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Research Output

Article

Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children.

Koot, B. G., van der Baan Slootweg, O. H., Bohte, A. E., Nederveen, A. J., van Werven, J. R., Tamminga-Smeulders, C. I., Merkus, M. P., Schaap, F. G., Jansen, P. L., Stoker, J. & Benninga, M. A., Mar 2013, In : Obesity. 21, 3, p. 583-590 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake.

van den Berg, S. A., Heemskerk, M. M., Geerling, J. J., van Klinken, J. B., Schaap, F. G., Bijland, S., Berbee, J. F., van Harmelen, V. J., Pronk, A. C., Schreurs, M., Havekes, L. M., Rensen, P. C. & van Dijk, K. W., Aug 2013, In : Faseb Journal. 27, 8, p. 3354-3362 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bile acid receptors as targets for drug development

Schaap, F. G., Trauner, M. & Jansen, P. L., 1 Jan 2014, In : Nature Reviews Gastroenterology & Hepatology. 11, 1, p. 55-67 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bile acids drive the newborn's gut microbiota maturation

van Best, N., Rolle-Kampczyk, U., Schaap, F. G., Basic, M., Damink, S. W. M. O., Bleich, A., Savelkoul, P. H. M., von Bergen, M., Penders, J. & Hornef, M. W., 23 Jul 2020, In : Nature Communications. 11, 1, 13 p., 3692.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bile salts predict liver regeneration in rabbit model of portal vein embolization

Hoekstra, L. T., Rietkerk, M., van Lienden, K. P., van den Esschert, J. W., Schaap, F. G. & van Gulik, T. M., 1 Jan 2012, In : Journal of Surgical Research. 178, 2, p. 773-8

Research output: Contribution to journalArticleAcademicpeer-review

Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects

Lips, M. A., de Groot, G. H., Berends, F. J., Wiezer, R., van Wagensveld, B. A., Swank, D. J., Luijten, A., van Dijk, K. W., Pijl, H., Jansen, P. L. M. & Schaap, F. G., 1 Jan 2014, In : Clinical Endocrinology.

Research output: Contribution to journalArticleAcademicpeer-review

Can plasma bile salt, triglycerides, and apoA-V levels predict liver regeneration?

Hoekstra, L. T., van Lienden, K. P., Schaap, F. G., Chamuleau, R. A., Bennink, R. J. & van Gulik, T. M., 1 Jan 2012, In : World Journal of Surgery. 36, 12, p. 2901-8

Research output: Contribution to journalArticleAcademicpeer-review

Cathepsin D regulates lipid metabolism in murine steatohepatitis

Houben, T., Oligschlaeger, Y., Hendrikx, T., Bitorina, A. V., Walenbergh, S. M. A., van Gorp, P. J., Gijbels, M. J. J., Friedrichs, S., Plat, J., Schaap, F. G., Luetjohann, D., Hofker, M. H. & Shiri-Sverdlov, R., 14 Jun 2017, In : Scientific Reports. 7, 10 p., 3494.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cholic acid therapy in Zellweger spectrum disorders

Berendse, K., Klouwer, F. C. C., Koot, B. G. P., Kemper, E. M., Ferdinandusse, S., Koelfat, K. V. K., Lenicek, M., Schaap, F. G., Waterham, H. R., Vaz, F. M., Engelen, M., Jansen, P. L. M., Wanders, R. J. A. & Poll-The, B. T., Nov 2016, In : Journal of Inherited Metabolic Disease. 39, 6, p. 859-868

Research output: Contribution to journalArticleAcademicpeer-review

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Flinders, B., Huizing, L. R. S., van Heerden, M., Cuyckens, F., Neumann, U. P., van der Laan, L. J. W., Damink, S. W. M. O., Heeren, R. M. A., Schaap, F. G. & Vreeken, R. J., 16 Oct 2018, In : Analytical Chemistry. 90, 20, p. 11835-11846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Differential effects of a 40-hour fast and bile acid supplementation on human GLP-1 and FGF19 responses

