No photo of Danyel Jennen

Danyel Jennen

Dr.

20072019
If you made any changes in Pure these will be visible here soon.

Research Output 2007 2019

  • 62 Article
  • 2 Conference Abstract/Poster in journal
  • 1 Chapter
  • 1 Review article
2019

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

Rodrigues, D., Souza, T., Jennen, D. G. J., Lemmens, L., Kleinjans, J. C. S. & de Kok, T. M., Jul 2019, In : Cancer Treatment Reviews. 77, p. 57-66 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Open Access

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Hiemstra, S., Ramaiahgari, S. C., Wink, S., Callegaro, G., Coonen, M., Meerman, J., Jennen, D., van den Nieuwendijk, K., Dankers, A., Snoeys, J., de Bont, H., Price, L. & van de Water, B., Oct 2019, In : Archives of Toxicology. 93, 10, p. 2895-2911 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

Jiang, J., Messner, S., Kelm, J. M., van Herwijnen, M., Jennen, D. G. J., Kleinjans, J. C. & de Kok, T. M., 15 Sep 2019, In : Toxicology Letters. 312, p. 34-44 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integration of extracellular metabolomics and intracellular transcriptomics to unravel the mechanisms of 5-FU-induced gastrointestinal toxicity

Souza, T., Rodrigues, D. F., Schrooders, Y., Coyle, L., Vappiani, J., Sevin, D., Jennen, D., Kleinjans, J. C. S. & de Kok, T. M., 15 Oct 2019, In : Toxicology Letters. 314, p. S148-S149 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Transcriptomic approach to improve the understanding of 5-fluorouracil (5-FU) induced intestinal toxicity in vitro and in vivo

Rodrigues, D. F., de Souza, T., Coyle, L., Schrooders, Y., Jardi, F., de Jonghe, S., van Heerden, M., Lammens, L., Jennen, D., Kleinjans, J. C. & de Kok, T. M., 15 Oct 2019, In : Toxicology Letters. 314, p. S88-S89 2 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

2018

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury

Souza, T., Trairatphisan, P., Pinero, J., Furlong, L., Saez-Rodriguez, J., Kleinjans, J. & Jennen, D., 20 Nov 2018, In : Frontiers in Genetics. 9, 12 p., 527.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transcriptomic study of the toxic mechanism triggered by beauvericin in Jurkat cells

Escriva, L., Jennen, D., Caiment, F. & Manyes, L., 1 Mar 2018, In : Toxicology Letters. 284, p. 213-221 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

Buesen, R., Chorley, B. N., Lima, B. D. S., Daston, G., Deferme, L., Ebbels, T., Gant, T. W., Goetz, A., Greally, J., Gribaldo, L., Hackermueller, J., Hubesch, B., Jennen, D., Johnson, K., Kanno, J., Kauffmann, H-M., Laffont, M., McMullen, P., Meehan, R., Pemberton, M. & 14 others, Perdichizzi, S., Piersma, A. H., Sauer, U. G., Schmidt, K., Seitz, H., Sumida, K., Tollefsen, K. E., Tong, W., Tralau, T., van Ravenzwaay, B., Weber, R. J. M., Worth, A., Yauk, C. & Poole, A., Dec 2017, In : Regulatory Toxicology and Pharmacology. 91, p. S3-S13 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds

Hendrickx, D. M., Souza, T., Jennen, D. G. J. & Kleinjans, J. C. S., Jun 2017, In : Archives of Toxicology. 91, 6, p. 2343-2352 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inferring transcription factor activity from microarray data reveals novel targets for toxicological investigations

Souza, T. M., van den Beucken, T., Kleinjans, J. C. S. & Jennen, D. G. J., 15 Aug 2017, In : Toxicology. 389, p. 101-107 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury

Jiang, J., Mathijs, K., Timmermans, L., Claessen, S. M., Hecka, A., Weusten, J., Peters, R., van Delft, J. H., Kleinjans, J. C. S., Jennen, D. G. J. & de Kok, T. M., 1 Oct 2017, In : Toxicology and Applied Pharmacology. 332, p. 100-108 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women

Vrijens, K., Winckelmans, E., Tsamou, M., Baeyens, W., De Boever, P., Jennen, D., de Kok, T. M., Den Hond, E., Lefebvre, W., Plusquin, M., Reynders, H., Schoeters, G., Van Larebeke, N., Vanpoucke, C., Kleinjans, J. & Nawrot, T. S., Apr 2017, In : Environmental Health Perspectives. 125, 4, p. 660-669 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The idiosyncratic drug-induced gene expression changes in HepG2 cells

Jiang, J., Mathijs, K., Timmermans, L., Claessen, S. M., Hecka, A., Weusten, J., Peters, R., van Delft, J. H., Kleinjans, J. C. S., Jennen, D. G. J. & de Kok, T. M., Oct 2017, In : Data in brief. 14, p. 462-468 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis

Van den Hof, W. F. P. M., Coonen, M. L. J., van Herwijnen, M., Brauers, K., Jennen, D., Damink, S. W. M. O., Schaap, F. G. & Kleinjans, J. C. S., Oct 2017, In : Toxicology in Vitro. 44, p. 322-329 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Xenobiotic metabolism in differentiated human bronchial epithelial cells

Boei, J. J. W. A., Vermeulen, S., Klein, B., Hiemstra, P. S., Verhoosel, R. M., Jennen, D. G. J., Lahoz, A., Gmuender, H. & Vrieling, H., May 2017, In : Archives of Toxicology. 91, 5, p. 2093-2105 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure

Hebels, D., Rasche, A., Herwig, R., van Westen, G. J. P., Jennen, D. & Kleinjans, J., 2016, In Silico Methods for Predicting Drug Toxicity. Benfenati, E. (ed.). 1 ed. Humana Press, Vol. 1425. p. 339-359 (Methods in molecular biology).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

3 Citations (Scopus)

Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood

Pennings, J. L. A., Jennen, D. G. J., Nygaard, U. C., Namork, E., Haug, L. S., van Loveren, H. & Granum, B., 3 Mar 2016, In : Journal of Immunotoxicology. 13, 2, p. 173-180

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective

Herwig, R., Gmuender, H., Corvi, R., Bloch, K. M., Brandenburg, A., Castell, J., Ceelen, L., Chesne, C., Doktorova, T. Y., Jennen, D., Jennings, P., Limonciel, A., Lock, E. A., McMorrow, T., Phrakonkham, P., Radford, R., Slattery, C., Stierum, R., Vilardell, M., Wittenberger, T. & 4 others, Yildirimman, R., Ryan, M., Rogiers, V. & Kleinjans, J., Sep 2016, In : Archives of Toxicology. 90, 9, p. 2215-2229

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis

Souza, T., Jennen, D., van Delft, J., van Herwijnen, M., Kyrtoupolos, S. & Kleinjans, J., Jun 2016, In : Archives of Toxicology. 90, 6, p. 1449-1458

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking

Georgiadis, P., Hebels, D. G., Valavanis, I., Liampa, I., Bergdahl, I. A., Johansson, A., Palli, D., Chadeau-Hyam, M., Chatziioannou, A., Jennen, D. G. J., Krauskopf, J., Jetten, M. J., Kleinjans, J. C. S., Vineis, P. & Kyrtopoulos, S. A., 3 Feb 2016, In : Scientific Reports. 6, 20544.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Transcriptomic and metabolomic data integration

Cavill, R., Jennen, D., Kleinjans, J. & Briedé, J., Sep 2016, In : Briefings in Bioinformatics. 17, 5, p. 891-901

Research output: Contribution to journalArticleAcademicpeer-review

2015

Bayesian Network Inference. Enables Unbiased Phenotypic Anchoring of Transcriptomic Responses to Cigarette Smoke in Humans

Jennen, D. G. J., van Leeuwen, D. M., Hendrick, D. M., Gottschalk, R. W. H., van Delft, J. H. M. & Kleinjans, J. C. S., Oct 2015, In : Chemical Research in Toxicology. 28, 10, p. 1936-1948

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens

Espin-Perez, A., de Kok, T. M. C. M., Jennen, D. G. J., Hendrickx, D. M., De Coster, S., Schoeters, G., Baeyens, W., van Larebeke, N. & Kleinjans, J. C. S., Oct 2015, In : Carcinogenesis. 36, 10, p. 1154-1161

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

diXa: a data infrastructure for chemical safety assessment

Hendrickx, D., Aerts, H., Caiment, F., Clark, D., Ebbels, T. M., Evelo, C. T., Gmuender, H., Hebels, D. G., Herwig, R., Hescheler, J., Jennen, D. G., Jetten, M. J., Kanterakis, S., Keun, H. C., Matser, V., Overington, J. P., Pilicheva, E., Sarkans, U., Segura-Lepe, M. P., Sotiriadou, I. & 4 others, Wittenberger, T., Wittwehr, C., Zanzi, A. & Kleinjans, J. C., 1 May 2015, In : Bioinformatics. 31, 9, p. 1505-1507 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

van Breda, S. G. J., Claessen, S. M. H., Lo, K., van Herwijnen, M., Brauers, K. J. J., Lisanti, S., Theunissen, D. H. J., Jennen, D. G. J., Gaj, S., de Kok, T. & Kleinjans, J. C. S., Nov 2015, In : Archives of Toxicology. 89, 11, p. 1959-1969

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
16 Citations (Scopus)

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

Jiang, J., Briede, J. J., Jennen, D. G. J., Van Summeren, A., Saritas-Brauers, K., Schaart, G., Kleinjans, J. C. S. & de Kok, T. M. C. M., 16 Apr 2015, In : Toxicology Letters. 234, 2, p. 139-150

