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2019
Open Access

Protection against neutrophil extracellular trap (NET) toxicity by antioxidant monoHER

Astuti, P., Beurskens, D., Vajen, T., Nicolaes, G., Zhang, M. & Guido, H., 2019, In : Makara Journal of Health Research. 23, 2, p. 108-115 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

The cardiovascular side effects of Ma Huang due to its use in isolation in the Western world

Zhang, M., Schiffers, P., Janssen, G., Vrolijk, M., Vangrieken, P. & Haenen, G. R. M. M., 1 Feb 2018, In : European Journal of Integrative Medicine. 18, p. 18-22 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The chemical reactivity of (-)-epicatechin quinone mainly resides in its Bring

Zhang, M., Vervoort, L., Moalin, M., Mommers, A., Douny, C., den Hartog, G. J. M. & Haenen, G. R. M. M., 20 Aug 2018, In : Free Radical Biology and Medicine. 124, p. 31-39 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine

Zhang, M., Vrolijk, M. & Haenen, G. R. M. M., Jan 2018, In : International journal of molecular sciences. 19, 1, 12 p., 18.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017
Open Access

Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress

van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M-J., Haenen, G. R. M. M., Heijink, I. H., Rouschop, K. M. A., Dubois, L. J. & Lambin, P., 3 Aug 2017, In : PLOS ONE. 12, 8, 13 p., 0182508.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells

Shi, Q., Boots, A. W., Maas, L., Veith, C., van Kuijk, K., Haenen, G. R., Godschalk, R. W. & Van Schooten, F. J., 15 Apr 2017, In : Toxicology. 381, p. 64-74 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Silver nanoparticles induce hormesis in A549 human epithelial cells

Sthijns, M. M. J. P. E., Thongkam, W., Albrecht, C., Hellack, B., Bast, A., Haenen, G. R. M. M. & Schins, R. P. F., Apr 2017, In : Toxicology in Vitro. 40, p. 223-233 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial

Baumgartner, S., Mensink, R. P., Haenen, G. R., Bast, A., Binder, C. J., Bekers, O., Husche, C., Luetjohann, D. & Plat, J., 10 Nov 2017, In : Scientific Reports. 7, 9 p., 15288.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Potential of Flavonoids in the Treatment of Non-alcoholic Fatty Liver Disease

van de Wier, B., Koek, G. H., Bast, A. & Haenen, G. R. M., 2017, In : Critical Reviews in Food Science and Nutrition. 57, 4, p. 834-855 22 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Hageman, G. J., Bast, A. & Haenen, G. R. M. M., Oct 2017, In : Toxicology in Vitro. 44, p. 206-212 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

van Gisbergen, M. W., Cebula, M., Zhang, J., Ottosson-Wadlund, A., Dubois, L., Lambin, P., Tew, K. D., Townsend, D. M., Haenen, G. R. M. M., Drittij - Reijnders, M. J., Saneyoshi, H., Araki, M., Shishido, Y., Ito, Y., Arner, E. S. J., Abe, H., Morgenstern, R. & Johansson, K., Jun 2016, In : Molecular Pharmaceutics. 13, 6, p. 2010-2025

Research output: Contribution to journalArticleAcademicpeer-review

Does Ataxia Telangiectasia Mutated (ATM) protect testicular and germ cell DNA integrity by regulating the redox status?

Godschalk, R. W. L., Vanhees, K., Maas, L., Drittij - Reijnders, M. J., Pachen, D., van Doorn-Khosrovani, S. V. W., van Schooten, F. J. & Haenen, G. R. M. M., Aug 2016, In : Reproductive Toxicology. 63, p. 169-173

Research output: Contribution to journalArticleAcademicpeer-review

Iron Supplements and Magnesium Peroxide: An Example of a Hazardous Combination in Self-Medication

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 4, p. 412-417

Research output: Contribution to journalArticleAcademicpeer-review

Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?