van Nierop, F. S., Meessen, E. C. E., Nelissen, K. G. M., Achterbergh, R., Lammers, L. A., Vaz, F. M., Mathot, R. A. A., Klumpen, H-J., Damink, S. W. O., Schaap, F. G., Romijn, J. A., Kemper, E. M. & Soeters, M. R., Sep 2019, In : American Journal of Physiology : Endocrinology and Metabolism. 317, 3, p. E494-E502 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study

de Groot, P. F., Belzer, C., Aydin, O., Levin, E., Levels, J. H., Aalvink, S., Boot, F., Holleman, F., van Raalte, D. H., Scheithauer, T. P., Simsek, S., Schaap, F. G., Damink, S. W. M. O., Roep, B. O., Hoekstra, J. B., de Vos, W. M. & Nieuwdorp, M., 6 Dec 2017, In : PLOS ONE. 12, 12, 14 p., 0188475.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Duodenal-jejunal lining increases postprandial unconjugated bile acid responses and disrupts the bile acid-FXR-FGF19 axis in humans

van Nierop, F. S., de Jonge, C., Kulik, W., Bouvy, N., Schaap, F. G., Damink, S. W. O., Rensen, S., Romijn, J. A., Greve, J. W. M. & Soeters, M. R., Apr 2019, In : Metabolism-Clinical and Experimental. 93, p. 25-32 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of obeticholic acid on liver regeneration following portal vein embolization in an experimental model

Olthof, P. B., Huisman, F., Schaap, F. G., van Lienden, K. P., Bennink, R. J., van Golen, R. F., Heger, M., Verheij, J., Jansen, P. L., Damink, S. W. O. & van Gulik, T. M., Apr 2017, In : British Journal of Surgery. 104, 5, p. 590-599 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of Plasmapheresis on Cholestatic Pruritus and Autotaxin Activity During Pregnancy

Heerkens, M., Dedden, S., Scheepers, H., Van Paassen, P., Masclee, A., de Die-Smulders, C., Olde Damink, S. W. M., Schaap, F. G., Jansen, P., Koek, G., Beuers, U. & Verbeek, J., Jun 2019, In : Hepatology. 69, 6, p. 2707-2710 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health

Dilger, K., Hohenester, S., Winkler Budenhofer, U., Bastiaansen, B. A., Schaap, F. G., Rust, C. & Beuers, U., 1 Jan 2012, In : Journal of Hepatology. 57, 1, p. 133-40

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects

van Nierop, F. S., Kulik, W., Endert, E., Schaap, F. G., Damink, S. W. O., Romijn, J. A. & Soeters, M. R., Dec 2017, In : Clinical Nutrition. 36, 6, p. 1615-1620 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress.

Schaap, F. G., Kremer, A. E., Lamers, W. H., Jansen, P. L. & Gaemers, I. C., Apr 2013, In : Biochimie. 95, 4, p. 692-699 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

FXR, intestinal FiXeR of hepatocellular carcinoma?

Schaap, F. G., Jansen, P. L. M. & Olde Damink, S. W. M., 1 Jan 2015, In : Hepatology. 61, 1, p. 21-23 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

van Golen, R. F., Olthof, P. B., Lionarons, D. A., Reiniers, M. J., Alles, L. K., Uz, Z., de Haan, L., Ergin, B., de Waart, D. R., Maas, A., Verheij, J., Jansen, P. L., Darnink, S. W. O., Schaap, F. G., van Gulik, T. M. & Heger, M., 8 Nov 2018, In : Scientific Reports. 8, 10 p., 16529.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients

Koelfat, K. V. K., Plummer, M. P., Schaap, F. G., Lenicek, M., Jansen, P. L. M., Deane, A. M. & Damink, S. W. M. O., Jul 2019, In : Hepatology. 70, 1, p. 308-318 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis

Nijmeijer, R. M., Schaap, F. G., Smits, A. J., Kremer, A. E., Akkermans, L. M., Kroese, A. B., Rijkers, G. T., Schipper, M. E., Verheem, A., Wijmenga, C., Gooszen, H. G. & van Erpecum, K. J., 1 Jan 2014, In : PLOS ONE. 9, 12, e114393.

