If you made any changes in Pure these will be visible here soon.

Research Output

2019

Connecting West and East

Zhang, M., Moalin, M. & Haenen, G. R. M. M., 1 May 2019, In : International journal of molecular sciences. 20, 9, 5 p., 2333.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Connecting Western and Eastern Medicine from an Energy Perspective

Zhang, M., Moalin, M., Vervoort, L., Li, Z. W., Wu, W. B. & Haenen, G., 21 Mar 2019, In : International journal of molecular sciences. 20, 6, 10 p., 1512.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

Protection against neutrophil extracellular trap (NET) toxicity by antioxidant monoHER

Astuti, P., Beurskens, D., Vajen, T., Nicolaes, G., Zhang, M. & Guido, H., 2019, In : Makara Journal of Health Research. 23, 2, p. 108-115 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

The cardiovascular side effects of Ma Huang due to its use in isolation in the Western world

Zhang, M., Schiffers, P., Janssen, G., Vrolijk, M., Vangrieken, P. & Haenen, G. R. M. M., 1 Feb 2018, In : European Journal of Integrative Medicine. 18, p. 18-22 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The chemical reactivity of (-)-epicatechin quinone mainly resides in its Bring

Zhang, M., Vervoort, L., Moalin, M., Mommers, A., Douny, C., den Hartog, G. J. M. & Haenen, G. R. M. M., 20 Aug 2018, In : Free Radical Biology and Medicine. 124, p. 31-39 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine

Zhang, M., Vrolijk, M. & Haenen, G. R. M. M., Jan 2018, In : International journal of molecular sciences. 19, 1, 12 p., 18.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

We are stardust

Haenen, G. R. M. M., 12 Jan 2018, Maastricht: Maastricht University. 10 p.

Research output: Book/ReportInaugural speechPopular

Open Access
File
227 Downloads (Pure)
2017

Activation versus inhibition of microsomal glutathione S-transferase activity by acrolein. Dependence on the concentration and time of acrolein exposure

Sthijns, M. M. J. P. E., den Hartog, G. J. M., Scasso, C., Haenen, J. P., Bast, A. & Haenen, G. R. M. M., 25 Sep 2017, In : Chemico-Biological Interactions. 275, p. 116-120 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress

van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M-J., Haenen, G. R. M. M., Heijink, I. H., Rouschop, K. M. A., Dubois, L. J. & Lambin, P., 3 Aug 2017, In : PLOS ONE. 12, 8, 13 p., 0182508.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells

Shi, Q., Boots, A. W., Maas, L., Veith, C., van Kuijk, K., Haenen, G. R., Godschalk, R. W. & Van Schooten, F. J., 15 Apr 2017, In : Toxicology. 381, p. 64-74 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress

Sthijns, M. M. J. P. E., Schiffers, P. M., Janssen, G. M., Lemmens, K. J. A., Ides, B., Vangrieken, P., Bouwman, F. G., Mariman, E. C., Pader, I., Arner, E. S. J., Johansson, K., Bast, A. & Haenen, G. R. M. M., May 2017, In : Biochimica et Biophysica Acta-general Subjects. 1861, 5, p. 1177-1189 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Silver nanoparticles induce hormesis in A549 human epithelial cells

Sthijns, M. M. J. P. E., Thongkam, W., Albrecht, C., Hellack, B., Bast, A., Haenen, G. R. M. M. & Schins, R. P. F., Apr 2017, In : Toxicology in Vitro. 40, p. 223-233 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial

Baumgartner, S., Mensink, R. P., Haenen, G. R., Bast, A., Binder, C. J., Bekers, O., Husche, C., Luetjohann, D. & Plat, J., 10 Nov 2017, In : Scientific Reports. 7, 9 p., 15288.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Potential of Flavonoids in the Treatment of Non-alcoholic Fatty Liver Disease

van de Wier, B., Koek, G. H., Bast, A. & Haenen, G. R. M., 2017, In : Critical Reviews in Food Science and Nutrition. 57, 4, p. 834-855 22 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Hageman, G. J., Bast, A. & Haenen, G. R. M. M., Oct 2017, In : Toxicology in Vitro. 44, p. 206-212 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

van Gisbergen, M. W., Cebula, M., Zhang, J., Ottosson-Wadlund, A., Dubois, L., Lambin, P., Tew, K. D., Townsend, D. M., Haenen, G. R. M. M., Drittij - Reijnders, M. J., Saneyoshi, H., Araki, M., Shishido, Y., Ito, Y., Arner, E. S. J., Abe, H., Morgenstern, R. & Johansson, K., Jun 2016, In : Molecular Pharmaceutics. 13, 6, p. 2010-2025

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Does Ataxia Telangiectasia Mutated (ATM) protect testicular and germ cell DNA integrity by regulating the redox status?

