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Research Output

  • 48 Article
  • 3 Review article
  • 2 Comment/Letter to the editor
  • 1 Inaugural speech
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Article
2019

Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma

Siebert, C., Ciato, D., Murakami, M., Frei-Stuber, L., Perez-Rivas, L. G., Monteserin-Garcia, J. L., Noelting, S., Maurer, J., Feuchtinger, A., Walch, A. K., Haak, H. R., Bertherat, J., Mannelli, M., Fassnacht, M., Korpershoek, E., Reincke, M., Stalla, G. K., Hantel, C. & Beuschlein, F., 19 Jul 2019, In : Frontiers in Endocrinology. 10, 15 p., 487.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Higher In-Hospital Mortality in Patients with Nonspecific Complaints Presenting to the Emergency Department

Wachelder, J., Stassen, P. M., Fourmanov, R. S., Nickel, C. H. & Haak, H. R., 2019, In : Acute Medicine. 18, 4, p. 232-238 7 p.

Research output: Contribution to journalArticleAcademic

Long-term treatment effect in cerebrotendinous xanthomatosis depends on age at treatment start

Stelten, B. M. L., Huidekoper, H. H., van de Warrenburg, B. P. C., Brilstra, E. H., Hollak, C. E. M., Haak, H. R., Kluijtmans, L. A. J., Wevers, R. A. & Verrips, A., 8 Jan 2019, In : Neurology. 92, 2, p. E83-E95 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Morbidity and mortality of bone metastases in advanced adrenocortical carcinoma: a multicenter retrospective study

Berruti, A., Libe, R., Lagana, M., Ettaieb, H., Sukkari, M. A., Bertherat, J., Feelders, R. A., Grisanti, S., Cartry, J., Mazziotti, G., Sigala, S., Baudin, E., Haak, H., Habra, M. A. & Terzolo, M., May 2019, In : European Journal of Endocrinology. 180, 5, p. 311-320 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

No age thresholds in the emergency department: A retrospective cohort study on age differences

Fuchs, C., Celik, B., Brouns, S. H. A., Kaymak, U. & Haak, H. R., 30 Jan 2019, In : PLOS ONE. 14, 1, 11 p., 0210743.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Patient's perspective on improving the quality of acute medical care: determining patient reported outcomes

Kremers, M. N. T., Zaalberg, T., van den Ende, E. S., van Beneden, M., Holleman, F., Nanayakkara, P. W. B. & Haak, H. R., 2019, In : BMJ Open Quality. 8, 3, e000736.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Performance of the Manchester triage system in older emergency department patients: a retrospective cohort study

Brouns, S. H. A., Mignot-Evers, L., Derkx, F., Lambooij, S. L., Dieleman, J. P. & Haak, H. R., 7 Jan 2019, In : BMC Emergency Medicine. 19, 11 p., 3.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Strengths and weaknesses of the acute care systems in the United Kingdom and the Netherlands: what can we learn from each other?

Kremers, M. N. T., Nanayakkara, P. W. B., Levi, M., Bell, D. & Haak, H. R., 26 Jul 2019, In : BMC Emergency Medicine. 19, p. 1-7 7 p., 40.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Changes in glucose-lowering drug use before and after cancer diagnosis in patients with diabetes

Zanders, M. M. J., Haak, H. R., van Herk-Sukel, M. P. P., Herings, R. M. C., van de Poll-Franse, L. V. & Johnson, J. A., 1 Feb 2018, In : Diabetes & Metabolism. 44, 1, p. 22-29 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors

Fassnacht, M., Dekkers, O. M., Else, T., Gaudin, E., Berruti, A., de Krijger, R. R., Haak, H. R., Mihail, R., Assie, G. & Terzolo, M., Oct 2018, In : European Journal of Endocrinology. 179, 4, p. G1-G46 46 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gastrointestinal cancer incidence in type 2 diabetes mellitus; results from a large population-based cohort study in the UK

de Jong, R. G. P. J., Peeters, P. J. H. L., Burden, A. M., de Bruin, M. L., Haak, H. R., Masclee, A. A. M., de Vries, F. & Janssen-Heijnen, M. L. G., Jun 2018, In : Cancer Epidemiology. 54, p. 104-111 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Outcome of elderly emergency department patients hospitalised on weekends: a retrospective cohort study

