20032019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 88 Article
  • 5 Review article
  • 2 Comment/Letter to the editor
  • 1 Doctoral Thesis
2019

Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer

Panova-Noeva, M., Neu, M. A., Eckerle, S., Spix, C., Schneider, A., Schmidtmann, I., Spronk, H. M., Pfeiffer, N., Beutel, M., Lackner, K. J., Muenzel, T., ten Cate, H., Merzenich, H., Faber, J. & Wild, P. S., Apr 2019, In : Clinical research in cardiology. 108, 4, p. 438-447 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of the PAR-1 Antagonist Vorapaxar on Platelet Activation and Coagulation Biomarkers in Patients with Stable Coronary Artery Disease

Olie, R. H., van der Meijden, P. E. J., Spronk, H. M. H., van Oerle, R., Barvik, S., Bonarjee, V. V. S., Ten Cate, H. & Nilsen, D. W. T., Jul 2019, In : TH open : companion journal to thrombosis and haemostasis. 3, 3, p. e259-e262 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access

Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils

Heestermans, M., Salloum-Asfar, S., Streef, T., Laghmani, E. H., Salvatori, D., Luken, B. M., Zeerleder, S. S., Spronk, H. M. H., Korporaal, S. J., Kirchhofer, D., Wagenaar, G. T. M., Versteeg, H. H., Reitsma, P. H., Renne, T. & van Vlijmen, B. J. M., 9 May 2019, In : Blood. 133, 19, p. 2090-2099 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes

Posthuma, J. J., Posma, J. J. N., Schep, G., Bender, M. M. H., van Oerle, R., van der Wal, A. C., Ten Cate, H. & Spronk, H. M. H., Apr 2019, In : Journal of Vascular Surgery. 69, 4, p. 1243-1250 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a population-based sample

Panova-Noeva, M., Wagner, B., Nagler, M., Arnold, N., Prochaska, J. H., Eckerle, S., Spronk, H. M., Merzenich, H., Wingerter, A., Schneider, A., Danckwardt, S., ten Cate, H., Faber, J. & Wild, P. S., 27 Dec 2019, In : Scientific Reports. 9, 9 p., 20090.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases

Posma, J. J., Grover, S. P., Hisada, Y., Owens, A. P., Antoniak, S., Spronk, H. M. & Mackman, N., Jan 2019, In : Arteriosclerosis Thrombosis and Vascular Biology. 39, 1, p. 13-24 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease

Kremers, B. M. M., Birocchi, S., van Oerle, R., Zeerleder, S., Spronk, H. M. H., Mees, B. M. E., Luken, B. M., ten Cate, H. & ten Cate-Hoek, A. J., 2 Apr 2019, In : Frontiers in cardiovascular medicine. 6, p. 1-11 11 p., 33.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice

Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H. & Spronk, H. M. H., 7 Mar 2019, In : Scientific Reports. 9, 9 p., 3909.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Use of "C9/11 Mismatch" Control Small Interfering RNA Reveals Sequence-Related Off-Target Effect on Coagulation of an Small Interfering RNA Targeting Mouse Coagulation Factor XII

Heestermans, M., de Jong, A., van Tilburg, S., Reitsma, P. H., Versteeg, H. H., Spronk, H. M. & van Vlijmen, B. J. M., Aug 2019, In : Nucleic Acid Therapeutics. 29, 4, p. 218-223 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution

Grottke, O., van Ryn, J., Zentai, C., Gan, G., Honickel, M., Rossaint, R., Ten Cate, H. & Spronk, H. M. H., 7 Jan 2019, In : PLOS ONE. 14, 1, p. e0209350 15 p., 0209350.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis

Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., Asquith, N. & 43 others, Heemskerk, J., Heinzmann, A., Moorlag, M., Mackman, N., van der Meijden, P., Meijers, J. C. M., Heestermans, M., Renne, T., Dolleman, S., Chayoua, W., Ariens, R. A. S., Baaten, C. C., Nagy, M., Kuliopulos, A., Posma, J. J., Harrison, P., Vries, M. J., Crijns, H. J. G. M., Dudink, E. A. M. P., Buller, H. R., Henskens, Y. M. C., Sjalander, A., Zwaveling, S., Erkuner, O., Eikelboom, J. W., Gulpen, A., Peeters, F. E. C. M., Douxfils, J., Olie, R. H., Baglin, T., Leader, A., Schotten, U., Scaf, B., van Beusekom, H. M. M., Mosnier, L. O., van der Vorm, L., Declerck, P., Visser, M., Dippel, D. W. J., Strijbis, V. J., Pertiwi, K., ten Cate-Hoek, A. J. & ten Cate, H., 1 Feb 2018, In : Thrombosis and Haemostasis. 118, 2, p. 229-250 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2