Godschalk, R. W. L., Vanhees, K., Maas, L., Drittij - Reijnders, M. J., Pachen, D., van Doorn-Khosrovani, S. V. W., van Schooten, F. J. & Haenen, G. R. M. M., Aug 2016, In : Reproductive Toxicology. 63, p. 169-173

Research output: Contribution to journalArticleAcademicpeer-review

EFFECTS OF VITAMIN E OR LIPOIC ACID SUPPLEMENTATION ON FASTING OXYPHYTOSTEROL CONCENTRATIONS IN SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE OR TYPE II DIABETES

Baumgartner, S., Mensink, R. P., Haenen, G., Bast, A., Binder, C., Bekers, O., Husche, C., Luetjohann, D. & Plat, J., Sep 2016, In : Atherosclerosis. 252, p. E89-E89 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Iron Supplements and Magnesium Peroxide: An Example of a Hazardous Combination in Self-Medication

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 4, p. 412-417

Research output: Contribution to journalArticleAcademicpeer-review

Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?

Pijls, K., Jonkers, D., Elizalde Vilalta, M., Drittij - Reijnders, M. J., Haenen, G., Bast, A., Masclee, A. & Koek, G., 2016, In : Annals of Hepatology. 15, 3, p. 402-409 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

van Kuijk, S. J. A., Gieling, R. G., Niemans, R., Lieuwes, N. G., Biemans, R., Telfer, B. A., Haenen, G. R. M. M., Yaromina, A., Lambin, P., Dubois, L. J. & Williams, K. J., 11 Aug 2016, In : PLOS ONE. 11, 8, e0161040.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase

Randall, M., Haenen, G. R., Bouwman, F. G., Vliet, A. V. & Bast, A., 5 Jan 2016, In : Toxicology Letters. 240, 1, p. 43-49 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Time in Redox Adaptation Processes: From Evolution to Hormesis

Sthijns, M. M. J. P. E., Weseler, A. R., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : International journal of molecular sciences. 17, 10, 1649.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

Heyninck, K., Sabbe, L., Chirumamilla, C. S., Szic, K. S. V., Veken, P. V., Lemmens, K. J. A., Lahtela-Kakkonen, M., Naulaerts, S., de Beeck, K. O., Laukens, K., Van Camp, G., Weseler, A. R., Bast, A., Haenen, G. R. M. M., Haegeman, G. & Berghe, W. V., 1 Jun 2016, In : Biochemical Pharmacology. 109, p. 48-61

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2015

Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Bast, A. & Haenen, G. R., Dec 2015, In : Basic & Clinical Pharmacology & Toxicology. 117, 6, p. 427-432 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chemical characteristics for optimizing CYP2E1 inhibition

van de Wier, B., Balk, J. M., Bast, A., Koek, G. H. & Haenen, G. R., 5 Dec 2015, In : Chemico-Biological Interactions. 242, p. 139-144 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Editorial: enhancing gluten digestion in the stomach- a further help to minimise unintentional ingestion? Authors' reply

Salden, B. N., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F. & Masclee, A. A., Aug 2015, In : Alimentary Pharmacology & Therapeutics. 42, 4, p. 485 1 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Letter: gluten digestion in the stomach and duodenum by Aspergillus niger-derived enzyme - things to ponder. Authors' reply

Salden, B. N., Montserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F. & Masclee, A. A., Oct 2015, In : Alimentary Pharmacology & Therapeutics. 42, 7, p. 946-947 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Nutritional Antioxidants: It Is Time to Categorise

Bast, A. & Haenen, G., 2015, Antioxidants in Sport Nutrition. Lamprecht, M. (ed.). Boca Raton: CRC Press, Taylor & Frances Group, p. 17-38

