20032019

Research output per year

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Research Output

2019

A comparison between the abdominal and femoral adipose tissue proteome of overweight and obese women

Vogel, M. A. A., Wang, P., Bouwman, F. G., Hoebers, N., Blaak, E. E., Renes, J., Mariman, E. C. & Goossens, G. H., 12 Mar 2019, In : Scientific Reports. 9, p. 1-9 9 p., 4202.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle

Petrick, H. L., Pignanelli, C., Barbeau, P-A., Churchward-Venne, T. A., Dennis, K. M. J. H., van Loon, L. J. C., Burr, J. F., Goossens, G. H. & Holloway, G. P., Aug 2019, In : Journal of Physiology. 597, 15, p. 3985-3997 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans

van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T. & Blaak, E. E., Dec 2019, In : Diabetes. 68, 12, p. 2247-2258 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The ABCD of Obesity: An EASO Position Statement on a Diagnostic Term with Clinical and Scientific Implications

Fruhbeck, G., Busetto, L., Dicker, D., Yumuk, V., Goossens, G. H., Hebebrand, J., Halford, J. G. C., Farpour-Lambert, N. J., Blaak, E. E., Woodward, E. & Toplak, H., 2019, In : Obesity Facts. 12, 2, p. 131-136 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Impact of Dairy Products in the Development of Type 2 Diabetes: Where Does the Evidence Stand in 2019?

Guo, J., Givens, D. I., Astrup, A., Bakker, S. J. L., Goossens, G. H., Kratz, M., Marette, A., Pijl, H. & Soedamah-Muthu, S. S., Nov 2019, In : Advances in Nutrition. 10, 6, p. 1066-1075 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access
2018

Abdominal subcutaneous adipose tissue gene expression in relation to tissue-specific insulin resistance in human obesity

CODAM study, Maastricht Study & DiOGenes Consortium, Oct 2018, In : Diabetologia. 61, p. S110-S110 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Verboven, K., Wouters, K., Gaens, K., Hansen, D., Bijnen, M., Wetzels, S., Stehouwer, C. D., Goossens, G. H., Schalkwijk, C. G., Blaak, E. E. & Jocken, J. W., 16 Mar 2018, In : Scientific Reports. 8, 8 p., 4677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity

Xu, Q., Mariman, E. C. M., Roumans, N. J. T., Vink, R. G., Goossens, G. H., Blaak, E. E. & Jocken, J. W. E., 1 Jan 2018, In : Adipocyte. 7, 1, p. 12-19 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue oxygenation is associated with insulin sensitivity independently of adiposity in obese men and women

Goossens, G. H., Vogel, M. A. A., Vink, R. G., Mariman, E. C., van Baak, M. A. & Blaak, E. E., Sep 2018, In : Diabetes Obesity & Metabolism. 20, 9, p. 2286-2290 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training

Verboven, K., Stinkens, R., Hansen, D., Wens, I., Frederix, I., Eijnde, B. O., Jocken, J. W. E., Goossens, G. H. & Blaak, E. E., 16 Aug 2018, In : Clinical Science. 132, 15, p. 1685-1698 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans

Vogel, M. A. A., Jocken, J. W. E., Sell, H., Hoebers, N., Essers, Y., Rouschop, K. M. A., Cajlakovic, M., Blaak, E. E. & Goossens, G. H., Oct 2018, In : Journal of Clinical Endocrinology & Metabolism. 103, 10, p. 3688-3697 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions

Trouwborst, I., Bowser, S. M., Goossens, G. H. & Blaak, E. E., 4 Sep 2018, In : Frontiers in nutrition. 5, 14 p., 77.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Effect of diet-induced weight loss on angiopoietin-like protein 4 and adipose tissue lipid metabolism in overweight and obese humans

van der Kolk, B. W., Vink, R. G., Jocken, J. W. E., Roumans, N. J. T., Goossens, G. H., Mariman, E. C. M., van Baak, M. A. & Blaak, E. E., Jul 2018, In : Physiological Reports. 6, 13, 10 p., e13735.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of Sacubitril/Valsartan on Exercise-Induced Lipid Metabolism in Patients With Obesity and Hypertension

Engeli, S., Stinkens, R., Heise, T., May, M., Goossens, G. H., Blaak, E. E., Havekes, B., Jax, T., Albrecht, D., Pal, P., Tegtbur, U., Haufe, S., Langenickel, T. H. & Jordan, J., 1 Jan 2018, In : Hypertension. 71, 1, p. 70-77 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of gut microbiota manipulation on ex vivo lipolysis in human abdominal subcutaneous adipocytes

