20132019

Research output per year

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Research Output

2019

Hybrid ligands with calixarene and thiodigalactoside groups: galectin binding and cytotoxicity

Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H. & Pieters, R. J., 21 Aug 2019, In : Organic Chemistry Frontiers. 6, 16, p. 2981-2990 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

SecScan: a general approach for mapping disulfide bonds in synthetic and recombinant peptides and proteins

Denisov, S. S., Ippel, J. H., Mans, B. J., Dijkgraaf, I. & Hackeng, T. M., 4 Feb 2019, In : Chemical Communications. 55, 10, p. 1374-1377 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation

Streefkerk, D. E., Schmidt, M., Ippel, J. H., Hackeng, T. M., Nuijens, T., Timmerman, P. & van Maarseveen, J. H., 5 Apr 2019, In : Organic Letters. 21, 7, p. 2095-2100 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2

Denisov, S. S., Ippel, J. H., Heinzmann, A. C. A., Koenen, R. R., Ortega-Gomez, M., Soehnlein, O., Hackeng, T. M. & Dijkgraaf, I., 16 Aug 2019, In : Journal of Biological Chemistry. 294, 33, p. 12370-12379 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A One-Pot "Triple-C" Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides

Richelle, G. J. J., Schmidt, M., Ippel, H., Hackeng, T. M., van Maarseveen, J. H., Nuijens, T. & Timmerman, P., 17 Sep 2018, In : Chembiochem. 19, 18, p. 1934-1938 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Optical signature of nerve tissue-Exploratory ex vivo study comparing optical, histological, and molecular characteristics of different adipose and nerve tissues

Balthasar, A. J. R., Bydlon, T. M., Ippel, H., van der Voort, M., Hendriks, B. H. W., Lucassen, G. W., van Geffen, G-J., van Kleef, M., van Dijk, P. & Lataster, A., 1 Nov 2018, In : Lasers in Surgery and Medicine. 50, 9, p. 948-960 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., Nicolaes, G. A. F. & 8 others, Doering, Y., Soehnlein, O., Lutgens, E., Heemskerk, J. W. M., Koenen, R. R., Mayo, K. H., Hackeng, T. M. & Weber, C., 5 Apr 2017, In : Science Translational Medicine. 9, 384, 14 p., eaah6650.

Research output: Contribution to journalArticleAcademicpeer-review

Omniligase-1: A Powerful Tool for Peptide Head-to-Tail Cyclization

Schmidt, M., Toplak, A., Quaedflieg, P. J. L. M., Ippel, H., Richelle, G. J. J., Hackeng, T. M., van Maarseveen, J. H. & Nuijens, T., 19 Jun 2017, In : Advanced Synthesis & Catalysis. 359, 12, p. 2050-2055 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain

Miller, M. C., Ippel, H., Suylen, D., Klyosov, A. A., Traber, P. G., Hackeng, T. & Mayo, K. H., Jan 2016, In : Glycobiology. 26, 1, p. 88-99

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR

Ippel, H., Miller, M. C., Vertesy, S., Zheng, Y., Javier Canada, F., Suylen, D., Umemoto, K., Romano, C., Hackeng, T., Tai, G., Leffler, H., Kopitz, J., Andre, S., Kuebler, D., Jimenez-Barbero, J., Oscarson, S., Gabius, H-J. & Mayo, K. H., Aug 2016, In : Glycobiology. 26, 8, p. 888-903

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Probing Functional Heteromeric Chemokine Protein-Protein Interactions through Conformation-Assisted Oxime Ligation

Agten, S. M., Koenen, R. R., Ippel, H., Eckardt, V., von Hundelshausen, P., Mayo, K. H., Weber, C. & Hackeng, T. M., 21 Nov 2016, In : Angewandte Chemie-International Edition. 55, 48, p. 14963-14966

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2015

A novel approach for the intravenous delivery of leuprolide using core-cross-linked polymeric micelles

Hu, Q., van Gaal, E. V. B., Brundel, P., Ippel, H., Hackeng, T., Rijcken, C. J. F., Storm, G., Hennink, W. E. & Prakash, J., 10 May 2015, In : Journal of Controlled Release. 205, p. 98-108

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

H-1, C-13, and N-15 backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3

Ippel, H., Miller, M. C., Berbis, M. A., Suylen, D., Andre, S., Hackeng, T. M., Canada, F. J., Weber, C., Gabius, H-J., Jimenez-Barbero, J. & Mayo, K. H., Apr 2015, In : Biomolecular Nmr Assignments. 9, 1, p. 59-63

Research output: Contribution to journalArticleAcademicpeer-review

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

Alard, J-E., Ortega-Gomez, A., Wichapong, K., Bongiovanni, D., Horckmans, M., Megens, R. T. A., Leoni, G., Ferraro, B., Rossaint, J., Paulin, N., Ng, J., Ippel, H., Suylen, D., Hinkel, R., Blanchet, X., Gaillard, F., D'Amico, M., von Hundelshausen, P., Zarbock, A., Scheiermann, C. & 6 others, Hackeng, T. M., Steffens, S., Kupatt, C., Nicolaes, G. A. F., Weber, C. & Soehnlein, O., 9 Dec 2015, In : Science Translational Medicine. 7, 317, 317ra196.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2014

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

Karagoz, G. E., Duarte, A. M. S., Akoury, E., Ippel, H., Biernat, J., Luengo, T. M., Radli, M., Didenko, T., Nordhues, B. A., Veprintsev, D. B., Dickey, C. A., Mandelkow, E., Zweckstetter, M., Boelens, R., Madl, T. & Rudiger, S. G. D., 27 Feb 2014, In : Cell. 156, 5, p. 963-974

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner

Berbis, M. A., Andre, S., Canada, F. J., Pipkorn, R., Ippel, H., Mayo, K. H., Kuebler, D., Gabius, H-J. & Jimenez-Barbero, J., 3 Jan 2014, In : Biochemical and Biophysical Research Communications. 443, 1, p. 126-131

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
2013

Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid

Agten, S. M., Suylen, D., Ippel, H., Kokozidou, M., Tans, G., van de Vijver, P., Koenen, R. R. & Hackeng, T. M., 16 Dec 2013, In : Chembiochem. 14, 18, p. 2431-2434

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Protein lysine-N zeta alkylation and O-phosphorylation mediated by DTT-generated reactive oxygen species

Kumar, N., Ippel, H., Weber, C., Hackeng, T. & Mayo, K. H., Mar 2013, In : Protein Science. 22, 3, p. 327-346

Research output: Contribution to journalArticleAcademicpeer-review

Some notes on fatal acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in a two-year-old warmblood stallion and European tar spot (Rhytisma acerinum)

van der Kolk, J. H., Boelens, R., Halkes, S. B. A., Wijnberg, I. D., de Sain-van der Velden, M. G. M. & Ippel, J. H., 1 Mar 2013, In : Veterinary Quarterly. 33, 1, p. 51-55

Research output: Contribution to journalArticleAcademicpeer-review