Pijls, K., Jonkers, D., Elizalde Vilalta, M., Drittij - Reijnders, M. J., Haenen, G., Bast, A., Masclee, A. & Koek, G., 2016, In : Annals of Hepatology. 15, 3, p. 402-409 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

van Kuijk, S. J. A., Gieling, R. G., Niemans, R., Lieuwes, N. G., Biemans, R., Telfer, B. A., Haenen, G. R. M. M., Yaromina, A., Lambin, P., Dubois, L. J. & Williams, K. J., 11 Aug 2016, In : PLOS ONE. 11, 8, e0161040.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase

Randall, M., Haenen, G. R., Bouwman, F. G., Vliet, A. V. & Bast, A., 5 Jan 2016, In : Toxicology Letters. 240, 1, p. 43-49 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Time in Redox Adaptation Processes: From Evolution to Hormesis

Sthijns, M. M. J. P. E., Weseler, A. R., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : International journal of molecular sciences. 17, 10, 1649.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

Heyninck, K., Sabbe, L., Chirumamilla, C. S., Szic, K. S. V., Veken, P. V., Lemmens, K. J. A., Lahtela-Kakkonen, M., Naulaerts, S., de Beeck, K. O., Laukens, K., Van Camp, G., Weseler, A. R., Bast, A., Haenen, G. R. M. M., Haegeman, G. & Berghe, W. V., 1 Jun 2016, In : Biochemical Pharmacology. 109, p. 48-61

Research output: Contribution to journalArticleAcademicpeer-review

2015

Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Bast, A. & Haenen, G. R., Dec 2015, In : Basic & Clinical Pharmacology & Toxicology. 117, 6, p. 427-432 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chemical characteristics for optimizing CYP2E1 inhibition

van de Wier, B., Balk, J. M., Bast, A., Koek, G. H. & Haenen, G. R., 5 Dec 2015, In : Chemico-Biological Interactions. 242, p. 139-144 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial

Balk, J. M., Haenen, G. R. M., Koc, O. M., Peters, R., Bast, A., van der Vijgh, W. J. F. & Koek, G. H., 1 Jan 2015, In : Pharmacogenomics and personalized medicine. 8, p. 137-144 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Paracetamol as a Post Prandial Marker for Gastric Emptying, A Food-Drug Interaction on Absorption

Bartholomé, R., Salden, B., Vrolijk, M. F., Troost, F. J., Masclee, A., Bast, A. & Haenen, G. R. M. M., 9 Sep 2015, In : PLOS ONE. 10, 9, 9 p., e0136618.

Research output: Contribution to journalArticleAcademicpeer-review

Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers

Salden, B., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F. & Masclee, A. A., 1 Jan 2015, In : Alimentary Pharmacology & Therapeutics. 42, 3, p. 273-285

Research output: Contribution to journalArticleAcademicpeer-review

The contribution of the major metabolite 4'-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER

Lemmens, K. J., Herst, P. M., Housmans, B. A., Moalin, M., van der Vijgh, W. J., Bast, A. & Haenen, G. R., 5 Sep 2015, In : Chemico-Biological Interactions. 239, p. 146-152 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD

Lemmens, K., van de Wier, B., Koek, G. H., Köhler, E. S., Drittij, M. J., van der Vijgh, W., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Biochemical and Biophysical Research Communications. 456, 1, p. 179-182

Research output: Contribution to journalArticleAcademicpeer-review

The shifting perception on antioxidants: The case of vitamin E and beta-carotene

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Godschalk, R. W., van Schooten, F. J., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Redox Biology. 4C, p. 272-278

Research output: Contribution to journalArticleAcademic

The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation

Vrolijk, M. F., Haenen, G. R., Opperhuizen, A., Jansen, E. H., Schiffers, P. M. & Bast, A., 5 Jan 2015, In : European Journal of Pharmacology. 746, p. 132-137 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Toxicity of Antioxidants

Rezk, B., van der Vijgh, W. J. F., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Toxicology and Forensic Medicine. 1, 1, 1000TFMOJ1e002.

