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Research output per year

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2020

Analysis of 4-fluoroamphetamine in cerumen after controlled oral application

Meier, S. I., Petzel-Witt, S., Schubert-Zsilavecz, M., de Sousa Fernandes Perna, E. B., Theunissen, E. L., Ramaekers, J. G. & Toennes, S. W., Jul 2020, In : Drug Testing and Analysis. 12, 7, p. 968-974 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance

Ramaekers, J. G., Mason, N. L. & Theunissen, E. L., Jul 2020, In : European Neuropsychopharmacology. 36, p. 191-205 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Excretion of 4-fluoroamphetamine and three metabolites in urine after controlled oral ingestion

Toennes, S. W., Schneider, D., Pogoda, W., Paulke, A., Wunder, C., Theunissen, E. L., Perna, E. B. D. S. F. & Ramaekers, J. G., 3 Feb 2020, In : Journal of Pharmaceutical and Biomedical Analysis. 179, 8 p., 113008.

Research output: Contribution to journalArticleAcademicpeer-review

Mephedrone and Alcohol Interactions in Humans

Papaseit, E., Pérez-Mañá, C., de Sousa Fernandes Perna, E. B., Olesti, E., Mateus, J., Kuypers, K. P. C., Theunissen, E. L., Fonseca, F., Torrens, M., Ramaekers, J. G., de la Torre, R. & Farré, M., 28 Jan 2020, In : Frontiers in Pharmacology. 10, 17 p., 1588.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Semiquantitative Activity-Based Detection of JWH-018, a Synthetic Cannabinoid Receptor Agonist, in Oral Fluid after Vaping

Cannaert, A., Fernandez, M. D. M. R., Theunissen, E. L., Ramaekers, J. G., Wille, S. M. R. & Stove, C. P., 21 Apr 2020, In : Analytical Chemistry. 92, 8, p. 6065-6071 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019
Open Access

Cannabis induced increase in striatal glutamate associated with loss of functional corticostriatal connectivity

Mason, N. L., Theunissen, E. L., Hutten, N. R. P. W., Tse, D. H. Y., Toennes, S. W., Stiers, P. & Ramaekers, J. G., Dec 2019, In : European Neuropsychopharmacology. 29, 2, p. 247-256 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cocaine enhances figural, but impairs verbal 'flexible' divergent thinking

Hutten, N. R. P. W., Steenbergen, L., Colzato, L. S., Hommel, B., Theunissen, E. L., Ramaekers, J. G. & Kuypers, K. P. C., Jul 2019, In : European Neuropsychopharmacology. 29, 7, p. 813-824 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacokinetic properties of 4-fluoroamphetamine in serum and oral fluid after oral ingestion

Toennes, S. W., Schneider, D., Pogoda, W., Paulke, A., Wunder, C., Theunissen, E. L., Kuypers, K. P. C., de Sousa Fernandes Perna, E. & Ramaekers, J. G., Jul 2019, In : Drug Testing and Analysis. 11, 7, p. 1028-1034 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users

Mason, N. L., Theunissen, E. L., Hutten, N. R. P. W., Tse, D. H. Y., Toennes, S. W., Jansen, J. F. A., Stiers, P. & Ramaekers, J. G., 22 Dec 2019, In : Addiction Biology. 9 p., e12870.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A single dose of cocaine enhances prospective memory performance

Hutten, N. RPW., Kuypers, K. PC., van Wel, J. HP., Theunissen, E. L., Toennes, S. W., Verkes, R-J. & Ramaekers, J. G., Aug 2018, In : Journal of Psychopharmacology. 32, 8, p. 883–892 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter

Kuypers, K. P. C., de la Torre, R., Farre, M., Xicota, L., Perna, E. B. D. S. F., Theunissen, E. L. & Ramaekers, J. G., 18 Jan 2018, In : Scientific Reports. 8, 7 p., 1061.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine

Kuypers, K. P. C., de Sousa Fernandes Perna, E. B., Dolder, P. C., Toennes, S. W., Theunissen, E. L., Mason, N. L., Hutten, N. R. P. W. & Ramaekers, J. G., Aug 2018, In : Psychopharmacology. 235, 8, p. 2349-2356 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Excretion of metabolites of the synthetic cannabinoid JWH-018 in urine after controlled inhalation

Toennes, S. W., Geraths, A., Pogoda, W., Paulke, A., Wunder, C., Theunissen, E. L. & Ramaekers, J. G., 20 Feb 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 150, p. 162-168 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacokinetic properties of the synthetic cannabinoid JWH-018 in oral fluid after inhalation