Research output: Contribution to journalArticleAcademicpeer-review

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Kootte, R. S., Levin, E., Salojarvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Damink, S. W. M. O. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., 3 Oct 2017, In : Cell Metabolism. 26, 4, p. 611-619.e6 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

Suijker, J., Oosting, J., Koornneef, A., Struys, E. A., Salomons, G. S., Schaap, F. G., Waaijer, C. J., Wijers-Koster, P. M., Briaire-de Bruijn, I. H., Haazen, L., Riester, S. M., Dudakovic, A., Danen, E., Cleton-Jansen, A. M., van Wijnen, A. J. & Bovee, J. V., 1 Jan 2015, In : Oncotarget. 6, 14, p. 12505-12509

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal failure to produce FGF19: A culprit in intestinal failure-associated liver disease?

van Erpecum, K. J. & Schaap, F. G., 1 Jan 2015, In : Journal of Hepatology. 62, 6, p. 1231-1233

Research output: Contribution to journalArticleAcademicpeer-review

Low-Dose Lipopolysaccharide Causes Biliary Injury by Blood Biliary Barrier Impairment in a Rat Hepatic Ischemia/Reperfusion Model

Reiling, J., Bridle, K. R., Gijbels, M., Schaap, F. G., Jaskowski, L., Santrampurwala, N., Britton, L. J., Campbell, C. M., Damink, S. W. M. O., Crawford, D. H. G., Dejong, C. H. C. & Fawcett, J., Feb 2017, In : Liver Transplantation. 23, 2, p. 194-206 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 in tumors

Schaap, F. G., French, P. J. & Bovee, J. V., 1 Jan 2013, In : Advances in Anatomic Pathology. 20, 1, p. 32-38 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis

Vesterhus, M., Holm, A., Hov, J. R., Nygard, S., Schrumpf, E., Melum, E., Thorbjornsen, L. W., Paulsen, V., Lundin, K., Dale, I., Gilja, O. H., Zweers, S. J. L. B., Vatn, M., Schaap, F. G., Jansen, P. L. M., Ueland, T., Rosjo, H., Moum, B., Ponsioen, C. Y., Boberg, K. M. & 3 others, Farkkila, M., Karlsen, T. H. & Lund-Johansen, F., Jun 2017, In : Journal of Hepatology. 66, 6, p. 1214-1222 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans

Kim Mc van, M., Dello, S. A., de Jong, M. C., van Eijk, H. M., de Kok, T. M., Briedé, J. J., Schaap, F. G., Damink, S. W. O. & Dejong, C. H., 30 Jul 2018, In : Journal of clinical and translational research. 3, Suppl 2, p. 366-374 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease

Koelfat, K. V. K., Schaap, F. G., Hodin, C. M. J. M., Visschers, R. G. J., Svavarsson, B. I., Lenicek, M., Shiri-Sverdlov, R., Lenaerts, K. & Damink, S. W. M. O., Oct 2017, In : Clinical Nutrition. 36, 5, p. 1403-1410 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis

van Schaik, F. D., Gadaleta, R. M., Schaap, F. G., van Mil, S. W., Siersema, P. D., Oldenburg, B. & van Erpecum, K. J., 26 Nov 2012, In : PLOS ONE. 7, 11, 8 p., 49706.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevention and reversal of hepatic steatosis with a high-protein diet in mice

Garcia Caraballo, S., Comhair, T. M., Verheyen, F. K., Gaemers, I., Schaap, F. G., Houten, S. M., Hakvoort, T. B., Dejong, C. H. C., Lamers, W. H. & Köhler, S. E., 1 Jan 2013, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1832, 5, p. 685-695

Research output: Contribution to journalArticleAcademicpeer-review

Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge

Zweers, S. J., de Vries, E. M., Lenicek, M., Tolenaars, D., de Waart, D. R., Koelfat, K. V. K., Groen, A. K., Damink, S. W. M. O., Beuers, U., Ponsioen, C., Jansen, P. L. M. & Schaap, F. G., Jan 2017, In : Hepatology International. 11, 1, p. 132-140 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Role of fibroblast growth factor 19 in the control of glucose homeostasis