Brouns, S. H. A., Wachelder, J. J., Jonkers, F. S., Lambooij, S. L., Dieleman, J. P. & Haak, H. R., 7 Mar 2018, In : BMC Emergency Medicine. 18, 7 p., 9.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial

Alam, N., Oskam, E., Stassen, P. M., van Exter, P., van de Ven, P. M., Haak, H. R., Holleman, F., van Zanten, A., van Leeuwen-Nguyen, H., Bon, V., Duineveld, B. A. M., Panday, R. S. N., Kramer, M. H. H., Nanayakkara, P. W. B. & PHANTASI Trial Investigators; ORCA Onderzoeks Consortium Acute, 1 Jan 2018, In : The Lancet Respiratory medicine. 6, 1, p. 40-50 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Quality and Quantity of Sleep and Factors Associated With Sleep Disturbance in Hospitalized Patients

Wesselius, H. M., van den Ende, E. S., Alsma, J., ter Maaten, J. C., Schuit, S. C. E., Stassen, P. M., de Vries, O. J., Kaasjager, K. H. A. H., Haak, H. R., van Doormaal, F. F., Hoogerwerf, J. J., Terwee, C. B., van de Ven, P. M., Bosch, F. H., van Someren, E. J. W., Nanayakkara, P. W. B. & Onderzoeks Consortium Acute Genees, 1 Sep 2018, In : JAMA Internal Medicine. 178, 9, p. 1201-1208 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Unenhanced CT imaging is highly sensitive to exclude pheochromocytoma: a multicenter study

Buitenwerf, E., Korteweg, T., Visser, A., Haag, C. M. S. C., Feelders, R. A., Timmers, H. J. L. M., Canu, L., Haak, H. R., Bisschop, P. H. L. T., Eekhoff, E. M. W., Corssmit, E. P. M., Krak, N. C., Rasenberg, E., van den Bergh, J., Stoker, J., Greuter, M. J. W., Dullaart, R. P. F., Links, T. P. & Kerstens, M. N., 1 May 2018, In : European Journal of Endocrinology. 178, 5, p. 431-437 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Applicability of the modified Emergency Department Work Index (mEDWIN) at a Dutch emergency department

Brouns, S. H. A., van der Schuit, K. C. H., Stassen, P. M., Lambooij, S. L. E., Dieleman, J., Vanderfeesten, I. T. P. & Haak, H. R., 10 Mar 2017, In : PLOS ONE. 12, 3, 14 p., e0173387.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma

Sbiera, S., Sbiera, I., Ruggiero, C., Doghman-Bouguerra, M., Korpershoek, E., de Krijger, R. R., Ettaieb, H., Haak, H., Volante, M., Papotti, M., Reimondo, G., Terzolo, M., Luconi, M., Nesi, G., Mannelli, M., Libe, R., Ragazzon, B., Assie, G., Bertherat, J., Altieri, B. & 6 others, Fadda, G., Rogowski-Lehmann, N., Reincke, M., Beuschlein, F., Fassnacht, M. & Lalli, E., Sep 2017, In : Journal of Clinical Endocrinology & Metabolism. 102, 9, p. 3491-3498 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Association of socioeconomic status with outcomes in older adult community-dwelling patients after visiting the emergency department: a retrospective cohort study

Wachelder, J. J. H., van Drunen, I., Stassen, P. M., Brouns, S. H. A., Lambooij, S. L. E., Aarts, M. J. & Haak, H. R., Dec 2017, In : BMJ Open. 7, 12, 8 p., e019318.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

Nabben, M., Schmitz, J. P. J., Ciapaite, J., le Clercq, C. M. P., van Riel, N. A., Haak, H. R., Nicolay, K., de Coo, I. F. M., Smeets, H., Praet, S. F., van Loon, L. J. & Prompers, J. J., 1 May 2017, In : American Journal of Physiology-regulatory Integrative and Comparative Physiology. 312, 5, p. R689-R701 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Elderly emergency patients presenting with non-specific complaints: Characteristics and outcomes