Tilburg, J., Adili, R., Nair, T. S., Hawley, M. E., Tuk, D. C., Jackson, M., Spronk, H. M., Versteeg, H. H., Carey, T. E., van Vlijmen, B. J. M., Maracle, C. X. & Holinstat, M., Nov 2018, In : Thrombosis Research. 171, p. 155-159 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study

Panova-Noeva, M., Schulz, A., Spronk, H. M., Beicht, A., Laubert-Reh, D., van Oerle, R., Arnold, N., Prochaska, J. H., Blettner, M., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., ten Cate, H. & Wild, P. S., 1 May 2018, In : Thrombosis and Haemostasis. 118, 5, p. 873-882 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Coagulation and inflammation in long-term cancer survivors: results from the adult population

Panova-Noeva, M., Schulz, A., Arnold, N., Hermanns, M. I., Prochaska, J. H., Laubert-Reh, D., Spronk, H. M., Blettner, M., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., ten Cate, H. & Wild, P. S., 1 Apr 2018, In : Journal of Thrombosis and Haemostasis. 16, 4, p. 699-708 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients

Mackman, N., Spronk, H. M. H., Stouffer, G. A. & ten Cate, H., 1 Apr 2018, In : Arteriosclerosis Thrombosis and Vascular Biology. 38, 4, p. 726-732 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Inhibitory mechanisms of very low-dose rivaroxaban in non-ST-elevation myocardial infarction

Borst, O., Munzer, P., Alnaggar, N., Geue, S., Tegtmeyer, R., Rath, D., Droppa, M., Seizer, P., Heitmeier, S., Heemskerk, J. W. M., Jennings, L. K., Storey, R. F., Angiolillo, D. J., Rocca, B., Spronk, H., Ten Cate, H., Gawaz, M. & Geisler, T., 27 Mar 2018, In : Blood advances. 2, 6, p. 715-730 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study

Eggebrecht, L., Prochaska, J. H., Schulz, A., Arnold, N., Juenger, C., Goebel, S., Laubert-Reh, D., Binder, H., Beutel, M. E., Pfeiffer, N., Blankenberg, S., Lackner, K. J., Spronk, H. M., ten Cate, H., Muenzel, T. & Wild, P. S., 4 Sep 2018, In : Journal of the American Heart Association. 7, 17, 25 p., 008650.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrating platelet and coagulation activation in fibrin clot formation

Swieringa, F., Spronk, H. M. H., Heemskerk, J. W. M. & van der Meijden, P. E. J., Jul 2018, In : Research and practice in thrombosis and haemostasis. 2, 3, p. 450-460 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

No Association between Thrombin Generation and Intra-Plaque Haemorrhage in Symptomatic Carotid Atherosclerotic Plaques: The Plaque at RISK (PARISK) Study

Crombag, G. A. J. C., Spronk, H. M., Nelemans, P., Schreuder, F. H. B. M., Truijman, M. T. B., van Dijk, A. C., de Rotte, A. A. J., Liem, M. I., Daemen, M. J. A. P., van der Steen, A. F. W., Mess, W. H., Nederkoorn, P. J., Hendrikse, J., van der Lugt, A., Wildberger, J. E., ten Cate, H., van Oostenbrugge, R. J. & Kooi, M. E., 1 Aug 2018, In : Thrombosis and Haemostasis. 118, 8, p. 1461-1469 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study

Mulder, B. A., Geelhoed, B., van der Harst, P., Spronk, H. M., Van Gelder, I. C., Asselbergs, F. W. & Rienstra, M., 1 Dec 2018, In : International Journal of Cardiology. 272, p. 208-210 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pleiotropic effects of the hemostatic system

Kremers, B. M. M., Ten Cate, H. & Spronk, H. M. H., 1 Aug 2018, In : Journal of Thrombosis and Haemostasis. 16, 8, p. 1464-1473 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Tissue factor (:Factor VIIa) in the heart and vasculature: More than an envelope

D'Alessandro, E., Posma, J. J. N., Spronk, H. M. H. & ten Cate, H., 1 Aug 2018, In : Thrombosis Research. 168, p. 130-137 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2017

Dose requirements for idarucizumab reversal of dabigatran in a lethal porcine trauma model with continuous bleeding

