1993 …2019

Research output per year

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Research Output

2019

A comparison between the abdominal and femoral adipose tissue proteome of overweight and obese women

Vogel, M. A. A., Wang, P., Bouwman, F. G., Hoebers, N., Blaak, E. E., Renes, J., Mariman, E. C. & Goossens, G. H., 12 Mar 2019, In : Scientific Reports. 9, p. 1-9 9 p., 4202.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Distal versus proximal intestinal short-chain fatty acid release in man

Neis, E. P. J. G., van Eijk, H. M. H., Lenaerts, K., Damink, S. W. M. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Apr 2019, In : Gut. 68, 4, p. 764-765 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome

Gulseth, H. L., Gjelstad, I. M. F., Tiereny, A. C., McCarthy, D., Lovegrove, J. A., Defoort, C., Blaak, E. E., Lopez-Miranda, J., Dembinska-Kiec, A., Riserus, U., Roche, H. M., Drevon, C. A. & Birkeland, K., May 2019, In : European Journal of Endocrinology. 180, 5, p. 321-328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut microbial metabolites in obesity, NAFLD and T2DM

Canfora, E. E., Meex, R. C. R., Venema, K. & Blaak, E. E., May 2019, In : Nature Reviews Endocrinology. 15, 5, p. 261-273 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children

Zhong, H., Penders, J., Shi, Z., Ren, H., Cai, K., Fang, C., Ding, Q., Thijs, C., Blaak, E. E., Stehouwer, C. D. A., Xu, X., Yang, H., Wang, J., Wang, J., Jonkers, D. M. A. E., Masclee, A. A. M., Brix, S., Li, J., Arts, I. C. W. & Kristiansen, K., 4 Jan 2019, In : Microbiome. 7, 14 p., 2.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes

Meex, R. C. R., Blaak, E. E. & van Loon, L. J. C., Sep 2019, In : Obesity Reviews. 20, 9, p. 1205-1217 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Plasma lipid profiling of tissue-specific insulin resistance in human obesity

DiOGenes Consortium, May 2019, In : International Journal of Obesity. 43, 5, p. 989-998 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans

van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T. & Blaak, E. E., Dec 2019, In : Diabetes. 68, 12, p. 2247-2258 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The ABCD of Obesity: An EASO Position Statement on a Diagnostic Term with Clinical and Scientific Implications

Fruhbeck, G., Busetto, L., Dicker, D., Yumuk, V., Goossens, G. H., Hebebrand, J., Halford, J. G. C., Farpour-Lambert, N. J., Blaak, E. E., Woodward, E. & Toplak, H., 2019, In : Obesity Facts. 12, 2, p. 131-136 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity

Hernandez, M. A. G., Canfora, E. E., Jocken, J. W. E. & Blaak, E. E., Aug 2019, In : Nutrients. 11, 8, 32 p., 1943.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Vitamin D deficiency in the aetiology of obesity-related insulin resistance

Pramono, A., Jocken, J. W. E. & Blaak, E. E., Jul 2019, In : Diabetes-metabolism Research and Reviews. 35, 5, 10 p., 3146.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

Abdominal subcutaneous adipose tissue gene expression in relation to tissue-specific insulin resistance in human obesity

CODAM study, Maastricht Study & DiOGenes Consortium, Oct 2018, In : Diabetologia. 61, p. S110-S110 1 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Verboven, K., Wouters, K., Gaens, K., Hansen, D., Bijnen, M., Wetzels, S., Stehouwer, C. D., Goossens, G. H., Schalkwijk, C. G., Blaak, E. E. & Jocken, J. W., 16 Mar 2018, In : Scientific Reports. 8, 8 p., 4677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity

Xu, Q., Mariman, E. C. M., Roumans, N. J. T., Vink, R. G., Goossens, G. H., Blaak, E. E. & Jocken, J. W. E., 1 Jan 2018, In : Adipocyte. 7, 1, p. 12-19 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue oxygenation is associated with insulin sensitivity independently of adiposity in obese men and women

Goossens, G. H., Vogel, M. A. A., Vink, R. G., Mariman, E. C., van Baak, M. A. & Blaak, E. E., Sep 2018, In : Diabetes Obesity & Metabolism. 20, 9, p. 2286-2290 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Adrenergically and non-adrenergically mediated human adipose tissue lipolysis during acute exercise and exercise training

