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Research Output 2003 2019

2019

Adipose tissue macrophages do not affect atherosclerosis development in mice

Bijnen, M., van de Gaar, J., Vroomen, M., Gijbels, M. J., de Winther, M., Schalkwijk, C. G. & Wouters, K., Feb 2019, In : Atherosclerosis. 281, p. 31-37 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

15 Oct 2019, In : Biological Psychiatry. 86, 8, p. 599-607 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., Frayling, T. & 30 others, Gharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Mueler-Nurasyid, M., Nauck, M., Stehouwer, C. D. A., Isaacs, A., Schalkwijk, C. G., Stehouwer, C. D. A., van der Kallen, C. J. H. & van Greevenbroek, M. M. J., 24 Jul 2019, In : Nature Communications. 10, 12 p., 3300.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer

Nokin, M-J., Bellier, J., Durieux, F., Peulen, O., Rademaker, G., Gabriel, M., Monseur, C., Charloteaux, B., Verbeke, L., van Laere, S., Roncarati, P., Herfs, M., Lambert, C., Scheijen, J., Schalkwijk, C., Colige, A., Caers, J., Delvenne, P., Turtoi, A., Castronovo, V. & 1 others, Bellahcene, A., 23 Jan 2019, In : Breast Cancer Research. 21, 19 p., 11.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

Wetzels, S., Vanmierlo, T., Scheijen, J. L. J. M., van Horssen, J., Amor, S., Somers, V., Schalkwijk, C. G., Hendriks, J. J. A. & Wouters, K., 24 Apr 2019, In : Frontiers in Immunology. 10, 9 p., 855.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease

Hanssen, N. M. J., Stehouwer, C. D. A. & Schalkwijk, C. G., Jan 2019, In : Current Opinion in Nephrology and Hypertension. 28, 1, p. 26-33 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content

Simons, N., Debray, F-G., Schaper, N. C., Kooi, M. E., Feskens, E. J. M., Hollak, C. E. M., Lindeboom, L., Koek, G. H., Bons, J. A. P., Lefeber, D. J., Hodson, L., Schalkwijk, C. G., Stehouwer, C. D. A., Cassiman, D. & Brouwers, M. C. G. J., Nov 2019, In : Journal of Clinical Endocrinology & Metabolism. 104, 11, p. 5053-5061 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study

Martens, R. J. H., Broers, N. J. H., Canaud, B., Christiaans, M. H. L., Cornelis, T., Gauly, A., Hermans, M. M. H., Konings, C. J. A. M., van Der Sande, F. M., Scheijen, J. L. J. M., Stifft, F., Wirtz, J. J. J. M., Kooman, J. P. & Schalkwijk, C. G., 13 Aug 2019, In : PLOS ONE. 14, 8, 18 p., 0221058.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Skewed X-inactivation is common in the general female population

Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, K., Draisma, H. H. M., White, S. J., Santen, G. W. E., Lopes, S. M. C. D. S., Heijmans, B. T., van Meurs, J., Jansen, R., Franke, L., Kielbasa, S. M., den Dunnen, J. T., 't Hoen, P. A. C., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. M. J. & 30 others, Da Stehouwer, C., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., Isaacs, A., van Dijk, F., Li, M., Isaacs, A., Cox, D. R., Li, Y., Chen, R., Li, N., Wang, J. & van Ommen, G. J., Mar 2019, In : European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans

van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., Astrup, A., Valsesia, A., Langin, D., van der Kallen, C. J. H., Eussen, S. J. P. M., Schalkwijk, C. G., Stehouwer, C. D. A., Goossens, G. H., Arts, I. C. W., Jocken, J. W. E., Evelo, C. T. & Blaak, E. E., Dec 2019, In : Diabetes. 68, 12, p. 2247-2258 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Verboven, K., Wouters, K., Gaens, K., Hansen, D., Bijnen, M., Wetzels, S., Stehouwer, C. D., Goossens, G. H., Schalkwijk, C. G., Blaak, E. E. & Jocken, J. W., 16 Mar 2018, In : Scientific Reports. 8, 8 p., 4677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice

Bijnen, M., Josefs, T., Cuijpers, I., Maalsen, C. J., van de Gaar, J., Vroomen, M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G. & Wouters, K., Jul 2018, In : Gut. 67, 7, p. 1317-1327 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A SNP panel for identification of DNA and RNA specimens

Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., Jansen, R., van Meurs, J., Heijmans, B. T., Boomsma, D. I., van Dongen, J. & 44 others, Hottenga, J-J., Slagboom, P. E., Suchiman, H. E. D., van Iterson, M., van Zwet, E. W., 't Hoen, P., Pool, R., van Greevenbroek, M., Stehouwer, C., van der Kallen, C., Schalkwijk, C., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., Bot, J., Zhernakova, D. V., Van't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Bonder, M. J., van Dijk, F., van Galen, M., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., Isaacs, A. & Franke, L., 25 Jan 2018, In : BMC Genomics. 19, 90, 12 p., 90.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Association between bone metabolism regulators and arterial stiffness in type 2 diabetes patients

Sharif, S., Bots, M. L., Schalkwijk, C., Stehouwer, C. D. A., Visseren, F. L. J. & Westerink, J., Dec 2018, In : Nutrition Metabolism and Cardiovascular Diseases. 28, 12, p. 1245-1252 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

Gala, T. D. L. H., Herder, C., Rutters, F., Carstensen-Kirberg, M., Huth, C., Stehouwer, C. D. A., Nijpels, G., Schalkwijk, C., Flyvbjerg, A., Franks, P. W., Dekker, J., Meisinger, C., Koenig, W., Roden, M., Rathmann, W., Peters, A. & Thorand, B., Nov 2018, In : Diabetes-metabolism Research and Reviews. 34, 8, 9 p., 3063.

Research output: Contribution to journalArticleAcademicpeer-review

Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis

Simons, P. I. H. G., Simons, N., Stehouwer, C. D. A., Schalkwijk, C. G., Schaper, N. C. & Brouwers, M. C. G. J., 23 Oct 2018, In : PLOS ONE. 13, 10, 14 p., 0206174.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes

Peeters, S. A., Engelen, L., Buijs, J., Theilade, S., Rossing, P., Schalkwijk, C. G. & Stehouwer, C. D. A., 1 Mar 2018, In : Journal of Diabetes and Its Complications. 32, 3, p. 325-329 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Biomarkers of inflammation and endothelial dysfunction as predictors of pulse pressure and incident hypertension in type 1 diabetes: a 20 year life-course study in an inception cohort

Ferreira, I., Hovind, P., Schalkwijk, C. G., Parving, H-H., Stehouwer, C. D. A. & Rossing, P., 1 Jan 2018, In : Diabetologia. 61, 1, p. 231-241 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes

't Hart, L. M., Vogelzangs, N., Mook-Kanamori, D. O., Brahimaj, A., Nano, J., van der Heijden, A. A. W. A., van Dijk, K. W., Slieker, R. C., Steyerberg, E. W., Ikram, M. A., Beekman, M., Boomsma, D. I., van Duijn, C. M., Slagboom, P. E., Stehouwer, C. D. A., Schalkwijk, C. G., Arts, I. C. W., Dekker, J. M., Dehghan, A., Muka, T. & 3 others, van der Kallen, C. J. H., Nijpels, G. & van Greevenbroek, M. M. J., Dec 2018, In : Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4569-4579 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bone markers and cardiovascular risk in type 2 diabetes patients

Zwakenberg, S. R., van der Schouw, Y. T., Schalkwijk, C. G., Spijkerman, A. M. W. & Beulens, J. W. J., 23 Mar 2018, In : Cardiovascular Diabetology. 17, 7 p., 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population

Mitsides, N., Cornelis, T., Broers, N. J. H., Diederen, N. M. P., Brenchley, P., van der Sande, F. M., Schalkwijk, C., Kooman, J. P. & Mitra, S., 1 Jan 2018, In : Blood Purification. 45, 4, p. 356-363 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Wetzels, S., Bijnen, M., Wijnands, E., Biessen, E. A. L., Schalkwijk, C. G. & Wouters, K., 1 Mar 2018, In : Journal of visualized experiment. 133, 9 p., e57319 .