Wachelder, J. J. H., Stassen, P. M., Hubens, L. P. A. M., Brouns, S. H. A., Lambooij, S. L. E., Dieleman, J. P. & Haak, H. R., 30 Nov 2017, In : PLOS ONE. 12, 11, 11 p., e0188954.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Higher risk of colorectal cancer in patients with newly diagnosed diabetes mellitus before the age of colorectal cancer screening initiation

de Kort, S., Masclee, A. A. M., Sanduleanu, S., Weijenberg, M. P., van Herk-Sukel, M. P. P., Oldenhof, N. J. J., van den Bergh, J. P. W., Haak, H. R. & Janssen-Heijnen, M. L., 24 Apr 2017, In : Scientific Reports. 7, 8 p., 46527.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of detection bias on the risk of gastrointestinal cancer and its subsites in type 2 diabetes mellitus

de Jong, R. G. P. J., Burden, A. M., de Kort, S., van Herk-Sukel, M. P. P., Vissers, P. A. J., Janssen, P. K. C., Haak, H. R., Masclee, A. A. M., de Vries, F. & Janssen-Heijnen, M. L. G., Jul 2017, In : European Journal of Cancer. 79, p. 61-71 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes

van Herpt, T. T. W., Lemmers, R. F. H., van Hoek, M., Langendonk, J. G., Erdtsieck, R. J., Bravenboer, B., Lucas, A., Mulder, M. T., Haak, H. R., Lieverse, A. G. & Sijbrands, E. J. G., 19 Jun 2017, In : Diabetology & Metabolic Syndrome. 9, 10 p., 47.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

No Decreased Risk of Gastrointestinal Cancers in Users of Metformin in The Netherlands; A Time-Varying Analysis of Metformin Exposure

de Jong, R. G., Burden, A. M., de Kort, S., van Herk-Sukel, M. P., Vissers, P. A., Janssen, P. K., Haak, H. R., Masclee, A. A., de Vries, F. & Janssen-Heijnen, M. L., May 2017, In : Cancer prevention research. 10, 5, p. 290-297 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Patients' and providers' perceptions of the preventability of hospital readmission: a prospective, observational study in four European countries

van Galen, L. S., Brabrand, M., Cooksley, T., van de Ven, P. M., Merten, H., So, R. K. L., van Hooff, L., Haak, H. R., Kidney, R. M., Nickel, C. H., Soong, J. T. Y., Weichert, I., Kramer, M. H. H., Subbe, C. P., Nanayakkara, P. W. B. & Safer Home Consortium, Dec 2017, In : BMJ Quality & Safety. 26, 12, p. 958-969 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Peritoneal Metastases from Gastroenteropancreatic Neuroendocrine Tumors: Incidence, Risk Factors and Prognosis

Madani, A., Thomassen, I., van Gestel, Y. R. B. M., van der Bilt, J. D. W., Haak, H. R., de Hingh, I. H. J. T. & Lemmens, V. E. P. P., Aug 2017, In : Annals of Surgical Oncology. 24, 8, p. 2199-2205 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Power of Flash Mob Research Conducting a Nationwide Observational Clinical Study on Capillary Refill Time in a Single Day

Alsma, J., van Saase, J. L. C. M., Nanayakkara, P. W. B., Schouten, W. E. M. I., Baten, A., Bauer, M. P., Holleman, F., Ligtenberg, J. J. M., Stassen, P. M., Kaasjager, K. H. A. H., Haak, H. R., Bosch, F. H., Schuit, S. C. E. & Famous Study Grp, May 2017, In : Chest. 151, 5, p. 1106-1113 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Concept Development of the Eindhoven Diabetes Education Simulator Project

Maas, A. H., van der Molen, P., van de Vijver, R., Chen, W., van Pul, C., Cottaar, E. J. E., van Riel, N. A. W., Hilbers, P. A. J. & Haak, H. R., 1 Apr 2016, In : Games for Health Journal. 5, 2, p. 120-127

Research output: Contribution to journalArticleAcademicpeer-review

Impact of cancer diagnosis and treatment on glycaemic control among individuals with colorectal cancer using glucose-lowering drugs

