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Research Output

2020

Bile acids drive the newborn's gut microbiota maturation

van Best, N., Rolle-Kampczyk, U., Schaap, F. G., Basic, M., Damink, S. W. M. O., Bleich, A., Savelkoul, P. H. M., von Bergen, M., Penders, J. & Hornef, M. W., 23 Jul 2020, In : Nature Communications. 11, 1, 13 p., 3692.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
2019

Differential effects of a 40-hour fast and bile acid supplementation on human GLP-1 and FGF19 responses

van Nierop, F. S., Meessen, E. C. E., Nelissen, K. G. M., Achterbergh, R., Lammers, L. A., Vaz, F. M., Mathot, R. A. A., Klumpen, H-J., Damink, S. W. O., Schaap, F. G., Romijn, J. A., Kemper, E. M. & Soeters, M. R., Sep 2019, In : American Journal of Physiology : Endocrinology and Metabolism. 317, 3, p. E494-E502 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Duodenal-jejunal lining increases postprandial unconjugated bile acid responses and disrupts the bile acid-FXR-FGF19 axis in humans

van Nierop, F. S., de Jonge, C., Kulik, W., Bouvy, N., Schaap, F. G., Damink, S. W. O., Rensen, S., Romijn, J. A., Greve, J. W. M. & Soeters, M. R., Apr 2019, In : Metabolism-Clinical and Experimental. 93, p. 25-32 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of Plasmapheresis on Cholestatic Pruritus and Autotaxin Activity During Pregnancy

Heerkens, M., Dedden, S., Scheepers, H., Van Paassen, P., Masclee, A., de Die-Smulders, C., Olde Damink, S. W. M., Schaap, F. G., Jansen, P., Koek, G., Beuers, U. & Verbeek, J., Jun 2019, In : Hepatology. 69, 6, p. 2707-2710 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients

Koelfat, K. V. K., Plummer, M. P., Schaap, F. G., Lenicek, M., Jansen, P. L. M., Deane, A. M. & Damink, S. W. M. O., Jul 2019, In : Hepatology. 70, 1, p. 308-318 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy

Klouwer, F. C. C., Koot, B. G. P., Berendse, K., Kemper, E. M., Ferdinandusse, S., Koelfat, K. V. K., Lenicek, M., Vaz, F. M., Engelen, M., Jansen, P. L. M., Wanders, R. J. A., Waterham, H. R., Schaap, F. G. & Poll-The, B. T., Mar 2019, In : Journal of Inherited Metabolic Disease. 42, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Flinders, B., Huizing, L. R. S., van Heerden, M., Cuyckens, F., Neumann, U. P., van der Laan, L. J. W., Damink, S. W. M. O., Heeren, R. M. A., Schaap, F. G. & Vreeken, R. J., 16 Oct 2018, In : Analytical Chemistry. 90, 20, p. 11835-11846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Farnesoid X Receptor (FXR) Agonist Obeticholic Acid (OCA) Restores Liver Regeneration after Partial Hepatectomy in Bile Acid Deprived Rats but Does Not Overdrive Natural FXR Activation in the Physiologic Process of Liver Regeneration

Dahrenmoller, C., Schaap, F. G., Damink, S. O., Van Mierlo, K., Jansen, P. L. M., Horsmans, Y. & Leclercq, I. A., 1 Oct 2018, In : Hepatology. 68, p. 827A-828A 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

van Golen, R. F., Olthof, P. B., Lionarons, D. A., Reiniers, M. J., Alles, L. K., Uz, Z., de Haan, L., Ergin, B., de Waart, D. R., Maas, A., Verheij, J., Jansen, P. L., Darnink, S. W. O., Schaap, F. G., van Gulik, T. M. & Heger, M., 8 Nov 2018, In : Scientific Reports. 8, 10 p., 16529.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans

Kim Mc van, M., Dello, S. A., de Jong, M. C., van Eijk, H. M., de Kok, T. M., Briedé, J. J., Schaap, F. G., Damink, S. W. O. & Dejong, C. H., 30 Jul 2018, In : Journal of clinical and translational research. 3, Suppl 2, p. 366-374 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of macrophages in the development of biliary injury in a lipopolysaccharide-aggravated hepatic ischaemia-reperfusion model