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

MagiCMicroRna: a web implementation of AgiMicroRna using shiny

Coonen, M. L. J., Theunissen, D., Kleinjans, J. C. S. & Jennen, D. G. J., 26 Mar 2015, In : Source code for biology and medicine. 10, 4.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study

Hendrickx, D. M., Jennen, D. G. J., Briede, J. J., Cavill, R., de Kok, T. M. & Kleinjans, J. C. S., 1 Jul 2015, In : Bioinformatics. 31, 13, p. 2115-2122

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity

Jiang, J., Briede, J. J., Jennen, D. G. J., Kleinjans, J. C. S. & de Kok, T. M. C. M., 15 Jun 2015, In : Toxicology Letters. 235, 3, p. 218-219

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

The exposome concept in a human nutrigenomics study: Evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures

Van Breda, S. G. J., Wilms, L. C., Gaj, S., Jennen, D. G. J., Bried??, J. J., Kleinjans, J. C. S. & De Kok, T. M. C. M., 2015, In : Mutagenesis. 30, 6, p. 723-731 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
16 Citations (Scopus)

Assessing compound carcinogenicity in vitro using connectivity mapping

Caiment, F., Tsamou, M., Jennen, D. & Kleinjans, J., Jan 2014, In : Carcinogenesis. 35, 1, p. 201-207

Research output: Contribution to journalArticleAcademicpeer-review

2013
14 Citations (Scopus)

Gender-specific transcriptomic response to environmental exposure in flemish adults

De Coster, S., van Leeuwen, D. M., Jennen, D. G. J., Koppen, G., Den Hond, E., Nelen, V., Schoeters, G., Baeyens, W., van Delft, J. H. M., Kleinjans, J. C. S. & van Larebeke, N., Aug 2013, In : Environmental and Molecular Mutagenesis. 54, 7, p. 574-588

Research output: Contribution to journalArticleAcademicpeer-review

Pathways for Ligand Activated Nuclear Receptors to Unravel the Genomic Responses Induced by Hepatotoxicants

Fijten, R. R. R., Jennen, D. G. J. & van Delft, J. H. M., Dec 2013, In : Current Drug Metabolism. 14, 10, p. 1022-1028

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Time series analysis of oxidative stress response patterns in HepG2: A toxicogenomics approach

Deferme, L., Briede, J. J., Claessen, S. M. H., Jennen, D. G. J., Cavil, R. & Kleinjans, J. C. S., 5 Apr 2013, In : Toxicology. 306, p. 24-34

Research output: Contribution to journalArticleAcademicpeer-review

2012
28 Citations (Scopus)

A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo

Magkoufopoulou, C., Claessen, S. M. H., Tsamou, M., Jennen, D. G. J., Kleinjans, J. C. S. & van Delft, J. H. M., Jul 2012, In : Carcinogenesis. 33, 7, p. 1421-1429

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

Jetten, M. J. A., Gaj, S., Ruiz-Aracama, A., de Kok, T. M., van Delft, J. H. M., Lommen, A., van Someren, E. P., Jennen, D. G. J., Claessen, S. M., Peijnenburg, A. A. C. M., Stierum, R. H. & Kleinjans, J. C. S., 15 Mar 2012, In : Toxicology and Applied Pharmacology. 259, 3, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

Performance of in vitro gamma H2AX assay in HepG2 cells to predict in vivo genotoxicity

Tsamou, M., Jennen, D. G. J., Claessen, S. M. H., Magkoufopoulou, C., Kleinjans, J. C. S. & van Delft, J. H. M., Nov 2012, In : Mutagenesis. 27, 6, p. 645-652

Research output: Contribution to journalArticleAcademicpeer-review

2011

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Ruiz-Aracama, A., Peijnenburg, A. A. C. M., Kleinjans, J., Jennen, D., van Delft, J., Hellfrisch, C. & Lommen, A., 20 May 2011, In : BMC Genomics. 12, p. 19

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells

Magkoufopoulou, C., Claessen, S. M. H., Jennen, D. G. J., Kleinjans, J. C. S. & van Delft, J. H. M., Sep 2011, In : Mutagenesis. 26, 5, p. 593-604

Research output: Contribution to journalArticleAcademicpeer-review

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Jennen, D., Ruiz-Aracama, A., Magkoufopoulou, C., Peijnenburg, A. A. C. M., Lommen, A., van Delft, J. & Kleinjans, J., 31 Aug 2011, In : BMC Systems Biology. 5, p. 13

Research output: Contribution to journalArticleAcademicpeer-review

Transcriptomic network analysis of micronuclei-related genes: a case study

van Leeuwen, D. M., Pedersen, M., Knudsen, L. E., Bonassi, S., Fenech, M., Kleinjans, J. C. S. & Jennen, D. G. J., Jan 2011, In : Mutagenesis. 26, 1, p. 27-32

Research output: Contribution to journalArticleAcademicpeer-review