Zanders, M. M. J., van Herk-Sukel, M. P. P., Herings, R. M. C., van de Poll-Franse, L. V. & Haak, H. R., Oct 2016, In : Acta Diabetologica. 53, 5, p. 727-735

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Synchronous vs. Metachronous Metastases in Adrenocortical Carcinoma: an Analysis of the Dutch Adrenal Network

Ettaieb, M. H. T., Duker, J. C., Feelders, R. A., Corssmit, E. P. M., van Oordt, C. W. M. D. H., Timmers, H. J. L. M., Kerstens, M. N., Wilmink, J. W., Zelissen, P. M., Havekes, B. & Haak, H. R., Dec 2016, In : Hormones and Cancer. 7, 5-6, p. 336-344

Research output: Contribution to journalArticleAcademicpeer-review

2015

Adrenal Tumors with Unexpected Outcome: A Review of the Literature

Kerkhofs, T. M., Roumen, R. M., Demeyere, T. B., van der Linden, A. N. & Haak, H. R., 1 Jan 2015, In : International Journal of Endocrinology. 2015, 7 p., 710514.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

A Physiology-Based Model Describing Heterogeneity in Glucose Metabolism: The Core of the Eindhoven Diabetes Education Simulator (E-DES)

Maas, A. H., Rozendaal, Y. J. W., van Pul, C., Hilbers, P. A. J., Cottaar, W. J., Haak, H. R. & van Riel, N. A. W., 13 Jan 2015, In : DST Journal of Diabetes Science and Technology. 9, 2, p. 282-292

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?

Zanders, M. M. J., van Herk-Sukel, M. P. P., Vissers, P. A. J., Herings, R. M. C., Haak, H. R. & van de Poll-Franse, L. V., 1 Jan 2015, In : British Journal of Cancer. 113, 3, p. 403-410

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Developing treatment for adrenocortical carcinoma

Kerkhofs, T. M. A., Ettaieb, M. H. T., Hermsen, I. G. C. & Haak, H. R., 1 Jan 2015, In : Endocrine-Related Cancer. 22, 6, p. R325-R338

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Development of a Pharmacokinetic Model of Mitotane: Toward Personalized Dosing in Adrenocortical Carcinoma

Kerkhofs, T. M. A., Derijks, L. J. J., Ettaieb, H., den Hartigh, J., Neef, K., Gelderblom, H., Guchelaar, H. J. & Haak, H. R., Feb 2015, In : Therapeutic Drug Monitoring. 37, 1, p. 58-65 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors

Kerkhofs, T. M. A., Kerstens, M. N., Kema, I. P., Willems, T. P. & Haak, H. R., Aug 2015, In : Hormones and Cancer. 6, 4, p. 168-175 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Impact of cancer on adherence to glucose-lowering drug treatment in individuals with diabetes

Zanders, M. M. J., Haak, H. R., van Herk-Sukel, M. P. P., van de Poll-Franse, L. V. & Johnson, J. A., 1 Jan 2015, In : Diabetologia. 58, 5, p. 951-960

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study

Fassnacht, M., Berruti, A., Baudin, E., Demeure, M. J., Gilbert, J., Haak, H., Kroiss, M., Quinn, D. I., Hesseltine, E., Ronchi, C. L., Terzolo, M., Choueiri, T. K., Poondru, S., Fleege, T., Rorig, R., Chen, J., Stephens, A. W., Worden, F. & Hammer, G. D., 1 Jan 2015, In : Lancet oncology. 16, 4, p. 426-435

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Major Prognostic Role of Ki67 in Localized Adrenocortical Carcinoma After Complete Resection

Beuschlein, F., Weigel, J., Saeger, W., Kroiss, M., Wild, V., Daffara, F., Libé, R., Ardito, A., al Ghuzlan, A., Quinkler, M., Osswald, A., Ronchi, C. L., de Krijger, R., Feelders, R. A., Waldmann, J., Willenberg, H. S., Deutschbein, T., Stell, A., Reincke, M., Papotti, M. & 8 others, Baudin, E., Tissier, F., Haak, H. R., Loli, P., Terzolo, M., Allolio, B., Müller, H. H. & Fassnacht, M., 1 Jan 2015, In : Journal of Clinical Endocrinology & Metabolism. 100, 3, p. 841-849