Honickel, M., Spronk, H. M., Rossaint, R., Stoppe, C., van Ryn, J., ten Cate, H. & Grottke, O., Jul 2017, In : Thrombosis and Haemostasis. 117, 7, p. 1370-1378 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation

Spronk, H. M. H., De Jong, A. M., Verheule, S., De Boer, H. C., Maass, A. H., Lau, D. H., Rienstra, M., van Hunnik, A., Kuiper, M., Lumeij, S., Zeemering, S., Linz, D., Kamphuisen, P. W., ten Cate, H., Crijns, H. J., Van Gelder, I. C., van Zonneveld, A. J. & Schotten, U., 1 Jan 2017, In : European Heart Journal. 38, 1, p. 38-50 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
66 Downloads (Pure)

Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study

Kleinegris, M-C. F., Konings, J., Daemen, J. W., Henskens, Y., de Laat, B., Spronk, H. M. H., ten Cate-Hoek, A. J. & ten Cate, H., 20 Apr 2017, In : Frontiers in cardiovascular medicine. 4, 10 p., 23.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability

Panova-Noeva, M., Arnold, N., Hermanns, M. I., Prochaska, J. H., Schulz, A., Spronk, H. M., Binder, H., Pfeiffer, N., Beutel, M., Blankenberg, S., Zeller, T., Lotz, J., Muenzel, T., Lackner, K. J., ten Cate, H. & Wild, P. S., 6 Jan 2017, In : Scientific Reports. 7, 8 p., 40229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prethrombotic State in Young Very Low- Risk Patients With Atrial Fibrillation

Hobbelt, A. H., Spronk, H. M., Crijns, H. J. G. M., Ten Cate, H., Rienstra, M. & Van Gelder, I. C., 18 Apr 2017, In : Journal of the American College of Cardiology. 69, 15, p. 1990-1992 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2016

Coagulation and non-coagulation effects of thrombin

Posma, J. J. N., Posthuma, J. J. & Spronk, H. M. H., Oct 2016, In : Journal of Thrombosis and Haemostasis. 14, 10, p. 1908-1916

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Effects of Fibrinogen Concentrate on Thrombin Generation, Thromboelastometry Parameters, and Laboratory Coagulation Testing in a 24-Hour Porcine Trauma Model

Zentai, C., Solomon, C., van der Meijden, P. E. J., Spronk, H. M. H., Schnabel, J., Rossaint, R. & Grottke, O., Nov 2016, In : Clinical and Applied Thrombosis-Hemostasis. 22, 8, p. 749-759

Research output: Contribution to journalArticleAcademicpeer-review

Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events

Loeffen, R. A., van Oerle, R., Leers, M. P. G., Kragten, J. A., Crijns, H., Spronk, H. M. H. & ten Cate, H., 15 Jul 2016, In : PLOS ONE. 11, 7, 16 p., e0158355.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hemostatic Therapy Using Tranexamic Acid and Coagulation Factor Concentrates in a Model of Traumatic Liver Injury

Zentai, C., van der Meijden, P. E. J., Braunschweig, T., Hueck, N., Honickel, M., Spronk, H. M. H., Rossaint, R. & Grottke, O., Jul 2016, In : Anesthesia and Analgesia. 123, 1, p. 38-48

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma

van Beers, J. J. B. C., van Egmond, L. T., Wetzels, R. J. H., Verhezen, P. W. M., Beckers, E. A. M., van Oerle, R., Spronk, H. M. H., Straat, R. J. M. H. E. & Henskens, Y. M. C., Jul 2016, In : Vox Sanguinis. 111, 1, p. 33-42

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice

Heestermans, M., Salloum-Asfar, S., Salvatori, D., Laghmani, E. H., Luken, B. M., Zeerleder, S. S., Spronk, H. M. H., Korporaal, S. J., Wagenaar, G. T. M., Reitsma, P. H. & van Vlijmen, B. J. M., 26 May 2016, In : Blood. 127, 21, p. 2630-2637

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study

Panova-Noeva, M., Schulz, A., Hermanns, M. I., Grossmann, V., Pefani, E., Spronk, H. M. H., Laubert-Reh, D., Binder, H., Beutel, M., Pfeiffer, N., Blankenberg, S., Zeller, T., Muenzel, T., Lackner, K. J., ten Cate, H. & Wild, P. S., 14 Jan 2016, In : Blood. 127, 2, p. 251-259

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Therapy with activated prothrombin complex concentrate is effective in reducing dabigatran-associated blood loss in a porcine polytrauma model

