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Research Output 1994 2019

  • 83 Article
  • 1 Comment/Letter to the editor
  • 1 Doctoral Thesis
2019

Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion

Phielix, E., Begovatz, P., Gancheva, S., Bierwagen, A., Kornips, E., Schaart, G., Hesselink, M. K. C., Schrauwen, P. & Roden, M., 1 Nov 2019, In : JCI INSIGHT. 4, 21, 12 p., 127928.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of l-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study

Boon, M. R., Hanssen, M. J. W., Brans, B., Hulsman, C. J. M., Hoeks, J., Nahon, K. J., Bakker, C., van Klinken, J. B., Havekes, B., Schaart, G., Jazet, I. M., Rensen, P. C. N. & Lichtenbelt, W. D. V. M., Jan 2019, In : Diabetologia. 62, 1, p. 112-122 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

Gemmink, A., Daemen, S., Brouwers, B., Huntjens, P. R., Schaart, G., Moonen-Kornips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., 1 Mar 2018, In : Journal of Physiology. 596, 5, p. 857-868 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox

Daemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., Moonen-Komips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., Nov 2018, In : Molecular Metabolism. 17, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity

Lancel, S., Hesselink, M. K. C., Woldt, E., Rouille, Y., Dorchies, E., Delhaye, S., Duhem, C., Thorel, Q., Mayeuf-Louchart, A., Pourcet, B., Montel, V., Schaart, G., Beton, N., Picquet, F., Briand, O., Salles, J. P., Duez, H., Schrauwen, P., Bastide, B., Bailleul, B. & 2 others, Staels, B. & Sebti, Y., 3 May 2018, In : JCI INSIGHT. 3, 9, p. 1-13 13 p., e98081.

Research output: Contribution to journalArticleAcademicpeer-review

Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans

Nascimento, E. B. M., Sparks, L. M., Divoux, A., van Gisbergen, M. W., Broeders, E. P. M., Jorgensen, J. A., Schaart, G., Bouvy, N. D., Lichtenbelt, W. D. V. M. & Schrauwen, P., 1 Jan 2018, In : Obesity. 26, 1, p. 135-140 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians

Gemmink, A., Bakker, L. E. H., Guigas, B., Kornips, E., Schaart, G., Meinders, A. E., Jazet, I. M. & Hesselink, M. K. C., 14 Feb 2017, In : Scientific Reports. 7, 9 p., 42393.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats

van Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., Schrauwen, P., Hoeks, J. & Hesselink, M. K. C., 14 Mar 2016, In : Scientific Reports. 6, 22854.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial

Timmers, S., de Ligt, M., Phielix, E., van de Weijer, T., Hansen, J., Moonen-Kornips, E., Schaart, G., Kunz, I., Hesselink, M. K. C., Schrauwen-Hinderling, V. B. & Schrauwen, P., Dec 2016, In : Diabetes Care. 39, 12, p. 2211-2217

Research output: Contribution to journalArticleAcademicpeer-review

2015
15 Citations (Scopus)

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M., Reue, K., van Marken Lichtenbelt, W., Olivecrona, G., Rensen, P. C., Heeren, J. & Kersten, S., 17 Oct 2015, In : Elife. 4, 23 p., e08428.

Research output: Contribution to journalArticleAcademicpeer-review

Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects

van der Lans, A. A. J., Boon, M. R., Haks, M. C., Quinten, E., Schaart, G., Ottenhoff, T. H. & van Marken Lichtenbelt, W., 1 Jan 2015, In : Physiological Reports. 3, 7, e12394.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

Jiang, J., Briede, J. J., Jennen, D. G. J., Van Summeren, A., Saritas-Brauers, K., Schaart, G., Kleinjans, J. C. S. & de Kok, T. M. C. M., 16 Apr 2015, In : Toxicology Letters. 234, 2, p. 139-150

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D. & Schrauwen, P., Aug 2015, In : Nature Medicine. 21, 8, p. 863-865 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

