20122019

Research output per year

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Research Output

2019

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: Role of mitochondrial reactive nitrogen species (Retraction of Vol 279, Pg 43940, 2004)

Zou, M-H., Kirkpatrick, S. S., Davis, B. J., Nelson, J. S., Wiles, W. G., Schlattner, U., Neumann, D., Brownlee, M., Freeman, M. B. & Goldman, M. H., 6 Sep 2019, In : Journal of Biological Chemistry. 294, 36, p. 13525-13525 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

AMP-Activated Protein Kinase Signalling

Neumann, D. & Viollet, B., 1 Feb 2019, In : International journal of molecular sciences. 20, 3, 5 p., 766.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop

Liu, Y., Rodriguez-Calvo, R., Wang, S., Zhu, X., Broers, J. L. V., Glatz, J. F. C., Luiken, J. J. F. P. & Neumann, D., 23 Jan 2019, In : PLOS ONE. 14, 1, 14 p., 0210704.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target

Chanda, D., Neumann, D. & Glatz, J. F. C., Jan 2019, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 140, p. 51-56 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Assessment of AMPK-Stimulated Cellular Long-Chain Fatty Acid and Glucose Uptake

Luiken, J., Neumann, D., Glatz, J., Coumans, W., Chanda, D. & Nabben, M., 2018, AMPK Methods and Protocols. Neumann, D. & Viollet, B. (eds.). Humana Press, Vol. 1732. p. 343-361 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance

Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P. & Nabben, M., 1 May 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 5, p. 1960-1967 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy

de Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Neumann, D., Kohler, S. E. & Langen, R. C. J., 13 Sep 2018, In : PLOS ONE. 13, 9, 18 p., 0203630.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Is TAK1 a Direct Upstream Kinase of AMPK?

Neumann, D., 1 Aug 2018, In : International journal of molecular sciences. 19, 8, 8 p., 2412.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction

Liu, Y., Neumann, D., Glatz, J. F. C. & Luiken, J. J. F. P., Sep 2018, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 136, p. 131-141 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells

Ho, P-Y., Li, H., Pavlov, T. S., Tuerk, R. D., Tabares, D., Brunisholz, R., Neumann, D., Staruschenko, A. & Hallows, K. R., 20 Jul 2018, In : Journal of Biological Chemistry. 293, 29, p. 11612-11624 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes

Chanda, D., Oligschlaeger, Y., Geraets, I., Liu, Y., Zhu, X., Li, J., Nabben, M., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C. & Neumann, D., 28 Apr 2017, In : Journal of Biological Chemistry. 292, 17, p. 7105-7114 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction

Liu, Y., Steinbusch, L. K. M., Nabben, M., Kapsokalyvas, D., van Zandvoort, M., Schonleitner, P., Antoons, G., Simons, P. J., Coumans, W. A., Geomini, A., Chanda, D., Glatz, J. F. C., Neumann, D. & Luiken, J. J. F. P., 1 Jun 2017, In : Diabetes. 66, 6, p. 1521-1534 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes

Rodriguez-Calvo, R., Chanda, D., Oligschlaeger, Y., Miglianico, M., Coumans, W. A., Barroso, E., Tajes, M., Luiken, J. J. F. P., Glatz, J. F. C., Vazquez-Carrera, M. & Neumann, D., May 2017, In : Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1862, 5, p. 541-551 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells

Al-bataineh, M. M., Li, H., Ohmi, K., Gong, F., Marciszyn, A. L., Naveed, S., Zhu, X., Neumann, D., Wu, Q., Cheng, L., Fenton, R. A., Pastor-Soler, N. M. & Hallows, K. R., 1 Nov 2016, In : American Journal of Physiology-Renal Physiology. 311, 5, p. F890-F900

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E

Zhu, X., Dahlmans, V., Thali, R., Preisinger, C., Viollet, B., Voncken, J. W. & Neumann, D., Aug 2016, In : Journal of Biological Chemistry. 291, 33, p. 17020-17027

Research output: Contribution to journalArticleAcademicpeer-review

GSK-3 Inhibitors: Anti-Diabetic Treatment Associated with Cardiac Risk?

Nabben, M. & Neumann, D., Jun 2016, In : Cardiovascular Drugs and Therapy. 30, 3, p. 233-235

Research output: Contribution to journalEditorialAcademicpeer-review

In Vitro Methods to Study AMPK

Zhu, X., Voncken, W. & Neumann, D., 2016, AMP-activated Protein Kinase. Cordero, M. D. & Viollet, B. (eds.). Springer Verlag, Vol. 107. p. 471-489

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Macrophage Stimulating Protein Enhances Hepatic Inflammation in alpha NASH Model

Li, J., Chanda, D., van Gorp, P., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Debets, J., Oligschläger, Y., Gijbels, M. J. J., Neumann, D. & Shiri-Sverdlov, R., 29 Sep 2016, In : PLOS ONE. 11, 9, e0163843.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis

Chanda, D., Li, J., Oligschläger, Y., Jeurissen, M. L. J., Houben, T., Walenbergh, S. M. A., Shiri-Sverdlov, R. & Neumann, D., Sep 2016, In : Experimental and Molecular Medicine. 48, e258.