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial

Balk, J. M., Haenen, G. R. M., Koc, O. M., Peters, R., Bast, A., van der Vijgh, W. J. F. & Koek, G. H., 1 Jan 2015, In : Pharmacogenomics and personalized medicine. 8, p. 137-144 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Paracetamol as a Post Prandial Marker for Gastric Emptying, A Food-Drug Interaction on Absorption

Bartholomé, R., Salden, B., Vrolijk, M. F., Troost, F. J., Masclee, A., Bast, A. & Haenen, G. R. M. M., 9 Sep 2015, In : PLOS ONE. 10, 9, 9 p., e0136618.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Randomised clinical study: Aspergillus niger-derived enzyme digests gluten in the stomach of healthy volunteers

Salden, B., Monserrat, V., Troost, F. J., Bruins, M. J., Edens, L., Bartholomé, R., Haenen, G. R., Winkens, B., Koning, F. & Masclee, A. A., 1 Jan 2015, In : Alimentary Pharmacology & Therapeutics. 42, 3, p. 273-285

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

The contribution of the major metabolite 4'-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER

Lemmens, K. J., Herst, P. M., Housmans, B. A., Moalin, M., van der Vijgh, W. J., Bast, A. & Haenen, G. R., 5 Sep 2015, In : Chemico-Biological Interactions. 239, p. 146-152 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD

Lemmens, K., van de Wier, B., Koek, G. H., Köhler, E. S., Drittij, M. J., van der Vijgh, W., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Biochemical and Biophysical Research Communications. 456, 1, p. 179-182

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

The shifting perception on antioxidants: The case of vitamin E and beta-carotene

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Godschalk, R. W., van Schooten, F. J., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Redox Biology. 4C, p. 272-278

Research output: Contribution to journalArticleAcademic

15 Citations (Scopus)

The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation

Vrolijk, M. F., Haenen, G. R., Opperhuizen, A., Jansen, E. H., Schiffers, P. M. & Bast, A., 5 Jan 2015, In : European Journal of Pharmacology. 746, p. 132-137 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Toxicity of Antioxidants

Rezk, B., van der Vijgh, W. J. F., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Toxicology and Forensic Medicine. 1, 1, 1000TFMOJ1e002.

Research output: Contribution to journalArticleAcademic

Toxicity of the anti-oxidants

Rezk, B. M., van der Vijgh, W., Bast, A. & Haenen, G., 2015, In : Toxicology and Forensic Medicine. 1, 1, p. e3-e4

Research output: Contribution to journalArticleAcademicpeer-review

2014

Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept.

Sthijns, M. M., Randall, M. J., Bast, A. & Haenen, G. R., 1 Jan 2014, In : Biochemical and Biophysical Research Communications. 446, 4, p. 1029-1034

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State

Milenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szarc Vel Szic, K., Heyninck, K., Laukens, K., Bizet, M., Defrance, M., Dedeurwaerder, S., Calonne, E., Fuks, F., Haegeman, G., Haenen, G. R., Bast, A. & Weseler, A. R., 24 Apr 2014, In : PLOS ONE. 9, 4, 13 p., e95527.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Glutathione revisited: a better scavenger than previously thought

Haenen, G. R. M. & Bast, A., 27 Nov 2014, In : Frontiers in Pharmacology. 5, 5 p., 260.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup

Hazewindus, M., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : PLOS ONE. 9, 12, e114387.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis

Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., Janssen, B. J. & 2 others, Daemen, M. J. & Sluimer, J. C., 1 Jan 2014, In : Arteriosclerosis Thrombosis and Vascular Biology. 34, 12, p. 2545-2553

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

The cocoa flavanol (-)-epicatechin protects the cortisol response.

Ruijters, E. J., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : Pharmacological Research. 79, p. 28-33 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

The effect of modified eggs and an egg-yolk based beverage on serum lutein and zeaxanthin concentrations and macular pigment optical density: results from a randomized trial

Kelly, E. R., Plat, J., Haenen, G. R., Kijlstra, A. & Berendschot, T. T., 27 Mar 2014, In : PLOS ONE. 9, 3, 9 p., 92659.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)