Research output: Contribution to journalArticleAcademic

Toxicity of the anti-oxidants

Rezk, B. M., van der Vijgh, W., Bast, A. & Haenen, G., 2015, In : Toxicology and Forensic Medicine. 1, 1, p. e3-e4

Research output: Contribution to journalArticleAcademicpeer-review

Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State

Milenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szarc Vel Szic, K., Heyninck, K., Laukens, K., Bizet, M., Defrance, M., Dedeurwaerder, S., Calonne, E., Fuks, F., Haegeman, G., Haenen, G. R., Bast, A. & Weseler, A. R., 24 Apr 2014, In : PLOS ONE. 9, 4, 13 p., e95527.

Research output: Contribution to journalArticleAcademicpeer-review

Glutathione revisited: a better scavenger than previously thought

Haenen, G. R. M. & Bast, A., 27 Nov 2014, In : Frontiers in Pharmacology. 5, 5 p., 260.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup

Hazewindus, M., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : PLOS ONE. 9, 12, e114387.

Research output: Contribution to journalArticleAcademicpeer-review

Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis

Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., Janssen, B. J. & 2 others, Daemen, M. J. & Sluimer, J. C., 1 Jan 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 12, p. 2545-2553

Research output: Contribution to journalArticleAcademicpeer-review

The cocoa flavanol (-)-epicatechin protects the cortisol response.

Ruijters, E. J., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : Pharmacological Research. 79, p. 28-33 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effect of modified eggs and an egg-yolk based beverage on serum lutein and zeaxanthin concentrations and macular pigment optical density: results from a randomized trial

Kelly, E. R., Plat, J., Haenen, G. R., Kijlstra, A. & Berendschot, T. T., 27 Mar 2014, In : PLOS ONE. 9, 3, 9 p., 92659.

Research output: Contribution to journalArticleAcademicpeer-review

The flavonoid 7-mono-O-(beta-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect

Lemmens, K. J., van de Wier, B., Vaes, N., Ghosh, M., van Zandvoort, M. A., van der Vijgh, W., Bast, A. & Haenen, G. R., Jun 2014, In : Toxicology in Vitro. 28, 4, p. 538-543 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Minor Structural Difference between the Antioxidants Quercetin and 4'O-Methylquercetin Has a Major Impact on Their Selective Thiol

Lemmens, K. J., Vrolijk, M. F., Bouwman, F. G., van der Vijgh, W. J., Bast, A. & Haenen, G. R., 1 Jan 2014, In : International journal of molecular sciences. 15, 5, p. 7475-7484

Research output: Contribution to journalArticleAcademicpeer-review

2013

Astaxanthin supplementation does not augment fat use or improve endurance performance.

Res, P. T., Cermak, N. M., Stinkens, R. E., Tollakson, T. J., Haenen, G. R. M. M., Bast, A. & van Loon, L. J. C., Jun 2013, In : Medicine and Science in Sports and Exercise. 45, 6, p. 1158-1165 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.

Nergiz-Unal, R., Kuijpers, M. J. E., de Witt, S. M., Heeneman, S., Feijge, M. A. H., Garcia Caraballo, S., Biessen, E. A., Haenen, G. R. M. M., Cosemans, J. M. & Heemskerk, J. W., 1 Jan 2013, In : Thrombosis Research. 131, 5, p. 411-417

Research output: Contribution to journalArticleAcademicpeer-review

Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial

Klinkenberg, L. J., Res, P. T., Haenen, G. R., Bast, A., van Loon, L. J., van Dieijen-Visser, M. P. & Meex, S. J., 1 Jan 2013, In : PLOS ONE. 8, 11, e79280.

Research output: Contribution to journalArticleAcademicpeer-review

Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production

van de Wier, B., Balk, J. M., Haenen, G. R. M. M., Giamouridis, D., Bakker, J. A., Bast, B. C., den Hartog, G. J. M., Koek, G. H. & Bast, A., 2 Aug 2013, In : Febs Letters. 587, 15, p. 2461-2466 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage

Vanhees, K., van Schooten, F. J., van Waalwijk van Doorn-Khosrovani, S. B., van Helden, S. H., Munnia, A., Peluso, M., Briedé, J. J., Haenen, G. R. M. M. & Godschalk, R. W. L., Apr 2013, In : Free Radical Biology and Medicine. 57, p. 154-161 8 p.

Research output: Contribution to journalArticleAcademicpeer-review