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Organisational Factors Induce Prolonged Emergency Department Length of Stay in Elderly Patients- A Retrospective Cohort Study

Brouns, S. H. A., Stassen, P. M., Lambooij, S. L. E., Dieleman, J., Vanderfeesten, I. T. P. & Haak, H. R., 1 Jan 2015, In : PLOS ONE. 10, 8, e0135066.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Prognostic factors in stage III-IV adrenocortical carcinomas (ACC): an European Network for the Study of Adrenal Tumor (ENSAT) study

Libé, R., Borget, I., Ronchi, C. L., Zaggia, B., Kroiss, M., Kerkhofs, T., Bertherat, J., Volante, M., Quinkler, M., Chabre, O., Bala, M., Tabarin, A., Beuschlein, F., Vezzosi, D., Deutschbein, T., Borson-Chazot, F., Hermsen, I., Stell, A., Fottner, C., Leboulleux, S. & 8 others, Hahner, S., Mannelli, M., Berruti, A., Haak, H., Terzolo, M., Fassnacht, M., Baudin, E. & ENSAT Network, T., Oct 2015, In : Annals of Oncology. 26, 10, p. 2119-2125 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2014

Adrenocortical carcinoma in children: First population-based clinicopathological study with long-term follow-up

Kerkhofs, T. M. A., Ettaieb, M. H. T., Verhoeven, R. H. A., Kaspers, G. J. L., Tissing, W. J. E., Loeffen, J., van den Heuvel-Eibrink, M. M., de Krijger, R. R. & Haak, H. R., Dec 2014, In : Oncology Reports. 32, 6, p. 2836-2844 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Colorectal cancer, diabetes and survival: Epidemiological insights

Zanders, M. M. J., Vissers, P. A. J., Haak, H. R. & van de Poll-Fransse, L. V., Apr 2014, In : Diabetes & Metabolism. 40, 2, p. 120-127 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Hyponatraemia in elderly emergency department patients: A marker of frailty

Brouns, S. H. A., Dortmans, M. K. J., Jonkers, F. S., Lambooij, S. L. E., Kuijper, A. & Haak, H. R., 1 Jan 2014, In : Netherlands Journal of Medicine. 72, 6, p. 311-317

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Prognostic Role of Overt Hypercortisolism in Completely Operated Patients with Adrenocortical Cancer

Berruti, A., Fassnacht, M., Haak, H., Else, T., Baudin, E., Sperone, P., Kroiss, M., Kerkhofs, T., Williams, A. R., Ardito, A., Leboulleux, S., Volante, M., Deutschbein, T., Feelders, R., Ronchi, C., Grisanti, S., Gelderblom, H., Porpiglia, F., Papotti, M., Hammer, G. D. & 2 others, Allolio, B. & Terzolo, M., 1 Jan 2014, In : European Urology. 65, 4, p. 832-838

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Short-term variation in plasma mitotane levels confirms the importance of trough level monitoring

Kerkhofs, T. M. A., Derijks, L. J. J., Ettaieb, M. H. T., Eekhoff, E. M., Neef, C., Gelderblom, H., den Hartigh, J., Guchelaar, H. J. & Haak, H. R., Dec 2014, In : European Journal of Endocrinology. 171, 6, p. 677-683 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Two patients with a neuroendocrine tumour of the small intestine and paraneoplastic myasthenia gravis

Hermans, M. A. W., Stelten, B. M. L., Haak, H. R., de Herder, W. W. & Dercksen, M. W., 1 Jan 2014, In : Endocrinology, Diabetes & Metabolism Case Reports. 2014, EDM140013.

Research output: Contribution to journalArticleAcademicpeer-review

Unmet information needs and impact of cancer in (long-term) thyroid cancer survivors: results of the PROFILES registry

Husson, O., Mols, F., Oranje, W. A., Haak, H. R., Nieuwlaat, W. A., Netea-Maier, R. T., Smit, J. W. A. & van de Poll-Fransse, L. V., 1 Jan 2014, In : Psycho-Oncology. 23, 8, p. 946-952

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)