Boon, M. R., Bakker, L. E. H., Haks, M. C., Quinten, E., Schaart, G., Van Beek, L., Wang, Y., Van Schinkel, L., Van Harmelen, V., Meinders, A. E., Ottenhoff, T. H. M., Van Dijk, K. W., Guigas, B., Jazet, I. M. & Rensen, P. C. N., Jan 2015, In : Clinical Science. 128, 2, p. 143-151

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Broeders, E. P., Nascimento, E. B. M., Havekes, B., Brans, B., Roumans, K. H. M., Tailleux, A., Schaart, G., Kouach, M., Charton, J., Deprez, B., Bouvy, N. D., Mottaghy, F., Staels, B., van Marken Lichtenbelt, W. & Schrauwen, P., 1 Sep 2015, In : Cell Metabolism. 22, 3, p. 418-426 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
22 Citations (Scopus)

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers - van Gogh, I., Schaart, G., Jeppesen, J., Kneppers, A., Mensink, M., Voshol, P. J., Olivecrona, G., Tan, N. S., Hesselink, M. K., Berbee, J. F., Rensen, P. C., Kalkhoven, E., Schrauwen, P. & Kersten, S., 18 Mar 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. E1043-E1052 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice

Noordmans, G. A., Huang, Y., Savage, H., van Dijk, M. C., Schaart, G., van den Bergh Weerman, M. A., Heeringa, P., Hillebrands, J. L., Korstanje, R. & van Goor, H., 1 Jan 2014, In : PLOS ONE. 9, 10, e111308.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.

Nabben, M., van Bree, B. W., Lenaers, E., Hoeks, J., Hesselink, M. K., Schaart, G., Gijbels, M. J., Glatz, J. F., da Silva, G. J., De Windt, L. J., Tian, R., Mike, E., Skapura, D. G., Wehrens, X. H. & Schrauwen, P., Nov 2014, In : Basic Research in Cardiology. 109, 6, 12 p., 447.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Reduced incorporation of Fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes.

Sparks, L. M., Bosma, M., Brouwers, B., van de Weijer, T., Bilet, L., Schaart, G., Kornips, E., Eichmann, T. O., Lass, A., Hesselink, M. K. & Schrauwen, P., May 2014, In : Diabetes. 63, 5, p. 1583-1593 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
17 Citations (Scopus)

Effects of Bezafibrate Treatment in a Patient and a Carrier With Mutations in the PNPLA2 Gene, Causing Neutral Lipid Storage Disease With Myopathy

van de Weijer, T., Havekes, B., Bilet, L., Hoeks, J., Sparks, L., Bosma, M., Paglialunga, S., Jorgensen, J., Janssen, M. C., Schaart, G., Sauerwein, H. P., Smeets, J. L., Wildberger, J. E., Zechner, R., Schrauwen-Hinderling, V. B., Hesselink, M. K. C. & Schrauwen, P., 1 Jan 2013, In : Circulation Research. 112, 5, p. e51-54

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

10 Citations (Scopus)

Increased Oxygen Consumption in Human Adipose Tissue From the "Brown Adipose Tissue" Region

Vijgen, G. H. E. J., Sparks, L. M., Bouvy, N. D., Schaart, G., Hoeks, J., van Marken Lichtenbelt, W. D. & Schrauwen, P., Jul 2013, In : Journal of Clinical Endocrinology & Metabolism. 98, 7, p. E1230-E1234 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Muscle fiber-type distribution, fiber-type-specific damage, and the Pompe disease phenotype

van den Berg, L. E., Drost, M. R., Schaart, G., de Laat, J., van Doorn, P. A., van der Ploeg, A. T. & Reuser, A. J., 1 Jan 2013, In : Journal of Inherited Metabolic Disease. 36, 5, p. 787-794

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Relationship of C5L2 receptor to skeletal muscle substrate utilization