Jocken, J. W. E., Reijnders, D., Canfora, E. E., Boekschoten, M. V., Plat, J., Goossens, G. H. & Blaak, E. E., 1 Jan 2018, In : Adipocyte. 7, 2, p. 106-112 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity

Stinkens, R., Brouwers, B., Jocken, J. W., Blaak, E. E., Teunissen-Beekman, M. F., Hesselink, M. K., van Baak, M. A., Schrauwen, P. & Goossens, G. H., Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1585-1593 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Short-Term Microbiota Manipulation and Forearm Substrate Metabolism in Obese Men: A Randomized, Double-Blind, Placebo-Controlled Trial

Reijnders, D., Goossens, G. H., Hermes, G. D. A., Smidt, H., Zoetendal, E. G. & Blaak, E. E., 1 Jan 2018, In : Obesity Facts. 11, 4, p. 318-326 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of angiotensin receptor neprilysin inhibition by sacubitril/valsartan on adipose tissue transcriptome and protein expression in obese hypertensive patients

Stinkens, R., van der Kolk, B. W., Jordan, J., Jax, T., Engeli, S., Heise, T., Jocken, J. W., May, M., Schindler, C., Havekes, B., Schaper, N., Albrecht, D., Kaiser, S., Hartmann, N., Letzkus, M., Langenickel, T. H., Goossens, G. H. & Blaak, E. E., 2 Mar 2018, In : Scientific Reports. 8, 7 p., 3933.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans

Most, J., Warnke, I., Boekschoten, M. V., Jocken, J. W. E., de Groot, P., Friedel, A., Bendik, I., Goossens, G. H. & Blaak, E. E., 1 Jan 2018, In : Adipocyte. 7, 3, p. 190-196 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017
Open Access

Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans

Vink, R. G., Roumans, N. J., Cajlakovic, M., Cleutjens, J. P. M., Boekschoten, M. V., Fazelzadeh, P., Vogel, M. A. A., Blaak, E. E., Mariman, E. C., van Baak, M. A. & Goossens, G. H., May 2017, In : International Journal of Obesity. 41, 5, p. 722-728 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women

Most, J., Penders, J., Lucchesi, M., Goossens, G. H. & Blaak, E. E., Sep 2017, In : European Journal of Clinical Nutrition. 71, 9, p. 1040-1045 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut microbiota composition strongly correlates to peripheral insulin sensitivity in obese men but not in women

Most, J., Goossens, G. H., Reijnders, D., Canfora, E. E., Penders, J. & Blaak, E. E., 2017, In : Beneficial Microbes. 8, 4, p. 557-562 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improved Insulin Sensitivity With Angiotensin Receptor Neprilysin Inhibition in Individuals With Obesity and Hypertension

Jordan, J., Stinkens, R., Jax, T., Engeli, S., Blaak, E. E., May, M., Havekes, B., Schindler, C., Albrecht, D., Pal, P., Heise, T., Goossens, G. H. & Langenickel, T. H., Feb 2017, In : Clinical Pharmacology & Therapeutics. 101, 2, p. 254-263 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans

Snijders, T., Nederveen, J. P., Verdijk, L. B., Houben, A. J. H. M., Goossens, G. H., Parise, G. & van Loon, L. J. C., May 2017, In : Physiological Reports. 5, 10, 5 p., e13278.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals

Canfora, E. E., van der Beek, C. M., Hermes, G. D. A., Goossens, G. H., Jocken, J. W. E., Holst, J. J., van Eijk, H. M., Venema, K., Smidt, H., Zoetendal, E. G., Dejong, C. H. C., Lenaerts, K. & Blaak, E. E., Jul 2017, In : Gastroenterology. 153, 1, p. 87-97.e3 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effects of amoxicillin and vancomycin on parameters reflecting cholesterol metabolism

Baumgartner, S., Reijnders, D., Konings, M. C. J. M., Groen, A. K., Luetjohann, D., Goossens, G. H., Blaak, E. E. & Plat, J., Oct 2017, In : Chemistry and Physics of Lipids. 207, p. 239-245 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

Goossens, G. H., Jun 2017, In : Obesity Facts. 10, 3, p. 207-215 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2016

Altered Skeletal Muscle Fatty Acid Handling in Subjects with Impaired Glucose Tolerance as Compared to Impaired Fasting Glucose

