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Research Output 2001 2019

2019

Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion

Phielix, E., Begovatz, P., Gancheva, S., Bierwagen, A., Kornips, E., Schaart, G., Hesselink, M. K. C., Schrauwen, P. & Roden, M., 1 Nov 2019, In : JCI INSIGHT. 4, 21, 12 p., 127928.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

Gemmink, A., Daemen, S., Brouwers, B., Huntjens, P. R., Schaart, G., Moonen-Kornips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., 1 Mar 2018, In : Journal of Physiology. 596, 5, p. 857-868 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox

Daemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., Moonen-Komips, E., Jorgensen, J., Hoeks, J., Schrauwen, P. & Hesselink, M. K. C., Nov 2018, In : Molecular Metabolism. 17, p. 71-81 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Benefits of Substitution Sitting with Standing and Walking in Free-living Conditions for Cardiometabolic Risk Markers, cognition and Mood in Overweight Adults

Duvivier, B. M. F. M., Schaper, N. C., Koster, A., van Kan, L., Peters, H. P. F., Adam, J. J., Giesbrecht, T., Kornips, E., Hulsbosch, M., Willems, P., Hesselink, M. K. C., Schrauwen, P. & Savelberg, H. H. C. M., 8 Jun 2017, In : Frontiers in physiology. 8, 9 p., 353.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians

Gemmink, A., Bakker, L. E. H., Guigas, B., Kornips, E., Schaart, G., Meinders, A. E., Jazet, I. M. & Hesselink, M. K. C., 14 Feb 2017, In : Scientific Reports. 7, 9 p., 42393.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2014
13 Citations (Scopus)

Reduced incorporation of Fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes.

Sparks, L. M., Bosma, M., Brouwers, B., van de Weijer, T., Bilet, L., Schaart, G., Kornips, E., Eichmann, T. O., Lass, A., Hesselink, M. K. & Schrauwen, P., May 2014, In : Diabetes. 63, 5, p. 1583-1593 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013
28 Citations (Scopus)

Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes

Sparks, L. M., Johannsen, N. M., Church, T. S., Earnest, C. P., Moonen-Kornips, E., Moro, C., Hesselink, M. K., Smith, S. R. & Schrauwen, P., Apr 2013, In : Journal of Clinical Endocrinology & Metabolism. 98, 4, p. 1694-1702 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Relationship of C5L2 receptor to skeletal muscle substrate utilization

Roy, C., Paglialunga, S., Schaart, G., Moonen-Kornips, E., Meex, R. C., Phielix, E., Hoeks, J., Hesselink, M. K., Cianflone, K. & Schrauwen, P., 27 Feb 2013, In : PLOS ONE. 8, 2, 8 p., 57494.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2012
9 Citations (Scopus)
27 Citations (Scopus)

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Phielix, E., Meex, R., Ouwens, DM., Sparks, L. M., Hoeks, J., Schaart, G., Kornips, C. F. P., Hesselink, M. K. C. & Schrauwen, P., Oct 2012, In : Diabetes. 61, 10, p. 2472-2478 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Kornips, C. F. P., Hesselink, M. K. C., Kunz, I., Schrauwen-Hinderling, V., Blaak, E. E., Auwerx, J. & Schrauwen, P., 1 Jan 2011, In : Cell Metabolism. 14, 5, p. 612-22

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure

Nabben, M., Hoeks, J., Kornips, C. F. P., Van Beurden, D., Briedé, J. J., Hesselink, M. K. C., Glatz, J. F. & Schrauwen, P., 15 Dec 2011, In : Febs Letters. 585, 24, p. 4010-4017 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice.

Nabben, M., Shabalina, I. G., Kornips, C. F. P., Van Beurden, D., Cannon, B., Schrauwen, P., Nedergaard, J. & Hoeks, J., 1 Jan 2011, In : Biochimica et Biophysica Acta-bioenergetics. 1807, 9, p. 1095-1105

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.

Timmers, S., Bosch, J., Towler, M. C., Schaart, G., Kornips, E., Mensink, R. P., Hesselink, M. K., Hardie, D. G. & Schrauwen, P., Feb 2010, In : Journal of Lipid Research. 51, 2, p. 352-359 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance.

Hoeks, J., van Herpen, N. A., Mensink, M. R., Kornips, C. F. P., Van Beurden, D., Hesselink, M. K. C. & Schrauwen, P., Sep 2010, In : Diabetes. 59, 9, p. 2117-2125 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2008
151 Citations (Scopus)

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients.

Phielix, E., Schrauwen-Hinderling, V., Mensink, M., Lenaers, E., Meex, R. C., Hoeks, J., Kooi, M. E., Kornips, E., Sels, J. P., Hesselink, M. K. & Schrauwen, P., 1 Jan 2008, In : Diabetes. 57, 11, p. 2943-2949

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding

Hoeks, J., Briede, J. J., de Vogel, J., Schaart, G., Nabben, M., Kornips, E., Hesselink, M. K. & Schrauwen, P., 1 Jan 2008, In : Febs Letters. 582, 4, p. 510-6

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)
2007
47 Citations (Scopus)

Reduced adipose tissue triglyceride synthesis and increased muscle fatty acid oxidation in C5L2 knockout mice

Paglialunga, S. A., Schrauwen, P., Roy, C., Moonen-Kornips, E., Lu, H., Hesselink, M. K., Deshaies, Y., Richard, D. & Cianflone, K., 1 Jan 2007, In : Journal of Endocrinology. 194, 2, p. 293-304

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis?

