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Research Output 2000 2019

2019

Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse

Kneppers, A., Leermakers, P., Pansters, N., Backx, E., Gosker, H., van Loon, L., Schols, A., Langen, R. & Verdijk, L., Jan 2019, In : Faseb Journal. 33, 1, p. 1288-1298 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease

Gosker, H. R., Clarke, G., de Theije, C. C., Cryan, J. E. & Schols, A. M. W. J., Jul 2019, In : Journal of Clinical Medicine. 8, 7, 7 p., 915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both?

Pelgrim, C. E., Peterson, J. D., Gosker, H. R., Schols, A. M. W. J., van Helvoort, A., Garssen, J., Folkerts, G. & Kraneveld, A. D., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 99-110 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access
2018
78 Downloads (Pure)

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

van Beers, M., Janssen, D. J. A., Gosker, H. R. & Schols, A. M. W. J., 2 Dec 2018, In : Expert Review of Respiratory Medicine. 12, 12, p. 1061-1074 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File
Open Access
Open Access

Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope?

Beijers, R. J. H. C. G., Gosker, H. R. & Schols, A. M. W. J., Mar 2018, In : Current Opinion in Clinical Nutrition and Metabolic Care. 21, 2, p. 138-144 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
52 Downloads (Pure)
Open Access
File

Unbiased analysis of skeletal muscle molecular responses upon pulmonary rehabilitation in advanced COPD

Kneppers, A., Haast, R., Langen, R., Verdijk, L., Leermakers, P., Gosker, H., Van Loon, L., Lainscak, M. & Schols, A., 15 Sep 2018, In : European Respiratory Journal. 52, S62, 2 p., OA1622.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

2017

Inactivation of glycogen synthase kinase-3 beta (GSK-3 beta) enhances skeletal muscle oxidative metabolism

Theeuwes, W. F., Gosker, H. R., Langen, R. C. J., Verhees, K. J. P., Pansters, N. A. M., Schols, A. M. W. J. & Remels, A. H. V., Dec 2017, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1863, 12, p. 3075-3086 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

46 Downloads (Pure)

Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia

Kneppers, A. E. M., Langen, R. C. J., Gosker, H. R., Verdijk, L. B., Lipovec, N. C., Leermakers, P. A., Kelders, M. C. J. M., de Theije, C. C., Omersa, D., Lainscak, M. & Schols, A. M. W. J., 1 Jul 2017, In : Journal of the American Medical Directors Association. 18, 7, p. 637.e1-637.e11 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

The development and validation of the Bronchiectasis Health Questionnaire

Spinou, A., Siegert, R. J., Guan, W., Patel, A. S., Gosker, H. R., Lee, K. K., Elston, C., Loebinger, M. R., Wilson, R., Garrod, R. & Birring, S. S., May 2017, In : European Respiratory Journal. 49, 5, 11 p., 1601532.

Research output: Contribution to journalArticleAcademicpeer-review

2016
2 Citations (Scopus)
23 Downloads (Pure)

Alterations in Skeletal Muscle Oxidative Phenotype in Mice Exposed to 3 Weeks of Normobaric Hypoxia

Slot, I. G. M., Schols, A. M. W. J., De Theije, C. C., Snepvangers, F. J. M. & Gosker, H. R., Feb 2016, In : Journal of Cellular Physiology. 231, 2, p. 377-392

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)

Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay

dos Santos, C., Hussain, S. N. A., Mathur, S., Picard, M., Herridge, M., Correa, J., Bain, A., Guo, Y., Advani, A., Advani, S. L., Tomlinson, G., Katzberg, H., Streutker, C. J., Cameron, J. I., Schols, A., Gosker, H. R. & Batt, J., 1 Oct 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 7, p. 821-830

Research output: Contribution to journalArticleAcademicpeer-review

19 Downloads (Pure)

Skeletal muscle mitophagy in chronic disease: implications for muscle oxidative capacity?

