20072019

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Article
2019

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Iglesias, V. S., van Hoof, S. J., Vaniqui, A., Schyns, L. E., Lieuwes, N., Yaromina, A., Spiegelberg, L., Groot, A. J., Verhaegen, F., Theys, J., Dubois, L. & Vooijs, M., 2019, In : British Journal of Radiology. 92, 1095, 10 p., 20180476.

Research output: Contribution to journalArticleAcademicpeer-review

Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity

Spiegelberg, L., van Hoof, S. J., Biemans, R., Lieuwes, N. G., Marcus, D., Niemans, R., Theys, J., Yaromina, A., Lambin, P., Verhaegen, F. & Dubois, L. J., Dec 2019, In : Radiotherapy and Oncology. 141, p. 247-255 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Spiegelberg, L., Houben, R., Niemans, R., de Ruysscher, D., Yaromina, A., Theys, J., Guise, C. P., Smaill, J. B., Patterson, A. V., Lambin, P. & Dubois, L. J., Feb 2019, In : Clinical and Translational Radiation Oncology. 15, p. 62-69 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Jutten, B., Keulers, T. G., Peeters, H. J. M., Schaaf, M. B. E., Savelkouls, K. G. M., Compter, I., Clarijs, R., Schijns, O. E. M. G., Ackermans, L., Teernstra, O. P. M., Zonneveld, M. I., Colaris, R. M. E., Dubois, L., Vooijs, M. A., Bussink, J., Sotelo, J., Theys, J., Lammering, G. & Rouschop, K. M. A., 1 Jan 2018, In : Autophagy. 14, 2, p. 283-295 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma

Narayan, R. S., Gasol, A., Slangen, P. L. G., Cornelissen, F. M. G., Lagerweij, T., Veldman, H. Y. Y. E., Dik, R., van den Berg, J., Slotman, B. J., Wurdinger, T., Haas-Kogan, D. A., Stalpers, L. J. A., Baumert, B. G., Westerman, B. A., Theys, J. & Sminia, P., 1 Feb 2018, In : Molecular Cancer Therapeutics. 17, 2, p. 347-354 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic Effects of NOTCH/gamma-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

Iglesias, V. S., Theys, J., Groot, A. J., Barbeau, L. M. O., Lemmens, A., Yaromina, A., Losen, M., Houben, R., Dubois, L. & Vooijs, M., 7 Nov 2018, In : Frontiers in Oncology. 8, 13 p., 460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress

Mowday, A. M., Guise, C. P., Ackerley, D. F., Minton, N. P., Lambin, P., Dubois, L. J., Theys, J., Smaill, J. B. & Patterson, A. V., Jul 2016, In : Cancers. 8, 7, 63.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in LdIr(-/-) Mice

Jeurissen, M. L. J., Walenbergh, S. M. A., Houben, T., Hendrikx, T., Li, J., Oligschläger, Y., van Gorp, P. J., Gijbels, M. J. J., Bitorina, A., Nessel, I., Radtke, F., Vooijs, M., Theys, J. & Shiri-Sverdlov, R., 29 Nov 2016, In : PLOS ONE. 11, 11, e0167199.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B. P., Theys, J., Short, S. C., Verhaegen, F. & Vooijs, M., 5 Jul 2016, In : Oncotarget. 7, 27, p. 41251-41264

Research output: Contribution to journalArticleAcademicpeer-review

Targeting Notch to overcome radiation resistance

Yahyanejad, S., Theys, J. & Vooijs, M., 16 Feb 2016, In : Oncotarget. 7, 7, p. 7610-7628

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2015

An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response

Yahyanejad, S., van Hoof, S. J., Theys, J., Barbeau, L. M. O., Granton, P. V., Paesmans, K., Verhaegen, F. & Vooijs, M., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 467-472

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Clostridium to treat cancer: dream or reality?

Theys, J. & Lambin, P., 2015, In : Annals of translational medicine. 3, Suppl 1, p. S21

Research output: Contribution to journalArticleAcademicpeer-review

Complementary Use of Bioluminescence Imaging and Contrast-Enhanced Micro-Computed Tomography in an Orthotopic Brain Tumor Model

Yahyanejad, S., Granton, P. V., Lieuwes, N. G., Gilmour, L., Dubois, L., Theys, J., Chalmers, A. J., Verhaegen, F. & Vooijs, M., Mar 2015, In : Molecular Imaging. 14

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Complete Genome Sequence of the Nonpathogenic Soil-Dwelling Bacterium Clostridium sporogenes Strain NCIMB 10696

Kubiak, A. M., Poehlein, A., Budd, P., Kuehne, S. A., Winzer, K., Theys, J., Lambin, P., Daniel, R. & Minton, N. P., 2015, In : Genome Announcements. 3, 4, e00942-15.

Research output: Contribution to journalArticleAcademicpeer-review

High dose rate and flattening filter free irradiation can be safely implemented in clinical practice

Dubois, L., Biemans, R., Reniers, B., Bosmans, G., Trani, D., Podesta, M., Kollaard, R., Rouschop, K. M. A., Theys, J., Vooijs, M., Pruschy, M., Verhaegen, F. & Lambin, P., 3 Oct 2015, In : International Journal of Radiation Biology. 91, 10, p. 778-785

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2014

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

Groot, A. J., Habets, R., Yahyanejad, S., Hodin, C. M., Reiss, K., Saftig, P., Theys, J. & Vooijs, M., Aug 2014, In : Molecular and Cellular Biology. 34, 15, p. 2822-2832

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo

Heap, J. T., Theys, J., Ehsaan, M., Kubiak, A. M., Dubois, L., Paesmans, K., Van Mellaert, L., Knox, R., Kuehne, S. A., Lambin, P. & Minton, N. P., Apr 2014, In : Oncotarget. 5, 7, p. 1761-1769

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
2013

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

Jutten, B., Keulers, T. G., Schaaf, M. B. E., Savelkouls, K., Theys, J., Span, P. N., Vooijs, M. A., Bussink, J. & Rouschop, K. M. A., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 479-483

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

High NOTCH activity induces radiation resistance in non small cell lung cancer

Theys, J., Yahyanejad, S., Habets, R., Span, P., Dubois, L., Paesmans, K., Kattenbeld, B., Cleutjens, J., Groot, A. J., Schuurbiers, O. C. J., Lambin, P., Bussink, J. & Vooijs, M., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 440-445

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2011

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Theys, J., Jutten, B., Habets, R., Paesmans, K., Groot, A. J., Lambin, P., Wouters, B. G., Lammering, G. & Vooijs, M., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 392-397

Research output: Contribution to journalArticleAcademicpeer-review

2010

Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability.

Schults, M. A. C., Timmermans, L., Godschalk, R. W. L., Theys, J., Wouters, B. G., van Schooten, F. J. & Chiu, R. K., 1 Jan 2010, In : Journal of Biological Chemistry. 285, 19, p. 14558-14564

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)
2009

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment.

Theys, J., Jutten, B., Dubois, L. J., Rouschop, K. M. A., Chiu, R. K., Li, Y., Paesmans, K., Lambin, P., Lammering, G. & Wouters, B. G., 1 Jan 2009, In : Radiotherapy and Oncology. 92, 3, p. 399-404

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)
2007

Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity

Langie, S. A., Knaapen, A. M., Ramaekers, C. H. M. A., Theys, J., Brun, J., Godschalk, R. W., van Schooten, F. J., Lambin, P., Gray, D. A., Wouters, B. G. & Chiu, R. K., 1 Jan 2007, In : Dna Repair. 6, 6, p. 852-862

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)