Verboven, K., Stinkens, R., Hansen, D., Wens, I., Frederix, I., Eijnde, B. O., Jocken, J. W. E., Goossens, G. H. & Blaak, E. E., 16 Aug 2018, In : Clinical Science. 132, 15, p. 1685-1698 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differences in Upper and Lower Body Adipose Tissue Oxygen Tension Contribute to the Adipose Tissue Phenotype in Humans

Vogel, M. A. A., Jocken, J. W. E., Sell, H., Hoebers, N., Essers, Y., Rouschop, K. M. A., Cajlakovic, M., Blaak, E. E. & Goossens, G. H., Oct 2018, In : Journal of Clinical Endocrinology & Metabolism. 103, 10, p. 3688-3697 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions

Trouwborst, I., Bowser, S. M., Goossens, G. H. & Blaak, E. E., 4 Sep 2018, In : Frontiers in nutrition. 5, 14 p., 77.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Effect of diet-induced weight loss on angiopoietin-like protein 4 and adipose tissue lipid metabolism in overweight and obese humans

van der Kolk, B. W., Vink, R. G., Jocken, J. W. E., Roumans, N. J. T., Goossens, G. H., Mariman, E. C. M., van Baak, M. A. & Blaak, E. E., Jul 2018, In : Physiological Reports. 6, 13, 10 p., e13735.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effect of Sacubitril/Valsartan on Exercise-Induced Lipid Metabolism in Patients With Obesity and Hypertension

Engeli, S., Stinkens, R., Heise, T., May, M., Goossens, G. H., Blaak, E. E., Havekes, B., Jax, T., Albrecht, D., Pal, P., Tegtbur, U., Haufe, S., Langenickel, T. H. & Jordan, J., 1 Jan 2018, In : Hypertension. 71, 1, p. 70-77 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of gut microbiota manipulation on ex vivo lipolysis in human abdominal subcutaneous adipocytes

Jocken, J. W. E., Reijnders, D., Canfora, E. E., Boekschoten, M. V., Plat, J., Goossens, G. H. & Blaak, E. E., 1 Jan 2018, In : Adipocyte. 7, 2, p. 106-112 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity

Stinkens, R., Brouwers, B., Jocken, J. W., Blaak, E. E., Teunissen-Beekman, M. F., Hesselink, M. K., van Baak, M. A., Schrauwen, P. & Goossens, G. H., Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1585-1593 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gastrointestinal Transit Time, Glucose Homeostasis and Metabolic Health: Modulation by Dietary Fibers

Muller, M., Canfora, E. E. & Blaak, E. E., Mar 2018, In : Nutrients. 10, 3, 18 p., 275.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Global testing of shifts in metabolic phenotype

Fazelzadeh, P., Hoefsloot, H. C. J., Hankemeier, T., Most, J., Kersten, S., Blaak, E. E., Boekschoten, M. & van Duynhoven, J., 4 Oct 2018, In : Metabolomics. 14, 10, 9 p., 139.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Short-Term Microbiota Manipulation and Forearm Substrate Metabolism in Obese Men: A Randomized, Double-Blind, Placebo-Controlled Trial

Reijnders, D., Goossens, G. H., Hermes, G. D. A., Smidt, H., Zoetendal, E. G. & Blaak, E. E., 1 Jan 2018, In : Obesity Facts. 11, 4, p. 318-326 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of angiotensin receptor neprilysin inhibition by sacubitril/valsartan on adipose tissue transcriptome and protein expression in obese hypertensive patients

Stinkens, R., van der Kolk, B. W., Jordan, J., Jax, T., Engeli, S., Heise, T., Jocken, J. W., May, M., Schindler, C., Havekes, B., Schaper, N., Albrecht, D., Kaiser, S., Hartmann, N., Letzkus, M., Langenickel, T. H., Goossens, G. H. & Blaak, E. E., 2 Mar 2018, In : Scientific Reports. 8, 7 p., 3933.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans

Most, J., Warnke, I., Boekschoten, M. V., Jocken, J. W. E., de Groot, P., Friedel, A., Bendik, I., Goossens, G. H. & Blaak, E. E., 1 Jan 2018, In : Adipocyte. 7, 3, p. 190-196 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