Leermakers, P. A. & Gosker, H. R., Nov 2016, In : Current Opinion in Clinical Nutrition and Metabolic Care. 19, 6, p. 427-433

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

VALIDATION OF THE KING'S SARCOIDOSIS QUESTIONNAIRE (KSQ) IN A DUTCH SARCOIDOSIS POPULATION

van Manen, M. J. G., Wapenaar, M., Strookappe, B., Drent, M., Elfferich, M., de Vries, J., Gosker, H. R., Birring, S. S., Patel, A. S., van den Toorn, L., van den Blink, B., Boomars, K., Hoitsma, E. & Wijsenbeek, M. S., 2016, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 33, 1, p. 75-82

Research output: Contribution to journalArticleAcademicpeer-review

2015
13 Citations (Scopus)

Differential sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy

de Theije, C. C., Langen, R. C., Lamers, W. H., Gosker, H. R., Schols, A. M. & Koehler, S. E., 15 Jan 2015, In : Journal of Applied Physiology. 118, 2, p. 200-211 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Effect of chronic hypoxia on RAGE and its soluble forms in lungs and plasma of mice

Gopal, P., Gosker, H. R., de Theije, C. C., Eurlings, I., Sell, D. R., Monnier, V. M. & Reynaert, N. L., May 2015, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1852, 5, p. 992-1000 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Impaired exercise training-induced muscle fiber hypertrophy and Akt/mTOR pathway activation in hypoxemic patients with COPD

Costes, F., Gosker, H. R., Feasson, L., Desgeorges, M., Kelders, M. C., Castells, J., Schols, A. M. & Freyssenet, D. G., 15 Apr 2015, In : Journal of Applied Physiology. 118, 8, p. 1040-1049 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Preserved muscle oxidative metabolic phenotype in newly diagnosed non-small cell lung cancer cachexia

Op den Kamp, C. M., Gosker, H. R., Lagarde, S., Tan, D. Y., Snepvangers, F. J., Dingemans, A-M. C., Langen, R. C. J. & Schols, A. M. W. J., Jun 2015, In : Journal of cachexia, sarcopenia and muscle. 6, 2, p. 164-173

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Rasch analysis and impact factor methods both yield valid and comparable measures of health status in interstitial lung disease

Patel, A. S., Siegert, R. J., Bajwah, S., Brignall, K., Gosker, H. R., Moxham, J., Maher, T. M., Renzoni, E. A., Wells, A. U., Higginson, I. J. & Birring, S. S., Sep 2015, In : Journal of Clinical Epidemiology. 68, 9, p. 1019-1027 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

TNF-alpha-Induced NF-kappa B Activation Stimulates Skeletal Muscle Glycolytic Metabolism Through Activation of HIF-1 alpha

Remels, A., Gosker, H., Koen Verhees, K. J. P., Langen, R. & Schols, A., 2015, In : Endocrinology. 156, 5, p. 1770-1781

Research output: Contribution to journalArticleAcademicpeer-review

2014
3 Citations (Scopus)

Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype.

Remels, A. H., Pansters, N. A. M., Gosker, H. R., Schols, A. M. & Langen, R. C., Mar 2014, In : American Journal of Physiology : Endocrinology and Metabolism. 306, 6, p. E615-E626 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

151 Citations (Scopus)

An official american thoracic society/european respiratory society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease

Maltais, F., Decramer, M., Casaburi, R., Barreiro, E., Burelle, Y., Debigare, R., Dekhuijzen, P. N., Franssen, F., Gayan-Ramirez, G., Gea, J., Gosker, H. R., Gosselink, R., Hayot, M., Hussain, S. N., Janssens, W., Polkey, M. I., Roca, J., Saey, D., Schols, A. M., Spruit, M. A. & 5 others, Steiner, M., Taivassalo, T., Troosters, T., Vogiatzis, I. & Wagner, P. D., 1 Jan 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 9, p. e15-62

