamant, M., van Eys, G., Ouwens, D. M., Bertrand, L., Glatz, J. F. C. & Luiken, J. J. F. P., Feb 2013, In : Journal of Molecular and Cellular Cardiology. 55, p. 165-173

Research output: Contribution to journalArticleAcademicpeer-review

2012
10 Citations (Scopus)

Caffeine-stimulated fatty acid oxidation is blunted in CD36 null mice

Lally, J. S. V., Jain, S. S., Han, X. X., Snook, L. A., Glatz, J. F. C., Luiken, J. J. F. P., McFarlan, J., Holloway, G. P. & Bonen, A., May 2012, In : Acta Physiologica. 205, 1, p. 71-81

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes

Angin, Y., Steinbusch, L. K. M., Simons, P. J., Greulich, S., Hoebers, N. T. H., Douma, K., van Zandvoort, M. A. M. J., Coumans, W. A., Wijnen, W., Diamant, M., Ouwens, D. M., Glatz, J. F. C. & Luiken, J. J. F. P., 15 Nov 2012, In : Biochemical Journal. 448, p. 43-53

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

In Vivo, Fatty Acid Translocase (CD36) Critically Regulates Skeletal Muscle Fuel Selection, Exercise Performance, and Training-induced Adaptation of Fatty Acid Oxidation

McFarlan, J. T., Yoshida, Y., Jain, S. S., Han, X-X., Snook, L. A., Lally, J., Smith, B. K., Glatz, J. F. C., Luiken, J. J. F. P., Sayer, R. A., Tupling, A. R., Chabowski, A., Holloway, G. P. & Bonen, A., 6 Jul 2012, In : Journal of Biological Chemistry. 287, 28, p. 23502-23516

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle

Jain, S. S., Snook, L. A., Glatz, J. F. C., Luiken, J. J. F. P., Holloway, G. P., Thurmond, D. C. & Bonen, A., 30 Jul 2012, In : Febs Letters. 586, 16, p. 2428-2435

Research output: Contribution to journalArticleAcademicpeer-review

Overexpression of Vesicle-associated Membrane Protein (VAMP) 3, but Not VAMP2, Protects Glucose Transporter (GLUT) 4 Protein Translocation in an in Vitro Model of Cardiac Insulin Resistance

Schwenk, R. W., Angin, Y., Steinbusch, L. K. M., Dirkx, E., Hoebers, N., Coumans, W. A., Bonen, A., Broers, J. L. V., van Eys, G. J. J. M., Glatz, J. F. C. & Luiken, J. J. F. P., 26 Oct 2012, In : Journal of Biological Chemistry. 287, 44, p. 37530-37539

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Protein Kinase D1 Is Essential for Contraction-induced Glucose Uptake but Is Not Involved in Fatty Acid Uptake into Cardiomyocytes

Dirkx, E., Schwenk, R. W., Coumans, W. A., Hoebers, N., Angin, Y., Viollet, B., Bonen, A., van Eys, G. J. J. M., Glatz, J. F. C. & Luiken, J. J. F. P., 17 Feb 2012, In : Journal of Biological Chemistry. 287, 8, p. 5871-5881

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser(315)

Dirkx, E., Cazorla, O., Schwenk, R. W., Lorenzen-Schmidt, I., Sadayappan, S., Van Lint, J., Carrier, L., van Eys, G. J. J. M., Glatz, J. F. C. & Luiken, J. J. F. P., Aug 2012, In : American Journal of Physiology-heart and Circulatory Physiology. 303, 3, p. H323-H331

Research output: Contribution to journalArticleAcademicpeer-review

2011

Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice

Steinbusch, L. K. M., Luiken, J. J. F. P., Vlasblom, R., Chabowski, A., Hoebers, N. T. H., Coumans, W. A., Vroegrijk, I. O. C. M., Voshol, P. J., Ouwens, D. M., Glatz, J. F. C. & Diamant, M., Oct 2011, In : American Journal of Physiology : Endocrinology and Metabolism. 301, 4, p. E618-E627

Research output: Contribution to journalArticleAcademicpeer-review

Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae

Simons, P. J., Kummer, J. A., Luiken, J. J. F. P. & Boon, L., 2011, In : Acta Histochemica. 113, 8, p. 839-843

Research output: Contribution to journalArticleAcademicpeer-review

High fat diet induced diabetic cardiomyopathy

Dirkx, E., Schwenk, R. W., Glatz, J. F. C., Luiken, J. J. F. P. & van Eys, G. J. J. M., Nov 2011, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 85, 5, p. 219-225

Research output: Contribution to journalArticleAcademicpeer-review

In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation

Holloway, G. P., Snook, L. A., Harris, R. J., Glatz, J. F. C., Luiken, J. J. F. P. & Bonen, A., Jan 2011, In : Journal of Physiology. 589, 1, p. 169-180

Research output: Contribution to journalArticleAcademicpeer-review

Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein

Nergiz-Unal, R., Lamers, M. M. E., Van Kruchten, R., Luiken, J. J., Cosemans, J. M. E. M., Glatz, J. F. C., Kuijpers, M. J. E. & Heemskerk, J. W. M., Sep 2011, In : Journal of Thrombosis and Haemostasis. 9, 9, p. 1835-1846

Research output: Contribution to journalArticleAcademicpeer-review

Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes

Steinbusch, L. K. M., Schwenk, R. W., Ouwens, D. M., Diamant, M., Glatz, J. F. C. & Luiken, J. J. F. P., Aug 2011, In : Cellular and Molecular Life Sciences. 68, 15, p. 2525-2538

Research output: Contribution to journalArticleAcademicpeer-review

2010

Adenosine Monophosphate-Activated Protein Kinase Activation, Substrate Transporter Translocation, and Metabolism in the Contracting Hyperthyroid Rat Heart

Heather, L. C., Cole, M. A., Atherton, H. J., Coumans, W. A., Evans, R. D., Tyler, D. J., Glatz, J. F. C., Luiken, J. J. F. P. & Clarke, K., Jan 2010, In : Endocrinology. 151, 1, p. 422-431

Research output: Contribution to journalArticleAcademicpeer-review

Differential regulation of cardiac glucose and fatty acid uptake by endosomal pH and actin filaments

Steinbusch, L. K. M., Wijnen, W., Schwenk, R. W., Coumans, W. A., Hoebers, N. T. H., Ouwens, D. M., Hoebers, N. T. H., Diamant, M., Bonen, A., Glatz, J. F. C. & Luiken, J. J. F. P., Jun 2010, In : American Journal of Physiology-Cell Physiology. 298, 6, p. C1549-C1559

Research output: Contribution to journalArticleAcademicpeer-review