Research output: Contribution to journalArticleAcademicpeer-review

Pharmacological Targeting of AMP-Activated Protein Kinase and Opportunities for Computer-Aided Drug Design

Miglianico, M., Nicolaes, G. A. F. & Neumann, D., 14 Apr 2016, In : Journal of Medicinal Chemistry. 59, 7, p. 2879-2893

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2 Citations (Scopus)

The interaction between AMPK beta 2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content

Oligschläger, Y., Miglianico, M., Dahlmans, V. E., Rubio-Villena, C., Chanda, D., Adelaida Garcia-Gimeno, M., Coumans, W. A., Liu, Y., Voncken, J. W., Luiken, J. J. F. P., Glatz, J. F. C., Sanz, P. & Neumann, D., 1 Apr 2016, In : Biochemical Journal. 473, 7, p. 937-947

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2015

AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression

Rodriguez-Calvo, R., Vazquez-Carrera, M., Masana, L. & Neumann, D., 2015, In : Ppar Research. 785783.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Cardiac contraction-induced GLUT4 translocation requires dual signaling input

Luiken, J. J. F. P., Glatz, J. F. C. & Neumann, D., Aug 2015, In : Trends in Endocrinology and Metabolism. 26, 8, p. 404-410

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
1 Citation (Scopus)

MK3 Modulation Affects BMI1-Dependent and Independent Cell Cycle Check-Points

Prickaerts, P., Niessen, H. E. C., Dahlmans, V. E. H., Spaapen, F., Salvaing, J., Vanhove, J., Geijselaers, C., Bartels, S. J. J., Partouns, I., Neumann, D., Speel, E-J., Takihara, Y., Wouters, B. G. & Voncken, J. W., 8 Apr 2015, In : PLOS ONE. 10, 4, e0118840.

Research output: Contribution to journalArticleAcademicpeer-review

The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation

Oligschlaeger, Y., Miglianico, M., Chanda, D., Scholz, R., Thali, R. F., Tuerk, R., Stapleton, D. I., Gooley, P. R. & Neumann, D., 1 May 2015, In : Journal of Biological Chemistry. 290, 18, p. 11715-11728

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
2014

Calcium signaling recruits substrate transporters GLUT4 and CD36 to the sarcolemma without increasing cardiac substrate uptake

Angin, Y., Schwenk, R. W., Nergiz-Unal, R., Hoebers, N., Heemskerk, J. W. M., Kuijpers, M. J., Coumans, W. A., van Zandvoort, M. A. M. J., Bonen, A., Neumann, D., Glatz, J. F. C. & Luiken, J., 15 Jul 2014, In : American Journal of Physiology : Endocrinology and Metabolism. 307, 2, p. E225-E236

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Cross-talk between Two Essential Nutrient-sensitive Enzymes O-GlcNAc TRANSFERASE ( OGT) AND AMP-ACTIVATED PROTEIN KINASE ( AMPK)

Bullen, J. W., Balsbaugh, J. L., Chanda, D., Shabanowitz, J., Hunt, D. F., Neumann, D. & Hart, G. W., 11 Apr 2014, In : Journal of Biological Chemistry. 289, 15, p. 10592-10606

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Protein kinase-D1 overexpression prevents lipid-induced cardiac insulin resistance

Dirkx, E., van Eys, G. J. J. M., Schwenk, R. W., Steinbusch, L. K. M., Hoebers, N., Coumans, W. A., Peters, T., Janssen, B. J., Brans, B., Vogg, A. T., Neumann, D., Glatz, J. F. C. & Luiken, J. J. F. P., Nov 2014, In : Journal of Molecular and Cellular Cardiology. 76, p. 208-217

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Regulation of brain-type creatine kinase by AMP-activated protein kinase: Interaction, phosphorylation and ER localization

Rios, S. R., Lamarche, F., Cottet-Rousselle, C., Klaus, A., Tuerk, R., Thali, R., Auchli, Y., Brunisholz, R., Neumann, D., Barret, L., Tokarska-Schlattner, M. & Schlattner, U., Aug 2014, In : Biochimica et Biophysica Acta-bioenergetics. 1837, 8, p. 1271-1283

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2013

AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney

Alzamora, R., Al-Bataineh, M. M., Liu, W., Gong, F., Li, H., Thali, R. F., Joho-Auchli, Y., Brunisholz, R. A., Satlin, L. M., Neumann, D., Hallows, K. R. & Pastor-Soler, N. M., Oct 2013, In : American Journal of Physiology-Renal Physiology. 305, 7, p. F943-F956

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2012

AMP-Activated Protein Kinase beta-Subunit Requires Internal Motion for Optimal Carbohydrate Binding

Bieri, M., Mobbs, J. I., Koay, A., Louey, G., Mok, Y-F., Hatters, D. M., Park, J-T., Park, K-H., Neumann, D., Stapleton, D. & Gooley, P. R., 18 Jan 2012, In : Biophysical Journal. 102, 2, p. 305-314

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

Chen, L., Wang, J., Zhang, Y-Y., Yan, S. F., Neumann, D., Schlattner, U., Wang, Z-X. & Wu, J-W., Jul 2012, In : Nature Structural and Molecular Biology. 19, 7, p. 716-+

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway

Garcia-Haro, L., Adelaida Garcia-Gimeno, M., Neumann, D., Beullens, M., Bollen, M. & Sanz, P., 30 Nov 2012, In : Febs Letters. 586, 23, p. 4241-4247

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Phosphocreatine Interacts with Phospholipids, Affects Membrane Properties and Exerts Membrane-Protective Effects

Tokarska-Schlattner, M., Epand, R. F., Meiler, F., Zandomeneghi, G., Neumann, D., Widmer, H. R., Meier, B. H., Epand, R. M., Saks, V., Wallimann, T. & Schlattner, U., 17 Aug 2012, In : PLOS ONE. 7, 8, e43178.

Research output: Contribution to journalArticleAcademicpeer-review

Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-activated Protein Kinase

King, J. D. J., Lee, J., Riemen, C. E., Neumann, D., Xiong, S., Foskett, J. K., Mehta, A., Muimo, R. & Hallows, K. R., 28 Sep 2012, In : Journal of Biological Chemistry. 287, 40, p. 33389-33400

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)