Reiling, J., Bridle, K. R., Schaap, F. G., Jaskowski, L., Santrampurwala, N., Britton, L. J., Campbell, C. M., Jansen, P. L. M., Damink, S. W. M. O., Crawford, D. H. G., Dejong, C. H. C. & Fawcett, J., Apr 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 4, p. 1284-1292 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Cathepsin D regulates lipid metabolism in murine steatohepatitis

Houben, T., Oligschlaeger, Y., Hendrikx, T., Bitorina, A. V., Walenbergh, S. M. A., van Gorp, P. J., Gijbels, M. J. J., Friedrichs, S., Plat, J., Schaap, F. G., Luetjohann, D., Hofker, M. H. & Shiri-Sverdlov, R., 14 Jun 2017, In : Scientific Reports. 7, 10 p., 3494.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study

de Groot, P. F., Belzer, C., Aydin, O., Levin, E., Levels, J. H., Aalvink, S., Boot, F., Holleman, F., van Raalte, D. H., Scheithauer, T. P., Simsek, S., Schaap, F. G., Damink, S. W. M. O., Roep, B. O., Hoekstra, J. B., de Vos, W. M. & Nieuwdorp, M., 6 Dec 2017, In : PLOS ONE. 12, 12, 14 p., 0188475.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of obeticholic acid on liver regeneration following portal vein embolization in an experimental model

Olthof, P. B., Huisman, F., Schaap, F. G., van Lienden, K. P., Bennink, R. J., van Golen, R. F., Heger, M., Verheij, J., Jansen, P. L., Damink, S. W. O. & van Gulik, T. M., Apr 2017, In : British Journal of Surgery. 104, 5, p. 590-599 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects

van Nierop, F. S., Kulik, W., Endert, E., Schaap, F. G., Damink, S. W. O., Romijn, J. A. & Soeters, M. R., Dec 2017, In : Clinical Nutrition. 36, 6, p. 1615-1620 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Kootte, R. S., Levin, E., Salojarvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Damink, S. W. M. O. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., 3 Oct 2017, In : Cell Metabolism. 26, 4, p. 611-619.e6 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Interactions between bile salts, gut microbiota, and hepatic innate immunity

Schubert, K., Damink, S. W. M. O., von Bergen, M. & Schaap, F. G., Sep 2017, In : Immunological Reviews. 279, 1, p. 23-35 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Looking into the future (remnant liver)

Lodewick, T. M., Schaap, F. G. & Damink, S. W. M. O., Feb 2017, In : Translational Cancer Research. 6, p. S131-S135 5 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Low-Dose Lipopolysaccharide Causes Biliary Injury by Blood Biliary Barrier Impairment in a Rat Hepatic Ischemia/Reperfusion Model

Reiling, J., Bridle, K. R., Gijbels, M., Schaap, F. G., Jaskowski, L., Santrampurwala, N., Britton, L. J., Campbell, C. M., Damink, S. W. M. O., Crawford, D. H. G., Dejong, C. H. C. & Fawcett, J., Feb 2017, In : Liver Transplantation. 23, 2, p. 194-206 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis

Vesterhus, M., Holm, A., Hov, J. R., Nygard, S., Schrumpf, E., Melum, E., Thorbjornsen, L. W., Paulsen, V., Lundin, K., Dale, I., Gilja, O. H., Zweers, S. J. L. B., Vatn, M., Schaap, F. G., Jansen, P. L. M., Ueland, T., Rosjo, H., Moum, B., Ponsioen, C. Y., Boberg, K. M. & 3 others, Farkkila, M., Karlsen, T. H. & Lund-Johansen, F., Jun 2017, In : Journal of Hepatology. 66, 6, p. 1214-1222 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease

Koelfat, K. V. K., Schaap, F. G., Hodin, C. M. J. M., Visschers, R. G. J., Svavarsson, B. I., Lenicek, M., Shiri-Sverdlov, R., Lenaerts, K. & Damink, S. W. M. O., Oct 2017, In : Clinical Nutrition. 36, 5, p. 1403-1410 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge

Zweers, S. J., de Vries, E. M., Lenicek, M., Tolenaars, D., de Waart, D. R., Koelfat, K. V. K., Groen, A. K., Damink, S. W. M. O., Beuers, U., Ponsioen, C., Jansen, P. L. M. & Schaap, F. G., Jan 2017, In : Hepatology International. 11, 1, p. 132-140 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases

Zhao, J., van Mierlo, K. M. C., Gómez-Ramírez, J., Kim, H., Pilgrim, C. H. C., Pessaux, P., Rensen, S. S., van der Stok, E. P., Schaap, F. G., Soubrane, O., Takamoto, T., Viganò, L., Winkens, B., Dejong, C. H. C., Olde Damink, S. W. M. & Chemotherapy-Associated Liver Injury (CALI) consortium, Jul 2017, In : British Journal of Surgery. 104, 8, p. 990-1002 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The Ascending Pathophysiology of Cholestatic Liver Disease

Jansen, P. L. M., Ghallab, A., Vartak, N., Reif, R., Schaap, F. G., Hampe, J. & Hengstler, J. G., Feb 2017, In : Hepatology. 65, 2, p. 722-738 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis

Van den Hof, W. F. P. M., Coonen, M. L. J., van Herwijnen, M., Brauers, K., Jennen, D., Damink, S. W. M. O., Schaap, F. G. & Kleinjans, J. C. S., Oct 2017, In : Toxicology in Vitro. 44, p. 322-329 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Cholangiocarcinoma, gone without the Wnt?

Noll, A. T. R., Cramer, T., Olde Damink, S. & Schaap, F., 18 Sep 2016, In : World Journal of Hepatology. 8, 26, p. 1093-1096 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Cholic acid therapy in Zellweger spectrum disorders

Berendse, K., Klouwer, F. C. C., Koot, B. G. P., Kemper, E. M., Ferdinandusse, S., Koelfat, K. V. K., Lenicek, M., Schaap, F. G., Waterham, H. R., Vaz, F. M., Engelen, M., Jansen, P. L. M., Wanders, R. J. A. & Poll-The, B. T., Nov 2016, In : Journal of Inherited Metabolic Disease. 39, 6, p. 859-868

Research output: Contribution to journalArticleAcademicpeer-review

Serum Autotaxin Activity Correlates with Pruritus in Pediatric Cholestatic Disorders

Kremer, A. E., Gonzales, E., Schaap, F. G., Oude Elferink, R. P., Jacquemin, E. & Beuers, U., Apr 2016, In : Journal of Pediatric Gastroenterology and Nutrition. 62, 4, p. 530-535 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The portal-drained viscera release fibroblast growth factor 19 in humans

Koelfat, K. V. K., Bloemen, J. G., Jansen, P., Dejong, K., Schaap, F. G. & Olde Damink, S. W. M., Dec 2016, In : Physiological Reports. 4, 24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The role of bile salts in liver regeneration

van de Laarschot, L. F. M., Jansen, P. L. M., Schaap, F. G. & Olde Damink, S., Sep 2016, In : Hepatology International. 10, 5, p. 733-740

Research output: Contribution to journalArticleAcademicpeer-review

Validation of the peak bilirubin criterion for outcome after partial hepatectomy

van Mierlo, K. M. C., Lodewick, T. M., Dhar, D. K., van Woerden, V., Kurstjens, R., Schaap, F. G., van Dam, R. M., Vyas, S., Malago, M., Dejong, C. H. C. & Olde Damink, S., Oct 2016, In : HPB. 18, 10, p. 806-812

Research output: Contribution to journalArticleAcademicpeer-review

2015

FXR, intestinal FiXeR of hepatocellular carcinoma?