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies

Wanders, A. J., Alssema, M., De Hoon, S. E. M., Feskens, E. J. M., van Woudenbergh, G. J., van der Kallen, C. J., Zock, P. L., Refsum, H., Drevon, C. A., Elshorbagy, A., Schalkwijk, C. G., Stehouwer, C. D. A., Dekker, J. M. & van Greevenbroek, M. M. J., 1 Jan 2018, In : Annals of Nutrition and Metabolism. 72, 2, p. 117-125 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes

Hanssen, N. M. J., Westerink, J., Scheijen, J. L. J. M., van der Graaf, Y., Stehouwer, C. D. A. & Schalkwijk, C. G., 1 Aug 2018, In : Diabetes Care. 41, 8, p. 1689-1695 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3 year trial

Out, M., Kooy, A., Lehert, P., Schalkwijk, C. A. & Stehouwer, C. D. A., 1 Feb 2018, In : Journal of Diabetes and Its Complications. 32, 2, p. 171-178 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Long-term treatment with metformin in type 2 diabetes and vitamin D levels: A post-hoc analysis of a randomized placebo-controlled trial

Out, M., Top, W. M. C., Lehert, P., Schalkwijk, C. A., Stehouwer, C. D. A. & Kooy, A., 1 Aug 2018, In : Diabetes Obesity & Metabolism. 20, 8, p. 1951-1956 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer

Bellahcene, A., Nokin, M-J., Castronovo, V. & Schalkwijk, C., 1 Apr 2018, In : Seminars in Cancer Biology. 49, p. 64-74 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Quercetin, but Not Epicatechin, Decreases Plasma Concentrations of Methylglyoxal in Adults in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial with Pure Flavonoids

Van den Eynde, M. D. G., Geleijnse, J. M., Scheijen, J. L. J. M., Hanssen, N. M. J., Dower, J. I., Afman, L. A., Stehouwer, C. D. A., Hollman, P. C. H. & Schalkwijk, C. G., Dec 2018, In : Journal of Nutrition. 148, 12, p. 1911-1916 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Reducing sitting time versus adding exercise: differential effects on biomarkers of endothelial dysfunction and metabolic risk

Duvivier, B. M. F. M., Bolijn, J. E., Koster, A., Schalkwijk, C. G., Savelberg, H. H. C. M. & Schaper, N. C., 5 Jun 2018, In : Scientific Reports. 8, 7 p., 8657.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study

Meesters, A., Den Bosch-Meevissen, Y. M. C. I., Weijzen, C. A. H., Buurman, W. A., Losen, M., Schepers, J., Thissen, M. R. T. M., Alberts, H. J. E. M., Schalkwijk, C. G. & Peters, M. L., Jun 2018, In : Journal of Behavioral Medicine. 41, 3, p. 385-397 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Effect of Sulforaphane on Glyoxalase I Expression and Activity in Peripheral Blood Mononuclear Cells

Alfarano, M., Pastore, D., Fogliano, V., Schalkwijk, C. G. & Oliviero, T., Nov 2018, In : Nutrients. 10, 11, 11 p., 1773.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Weight loss moderately affects the mixed meal challenge response of the plasma metabolome and transcriptome of peripheral blood mononuclear cells in abdominally obese subjects

Fazelzadeh, P., Hangelbroek, R. W. J., Joris, P. J., Schalkwijk, C. G., Esser, D., Afman, L., Hankemeier, T., Jacobs, D. M., Mihaleva, V. V., Kersten, S., Van Duynhoven, J. & Boekschoten, M. V., Apr 2018, In : Metabolomics. 14, 4, 13 p., 46.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls

Maessen, M. F. H., Schalkwijk, C. G., Verheggen, R. J. H. M., Aengevaeren, V. L., Hopman, M. T. E. & Eijsvogels, T. M. H., Oct 2017, In : Journal of Science and Medicine in Sport. 20, 10, p. 921-926 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access