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

Eurlings, I. M. J., Reynaert, N. L., van den Beucken, T., Gosker, H. R., de Theije, C. C., Verhamme, F. M., Bracke, K. R., Wouters, E. F. M. & Dentener, M. A., 16 Oct 2014, In : PLOS ONE. 9, 10, 11 p., e107757.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Classical NF-kappaB activation impairs skeletal muscle oxidative phenotype by reducing IKK-alpha expression

Remels, A. H., Gosker, H. R., Langen, R. C., Polkey, M., Sliwinski, P., Galdiz, J., van den Borst, B., Pansters, N. A. M. & Schols, A. M., Feb 2014, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1842, 2, p. 175-185 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Dietary fibre and fatty acids in chronic obstructive pulmonary disease risk and progression: a systematic review.

Fonseca Wald, E. L., van den Borst, B., Gosker, H. R. & Schols, A. M., Feb 2014, In : Respirology. 19, 2, p. 176-184 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Hypoxia differentially regulates muscle oxidative fiber type and metabolism in a HIF-1α-dependent manner

Slot, I. G., Schols, A. M. W. J., Vosse, B. A., Kelders, M. C. & Gosker, H. R., 1 Jan 2014, In : Cellular Signalling. 26, 9, p. 1837-1845

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

Schols, A. M., Ferreira, I. M., Franssen, F., Gosker, H. R., Janssens, W., Muscaritoli, M., Pison, C., Rutten-van Mölken, M. P. M. H., Slinde, F., Steiner, M. C., Tkacova, R. & Singh, S. J., Dec 2014, In : European Respiratory Journal. 44, 6, p. 1504-1520 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

The Muscle Oxidative Regulatory Response to Acute Exercise Is Not Impaired in Less Advanced COPD Despite a Decreased Oxidative Phenotype

Slot, I. G., van den Borst, B., Hellwig, V. A., Barreiro, E., Schols, A. M. W. J. & Gosker, H. R., 28 Feb 2014, In : PLOS ONE. 9, 2, 9 p., e90150.

Research output: Contribution to journalArticleAcademicpeer-review

2013
32 Citations (Scopus)

Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease

Guo, Y., Gosker, H. R., Schols, A. M. W. J., Kapchinsky, S., Bourbeau, J., Sandri, M., Jagoe, R. T., Debigare, R., Maltais, F., Taivassalo, T. & Hussain, S. N., 1 Jan 2013, In : American Journal of Respiratory and Critical Care Medicine. 188, 11, p. 1313-1320

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Central fat and peripheral muscle: partners in crime in chronic obstructive pulmonary disease

van den Borst, B., Gosker, H. R. & Schols, A. M. W. J., 1 Jan 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 8-13 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Characterization of the inflammatory and metabolic profile of adipose tissue in a mouse model of chronic hypoxia.

van den Borst, B., Schols, A. M. W. J., de Theije, C. C., Boots, A. W., Köhler, S. E., Goossens, G. H. & Gosker, H. R., Jun 2013, In : Journal of Applied Physiology. 114, 11, p. 1619-1628 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
22 Citations (Scopus)

Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (Copd); implications for stratified medicine?

Natanek, S. A., Gosker, H. R., Slot, I. G. M., Marsh, G. S., Hopkinson, N. S., Man, W. D., Tal Singer, R., Moxham, J., Kemp, P. R., Schols, A. M. & Polkey, M. I., Oct 2013, In : Muscle & Nerve. 48, 4, p. 488-497 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Loss of quadriceps muscle oxidative phenotype and decreased endurance in patients with mild-to-moderate COPD.

van den Borst, B., Slot, I. G. M., Hellwig, V. A. C. V., Vosse, B. A., Kelders, M. C., Barreiro, E., Schols, A. M. W. J. & Gosker, H. R., May 2013, In : Journal of Applied Physiology. 114, 9, p. 1319-1328 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Metabolic and structural changes in lower-limb skeletal muscle following neuromuscular electrical stimulation: a systematic review

Sillen, M. J., Franssen, F. M., Gosker, H. R., Wouters, E. F. & Spruit, M. A., 1 Jan 2013, In : PLOS ONE. 8, 9, e69391.