Schaap, F. G., Jansen, P. L. M. & Olde Damink, S. W. M., 1 Jan 2015, In : Hepatology. 61, 1, p. 21-23 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

Suijker, J., Oosting, J., Koornneef, A., Struys, E. A., Salomons, G. S., Schaap, F. G., Waaijer, C. J., Wijers-Koster, P. M., Briaire-de Bruijn, I. H., Haazen, L., Riester, S. M., Dudakovic, A., Danen, E., Cleton-Jansen, A. M., van Wijnen, A. J. & Bovee, J. V., 1 Jan 2015, In : Oncotarget. 6, 14, p. 12505-12509

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal failure to produce FGF19: A culprit in intestinal failure-associated liver disease?

van Erpecum, K. J. & Schaap, F. G., 1 Jan 2015, In : Journal of Hepatology. 62, 6, p. 1231-1233

Research output: Contribution to journalArticleAcademicpeer-review

Pituitary TSH controls bile salt synthesis

Jansen, P. L. M. & Schaap, F. G., 1 Jan 2015, In : Journal of Hepatology. 62, 5, p. 1005-1007

Research output: Contribution to journalEditorialAcademicpeer-review

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

Vaz, F. M., Paulusma, C. C., Huidekoper, H., de Ru, M., Lim, C., Koster, J., Ho-Mok, K., Bootsma, A. H., Groen, A. K., Schaap, F. G., Oude Elferink, R. P., Waterham, H. R. & Wanders, R. J., 1 Jan 2015, In : Hepatology. 61, 1, p. 260-267 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Bile acid receptors as targets for drug development

Schaap, F. G., Trauner, M. & Jansen, P. L., 1 Jan 2014, In : Nature Reviews Gastroenterology & Hepatology. 11, 1, p. 55-67 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects

Lips, M. A., de Groot, G. H., Berends, F. J., Wiezer, R., van Wagensveld, B. A., Swank, D. J., Luijten, A., van Dijk, K. W., Pijl, H., Jansen, P. L. M. & Schaap, F. G., 1 Jan 2014, In : Clinical Endocrinology.

Research output: Contribution to journalArticleAcademicpeer-review

How sweet it is to activate FXR.

Jansen, P. L. & Schaap, F. G., May 2014, In : Hepatology. 59, 5, p. 1665-1667 3 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Impact of Global Fxr Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the FXR Locus in Human Acute Pancreatitis

Nijmeijer, R. M., Schaap, F. G., Smits, A. J., Kremer, A. E., Akkermans, L. M., Kroese, A. B., Rijkers, G. T., Schipper, M. E., Verheem, A., Wijmenga, C., Gooszen, H. G. & van Erpecum, K. J., 1 Jan 2014, In : PLOS ONE. 9, 12, e114393.

Research output: Contribution to journalArticleAcademicpeer-review

Yin Yang 1 and farnesoid X receptor: a balancing act in non-alcoholic fatty liver disease?

Legry, V., Schaap, F. G., Delire, B., Horsmans, Y. & Leclercq, I. A., 1 Jan 2014, In : Gut. 63, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

2013

Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children.

Koot, B. G., van der Baan Slootweg, O. H., Bohte, A. E., Nederveen, A. J., van Werven, J. R., Tamminga-Smeulders, C. I., Merkus, M. P., Schaap, F. G., Jansen, P. L., Stoker, J. & Benninga, M. A., Mar 2013, In : Obesity. 21, 3, p. 583-590 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake.

van den Berg, S. A., Heemskerk, M. M., Geerling, J. J., van Klinken, J. B., Schaap, F. G., Bijland, S., Berbee, J. F., van Harmelen, V. J., Pronk, A. C., Schreurs, M., Havekes, L. M., Rensen, P. C. & van Dijk, K. W., Aug 2013, In : Faseb Journal. 27, 8, p. 3354-3362 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress.

Schaap, F. G., Kremer, A. E., Lamers, W. H., Jansen, P. L. & Gaemers, I. C., Apr 2013, In : Biochimie. 95, 4, p. 692-699 8 p.

Research output: Contribution to journalArticleAcademicpeer-review