Toennes, S. W., Geraths, A., Pogoda, W., Paulke, A., Wunder, C., Theunissen, E. L. & Ramaekers, J. G., Apr 2018, In : Drug Testing and Analysis. 10, 4, p. 644-650 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Brain reactivity to alcohol and cannabis marketing during sobriety and intoxication

de Sousa Fernandes Perna, E. B., Theunissen, E. L., Kuypers, K. P. C., Evers, E. A., Stiers, P., Toennes, S. W., Witteman, J., van Dalen, W. & Ramaekers, J. G., May 2017, In : Addiction Biology. 22, 3, p. 823–832 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacokinetic properties of the synthetic cannabinoid JWH-018 and of its metabolites in serum after inhalation

Toennes, S. W., Geraths, A., Pogoda, W., Paulke, A., Wunder, C., Theunissen, E. L. & Ramaekers, J. G., 5 Jun 2017, In : Journal of Pharmaceutical and Biomedical Analysis. 140, p. 215-222 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking

Kuypers, K. P. C., Riba, J., de la Fuente Revenga, M., Barker, S., Theunissen, E. L. & Ramaekers, J. G., Sep 2016, In : Psychopharmacology. 233, 18, p. 3395–3403 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
203 Downloads (Pure)

Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes

Ramaekers, J. G., van Wel, J. H., Spronk, D., Franke, B., Kenis, G., Toennes, S. W., Kuypers, K. P. C., Theunissen, E. L., Stiers, P. & Verkes, R. J., 2016, In : Brain Imaging and Behavior. 10, p. 1254–1263

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cannabis and tolerance: acute drug impairment as a function of cannabis use history

Ramaekers, J. G., van Wel, J. H., Spronk, D. B., Toennes, S. W., Kuypers, K. P. C., Theunissen, E. L. & Verkes, R. J., 26 May 2016, In : Scientific Reports. 6, 8 p., 26843.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
184 Downloads (Pure)

Neurocognitive performance following acute mephedrone administration, with and without alcohol

de Sousa Fernandes Perna, E. B., Papaseit, E., Pérez-Mañá, C., Mateus, J., Theunissen, E. L., Kuypers, K. P. C., de la Torre, R., Farré, M. & Ramaekers, J. G., Dec 2016, In : Journal of Psychopharmacology. 30, 12, p. 1305–1312 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

On-the-road driving performance after use of the antihistamines mequitazine and l-mequitazine, alone and with alcohol

van der Sluiszen, N. N. J. J. M., Vermeeren, A., Jongen, S., Theunissen, E. L., van Oers, A. C. M., Van Leeuwen, C. J., Maret, A., Desforges, C., Delarue, A. & Ramaekers, J. G., Sep 2016, In : Psychopharmacology. 233, 18, p. 3461–3469 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
180 Downloads (Pure)

Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure

De Sousa Fernandes Perna, E. B., Theunissen, E. L., Kuypers, K. P. C., Toennes, S. W. & Ramaekers, J. G., Sep 2016, In : Psychopharmacology. 233, 18, p. 3331–3340 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
175 Downloads (Pure)

Verbal memory impairment in polydrug ecstasy users: A clinical perspective

Kuypers, K. P. C., Theunissen, E. L., van Wel, J. H. P., de Sousa, E. B., Perna, F., Linssen, A., Sambeth, A., Schultz, B. G. & Ramaekers, J. G., 23 Feb 2016, In : PLOS ONE. 11, 2, 0149438.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
1 Citation (Scopus)
168 Downloads (Pure)
2015

MDMA, cannabis, and cocaine produce acute dissociative symptoms

van Heugten-Van der Kloet, D., Giesbrecht, T., van Wel, J., Bosker, W. M., Kuypers, K. P. C., Theunissen, E. L., Spronk, D. B., Verkes, R. J., Merckelbach, H. & Ramaekers, J. G., 30 Aug 2015, In : Psychiatry Research. 228, 3, p. 907-912 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Psychedelic symptoms of cannabis and cocaine use as a function of trait impulsivity

van Wel, J. H. P., Spronk, D. B., Kuypers, K. P. C., Theunissen, E. L., Toennes, S. W., Verkes, R. J. & Ramaekers, J. G., 1 Mar 2015, In : Journal of Psychopharmacology. 29, 3, p. 324-334 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W. & Ramaekers, J. G., 1 Jan 2015, In : Psychopharmacology. 232, 2, p. 343-353 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2014

Memory and mood during MDMA intoxication, with and without memantine pretreatment

de Sousa Fernandes Perna, E. B., Theunissen, E. L., Kuypers, K. P. C., Heckman, P., de la Torre, R., Farre, M. & Ramaekers, J. G., Dec 2014, In : Neuropharmacology. 87, p. 198-205 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
2013

A Randomized Trial on the Acute and Steady-State Effects of a New Antidepressant, Vortioxetine (Lu AA21004), on Actual Driving and Cognition