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Pathways associated with reduced quadriceps oxidative fibres and endurance in COPD.

Natanek, S. A., Gosker, H. R., Slot, I. G. M., Marsh, G. S., Hopkinson, N. S., Moxham, J., Kemp, P. R., Schols, A. M. W. J. & Polkey, M. I., Jun 2013, In : European Respiratory Journal. 41, 6, p. 1275-1283 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

Hoffmann, R. F., Zarrintan, S., Brandenburg, S. M., Kol, A., de Bruin, H. G., Jafari, S., van Dijk, F., Kalicharan, D., Kelders, M., Gosker, H. R., Ten Hacken, N. H., van der Want, J. J., van Oosterhout, A. J. & Heijink, I. H., 2 Oct 2013, In : Respiratory Research. 14, 1, p. 97 12 p., 97.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Reference values for vastus lateralis fiber type proportions and fiber size

Gosker, H. R. & Schols, A. M., Sep 2013, In : Journal of Applied Physiology. 115, 5, p. 771 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

13 Citations (Scopus)

Regulation of skeletal muscle oxidative phenotype by classical NF-κB signalling.

Remels, A. H. V., Gosker, H. R., de Bakker, J., Guttridge, D. C., Schols, A. M. W. J. & Langen, R. C. J., Aug 2013, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1832, 8, p. 1313-1325 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

The mechanisms of cachexia underlying muscle dysfunction in COPD.

Remels, A. H. V., Gosker, H. R., Langen, R. C. J. & Schols, A. M. W. J., May 2013, In : Journal of Applied Physiology. 114, 9, p. 1253-1262 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)
2012
21 Citations (Scopus)

Physical activity, nutritional status and systemic inflammation in COPD

Laveneziana, P., Palange, P. & ERS Research Seminar Faculty (incl. Gosker), H. R., Sep 2012, In : European Respiratory Journal. 40, 3, p. 522-529 8 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

37 Citations (Scopus)

The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease

van den Borst, B., Gosker, H. R., Koster, A., Yu, B., Kritchevsky, S. B., Liu, Y., Meibohm, B., Rice, T. B., Shlipak, M., Yende, S., Harris, T. B., Schols, A. M. W. J. & the Health, Aging, and Body Composition, H. ABC. S., 1 Jan 2012, In : American Journal of Clinical Nutrition. 96, 3, p. 516-526

Research output: Contribution to journalArticleAcademicpeer-review

2011
15 Citations (Scopus)

Hypoxia and muscle maintenance regulation: implications for chronic respiratory disease

de Theije, C., Costes, F., Langen, R. C., Pison, C. & Gosker, H. R., Nov 2011, In : Current Opinion in Clinical Nutrition and Metabolic Care. 14, 6, p. 548-553 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?

van den Borst, B., Koster, A., Yu, B., Gosker, H. R., Meibohm, B., Bauer, D. C., Kritchevsky, S. B., Liu, Y., Newman, A. B., Harris, T. B. & Schols, A. M., 1 Jan 2011, In : Thorax. 66, 11, p. 961-9

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Low-grade adipose tissue inflammation in patients with mild-to-moderate chronic obstructive pulmonary disease

van den Borst, B., Gosker, H. R., Wesseling, G. J., de Jager, W., Hellwig, V. A. C. V., Snepvangers, F. J. & Schols, A. M. W. J., 1 Jan 2011, In : American Journal of Clinical Nutrition. 94, 6, p. 1504-1512

Research output: Contribution to journalArticleAcademicpeer-review