19992020

Research output per year

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Research Output

2020

Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling

Houben, T., Bitorina, A., Oligschlaeger, Y., Jeurissen, M. L. J., Rensen, S., Kohler, S. E., Westerterp, M., Luetjohann, D., Theys, J., Romano, A., Plat, J. & Shiri-Sverdlov, R., Aug 2020, In : Journal of Pathology. 251, 4, p. 429-439 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Anatomy of rodent and human livers: What are the differences?

Kruepunga, N., Hakvoort, T. B. M., Hikspoors, J. P. J. M., Kohler, S. E. & Lamers, W. H., 1 May 2019, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1865, 5, p. 869-878 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Innervation of the human spleen: A complete hilum-embedding approach

Verlinden, T. J. M., van Dijk, P., Hikspoors, J., Herrler, A., Lamers, W. H. & Kohler, S. E., Mar 2019, In : Brain Behavior and Immunity. 77, p. 92-100 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

L-Arginine Synthesis from L-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo

Lange, S. M., McKell, M. C., Schmidt, S. M., Zhao, J., Crowther, R. R., Green, L. C., Bricker, R. L., Arnett, E., Kohler, S. E., Schlesinger, L. S., Setchell, K. D. R. & Qualls, J. E., 15 Mar 2019, In : Journal of Immunology. 202, 6, p. 1747-1754 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The development of the dorsal mesentery in human embryos and fetuses

Hikspoors, J. P. J. M., Kruepunga, N., Mommen, G. M. C., Peeters, J-M. P. W. U., Hulsman, C. J. M., Kohler, S. E. & Lamers, W. H., Aug 2019, In : Seminars in Cell & Developmental Biology. 92, p. 18-26 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2018

Deletion of endothelial arginase 1 does not improve vasomotor function in diabetic mice

Chennupati, R., Meens, M. J., Janssen, B. J., van Dijk, P., Hakvoort, T. B. M., Lamers, W. H., De Mey, J. G. R. & Koehler, S. E., Jun 2018, In : Physiological Reports. 6, 11, 13 p., 13717.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Disentangling the higher risks of type 2 diabetes in lower educated people.

Bosma, H., Qi, Y., van Boxtel, M., Kohler, S., Schaper, N., Schram, M., Stehouwer, C. & Koster, A., Nov 2018, In : European Journal of Public Health. 28, p. 50-51 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Ceelen, J. J. M., van Gorp, R. H., Hermans, J. J. R., Kohler, S. E. & Langen, R. C. J., 1 Jan 2018, In : Endocrinology. 159, 1, p. 519-534 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma

Cloots, R. H. E., Poynter, M. E., Terwindt, E., Lamers, W. H. & Kohler, S. E., 23 May 2018, In : Respiratory Research. 19, 12 p., 98.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy

de Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Neumann, D., Kohler, S. E. & Langen, R. C. J., 13 Sep 2018, In : PLOS ONE. 13, 9, 18 p., 0203630.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Science and art of teaching anatomy

Köhler, E. L., 22 Jun 2018, Maastricht: Maastricht University. 29 p.

Research output: Book/ReportInaugural speechPopular

Open Access
File
324 Downloads (Pure)

The development of the cloaca in the human embryo

Kruepunga, N., Hikspoors, J. P. J. M., Mekonen, H. K., Mommen, G. M. C., Meemon, K., Weerachatyanukul, W., Asuvapongpatana, S., Kohler, S. E. & Lamers, W. H., 1 Dec 2018, In : Journal of Anatomy. 233, 6, p. 724-739 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The human phrenic nerve serves as a morphological conduit for autonomic nerves and innervates the caval body of the diaphragm

Verlinden, T. J. M., van Dijk, P., Herrler, A., Vries, C. D. G., Lamers, W. H. & Kohler, S. E., 3 Aug 2018, In : Scientific Reports. 8, 10 p., 11697.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice

Cloots, R. H. E., Sankaranarayanan, S., Poynter, M. E., Terwindt, E., van Dijk, P., Lamers, W. H. & Kohler, S. E., 28 Nov 2017, In : BMC Pulmonary Medicine. 17, 15 p., 158.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dietary treatment of fatty liver: High dietary protein content has an antisteatotic and antiobesogenic effect in mice

Caraballo, S. C. G., Comhair, T. M., Dejong, C. H. C., Lamers, W. H. & Koehler, S. E., Jul 2017, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1863, 7, p. 1789-1804 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human liver segments: role of cryptic liver lobes and vascular physiology in the development of liver veins and left-right asymmetry

Hikspoors, J. P. J. M., Peeters, M. M. J. P., Kruepunga, N., Mekonen, H. K., Mommen, G. M. C., Kohler, S. E. & Lamers, W. H., 7 Dec 2017, In : Scientific Reports. 7, 12 p., 17109.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pivotal Role of Glutamine Synthetase in Ammonia Detoxification

Hakvoort, T. B. M., He, Y., Kulik, W., Vermeulen, J. L. M., Duijst, S., Ruijter, J. M., Runge, J. H., Deutz, N. E. P., Koehler, S. E. & Lamers, W. H., Jan 2017, In : Hepatology. 65, 1, p. 281-293 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The fate of the vitelline and umbilical veins during the development of the human liver

Hikspoors, J. P. J. M., Peeters, M. M. J. P., Mekonen, H. K., Kruepunga, N., Mommen, G. M. C., Cornillie, P., Kohler, S. E. & Lamers, W. H., Nov 2017, In : Journal of Anatomy. 231, 5, p. 718-735 18 p.

