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Research Output 2003 2016

2016
3 Citations (Scopus)

Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3

Adriaens, M. E., Prickaerts, P., Beucken, T. V. D., Koch, E., Dubois, L., Dahlmans, V. E. H., Gits, C., Evelo, C. T. A., Chan-Seng-Yue, M., Wouters, B. G. & Voncken, W., 26 Oct 2016, In : Epigenetics & Chromatin. 9, p. 46 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

MATE2 Expression Is Associated with Cancer Cell Response to Metformin

Chowdhury, S., Yung, E., Pintilie, M., Muaddi, H., Chaib, S., Yeung, M., Fusciello, M., Sykes, J., Pitcher, B., Hagenkort, A., Mckee, T., Vellanki, R., Chen, E., Bristow, R. G., Wouters, B. G. & Koritzinsky, M., 13 Dec 2016, In : PLOS ONE. 11, 12, e0165214.

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia

Adriaens, M. E., Prickaerts, P., Chan-Seng-Yue, M., van den Beucken, T., Dahlmans, V. E. H., Eijssen, L. M., Beck, T., Wouters, B. G., Voncken, W. & Evelo, C. T. A., 1 Nov 2016, In : Epigenetics & Chromatin. 9, 48.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
7 Citations (Scopus)

Integrating RAS Status into Prognostic Signatures for Adenocarcinomas of the Lung

Starmans, M. H. W., Pintilie, M., Chan-Seng-Yue, M., Moon, N. C., Haider, S., Nguyen, F., Lau, S. K., Liu, N., Kasprzyk, A., Wouters, B. G., Der, S. D., Shepherd, F. A., Jurisica, I., Penn, L. Z., Tsao, M-S., Lambin, P. & Boutros, P. C., 15 Mar 2015, In : Clinical Cancer Research. 21, 6, p. 1477-1486

Research output: Contribution to journalArticleAcademicpeer-review

MK3 Modulation Affects BMI1-Dependent and Independent Cell Cycle Check-Points

Prickaerts, P., Niessen, H. E. C., Dahlmans, V. E. H., Spaapen, F., Salvaing, J., Vanhove, J., Geijselaers, C., Bartels, S. J. J., Partouns, I., Neumann, D., Speel, E-J., Takihara, Y., Wouters, B. G. & Voncken, J. W., 8 Apr 2015, In : PLOS ONE. 10, 4, e0118840.

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

Pettersen, E. O., Ebbesen, P., Gieling, R. G., Williams, K. J., Dubois, L., Lambin, P., Ward, C., Meehan, J., Kunkler, I. H., Langdon, S. P., Ree, A. H., Flatmark, K., Lyng, H., Calzada, M. J., del Peso, L., Landazuri, M. O., Goerlach, A., Flamm, H., Kieninger, J., Urban, G. & 27 others, Weltin, A., Singleton, D. C., Haider, S., Buffa, F. M., Harris, A. L., Scozzafava, A., Supuran, C. T., Moser, I., Jobst, G., Busk, M., Toustrup, K., Overgaard, J., Alsner, J., Pouyssegur, J., Chiche, J., Mazure, N., Marchiq, I., Parks, S., Ahmed, A., Ashcroft, M., Pastorekova, S., Cao, Y., Rouschop, K. M., Wouters, B. G., Koritzinsky, M., Mujcic, H. & Cojocari, D., 2015, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 30, 5, p. 689-721

Research output: Contribution to journalArticleAcademicpeer-review

2014
37 Citations (Scopus)

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Rupaimoole, R., Wu, S. Y., Pradeep, S., Ivan, C., Pecot, C. V., Gharpure, K. M., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., Zand, B., Dalton, H. J., Filant, J., Miller, J. B., Lu, C., Sadaoui, N. C., Mangala, L. S., Taylor, M., van den Beucken, T., Koch, E., Rodriguez-Aguayo, C. & 9 others, Huang, L., Bar-Eli, M., Wouters, B. G., Radovich, M., Ivan, M., Calin, G. A., Zhang, W., Lopez-Berestein, G. & Sood, A. K., 2014, In : Nature Communications. 5, 5202.

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

van den Beucken, T., Koch, E., Chu, K., Rupaimoole, R., Prickaerts, P., Adriaens, M., Voncken, J. W., Harris, A. L., Buffa, F. M., Haider, S., Starmans, M. H., Yao, C. Q., Ivan, M., Ivan, C., Pecot, C. V., Boutros, P. C., Sood, A. K., Koritzinsky, M. & Wouters, B. G., 2014, In : Nature Communications. 5, p. 5203 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Hypoxia Signaling and the Metastatic Phenotype

Mujcic, H., Hill, R. P., Koritzinsky, M. & Wouters, B. G., 2014, In : Current Molecular Medicine. 14, 5, p. 565-579

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage

Ramaekers, C. H. M. A., van den Beucken, T., Bristow, R. G., Chiu, R. K., Durocher, D. & Wouters, B. G., 28 Feb 2014, In : PLOS ONE. 9, 2, e89997.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Hypoxia and metastasis in an orthotopic cervix cancer xenograft model

Chaudary, N., Mujcic, H., Wouters, B. G. & Hill, R. P., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 506-510

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

Nagelkerke, A., Bussink, J., Mujcic, H., Wouters, B. G., Lehmann, S., Sweep, F. C. G. J. & Span, P. N., 2013, In : Breast Cancer Research. 15, 1, R2.

