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Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals

Mandaviya, P. R., Joehanes, R., Brody, J., Castillo-Fernandez, J. E., Dekkers, K. F., Do, A. N., Graff, M., Hänninen, I. K., Tanaka, T., de Jonge, E. A. L., Kiefte-de Jong, J. C., Absher, D. M., Aslibekyan, S., de Rijke, Y. B., Fornage, M., Hernandez, D. G., Hurme, M. A., Ikram, M. A., Jacques, P. F., Justice, A. E. & 28 others, Kiel, D. P., Lemaitre, R. N., Mendelson, M. M., Mikkilä, V., Moore, A. Z., Pallister, T., Raitakari, O. T., Schalkwijk, C. G., Sha, J., Slagboom, E. P. E., Smith, C. E., Stehouwer, C. D. A., Tsai, P-C., Uitterlinden, A. G., van der Kallen, C. J. H., van Heemst, D., Arnett, D. K., Bandinelli, S., Bell, J. T., Heijmans, B. T., Lehtimäki, T., Levy, D., North, K. E., Sotoodehnia, N., van Greevenbroek, M. M. J., van Meurs, J. B. J., Heil, S. G. & BIOS Consortium, CHARGE Consortium Epigenetics Working Group, CHARGE Consortium Nutrition Working Group, Aug 2019, In : American Journal of Clinical Nutrition. 110, 2, p. 437-450 14 p., 15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Consumption of dairy products in relation to the presence of clinical knee osteoarthritis: The Maastricht Study

Denissen, K. F. M., Boonen, A., Nielen, J. T. H., Feitsma, A. L., van den Heuvel, E. G. H. M., Emans, P. J., Stehouwer, C. D. A., Sep, S. J. S., van Dongen, M. C. J. M., Dagnelie, P. C. & Eussen, S. J. P. M., Oct 2019, In : European Journal of Nutrition. 58, 7, p. 2693-2704 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dynamic sitting: Measurement and associations with metabolic health

van der Berg, J. D., Stehouwer, C. D. A., Bosma, H., Caserotti, P., Eiriksdottir, G., Arnardottir, N. Y., Van Domelen, D. R., Brychta, R. J., Chen, K. Y., Sveinsson, T., Johannsson, E., Launer, L. J., Gudnason, V., Jonsson, P. V., Harris, T. B. & Koster, A., 3 Aug 2019, In : Journal of Sports Sciences. 37, 15, p. 1746-1754 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., Boomsma, D., Heijmans, B. T., t'Hoen, P. A. G., van Meurs, J., Isaacs, A., Jansen, R., Franke, L., Pool, R. & 31 others, Hottenga, J. J., van Greevenbroek, M. M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., Zhernakova, D., van t'Hof, P. & BIOS Consortium, 15 Oct 2019, In : Biological Psychiatry. 86, 8, p. 599-607 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children

Zhong, H., Penders, J., Shi, Z., Ren, H., Cai, K., Fang, C., Ding, Q., Thijs, C., Blaak, E. E., Stehouwer, C. D. A., Xu, X., Yang, H., Wang, J., Wang, J., Jonkers, D. M. A. E., Masclee, A. A. M., Brix, S., Li, J., Arts, I. C. W. & Kristiansen, K., 4 Jan 2019, In : Microbiome. 7, 14 p., 2.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Incidence of cardiovascular disease in familial combined hyperlipidemia: A 15-year follow-up study

Luijten, J., van Greevenbroek, M. M. J., Schaper, N. C., Meex, S. J. R., van der Steen, C., Meijer, L. J., de Boer, D., de Graaf, J., Stehouwer, C. D. A. & Brouwers, M. C. G. J., Jan 2019, In : Atherosclerosis. 280, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Onderwater, G. L. J., Ligthart, L., Bot, M., Demirkan, A., Fu, J., van der Kallen, C. J. H., Vijfhuizen, L. S., Pool, R., Liu, J., Vanmolkot, F. H. M., Beekman, M., Wen, K., Amin, N., Thesing, C. S., Pijpers, J. A., Kies, D. A., Zielman, R., de Boer, I., van Greevenbroek, M. M. J., Arts, I. C. W. & 17 others, Milaneschi, Y., Schram, M. T., Dagnelie, P. C., Franke, L., Ikram, M. A., Ferrari, M. D., Goeman, J. J., Slagboom, P. E., Wijmenga, C., Stehouwer, C. D. A., Boomsma, D. I., van Duijn, C. M., Penninx, B. W., 't Hoen, P. A. C., Terwindt, G. M., van den Maagdenberg, A. M. J. M. & BBMRI Metabolomics Consortium, 16 Apr 2019, In : Neurology. 92, 16, p. E1899-E1911 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., Frayling, T. & 32 others, Gharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Mueler-Nurasyid, M., Nauck, M., Stehouwer, C. D. A., Isaacs, A., Schalkwijk, C. G., Stehouwer, C. D. A., van der Kallen, C. J. H., van Greevenbroek, M. M. J., eQTLGen Consortium & BIOS Consortium, 24 Jul 2019, In : Nature Communications. 10, 12 p., 3300.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression

BIOS Consortium, 1 Aug 2019, In : Human Molecular Genetics. 28, 15, p. 2477-2485 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content

Simons, N., Debray, F-G., Schaper, N. C., Kooi, M. E., Feskens, E. J. M., Hollak, C. E. M., Lindeboom, L., Koek, G. H., Bons, J. A. P., Lefeber, D. J., Hodson, L., Schalkwijk, C. G., Stehouwer, C. D. A., Cassiman, D. & Brouwers, M. C. G. J., Nov 2019, In : Journal of Clinical Endocrinology & Metabolism. 104, 11, p. 5053-5061 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serum Phosphate and Microvascular Function in a Population-Based Cohort

Ginsberg, C., Houben, A. J. H. M., Malhotra, R., Berendschot, T. T. J. M., Dagnelie, P. C., Kooman, J. P., Webers, C. A., Stehouwer, C. D. A. & Ix, J. H., 7 Nov 2019, In : Clinical journal of the American Society of Nephrology. 14, 11, p. 1626-1633 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sex differences in cardiovascular risk management for people with diabetes in primary care: a cross-sectional study

de Jong, M., Vos, R. C., de Ritter, R., van der Kallen, C. J., Sep, S. J., Woodward, M., Stehouwer, C. DA., Bots, M. L. & Peters, S. A., Jul 2019, In : BJGP Open. 3, 2, p. 1-11 bjgpopen19X101645.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Skewed X-inactivation is common in the general female population

Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, K., Draisma, H. H. M., White, S. J., Santen, G. W. E., Lopes, S. M. C. D. S., Heijmans, B. T., van Meurs, J., Jansen, R., Franke, L., Kielbasa, S. M., den Dunnen, J. T., 't Hoen, P. A. C., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. M. J. & 32 others, Da Stehouwer, C., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., Isaacs, A., van Dijk, F., Li, M., Isaacs, A., Cox, D. R., Li, Y., Chen, R., Li, N., Wang, J., van Ommen, G. J., BIOS Consortium & GoNL Consortium, Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans

van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T. & Blaak, E. E., Dec 2019, In : Diabetes. 68, 12, p. 2247-2258 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Association Between β-Blocker Use and Cardiorespiratory Fitness: The Maastricht Study

Nielen, J. T. H., de Vries, F., van der Velde, J. H. P. M., Savelberg, H. H. C. M., Schaper, N. C., Dagnelie, P. C., Henry, R. M. A., Schram, M., Stehouwer, C. D. A., Boonen, A., Koster, A. & van den Bemt, B. J. F., 1 Jan 2019, In : Journal of Cardiovascular Pharmacology and Therapeutics. 24, 1, p. 37-45 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Maastricht FFQ: Development and validation of a comprehensive food frequency questionnaire for the Maastricht study

van Dongen, M. C. J. M., Wijckmans-Duysens, N. E. G., den Biggelaar, L. J. C. J., Ocke, M. C., Meijboom, S., Brants, H. A. M., de Vries, J. H. M., Feskens, E. J. M., Bueno-de-Mesquita, H. B., Geelen, A., Stehouwer, C. D. A., Dagnelie, P. C. & Eussen, S. J. P. M., Jun 2019, In : Nutrition. 62, p. 39-46 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Trends in mortality, cardiovascular complications, and risk factors in type 2 diabetes

Heintjes, E. M., Houben, E., Beekman-Hendriks, W. L., Lighaam, E., Cremers, S. M., Penning-van Beest, F. J. A., Stehouwer, C. D. A. & Herings, R. M. C., Nov 2019, In : Netherlands Journal of Medicine. 77, 9, p. 317-329 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study

Tran-Duy, A., Connell, N. J., Vanmolkot, F. H., Souverein, P. C., de Wit, N. J., Stehouwer, C. D. A., Hoes, A. W., de Vries, F. & de Boer, A., Feb 2019, In : Journal of Internal Medicine. 285, 2, p. 205-214 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Verboven, K., Wouters, K., Gaens, K., Hansen, D., Bijnen, M., Wetzels, S., Stehouwer, C. D., Goossens, G. H., Schalkwijk, C. G., Blaak, E. E. & Jocken, J. W., 16 Mar 2018, In : Scientific Reports. 8, 8 p., 4677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice

Bijnen, M., Josefs, T., Cuijpers, I., Maalsen, C. J., van de Gaar, J., Vroomen, M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G. & Wouters, K., Jul 2018, In : Gut. 67, 7, p. 1317-1327 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

A gene variant near ATM affects the response to metformin and metformin plasma levels: a post hoc analysis of an RCT

Out, M., Becker, M. L., van Schaik, R. H., Lehert, P., Stehouwer, C. D. & Kooy, A., 1 Jun 2018, In : Pharmacogenomics. 19, 8, p. 715-726 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., BIOS Consortium, Jansen, R., van Meurs, J., Heijmans, B. T., Boomsma, D. I. & 45 others, van Dongen, J., Hottenga, J-J., Slagboom, P. E., Suchiman, H. E. D., van Iterson, M., van Zwet, E. W., 't Hoen, P., Pool, R., van Greevenbroek, M., Stehouwer, C., van der Kallen, C., Schalkwijk, C., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., Bot, J., Zhernakova, D. V., Van't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Bonder, M. J., van Dijk, F., van Galen, M., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., Isaacs, A. & Franke, L., 25 Jan 2018, In : BMC Genomics. 19, 90, 12 p., 90.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association between bone metabolism regulators and arterial stiffness in type 2 diabetes patients

Sharif, S., Bots, M. L., Schalkwijk, C., Stehouwer, C. D. A., Visseren, F. L. J., Westerink, J. & SMART Study Grp, Dec 2018, In : Nutrition Metabolism and Cardiovascular Diseases. 28, 12, p. 1245-1252 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease

Geijselaers, S. L. C., Aalten, P., Ramakers, I. H. G. B., De Deyn, P. P., Heijboer, A. C., Koek, H. L., OldeRikkert, M. G. M., Papma, J. M., Reesink, F. E., Smits, L. L., Stehouwer, C. D. A., Teunissen, C. E., Verhey, F. R. J., van der Flier, W. M., Biessels, G. J. & Inst Neurodegenerative Dis Study G, 1 Jan 2018, In : Journal of Alzheimer's Disease. 61, 1, p. 309-320 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

Gala, T. D. L. H., Herder, C., Rutters, F., Carstensen-Kirberg, M., Huth, C., Stehouwer, C. D. A., Nijpels, G., Schalkwijk, C., Flyvbjerg, A., Franks, P. W., Dekker, J., Meisinger, C., Koenig, W., Roden, M., Rathmann, W., Peters, A., Thorand, B. & IMI DIRECT Consortium, Nov 2018, In : Diabetes-metabolism Research and Reviews. 34, 8, 9 p., 3063.

Research output: Contribution to journalArticleAcademicpeer-review

Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes

Peeters, S. A., Engelen, L., Buijs, J., Theilade, S., Rossing, P., Schalkwijk, C. G. & Stehouwer, C. D. A., 1 Mar 2018, In : Journal of Diabetes and Its Complications. 32, 3, p. 325-329 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort

Ferreira, I., Hovind, P., Schalkwijk, C. G., Parving, H-H., Stehouwer, C. D. A. & Rossing, P., 1 Jan 2018, In : Diabetologia. 61, 1, p. 231-241 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes

't Hart, L. M., Vogelzangs, N., Mook-Kanamori, D. O., Brahimaj, A., Nano, J., van der Heijden, A. A. W. A., van Dijk, K. W., Slieker, R. C., Steyerberg, E. W., Ikram, M. A., Beekman, M., Boomsma, D. I., van Duijn, C. M., Slagboom, P. E., Stehouwer, C. D. A., Schalkwijk, C. G., Arts, I. C. W., Dekker, J. M., Dehghan, A., Muka, T. & 3 others, van der Kallen, C. J. H., Nijpels, G. & van Greevenbroek, M. M. J., Dec 2018, In : Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4569-4579 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Blood Pressure Variability, Arterial Stiffness, and Arterial Remodeling: The Maastricht Study

Zhou, T. L., Henry, R. M. A., Stehouwer, C. D. A., van Sloten, T. T., Reesink, K. D. & Kroon, A. A., 1 Oct 2018, In : Hypertension. 72, 4, p. 1002-1010 9 p.

Research output: Contribution to journalArticleAcademicpeer-review