Goossens, G. H., Moors, C. C. M., Jocken, J. W. E., van der Zijl, N. J., Jans, A., Konings, E., Diamant, M. & Blaak, E. E., Mar 2016, In : Nutrients. 8, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Altered skeletal muscle fatty acid handling is associated with the degree of insulin resistance in overweight and obese humans

van der Kolk, B. W., Goossens, G. H., Jocken, J. W. & Blaak, E. E., Dec 2016, In : Diabetologia. 59, 12, p. 2686-2696

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics

van der Kolk, B. W., Goossens, G. H., Jocken, J. W., Kersten, S. & Blaak, E. E., Jun 2016, In : Journal of Clinical Endocrinology & Metabolism. 101, 6, p. 2332-2339

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial

Most, J., Timmers, S., Warnke, I., Jocken, J. W. E., van Boekschoten, M., de Groot, P., Bendik, I., Schrauwen, P., Goossens, G. H. & Blaak, E. E., Jul 2016, In : American Journal of Clinical Nutrition. 104, 1, p. 215-227

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
1 Citation (Scopus)

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

Reijnders, D., Goossens, G. H., Hermes, G. D. A., Neis, E. P. J. G., van der Beek, K., Most, J., Holst, J. J., Lenaerts, K., Kootte, R. S., Nieuwdorp, M., Groen, A. K., Olde Damink, S., Boekschoten, M. V., Smidt, H., Zoetendal, E. G., Dejong, C. H. C. & Blaak, E. E., 12 Jul 2016, In : Cell Metabolism. 24, 1, p. 63-74

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation

Dirks, M. L., Wall, B. T., van de Valk, B., Holloway, T. M., Holloway, G. P., Chabowski, A., Goossens, G. H. & van Loon, L., Oct 2016, In : Diabetes. 65, 10, p. 2862-2875

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
2015

A 3-day EGCG-supplementation reduces interstitial lactate concentration in skeletal muscle of overweight subjects

Most, J., van Can, J. G., van Dijk, J. W., Goossens, G., Jocken, J., Hospers, J. J., Bendik, I. & Blaak, E. E., 1 Jan 2015, In : Scientific Reports. 5, 17896.

Research output: Contribution to journalArticleAcademicpeer-review

Adipose tissue dysfunction and impaired metabolic health in human obesity: a matter of oxygen?

Goossens, G. H. & Blaak, E. E., 1 Jan 2015, In : Frontiers in Endocrinology. 6, p. 55

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)

Moderate hypoxia exposure: a novel strategy to improve cardiometabolic profile in humans?

Vogel, M. A. A., Blaak, E. E. & Goossens, G. H., 1 Jan 2015, In : European Medical Journal Diabetes. 3, 1, p. 73-79

Research output: Contribution to journalArticleAcademicpeer-review

Targeting fatty acid metabolism to improve glucose metabolism

Stinkens, R. E., Goossens, G. H., Jocken, J. W. & Blaak, E. E., 1 Jan 2015, In : Obesity Reviews. 16, 9, p. 715-757

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
2014

Comment on Lecoultre et al. Ten Nights of Moderate Hypoxia Improves Insulin Sensitivity in Obese Humans. Diabetes Care 2013;36:e197-e198

Goossens, G. H., 1 Jan 2014, In : Diabetes Care. 37, 6, p. e155-156

Research output: Contribution to journalEditorialAcademicpeer-review

1 Citation (Scopus)
17 Citations (Scopus)

Targeting Adipose Tissue Lipid Metabolism to Improve Glucose Metabolism in Cardiometabolic Disease

Jocken, J. W. E., Goossens, G. H. & Blaak, E. E., 1 Jan 2014, In : EMJ Diabetes. 2014, 2, p. 273-282

Research output: Contribution to journalArticleAcademicpeer-review

The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men.

Konings, E., Timmers, S., Boekschoten, M. V., Goossens, G. H., Jocken, J. W., Afman, L. A., Muller, M., Schrauwen, P., Mariman, E. C. & Blaak, E. E., Mar 2014, In : International Journal of Obesity. 38, 3, p. 470-473 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
2013

Characterization of the inflammatory and metabolic profile of adipose tissue in a mouse model of chronic hypoxia.

van den Borst, B., Schols, A. M. W. J., de Theije, C. C., Boots, A. W., Köhler, S. E., Goossens, G. H. & Gosker, H. R., Jun 2013, In : Journal of Applied Physiology. 114, 11, p. 1619-1628 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance.

Jocken, J. W., Goossens, G. H., Boon, H., Mason, R. R., Essers, Y., Havekes, B., Watt, M. J., van Loon, L. J. C. & Blaak, E. E., Oct 2013, In : Diabetologia. 56, 10, p. 2255-2265 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)