Roy, C., Paglialunga, S., Schaart, G., Moonen-Kornips, E., Meex, R. C., Phielix, E., Hoeks, J., Hesselink, M. K., Cianflone, K. & Schrauwen, P., 27 Feb 2013, In : PLOS ONE. 8, 2, 8 p., 57494.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
95 Citations (Scopus)

Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

Woldt, E., Sebti, Y., Solt, L. A., Duhem, C., Lancel, S., Eeckhoute, J., Hesselink, M. K. C., Paquet, C., Delhaye, S., Shin, Y., Kamenecka, T. M., Schaart, G., Lefebvre, P., Neviere, R., Burris, T. P., Schrauwen, P., Staels, B. & Duez, H., 1 Jan 2013, In : Nature Medicine. 19, 8, p. 1039-1046

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Steep increase in myonuclear domain size during infancy

Delhaas, T., Van der Meer, S. F., Schaart, G., Degens, H. & Drost, M. R., Feb 2013, In : The Anatomical Record: advances in integrative anatomy and evolutionary biology. 296, 2, p. 192-197 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012
34 Citations (Scopus)

Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity

Timmers, S., Nabben, M., Bosma, M., van Bree, B., Lenaers, E., Van Beurden, D., Schaart, G., Westerterp-Plantenga, M. S., Langhans, W., Hesselink, M. K. C., Schrauwen-Hinderling, V. B. & Schrauwen, P., 17 Jul 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 29, p. 11711-11716 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

878 Citations (Scopus)

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

Wu, J., Bostrom, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerback, S., Schrauwen, P. & Spiegelman, B. M., 20 Jul 2012, In : Cell. 150, 2, p. 366-376 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Effects of adding exercise to a 16-week very low-calorie diet in obese, insulin-dependent type 2 diabetes mellitus patients.

Snel, M., Gastaldelli, A., Ouwens, DM., Hesselink, M. K. C., Schaart, G., Buzzigoli, E., Frolich, M., Romijn, J. A., Pijl, H., Meinders, A. E. & Jazet, I. M., Jul 2012, In : Journal of Clinical Endocrinology & Metabolism. 97, 7, p. 2512-2520 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hibernoma with metabolic impact?

Vijgen, G. H. E. J., Bouvy, N. D., Smidt, M. L., Kooreman, L., Schaart, G. & van Marken Lichtenbelt, W. D., 1 Jan 2012, In : BMJ case Reports. 2012

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Phielix, E., Meex, R., Ouwens, DM., Sparks, L. M., Hoeks, J., Schaart, G., Kornips, C. F. P., Hesselink, M. K. C. & Schrauwen, P., Oct 2012, In : Diabetes. 61, 10, p. 2472-2478 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels.

Bosma, M., Hesselink, M. K. C., Sparks, L. M., Timmers, S., Ferraz, M. J., Mattijssen, F., Van Beurden, D., Schaart, G., de Baets, M. H. V., Verheyen, F. K., Kersten, S. & Schrauwen, P., Nov 2012, In : Diabetes. 61, 11, p. 2679-2690 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis

Smeele, K. M., Eerbeek, O., Schaart, G., Koeman, A., Bezemer, R., Nelson, J. K., Ince, C., Nederlof, R., Boek, M., Laakso, M., Haan, A., Drost, M. R., Hollmann, M. W. & Zuurbier, C. J., Aug 2012, In : Journal of Applied Physiology. 113, 4, p. 608-618 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

66 Citations (Scopus)

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria.

Bosma, M., Minnaard, R., Sparks, L. M., Schaart, G., Losen, M. R., de Baets, M. H. V., Duimel, H., Kersten, S., Bickel, P. E., Schrauwen, P. & Hesselink, M. K. C., Feb 2012, In : Histochemistry and Cell Biology. 137, 2, p. 205-216 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011
12 Citations (Scopus)

High fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance

Hoeks, J., de Wilde, J., Hulshof, M. F., van den Berg, S. A., Schaart, G., van Dijk, K. W., Smit, E. & Mariman, E. C., 28 Nov 2011, In : PLOS ONE. 6, 11, 10 p., 27274.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
24 Citations (Scopus)
123 Downloads (Pure)