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Hypoxic Activation of the PERK/eIF2 alpha Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

Mujcic, H., Nagelkerke, A., Rouschop, K. M. A., Chung, S., Chaudary, N., Span, P. N., Clarke, B., Milosevic, M., Sykes, J., Hill, R. P., Koritzinsky, M. & Wouters, B. G., 15 Nov 2013, In : Clinical Cancer Research. 19, 22, p. 6126-6137

Research output: Contribution to journalArticleAcademicpeer-review

New small molecule inhibitors of UPR activation demonstrate that PERK, but not IRE1 alpha signaling is essential for promoting adaptation and survival to hypoxia

Cojocari, D., Vellanki, R. N., Sit, B., Uehling, D., Koritzinsky, M. & Wouters, B. G., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 541-547

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

Zannella, V. E., Dal Pra, A., Muaddi, H., McKee, T. D., Stapleton, S., Sykes, J., Glicksman, R., Chaib, S., Zamiara, P., Milosevic, M., Wouters, B. G., Bristow, R. G. & Koritzinsky, M., 15 Dec 2013, In : Clinical Cancer Research. 19, 24, p. 6741-6750

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

Schaaf, M. B. E., Cojocari, D., Keulers, T. G., Jutten, B., Starmans, M. H., de Jong, M. C., Begg, A. C., Savelkouls, K. G. M., Bussink, J., Vooijs, M., Wouters, B. G. & Rouschop, K. M. A., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 529-534

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

The Roles of Reactive Oxygen Species and Autophagy in Mediating the Tolerance of Tumor Cells to Cycling Hypoxia

Koritzinsky, M. & Wouters, B. G., Oct 2013, In : Seminars in Radiation Oncology. 23, 4, p. 252-261

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Two phases of disulfide bond formation have differing requirements for oxygen

Koritzinsky, M., Levitin, F., van den Beucken, T., Rumantir, R. A., Harding, N. J., Chu, K. C., Boutros, P. C., Braakman, I. & Wouters, B. G., 25 Nov 2013, In : Journal of Cell Biology. 203, 4, p. 615-627

Research output: Contribution to journalArticleAcademicpeer-review

2012

Cancer classification using the Immunoscore: a worldwide task force

Galon, J., Pages, F., Marincola, F. M., Angell, H. K., Thurin, M., Lugli, A., Zlobec, I., Berger, A., Bifulco, C., Botti, G., Tatangelo, F., Britten, C. M., Kreiter, S., Chouchane, L., Delrio, P., Arndt, H., Asslaber, M., Maio, M., Masucci, G. V., Mihm, M. & 44 others, Vidal-Vanaclocha, F., Allison, J. P., Gnjatic, S., Hakansson, L., Huber, C., Singh-Jasuja, H., Ottensmeier, C., Zwierzina, H., Laghi, L., Grizzi, F., Ohashi, P. S., Shaw, P. A., Clarke, B. A., Wouters, B. G., Kawakami, Y., Hazama, S., Okuno, K., Wang, E., O'Donnell-Tormey, J., Lagorce, C., Pawelec, G., Nishimura, M. I., Hawkins, R., Lapointe, R., Lundqvist, A., Khleif, S. N., Ogino, S., Gibbs, P., Waring, P., Sato, N., Torigoe, T., Itoh, K., Patel, P. S., Shukla, S. N., Palmqvist, R., Nagtegaal, I. D., Wang, Y., D'Arrigo, C., Kopetz, S., Sinicrope, F. A., Trinchieri, G., Gajewski, T. F., Ascierto, P. A. & Fox, B. A., 3 Oct 2012, In : Journal of Translational Medicine. 10, p. 205

Research output: Contribution to journalArticleAcademicpeer-review

Independent and functional validation of a multi-tumour-type proliferation signature

Starmans, M. H. W., Lieuwes, N. G., Span, P. N., Haider, S., Dubois, L., Nguyen, F., van Laarhoven, H. W., Sweep, F. C. G. J., Wouters, B. G., Boutros, P. C. & Lambin, P., 24 Jul 2012, In : British Journal of Cancer. 107, 3, p. 508-515

Research output: Contribution to journalArticleAcademicpeer-review

NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data

Waggott, D., Chu, K., Yin, S., Wouters, B. G., Liu, F-F. & Boutros, P. C., 1 Jun 2012, In : Bioinformatics. 28, 11, p. 1546-1548

Research output: Contribution to journalArticleAcademicpeer-review

The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer

Starmans, M. H. W., Chu, K. C., Haider, S., Francis Nguyen, Seigneuric, R., Magagnin, M. G., Koritzinsky, M., Kasprzyk, A., Boutros, P. C., Wouters, B. G. & Lambin, P., Mar 2012, In : Radiotherapy and Oncology. 102, 3, p. 436-443