Schaap, F. G., Jul 2012, In : Current Opinion in Clinical Nutrition and Metabolic Care. 15, 4, p. 386-391 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Serum Autotaxin Activity Correlates with Pruritus in Pediatric Cholestatic Disorders

Kremer, A. E., Gonzales, E., Schaap, F. G., Oude Elferink, R. P., Jacquemin, E. & Beuers, U., Apr 2016, In : Journal of Pediatric Gastroenterology and Nutrition. 62, 4, p. 530-535 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

Kremer, A. E., van Dijk, R., Leckie, P., Schaap, F. G., Kuiper, E. M., Mettang, T., Reiners, K. S., Raap, U., van Buuren, H. R., van Erpecum, K. J., Davies, N. A., Rust, C., Engert, A., Jalan, R. A., Oude Elferink, R. P. & Beuers, U., 1 Jan 2012, In : Hepatology. 56, 4, p. 1391-400

Research output: Contribution to journalArticleAcademicpeer-review

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

Vaz, F. M., Paulusma, C. C., Huidekoper, H., de Ru, M., Lim, C., Koster, J., Ho-Mok, K., Bootsma, A. H., Groen, A. K., Schaap, F. G., Oude Elferink, R. P., Waterham, H. R. & Wanders, R. J., 1 Jan 2015, In : Hepatology. 61, 1, p. 260-267 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy

Klouwer, F. C. C., Koot, B. G. P., Berendse, K., Kemper, E. M., Ferdinandusse, S., Koelfat, K. V. K., Lenicek, M., Vaz, F. M., Engelen, M., Jansen, P. L. M., Wanders, R. J. A., Waterham, H. R., Schaap, F. G. & Poll-The, B. T., Mar 2019, In : Journal of Inherited Metabolic Disease. 42, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The gut-liver axis

Visschers, R. G. J., Luyer, M. D. P., Schaap, F. G., Olde Damink, S. & Soeters, P. B., 1 Jan 2013, In : Current Opinion in Clinical Nutrition and Metabolic Care. 16, 5, p. 576-581

Research output: Contribution to journalArticleAcademicpeer-review

The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract

Zweers, S. J., Booij, K. A., Komuta, M., Roskams, T., Gouma, D. J., Jansen, P. L. & Schaap, F. G., Feb 2012, In : Hepatology. 55, 2, p. 575-583 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The portal-drained viscera release fibroblast growth factor 19 in humans

Koelfat, K. V. K., Bloemen, J. G., Jansen, P., Dejong, K., Schaap, F. G. & Olde Damink, S. W. M., Dec 2016, In : Physiological Reports. 4, 24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The role of bile salts in liver regeneration

van de Laarschot, L. F. M., Jansen, P. L. M., Schaap, F. G. & Olde Damink, S., Sep 2016, In : Hepatology International. 10, 5, p. 733-740

Research output: Contribution to journalArticleAcademicpeer-review

The role of macrophages in the development of biliary injury in a lipopolysaccharide-aggravated hepatic ischaemia-reperfusion model

Reiling, J., Bridle, K. R., Schaap, F. G., Jaskowski, L., Santrampurwala, N., Britton, L. J., Campbell, C. M., Jansen, P. L. M., Damink, S. W. M. O., Crawford, D. H. G., Dejong, C. H. C. & Fawcett, J., Apr 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 4, p. 1284-1292 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis

Van den Hof, W. F. P. M., Coonen, M. L. J., van Herwijnen, M., Brauers, K., Jennen, D., Damink, S. W. M. O., Schaap, F. G. & Kleinjans, J. C. S., Oct 2017, In : Toxicology in Vitro. 44, p. 322-329 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Validation of the peak bilirubin criterion for outcome after partial hepatectomy

van Mierlo, K. M. C., Lodewick, T. M., Dhar, D. K., van Woerden, V., Kurstjens, R., Schaap, F. G., van Dam, R. M., Vyas, S., Malago, M., Dejong, C. H. C. & Olde Damink, S., Oct 2016, In : HPB. 18, 10, p. 806-812

Research output: Contribution to journalArticleAcademicpeer-review