Theunissen, E., Street, D., Hojer, A. M., Vermeeren, A., van Oers, A. & Ramaekers, J. G., Jun 2013, In : Clinical Pharmacology & Therapeutics. 93, 6, p. 493-501 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Influence of Ethanol on the Pharmacokinetic Properties of (9)-Tetrahydrocannabinol in Oral Fluid

Toennes, S. W., Schneider, K., Wunder, C., Kauert, G. F., Moeller, M. R., Theunissen, E. L. & Ramaekers, J. G., Apr 2013, In : Journal of Analytical Toxicology. 37, 3, p. 152-158 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit

Ramaekers, J. G., Evers, E. A., Theunissen, E. L., Kuypers, K. P. C., Goulas, A. & Stiers, P., Sep 2013, In : Psychopharmacology. 229, 2, p. 219-226 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Psychomotor function in chronic daily Cannabis smokers during sustained abstinence

Bosker, W. M., Karschner, E. L., Lee, D., Goodwin, R. S., Hirvonen, J., Innis, R. B., Theunissen, E. L., Kuypers, K. P. C., Huestis, M. A. & Ramaekers, J. G., 2 Jan 2013, In : PLOS ONE. 8, 1, 7 p., 53127.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
25 Citations (Scopus)

Single doses of THC and cocaine decrease proficiency of impulse control in heavy cannabis users

van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Toennes, S. W., Spronk, D. B., Verkes, R. J. & Ramaekers, J. G., Dec 2013, In : British Journal of Pharmacology. 170, 7, p. 1410-1420 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

The role of P-glycoprotein in CNS antihistamine effects

Conen, S., Theunissen, E. L., Vermeeren, A., van Ruitenbeek, P., Stiers, P., Mehta, M. A., Toennes, S. W. & Ramaekers, J. G., 1 Jan 2013, In : Psychopharmacology. 229, 1, p. 9-19

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
2012

A placebo-controlled study to assess Standardized Field Sobriety Tests performance during alcohol and cannabis intoxication in heavy cannabis users and accuracy of point of collection testing devices for detecting THC in oral fluid

Bosker, W. M., Theunissen, E. L., Conen, S., Kuypers, K. P. C., Jeffery, W. K., Walls, H. C., Kauert, G. F., Toennes, S. W., Moeller, M. R. & Ramaekers, J. G., Oct 2012, In : Psychopharmacology. 223, 4, p. 439-446 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Effects of acute MDMA intoxication on mood and impulsivity: role of the 5-HT(2) and 5-HT(1) receptors

van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Bosker, W. M., Bakker, K. & Ramaekers, J. G., 10 Jul 2012, In : PLOS ONE. 7, 7, 8 p., 40187.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

Medicinal Delta(9)-tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests

Bosker, W. M., Kuypers, K. P. C., Theunissen, E. L., Surinx, A., Blankespoor, R. J., Skopp, G., Jeffery, W. K., Walls, H. C., van Leeuwen, C. J. & Ramaekers, J. G., Oct 2012, In : Addiction. 107, 10, p. 1837-1844 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication

Theunissen, E., Kauert, G. F., Toennes, S. W., Moeller, M. R., Sambeth, A., Blanchard, M. M. & Ramaekers, J., 1 Jan 2012, In : Psychopharmacology. 220, 2, p. 341-350

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)
2011

Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers

Conen, S., Theunissen, E. L., Oers, A. C., Valiente, R. & Ramaekers, J. G., 1 Jan 2011, In : Journal of Psychopharmacology. 25, 11, p. 1517-1523

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Blockade of 5-HT(2) receptor selectively prevents MDMA-induced verbal memory impairment

van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Bosker, W. M., Bakker, K. & Ramaekers, J. G., 1 Jan 2011, In : Neuropsychopharmacology. 36, 9, p. 1932-1939

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Influence of ethanol on cannabinoid pharmacokinetic parameters in chronic users

Toennes, S. W., Schneider, K., Kauert, G., Wunder, C., Moeller, M. R., Theunissen, E. L. & Ramaekers, J. G., 1 Jan 2011, In : Analytical and Bioanalytical Chemistry. 400, 1, p. 145-152

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Residual effects of esmirtazapine on actual driving performance: Overall findings and an exploratory analysis into the role of CYP2D6 phenotype

Ramaekers, J. G., Conen, S., de Kam, P. J., Braat, S. H. J. G., Peeters, P., Theunissen, E. L. & Ivgy-may, N., 1 Jan 2011, In : Psychopharmacology. 215, 2, p. 321-332

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers

Conen, S., Theunissen, E. L., Vermeeren, A. & Ramaekers, J. G., 1 Jan 2011, In : Journal of Clinical Psychopharmacology. 31, 3, p. 294-301

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users

Ramaekers, J. G., Theunissen, E. L., de Brouwer, M., Toennes, S. W., Moeller, M. R. & Kauert, G., 1 Jan 2011, In : Psychopharmacology. 214, 2, p. 391-401

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)