Fallaize, R., Carvalho-Wells, A. L., Tierney, A. C., Marin, C., Kiec-Wilk, B., Dembinska-Kiec, A., Drevon, C. A., DeFoort, C., Lopez-Miranda, J., Riserus, U., Saris, W. H., Blaak, E. E., Roche, H. M. & Lovegrove, J. A., 24 Jul 2017, In : Scientific Reports. 7, 10 p., 6274.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Proposal of the European Association for the Study of Obesity to Improve the ICD-11 Diagnostic Criteria for Obesity Based on the Three Dimensions Etiology, Degree of Adiposity and Health Risk

Hebebrand, J., Holm, J-C., Woodward, E., Baker, J. L., Blaak, E., Schutz, D. D., Farpour-Lambert, N. J., Fruhbeck, G., Halford, J. G. C., Lissner, L., Micic, D., Mullerova, D., Roman, G., Schindler, K., Toplak, H., Visscher, T. L. S. & Yumuk, V., Aug 2017, In : Obesity Facts. 10, 4, p. 284-307 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating classical monocytes are associated with CD11c(+) macrophages in human visceral adipose tissue

Wouters, K., Gaens, K., Bijnen, M., Verboven, K., Jocken, J., Wetzels, S., Wijnands, E., Hansen, D., van Greevenbroek, M., Duijvestijn, A. M., Biessen, E. A. L., Blaak, E. E., Stehouwer, C. D. A. & Schalkwijk, C. G., 15 Feb 2017, In : Scientific Reports. 7, 8 p., 42665.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans

Vink, R. G., Roumans, N. J., Cajlakovic, M., Cleutjens, J. P. M., Boekschoten, M. V., Fazelzadeh, P., Vogel, M. A. A., Blaak, E. E., Mariman, E. C., van Baak, M. A. & Goossens, G. H., May 2017, In : International Journal of Obesity. 41, 5, p. 722-728 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of the interaction between diet composition and the PPM1K g enetic variant on insulin resistance and beta cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial

Goni, L., Qi, L., Cuervo, M., Milagro, F. I., Saris, W. H., MacDonald, I. A., Langin, D., Astrup, A., Arner, P., Oppert, J-M., Svendstrup, M., Blaak, E. E., Sorensen, T. I. A., Hansen, T. & Alfredo Martinez, J., Sep 2017, In : American Journal of Clinical Nutrition. 106, 3, p. 902-908 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women

Most, J., Penders, J., Lucchesi, M., Goossens, G. H. & Blaak, E. E., Sep 2017, In : European Journal of Clinical Nutrition. 71, 9, p. 1040-1045 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Gut microbiota composition strongly correlates to peripheral insulin sensitivity in obese men but not in women

Most, J., Goossens, G. H., Reijnders, D., Canfora, E. E., Penders, J. & Blaak, E. E., 2017, In : Beneficial Microbes. 8, 4, p. 557-562 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human splanchnic amino-acid metabolism

Neis, E. P. J. G., Sabrkhany, S., Hundscheid, I., Schellekens, D., Lenaerts, K., Damink, S. W. O., Blaak, E. E., Dejong, C. H. C. & Rensen, S. S., Jan 2017, In : Amino Acids. 49, 1, p. 161-172 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Improved Insulin Sensitivity With Angiotensin Receptor Neprilysin Inhibition in Individuals With Obesity and Hypertension

Jordan, J., Stinkens, R., Jax, T., Engeli, S., Blaak, E. E., May, M., Havekes, B., Schindler, C., Albrecht, D., Pal, P., Heise, T., Goossens, G. H. & Langenickel, T. H., Feb 2017, In : Clinical Pharmacology & Therapeutics. 101, 2, p. 254-263 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Kootte, R. S., Levin, E., Salojarvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Damink, S. W. M. O. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., 3 Oct 2017, In : Cell Metabolism. 26, 4, p. 611-619.e6 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Natriuretic peptides in the control of lipid metabolism and insulin sensitivity

Verboven, K., Hansen, D., Jocken, J. W. E. & Blaak, E. E., Nov 2017, In : Obesity Reviews. 18, 11, p. 1243-1259 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials

Hjorth, M. F., Ritz, C., Blaak, E. E., Saris, W. H. M., Langin, D., Poulsen, S. K., Larsen, T. M., Sorensen, T. I. A., Zohar, Y. & Astrup, A., Aug 2017, In : American Journal of Clinical Nutrition. 106, 2, p. 499-505 7 p.

Research output: Contribution to journalArticleAcademicpeer-review