Paradoxical Increase in TAG and DAG Content Parallel the Insulin Sensitizing Effect of Unilateral DGAT1 Overexpression in Rat Skeletal Muscle

Timmers, S., de Vogel-van den Bosch, J., Hesselink, M. K. C., Van Beurden, D., Schaart, G., Ferraz, M. J., Losen, M. R., Perez - Martinez, P., de Baets, M. H. V., Aerts, J. M. & Schrauwen, P., 14 Jan 2011, In : PLOS ONE. 6, 1, 11 p., 14503.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
11 Citations (Scopus)

The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats.

de Vogel-van den Bosch, J., Hoeks, J., Timmers, S., Houten, S. M., van Dijk, P. J., Boon, W., Van Beurden, D., Schaart, G., Kersten, S., Voshol, P. J., Wanders, R. J., Hesselink, M. K. C. & Schrauwen, P., Apr 2011, In : Obesity. 19, 4, p. 792-799 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)
2 Downloads (Pure)
2010
18 Citations (Scopus)

Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.

Lenaers, E., Feyter, H. M., Hoeks, J., Schrauwen, P., Schaart, G., Nabben, M., Nicolay, K., Prompers, J. J. & Hesselink, M. K., 1 Jan 2010, In : Obesity. 18, 6, p. 1100-1107

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling

Daniels, A., van Bilsen, M., Janssen, B. J. A., Brouns, A. E., Cleutjens, J. P. M., Roemen, T. H., Schaart, G., van der Velden, J., van der Vusse, G. J. & van Nieuwenhoven, F. A., Sep 2010, In : Acta Physiologica. 200, 1, p. 11-22 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice.

Smeele, K. M., Eerbeek, O., Koeman, A., Bezemer, R., Ince, C., Heikkinen, S., Laakso, M., Haan, A., Schaart, G., Drost, M. R., Hollmann, M. W. & Zuurbier, C. J., 1 Jan 2010, In : Pflugers Archiv-European Journal of Physiology. 459, 5, p. 705-712

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.

Timmers, S., Bosch, J., Towler, M. C., Schaart, G., Kornips, E., Mensink, R. P., Hesselink, M. K., Hardie, D. G. & Schrauwen, P., Feb 2010, In : Journal of Lipid Research. 51, 2, p. 352-359 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Regulation of mitochondrial biogenesis during myogenesis

Remels, A. H., Langen, R. C., Schrauwen, P., Schaart, G., Schols, A. M. & Gosker, H. R., 5 Feb 2010, In : Molecular and Cellular Endocrinology. 315, 1-2, p. 113-120 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
2009
48 Citations (Scopus)

Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.

Minnaard, R., Schrauwen, P., Schaart, G., Jorgensen, J. A., Lenaers, E., Mensink, M. & Hesselink, M. K., 1 Jan 2009, In : Journal of Clinical Endocrinology & Metabolism. 94, 10, p. 4077-4085

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

An 8-Week High-Fat Diet Induces Obesity and Insulin Resistance with Small Changes in the Muscle Transcriptome of C57BL/6J Mice

de Wilde, J., Smit, E., Mohren, R., Boekschoten, M. V., de Groot, P., van den Berg, S. A., Bijland, S., Voshol, P. J., van Dijk, K. W., de Wit, N. W., Bunschoten, A., Schaart, G., Hulshof, M. F. & Mariman, E. C. M., 1 Jan 2009, In : Journal of Nutrigenetics and Nutrigenomics. 2, 6, p. 280-291

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation

Driesen, R. B., Verheyen, F. K., Schaart, G., de Maziere, A., Viebahn, C., Prinzen, F. W., Lenders, M. H., Debie, W., Totzeck, A., Borgers, M. & Ramaekers, F. C., 1 Jan 2009, In : Cardiovascular Pathology. 18, 1, p. 19-27

Research output: Contribution to journalArticleAcademicpeer-review