Honickel, M., Maron, B., van Ryn, J., Braunschweig, T., ten Cate, H., Spronk, H. M. H., Rossaint, R. & Grottke, O., Feb 2016, In : Thrombosis and Haemostasis. 115, 2, p. 271-284

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Toll-like receptor 9 gene expression in the post-thrombotic syndrome, residual thrombosis and recurrent deep venous thrombosis: A case-control study

Cheung, Y. W., Bouman, A. C., Castoldi, E., Wielders, S. J., Spronk, H. M. H., ten Cate, H., Hoek - ten Cate, A. & ten Wolde, M., Apr 2016, In : Thrombosis Research. 140, p. 106-109

Research output: Contribution to journalArticleAcademicpeer-review

Validation of a modified thromboelastometry approach to detect changes in fibrinolytic activity

Kuiper, G-J., Kleinegris, M-C., van Oerle, R., Spronk, H., Lance, M., ten Cate, H. & Henskens, Y., 14 Jan 2016, In : Thrombosis Journal. 14, 13 p., 1.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)
2015

Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study

Loeffen, R., Winckers, K., Ford, I., Jukema, J. W., Robertson, M., Stott, D. J., Spronk, H. M., ten Cate, H. & Lowe, G. D., Aug 2015, In : Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 70, 8, p. 982-988

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study

Hermanns, M. I., Grossmann, V., Spronk, H. M. H., Schulz, A., Juenger, C., Laubert-Reh, D., Mazur, J., Gori, T., Zeller, T., Pfeiffer, N., Beutel, M., Blankenberg, S., Muenzel, T., Lackner, K. J., Hoek - ten Cate, A. J., ten Cate, H. & Wild, P. S., 6 May 2015, In : International Journal of Cardiology. 187, p. 166-174

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Idarucizumab, a Specific Dabigatran Reversal Agent, Reduces Blood Loss in a Porcine Model of Trauma With Dabigatran Anticoagulation

Grottke, O., Honickel, M., van Ryn, J., ten Cate, H., Rossaint, R. & Spronk, H. M., 29 Sep 2015, In : Journal of the American College of Cardiology. 66, 13, p. 1518-1519

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Prothrombin Complex Concentrate Is Effective in Treating the Anticoagulant Effects of Dabigatran in a Porcine Polytrauma Model

Honickel, M., Braunschweig, T., van Ryn, J., ten Cate, H., Spronk, H. M. H., Rossaint, R. & Grottke, O., Dec 2015, In : Anesthesiology. 123, 6, p. 1350-1361

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Recombinant Factor VIIa Reduces Bleeding after Blunt Liver Injury in a Pig Model of Dilutional Coagulopathy under Severe Hypothermia

Spronk, H. M. H., Braunschweig, T., Rossaint, R., Wuest, D. C., van Oerle, R., Lauritzen, B., Tolba, R. & Grottke, O., 22 Jun 2015, In : PLOS ONE. 10, 6, e0113979.

Research output: Contribution to journalArticleAcademicpeer-review

Short- and Long-term exercise induced alterations in haemostasis: a review of the literature

Posthuma, J. J., van der Meijden, P. E. J., ten Cate, H. & Spronk, H. M. H., May 2015, In : Blood Reviews. 29, 3, p. 171-178

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

The hypercoagulable profile of patients with stent thrombosis

Loeffen, R., Godschalk, T. C., van Oerle, R., Spronk, H. M. H., Hackeng, C. M., ten Berg, J. M. & ten Cate, H., 15 Jul 2015, In : Heart. 101, 14, p. 1126-1132

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Theme 2: Epidemiology, Biomarkers, and Imaging of Venous Thromboembolism (and postthrombotic syndrome)

Spronk, H. M. H., Cannegieter, S., Morange, P., Hackeng, T., Huisman, M., Nagler, M., Posthuma, J., Ninivaggi, M., Zwaveling, S., van der Hulle, T., Scheres, L. J. J., van Mens, T. E. & Mackman, N., Sep 2015, In : Thrombosis Research. 136, p. S8-S12

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2014

Cirrhosis patients have a coagulopathy that is associated with decreased clot formation capacity

Kleinegris, M. C., Bos, M. H., Roest, M., Henskens, Y., Ten Cate-Hoek, A., Van Deursen, C., Spronk, H. M., Reitsma, P. H., De Groot, P. G., ten Cate, H. & Koek, G., Oct 2014, In : Journal of Thrombosis and Haemostasis. 12, 10, p. 1647-1657 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)