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Research Output 2012 2019

Detrimental Effects of an Inhaled Phosphodiesterase-4 Inhibitor on Lung Inflammation in Ventilated Preterm Lambs Exposed to Chorioamnionitis Are Dose Dependent

Huetten, M. C., Fehrholz, M., Konrad, F. M., Ophelders, D., Kleintjes, C., Ottensmeier, B., Spiller, O. B., Glaser, K., Kramer, B. W. & Kunzmann, S., 1 Oct 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32, 6, p. 1-9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Why-aVF can be used in STAN as a proxy for scalp electrode-derived signal; reply to comments by Kjellmer et al.

Delhaas, T., Andriessen, P., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W. & Zwanenburg, A., 22 Aug 2019, In : PLOS ONE. 14, 8, 5 p., 0221220.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus

Gussenhoven, R., Westerlaken, R. J. J., Ophelders, D. R. M. G., Jobe, A. H., Kemp, M. W., Kallapur, S. G., Zimmermann, L. J., Sangild, P. T., Pankratova, S., Gressens, P., Kramer, B. W., Fleiss, B. & Wolfs, T. G. A. M., 19 Apr 2018, In : Journal of Neuroinflammation. 15, 13 p., 113.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

ST waveform analysis for monitoring hypoxic distress in fetal sheep after prolonged umbilical cord occlusion

Andriessen, P., Zwanenburg, A., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., 16 Apr 2018, In : PLOS ONE. 13, 4, 14 p., e0195978.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs

Wahl, H. B., Hutten, M. C., Monz, D., Tutdibi, E., Ophelders, D., Nikiforou, M., Tschernig, T., Gortner, L., Nohr, D., Biesalski, H. K. & Kramer, B. W., 1 Dec 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 31, 6, p. 323-330 8 p., 323-330.

Research output: Contribution to journalArticleAcademicpeer-review

2017

In Vivo Evaluation of the Acute Pulmonary Response to Poractant Alfa and Bovactant Treatments in Lung-Lavaged Adult Rabbits and in Preterm Lambs with Respiratory Distress Syndrome

Ricci, F., Salomone, F., Kuypers, E., Ophelders, D., Nikiforou, M., Willems, M., Krieger, T., Murgia, X., Huetten, M., Kramer, B. W. & Bianco, F., 31 Aug 2017, In : Frontiers in pediatrics. 5, 10 p., 186.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Open Access
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The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development

Gussenhoven, R., Ophelders, D. R. M. G., Kemp, M. W., Payne, M. S., Spiller, O. B., Beeton, M. L., Stock, S. J., Cillero-Pastor, B., Barre, F. P. Y., Heeren, R. M. A., Kessels, L., Stevens, B., Rutten, B. P., Kallapur, S. G., Jobe, A. H., Kramer, B. W. & Wolfs, T. G. A. M., 2017, In : Developmental Neuroscience. 39, 6, p. 472-486 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model

Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Jun 2016, In : Pediatric Research. 79, 6, p. 907-915

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A-K., Radtke, S., Peters, V., Janssen, L., Giebel, B. & Kramer, B. W., Jun 2016, In : Stem Cells Translational Medicine. 5, 6, p. 754-763

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Ophelders, D. R. M. G., Gussenhoven, R., Lammens, M., Kusters, B., Kemp, M. W., Newnham, J. P., Payne, M. S., Kallapur, S. G., Jobe, A. H., Zimmermann, L. J., Kramer, B. W. & Wolfs, T. G. A. M., 2 Feb 2016, In : Journal of Neuroinflammation. 13, 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetus

Willems, M. G. M., Ophelders, D. R. M. G., Nikiforou, M., Jellema, R. K., Butz, A., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 1 Jan 2016, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 310, 1, p. L1-L7

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells

Caron, M. M. J., Emans, P. J., Sanen, K., Surtel, D., Cremers, A., Ophelders, D., van Rhijn, L. W. & Welting, T. J. M., 6 Apr 2016, In : PLOS ONE. 11, 4, e0153162.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
3 Citations (Scopus)

Fully automated predictive intelligent control of oxygenation (PRICO) in resuscitation and ventilation of preterm lambs

Hütten, M. C., Goos, T. G., Ophelders, D., Nikiforou, M., Kuypers, E., Willems, M., Niemarkt, H. J., Dankelman, J., Andriessen, P., Mohns, T., Reiss, I. K. M. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 657-63 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain

Jellema, R. K., Ophelders, D. R. M. G., Zwanenburg, A., Nikiforou, M., Delhaas, T., Andriessen, P., Mays, R. W., Deans, R., Germeraad, W. T. V., Wolfs, T. G. A. M. & Kramer, B. W., 23 Dec 2015, In : Journal of Neuroinflammation. 12, p. 241

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

Hütten, M. C., Kuypers, E., Ophelders, D. R., Nikiforou, M., Jellema, R. K., Niemarkt, H. J., Fuchs, C., Tservistas, M., Razetti, R., Bianco, F. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 664-9 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Prophylactic Interleukin-2 Treatment Prevents Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis

Nikiforou, M., Vanderlocht, J., Chougnet, C. A., Jellema, R. K., Ophelders, D. R. M. G., Joosten, M., Kloosterboer, N., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Kramer, B. W. & Wolfs, T. G. A. M., Sep 2015, In : Inflammatory Bowel Diseases. 21, 9, p. 2026-2038

Research output: Contribution to journalArticleAcademicpeer-review

2014
6 Citations (Scopus)

Effects of less-invasive surfactant administration on oxygenation, pulmonary surfactant distribution, and lung compliance in spontaneously breathing preterm lambs

Niemarkt, H. J., Kuypers, E., Jellema, R., Ophelders, D., Huetten, M., Nikiforou, M., Kribs, A. & Kramer, B. W., Aug 2014, In : Pediatric Research. 76, 2, p. 166-170

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Miniaturization: The Clue to Clinical Application of the Artificial Placenta

Schoberer, M., Arens, J., Erben, A., Ophelders, D., Jellema, R. K., Kramer, B. W., Bruse, J. L., de Brouwer, P., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Mar 2014, In : Artificial Organs. 38, 3, p. 208-214

Research output: Contribution to journalArticleAcademicpeer-review

2013
28 Citations (Scopus)

Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., De Munter, S., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., Jennekens, W., Gavilanes, A. W. D., Seehase, M., Vles, H. J., Steinbusch, H., Andriessen, P., Wolfs, T. G. A. M. & Kramer, B. W., 24 Jan 2013, In : Journal of Neuroinflammation. 10, 13.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Intra-Amniotic Lipopolysaccharide and Maternal Betamethasone on Brain Inflammation in Fetal Sheep

Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Dudink, J., Nikiforou, M., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglasem, G. R., Kemp, M. W., Saito, M., Newnham, J. P., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., 17 Dec 2013, In : PLOS ONE. 8, 12, e81644.

Research output: Contribution to journalArticleAcademicpeer-review

Heart rate-mediated blood pressure control in preterm fetal sheep under normal and hypoxic-ischemic conditions

Zwanenburg, A., Jellema, R. K., Jennekens, W., Ophelders, D., Vullings, R., van Hunnik, A., van Pul, C., Bennet, L., Delhaas, T., Kramer, B. W. & Andriessen, P., Apr 2013, In : Pediatric Research. 73, 4, p. 420-426

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Mesenchymal Stem Cells Induce T-Cell Tolerance and Protect the Preterm Brain after Global Hypoxia-Ischemia

Jellema, R. K., Wolfs, T. G. A. M., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., Kuypers, E., Hopman, A. H. N., Dudink, J., Steinbusch, H. W., Andriessen, P., Germeraad, W. T. V., Vanderlocht, J. & Kramer, B. W., 26 Aug 2013, In : PLOS ONE. 8, 8, e73031.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia

Jellema, R. K., Passos, V. L., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Zwanenburg, A., De Munter, S., Nikiforou, M., Collins, J. J. P., Kuypers, E., Bos, G. M. J., Steinbusch, H. W., Vanderlocht, J., Andriessen, P., Germeraad, W. T. V. & Kramer, B. W., Dec 2013, In : Experimental Neurology. 250, p. 293-303

Research output: Contribution to journalArticleAcademicpeer-review

2012

New Surfactant with SP-B and C Analogs Gives Survival Benefit after Inactivation in Preterm Lambs

Seehase, M., Collins, J. J. P., Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Ospina, O. L., Perez-Gil, J., Bianco, F., Garzia, R., Razzetti, R. & Kramer, B. W., 16 Oct 2012, In : PLOS ONE. 7, 10, p. e47631

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

White matter injury following fetal inflammatory response syndrome induced by chorioamnionitis and fetal sepsis: Lessons from experimental ovine models

Kuypers, E., Ophelders, D., Jellema, R. K., Kunzmann, S., Gavilanes, A. W. & Kramer, B. W., Dec 2012, In : Early Human Development. 88, 12, p. 931-936

Research output: Contribution to journalArticleAcademicpeer-review