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Research Output 2007 2019

2019

Dynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns

Beijer, N. R. M., Nauryzgaliyeva, Z. M., Arteaga, E. M., Pieuchot, L., Anselme, K., van de Peppel, J., Vasilevich, A. S., Groen, N., Roumans, N., Hebels, D. G. A. J. & de Boer, J., 24 Jun 2019, In : Scientific Reports. 9, 14 p., 9099.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)

Espin-Perez, A., Hebels, D. G. A. J., Kiviranta, H., Rantakokko, P., Georgiadis, P., Botsivali, M., Bergdahl, I. A., Palli, D., Spath, F., Johansson, A., Chadeau-Hyam, M., Kyrtopoulos, S. A., Kleinjans, J. C. S. & de Kok, T. M. C. M., 24 Jan 2019, In : Scientific Reports. 9, p. 1-12 12 p., 746.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides

Mostafavi, N., Vlaanderen, J., Portengen, L., Chadeau-Hyam, M., Modig, L., Palli, D., Bergdahl, I. A., Brunekreef, B., Vineis, P., Hebels, D. G. A. J., Kleinjans, J. C. S., Krogh, V., Hoek, G., Georgiadis, P., Kyrtopoulos, S. A. & Vermeulen, R., May 2017, In : Epidemiology. 28, 3, p. 320-328 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

Chatziioannou, A., Georgiadis, P., Hebels, D. G., Liampa, I., Valavanis, I., Bergdahl, I. A., Johansson, A., Palli, D., Chadeau-Hyam, M., Siskos, A. P., Keun, H., Botsivali, M., de Kok, T. M. C. M., Perez, A. E., Kleinjans, J. C. S., Vineis, P. & Kyrtopoulos, S. A., 22 Feb 2017, In : Scientific Reports. 7, 13 p., 42870.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

cBiT: A transcriptomics database for innovative biomaterial engineering

Hebels, D. G. A. J., Carlier, A., Coonen, M. L. J., Theunissen, D. H. & de Boer, J., Dec 2017, In : Biomaterials. 149, p. 88-97 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

DNA methylation and exposure to ambient air pollution in two prospective cohorts

Plusquin, M., Guida, F., Polidoro, S., Vermeulen, R., Raaschou-Nielsen, O., Campanella, G., Hoek, G., Kyrtopoulos, S. A., Georgiadis, P., Naccarati, A., Sacerdote, C., Krogh, V., Bueno-de-Mesquita, H. B., Verschuren, W. M. M., Sayols-Baixeras, S., Panni, T., Peters, A., Hebels, D. G. A. J., Kleinjans, J., Vineis, P. & 1 others, Chadeau-Hyam, M., Nov 2017, In : Environment International. 108, p. 127-136 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

Georgiadis, P., Liampa, I., Hebels, D. G., Krauskopf, J., Chatziioannou, A., Valavanis, I., de Kok, T. M. C. M., Kleinjans, J. C. S., Bergdahl, I. A., Melin, B., Spaeth, F., Palli, D., Vermeulen, R. C. H., Vlaanderen, J., Chadeau-Hyam, M., Vineis, P. & Kyrtopoulos, S. A., 13 Sep 2017, In : BMC Genomics. 18, 15 p., 728.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage

Vlaanderen, J., Leenders, M., Chadeau-Hyam, M., Portengen, L., Kyrtopoulos, S. A., Bergdahl, I. A., Johansson, A-S., Hebels, D. D. G. A. J., de Kok, T. M. C. M., Vineis, P. & Vermeulen, R. C. H., 20 Mar 2017, In : BMC Genomics. 18, 8 p., 239.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Linking the Transcriptional Landscape of Bone Induction to Biomaterial Design Parameters

Groen, N., Yuan, H., Hebels, D. G. A. J., Kocer, G., Mbuyi, F., LaPointe, V., Truckenmuller, R., van Blitterswijk, C. A., Habibovic, P. & de Boer, J., 14 Mar 2017, In : Advanced Materials. 29, 10, 14 p., 1603259.

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery

Krauskopf, J., de Kok, T. M., Hebels, D. G., Bergdahl, I. A., Johansson, A., Spaeth, F., Kiviranta, H., Rantakokko, P., Kyrtopoulos, S. A. & Kleinjans, J. C., 23 Aug 2017, In : Scientific Reports. 7, 9 p., 9262.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

Kelly, R. S., Kiviranta, H., Bergdahl, I. A., Palli, D., Johansson, A-S., Botsivali, M., Vineis, P., Vermeulen, R., Kyrtopoulos, S. A., Kleinjans, J., de Kok, T., Hebels, D. & Chadeau-Hyam, M., 16 Feb 2017, In : Environmental Health. 16, 12 p., 9.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure

Hebels, D., Rasche, A., Herwig, R., van Westen, G. J. P., Jennen, D. & Kleinjans, J., 2016, In Silico Methods for Predicting Drug Toxicity. Benfenati, E. (ed.). 1 ed. Humana Press, Vol. 1425. p. 339-359 (Methods in molecular biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

6 Citations (Scopus)

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking

Georgiadis, P., Hebels, D. G., Valavanis, I., Liampa, I., Bergdahl, I. A., Johansson, A., Palli, D., Chadeau-Hyam, M., Chatziioannou, A., Jennen, D. G. J., Krauskopf, J., Jetten, M. J., Kleinjans, J. C. S., Vineis, P. & Kyrtopoulos, S. A., 3 Feb 2016, In : Scientific Reports. 6, 20544.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

ToxDB: pathway-level interpretation of drug-treatment data

Hardt, C., Beber, M. E., Rasche, A., Kamburov, A., Hebels, D. G., Kleinjans, J. C. & Herwig, R., 13 Apr 2016, In : Database-The Journal of Biological Databases and Curation. 2016, baw052.