Research output: Contribution to journalArticleAcademicpeer-review

The odd-carbon medium-chain fatty triglyceride triheptanoin does not reduce hepatic steatosis

Comhair, T. M., Caraballo, S. C. G., Dejong, C. H. C., Lamers, W. H. & Koehler, S. E., Feb 2017, In : Clinical Nutrition. 36, 1, p. 229-237 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Development of the Epaxial Muscles in the Human Embryo

Mekonen, H. K., Hikspoors, J. P. J. M., Mommen, G., Köhler, S. E. & Lamers, W. H., Apr 2016, In : Faseb Journal. 30, S1

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Development of the Epaxial Muscles in the Human Embryo

Mekonen, H. K., Hikspoors, J. P. J. M., Mommen, G., Köhler, E. L. & Lamers, W. H., Nov 2016, In : Clinical Anatomy. 29, 8, p. 1031-1045

Research output: Contribution to journalArticleAcademicpeer-review

2015

Development of the human infrahepatic inferior caval and azygos venous systems

Hikspoors, J. P., Soffers, J. H., Mekonen, H. K., Cornillie, P., Köhler, S. E. & Lamers, W. H., 1 Jan 2015, In : Journal of Anatomy. 226, 2, p. 113-125

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Development of the ventral body wall in the human embryo

Mekonen, H. K., Hikspoors, J. P., Mommen, G., Köhler, S. E. & Lamers, W. H., Nov 2015, In : Journal of Anatomy. 227, 5, p. 673-685 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Differential sensitivity of oxidative and glycolytic muscles to hypoxia-induced muscle atrophy

de Theije, C. C., Langen, R. C., Lamers, W. H., Gosker, H. R., Schols, A. M. & Koehler, S. E., 15 Jan 2015, In : Journal of Applied Physiology. 118, 2, p. 200-211 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Life goal attainment in the adaptation process after acquired brain injury: the influence of self-efficacy and of flexibility and tenacity in goal pursuit

Brands, I., Stapert, S., Köhler, S., Wade, D. & van Heugten, C., Jun 2015, In : Clinical Rehabilitation. 29, 6, p. 611-622 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD

Lemmens, K., van de Wier, B., Koek, G. H., Köhler, E. S., Drittij, M. J., van der Vijgh, W., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Biochemical and Biophysical Research Communications. 456, 1, p. 179-182

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

The growth pattern of the human intestine and its mesentery

Soffers, J. H., Hikspoors, J. P., Mekonen, H. K., Koehler, S. E. & Lamers, W. H., 1 Jan 2015, In : BMC Developmental Biology. 15, 31.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet

Strekalova, T., Evans, M., Costa-Nunes, J., Bachurin, S., Yeritsyan, N., Couch, Y., Steinbusch, H., Köhler, S., Lesch, K. P. & Anthony, D. C., 1 Jan 2015, In : Brain Behavior and Immunity. 48, p. 42-47

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
2014

A high-protein diet is anti-steatotic and has no pro-inflammatory side effects in dyslipidaemic APOE2 knock-in mice.

Garcia Caraballo, S., Comhair, T. M., Dejong, C. H., Lamers, W. H. & Kohler, S. E., 1 Jan 2014, In : British Journal of Nutrition. 112, 8, p. 11251-1265

Research output: Contribution to journalArticleAcademicpeer-review

Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice

Chennupati, R., Meens, M. J., Marion, V., Janssen, B. J., Lamers, W. H., de Mey, J. G. & Kohler, S. E., 17 Jul 2014, In : PLOS ONE. 9, 7, 10 p., e102264.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids

Garcia Caraballo, S., Comhair, T. M., Houten, S. M., Dejong, C. H., Lamers, W. H. & Koehler, S. E., Dec 2014, In : Journal of Nutritional Biochemistry. 25, 12, p. 1263-1274 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
2013

Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice

Cloots, R. H. E., Sankaranarayanan, S., de Theije, C. C., Poynter, M. E., Terwindt, E., van Dijk, P. J., Hakvoort, T. B., Lamers, W. H. & Köhler, S. E., 1 Jan 2013, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 305, 5, p. L364-376

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Characterization of the inflammatory and metabolic profile of adipose tissue in a mouse model of chronic hypoxia.

van den Borst, B., Schols, A. M. W. J., de Theije, C. C., Boots, A. W., Köhler, S. E., Goossens, G. H. & Gosker, H. R., Jun 2013, In : Journal of Applied Physiology. 114, 11, p. 1619-1628 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
13 Citations (Scopus)

Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes

Chennupati, R., Lamers, W. H., Köhler, S. E. & de Mey, J. G. R., 1 Jan 2013, In : British Journal of Pharmacology. 169, 7, p. 1486-1499

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Hepatic adaptation compensates inactivation of intestinal arginine biosynthesis in suckling mice

Marion, V., Sankaranarayanan, S., de Theije, C., van Dijk, P. J., Hakvoort, T. B., Lamers, W. H. & Köhler, E. S., 13 Jun 2013, In : PLOS ONE. 8, 6, 12 p., 67021.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Prevention and reversal of hepatic steatosis with a high-protein diet in mice

Garcia Caraballo, S., Comhair, T. M., Verheyen, F. K., Gaemers, I., Schaap, F. G., Houten, S. M., Hakvoort, T. B., Dejong, C. H. C., Lamers, W. H. & Köhler, S. E., 1 Jan 2013, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1832, 5, p. 685-695

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
2012

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

van den Bossche, J., Lamers, W. H., Köhler, E. S., Geuns, J. M., Alhonen, L., Uimari, A., Pirnes-Karhu, S., Van Overmeire, E., Morias, Y., Brys, L., Vereecke, L., De Baetselier, P. & Van Ginderachter, J. A., May 2012, In : Journal of Leukocyte Biology. 91, 5, p. 685-699 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
2011

Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2

Marion, V., Sankaranarayanan, S., de Theije, C. C., van Dijk, P. J., Lindsey, P. J., Lamers, M. C., Harding, H. P., Ron, D., Lamers, W. H. & Köhler, S. E., 18 Mar 2011, In : Journal of Biological Chemistry. 286, 11, p. 8866-8874 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Depressive symptoms and risk for dementia: a 9-year follow-up of the maastricht aging study

Köhler, S. E., van Boxtel, M., Jolles, J. & Verhey, F. R. J., 1 Jan 2011, In : American Journal of Geriatric Psychiatry. 19, 10, p. 902-905

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Dietary cholesterol, female gender and n-3 fatty acid deficiency are more important factors in the development of non-alcoholic fatty liver disease than the saturation index of the fat

Comhair, T. M., Garcia Caraballo, S. C., Dejong, C. H. C., Lamers, W. H. & Köhler, S. E., 1 Jan 2011, In : Nutrition & Metabolism. 8, 1, p. 4

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
16 Citations (Scopus)
147 Downloads (Pure)
2010

Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification.

He, Y., Hakvoort, T. B., Koehler, S. E., Vermeulen, J. L., de Waart, D. R., de Theije, C. C., Ten Have, G. A., van Eijk, H. M., Kunne, C., Labruyere, W. T., Houten, S. M., Sokolovic, M., Ruijter, J. M., Deutz, N. E. & Lamers, W. H., 26 Mar 2010, In : Journal of Biological Chemistry. 285, 13, p. 9516-9524 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Jan Drukker (11 April 1936-19 September 2009) Obituary

Kohler, S. E., 1 Jan 2010, In : Annals of Anatomy-Anatomischer Anzeiger. 192, 2, p. 63-64 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Jan Drukker (1936-2009) in remembrance.

van Mameren, H., Lamers, W. H., van der Wal, J. C. & Koehler, S. E., Apr 2010, In : Clinical Anatomy. 23, 3, p. 335-337 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2008

The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes

Köhler, E. S., Sankaranarayanan, S., van Ginneken, C. J., van Dijk, P., Vermeulen, J. L., Ruijter, J. M., Lamers, W. H. & Bruder, E., 1 Jan 2008, In : BMC Developmental Biology. 8, 1, p. 107

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
2006

Subcutaneous and intrahepatic growth of human hepatoblastoma in immunodeficient mice

Schnater, M. J., Bruder, E., Bertschin, S., Woodtli, T., de Theije, C. C., Pietsch, T., Aronson, D. C., von Schweinitz, D., Lamers, W. H. & Kohler, S. E., 1 Jan 2006, In : Journal of Hepatology. 45, 3, p. 377-386

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)
2005

How much intimacy is compatible with survival for a cardiomyocyte?

Lamers, W. H. & Köhler, S. E., 1 Jan 2005, In : Cardiovascular Research. 68, 1, p. 1-2

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Morphogenetic movements during cranial neural tube closure in the chick embryo and the effect of homocysteine

Brouns, M. R., Afman, L. A., Vanhauten, B. A., Hekking, J. W. M., Köhler, E. S. & van Straaten, H. W., 1 Jan 2005, In : Anatomy and Embryology. 210, 2, p. 81-90

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
2003

Is the liver a standby pancreas?

Köhler, S. E. & Lamers, W. H., 1 Jan 2003, In : Journal of Hepatology. 39, 6, p. 1098-1102

Research output: Contribution to journalArticleAcademicpeer-review

Where do we stand with hepatoblastoma? A review

Schnater, J. M., Köhler, S. E., Lamers, W. H., von Schweinitz, D. & Aronson, D. C., 1 Jan 2003, In : Cancer. 98, 4, p. 668-678

Research output: Contribution to journalArticleAcademicpeer-review

107 Citations (Scopus)