Mensink, M., Hesselink, M. K., Borghouts, L. B., Keizer, H. A., Moonen-Kornips, E., Schaart, G., Blaak, E. E. & Schrauwen, P., 1 Jan 2007, In : Diabetes Obesity & Metabolism. 9, 4, p. 594-596

Research output: Contribution to journalArticleAcademicpeer-review

2006
39 Citations (Scopus)

Reduced skeletal muscle UCP3 protein content in pre-diabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment.

Schrauwen, P., Mensink, M., Schaart, G., Kornips, E., Sels, J. P. J. E., Blaak, E. E., Russell, A. P. & Hesselink, M. K., 1 Jan 2006, In : Journal of Clinical Endocrinology & Metabolism. 91, 4, p. 1520-1525

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Short-term Training is Accompanied by a Down Regulation of ACC2 mRNA in Skeletal Muscle

Schrauwen-Hinderling, V. B., Hesselink, M. K., Moonen-Kornips, C. F., Schaart, G., Kooi, M. E., Saris, W. H. & Schrauwen, P., 1 Jan 2006, In : International Journal of Sports Medicine. 27, 10, p. 786-791

Research output: Contribution to journalArticleAcademicpeer-review

2005
32 Citations (Scopus)

DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content.

Roorda, B. D., Hesselink, M. K. C., Schaart, G., Moonen-Kornips, E., Martinez-Martinez, P., Losen, M., de Baets, M. H. V., Mensink, R. P. & Schrauwen, P., 1 Jan 2005, In : Journal of Lipid Research. 46, 2, p. 230-236

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Effect of 2 weeks of endurance training on uncoupling protein 3 content in untrained human subjects

Schrauwen, P., Russell, A. P., Kornips, E., Boon, N. & Hesselink, M. K., 1 Jan 2005, In : Acta Physiologica Scandinavica. 183, 3, p. 273-280

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)
113 Downloads (Pure)

Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet

Schrauwen-Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Kornips, C. F. P., Schaart, G., Mustard, K. J., Hardie, D. G., Saris, W. H. M., Nicolay, K. & Schrauwen, P., 1 Jan 2005, In : Obesity Research. 13, 12, p. 2088-2094

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2003
21 Citations (Scopus)

Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3

Russell, A. P., Schrauwen, P., Somm, E., Gastaldi, G., Hesselink, M. K. C., Schaart, G., Kornips, C. F. P., Lo, S. K., Bufano, D., Giacobino, J. P., Muzzin, P., Ceccon, M., Angelini, C. & Vergani, L., 1 Jan 2003, In : Journal of Clinical Endocrinology & Metabolism. 88, 12, p. 5921-5926 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

54 Citations (Scopus)
129 Downloads (Pure)

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo

Hesselink, M. K. C., Greenhaff, P. L., Constantin-Teodosu, D., Hultman, E., Saris, W. H. M., Nieuwlaat, R., Schaart, G., Kornips, C. F. P. & Schrauwen, P., 1 Jan 2003, In : Journal of Clinical Investigation. 111, 4, p. 479-486 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
44 Citations (Scopus)

UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects

Russell, P., Wadley, G., Hesselink, M. K. C., Schaart, G., Lo, S., Leger, B., Garnham, A., Kornips, C. F. P., Cameron-Smith, D., Giacobino, J. P., Muzzin, P., Snow, R. & Schrauwen, P., 1 Jan 2003, In : Pflugers Archiv-European Journal of Physiology. 445, 5, p. 563-569 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

88 Citations (Scopus)
169 Downloads (Pure)

Uncoupling protein 3 as a mitochondrial fatty acid anion exporter

Schrauwen, P., Hoeks, J., Schaart, G., Kornips, C. F. P., Binas, B., van der Vusse, G. J., van Bilsen, M., Luiken, J. J. F. P., Coort, S. L. M., Glatz, J. F., Saris, W. H. M. & Hesselink, M. K. C., 1 Jan 2003, In : Faseb Journal. 17, 15, p. 2272-2274 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2002
63 Citations (Scopus)
138 Downloads (Pure)

Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect

Schrauwen, P., Hesselink, M. K. C., Vaartjes, I., Kornips, C. F. P., Saris, W. H. M., Giacobino, J. P. & Russell, A., 1 Jan 2002, In : American Journal of Physiology : Endocrinology and Metabolism. 282, 1, p. E11-E17 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
39 Citations (Scopus)
165 Downloads (Pure)

Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter

Schrauwen, P., Schrauwen-Hinderling, V. B., Hesselink, M. K. C., Schaart, G., Kornips, C. F. P., Saris, W. H. M., Westerterp-Plantenga, M. S. & Langhans, W., 1 Jan 2002, In : Faseb Journal. 16, 12, p. 1688-1690 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
16 Citations (Scopus)

The effect of mild cold exposure on UCP3 mRNA expression and UCP3 protein content in humans

Schrauwen, P., Westerterp-Plantenga, M. S., Kornips, C. F. P., Schaart, G. & van Marken Lichtenbelt, W. D., 1 Jan 2002, In : International Journal of Obesity. 26, 4, p. 450-457 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2001
69 Citations (Scopus)

Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers.

Hesselink, M. K. C., Keizer, H. A., Borghouts, L., Schaart, G., Kornips, C. F. P., Slieker, L. J., Sloop, K. W., Saris, W. H. M. & Schrauwen, P., 1 Jan 2001, In : Faseb Journal. 15, 6, p. 1071-1073 3 p.

Research output: Contribution to journalArticleAcademicpeer-review