Research output: Contribution to journalArticleAcademicpeer-review

2015
7 Citations (Scopus)

diXa: a data infrastructure for chemical safety assessment

Hendrickx, D., Aerts, H., Caiment, F., Clark, D., Ebbels, T. M., Evelo, C. T., Gmuender, H., Hebels, D. G., Herwig, R., Hescheler, J., Jennen, D. G., Jetten, M. J., Kanterakis, S., Keun, H. C., Matser, V., Overington, J. P., Pilicheva, E., Sarkans, U., Segura-Lepe, M. P., Sotiriadou, I. & 4 others, Wittenberger, T., Wittwehr, C., Zanzi, A. & Kleinjans, J. C., 1 May 2015, In : Bioinformatics. 31, 9, p. 1505-1507 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
3 Citations (Scopus)

Elimination of Heparin Interference During Microarray Processing of Fresh and Biobank-Archived Blood Samples

Hebels, D. G. A. J., van Herwijnen, M. H. M., Brauers, K. J. J., de Kok, T. M. C. M., Chalkiadaki, G., Kyrtopoulos, S. A. & Kleinjans, J. C. S., Jul 2014, In : Environmental and Molecular Mutagenesis. 55, 6, p. 482-491

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity

Hebels, D. G. A., Jetten, M. J. A., Aerts, H. J. W., Herwig, R., Theunissen, D. H. J., Gaj, S., van Delft, J. H. & Kleinjans, J. C. S., Feb 2014, In : Biomarkers in Medicine. 8, 2, p. 185-200

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis

Chadeau-Hyam, M., Vermeulen, R. C. H., Hebels, D. G. A. J., Castagne, R., Campanella, G., Portengen, L., Kelly, R. S., Bergdahl, I. A., Melin, B., Hallmans, G., Palli, D., Krogh, V., Tumino, R., Sacerdote, C., Panico, S., de Kok, T. M. C. M., Smith, M. T., Kleinjans, J. C. S., Vineis, P. & Kyrtopoulos, S. A., May 2014, In : Annals of Oncology. 25, 5, p. 1065-1072

Research output: Contribution to journalArticleAcademicpeer-review

2013
48 Citations (Scopus)

Performance in Omics Analyses of Blood Samples in Long-Term Storage: Opportunities for the Exploitation of Existing Biobanks in Environmental Health Research

Hebels, D. G. A. J., Georgiadis, P., Keun, H. C., Athersuch, T. J., Vineis, P., Vermeulen, R., Portengen, L., Bergdahl, I. A., Hallmans, G., Palli, D., Bendinelli, B., Krogh, V., Tumino, R., Sacerdote, C., Panico, S., Kleinjans, J. C. S., de Kok, T. M. C. M., Smith, M. T. & Kyrtopoulos, S. A., Apr 2013, In : Environmental Health Perspectives. 121, 4, p. 480-487

Research output: Contribution to journalArticleAcademicpeer-review

2012
19 Citations (Scopus)

Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon.

Hebels, D., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., Vleugels Simon, C. B., Mares, W. G., Pierik, M. J., Masclee, A. A. M., Kleinjans, J. & de Kok, T. M., 1 Jan 2012, In : Food and Chemical Toxicology. 50, 2, p. 95-103

Research output: Contribution to journalArticleAcademicpeer-review

2011
12 Citations (Scopus)

N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer

Hebels, D. G., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., Vleugels Simon, C. B., Mares, W. G., Pierik, M. J., Masclee, A. A. M., Kleinjans, J. C. & de Kok, T. M., 1 Oct 2011, In : Cancer Letters. 309, 1, p. 1-10 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells

Hebels, D. G. A. J., Brauers, K. J. J., van Herwijnen, M. H. M., Georgiadis, P. A., Kyrtopoulos, S. A., Kleinjans, J. C. S. & de Kok, T. M. C. M., 15 Dec 2011, In : Toxicology Letters. 207, 3, p. 232-241

Research output: Contribution to journalArticleAcademicpeer-review

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells

Hebels, D. G. A. J., Jennen, D. G. J., van Herwijnen, M. H. M., Moonen, E. J. C., Pedersen, M., Knudsen, L. E., Kleinjans, J. C. S. & de Kok, T. M. C. M., Nov 2011, In : Mutagenesis. 26, 6, p. 753-761

Research output: Contribution to journalArticleAcademicpeer-review

2010
21 Citations (Scopus)

Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells.

Hebels, D. G. A. J., Briedé, J. J., Khampang, R., Kleinjans, J. C. S. & de Kok, T. M. C. M., 1 Jan 2010, In : Toxicological Sciences. 116, 1, p. 194-205

Research output: Contribution to journalArticleAcademicpeer-review

330 Downloads (Pure)
Open Access
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2009
27 Citations (Scopus)

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis

Hebels, D. G., Jennen, D. G., Kleinjans, J. C. & de Kok, T. M., 1 Jan 2009, In : Toxicological Sciences. 108, 2, p. 290-300

Research output: Contribution to journalArticleAcademicpeer-review

2007
50 Citations (Scopus)

Binary PAH-mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation.

Staal, Y. C., Hebels, D. G., van Herwijnen, M. H., Gottschalk, R. W., van Schooten, F. J. & van Delft, J. H., 1 Jan 2007, In : Carcinogenesis. 28, 12, p. 2632-2640

Research output: Contribution to journalArticleAcademicpeer-review