Research output: Contribution to journalArticleAcademicpeer-review

2011

AMPK regulates metabolism and survival in response to ionizing radiation

Zannella, V. E., Cojocari, D., Hilgendorf, S., Vellanki, R. N., Chung, S., Wouters, B. G. & Koritzinsky, M., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 293-299

Research output: Contribution to journalArticleAcademicpeer-review

A Simple but Highly Effective Approach to Evaluate the Prognostic Performance of Gene Expression Signatures

Starmans, M. H. W., Fung, G., Steck, H., Wouters, B. G. & Lambin, P., 7 Dec 2011, In : PLOS ONE. 6, 12, e28320.

Research output: Contribution to journalArticleAcademicpeer-review

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Rouschop, K. M. A., Dubois, L., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N., Keulers, T. G. H., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 385-391

Research output: Contribution to journalArticleAcademicpeer-review

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Theys, J., Jutten, B., Habets, R., Paesmans, K., Groot, A. J., Lambin, P., Wouters, B. G., Lammering, G. & Vooijs, M., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 392-397

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T

Ramaekers, C. H. M. A., van den Beucken, T., Meng, A., Kassam, S., Thoms, J., Bristow, R. G. & Wouters, B. G., Oct 2011, In : Radiotherapy and Oncology. 101, 1, p. 190-197

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxic Regulation and Prognostic Value of LAMP3 Expression in Breast Cancer

Nagelkerke, A., Mujcic, H., Bussink, J., Wouters, B. G., van Laarhoven, H. W. M., Sweep, F. C. G. J. & Span, P. N., 15 Aug 2011, In : Cancer. 117, 16, p. 3670-3681

Research output: Contribution to journalArticleAcademicpeer-review

Regulatory Functions of Ubiquitin in Diverse DNA Damage Responses

Ramaekers, C. H. M. A. & Wouters, B. G., 2011, In : Current Molecular Medicine. 11, 2, p. 152-169

Research output: Contribution to journalArticleAcademicpeer-review

Translational control is a major contributor to hypoxia induced gene expression

van den Beucken, T., Magagnin, M. G., Jutten, B., Seigneuric, R., Lambin, P., Koritzinsky, M. & Wouters, B. G., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 379-384

Research output: Contribution to journalArticleAcademicpeer-review

2010
27 Citations (Scopus)

Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability.

Schults, M. A. C., Timmermans, L., Godschalk, R. W. L., Theys, J., Wouters, B. G., van Schooten, F. J. & Chiu, R. K., 1 Jan 2010, In : Journal of Biological Chemistry. 285, 19, p. 14558-14564

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Regulation of PCNA polyubiquitination in human cells

Brun, J., Chiu, R. K., Wouters, B. G. & Gray, D. A., 1 Jan 2010, In : BMC Research Notes. 3, p. 85

Research output: Contribution to journalArticleAcademic

Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase

Mellor, H. R., Rouschop, K. M., Wigfield, S. M., Wouters, B. G. & Harris, A. L., 1 Jun 2010, In : Biochemical Pharmacology. 79, 11, p. 1562-1572

Research output: Contribution to journalArticleAcademicpeer-review

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., Lambin, P., van der Kogel, A. J., Koritzinsky, M. & Wouters, B. G., Jan 2010, In : Journal of Clinical Investigation. 120, 1, p. 127-141

Research output: Contribution to journalArticleAcademicpeer-review

2009
19 Citations (Scopus)

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment.

Theys, J., Jutten, B., Dubois, L. J., Rouschop, K. M. A., Chiu, R. K., Li, Y., Paesmans, K., Lambin, P., Lammering, G. & Wouters, B. G., 1 Jan 2009, In : Radiotherapy and Oncology. 92, 3, p. 399-404

Research output: Contribution to journalArticleAcademicpeer-review

2008

Evaluating the importance of apoptosis and other determinants of cell death and survival.

Wouters, B. G. & Chiu, R. K., 1 Jan 2008, Cancer drug discovery and development: Apoptosis, senescence and cancer.. Dewritz, D. A., Holt, S. E. & Grant, S. (eds.). Totowa NJ: Humana Press

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

12 Citations (Scopus)

hMMS2 serves a redundant role in human PCNA polyubiquitination

Brun, J., Chiu, R. K., Lockhart, K., Xiao, W., Wouters, B. G. & Gray, D. A., 1 Jan 2008, In : BMC Molecular Biology. 9, p. 24

Research output: Contribution to journalArticleAcademicpeer-review

2007
6 Citations (Scopus)

Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity

Langie, S. A., Knaapen, A. M., Ramaekers, C. H. M. A., Theys, J., Brun, J., Godschalk, R. W., van Schooten, F. J., Lambin, P., Gray, D. A., Wouters, B. G. & Chiu, R. K., 1 Jan 2007, In : Dna Repair. 6, 6, p. 852-862

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Impact of supervised gene signatures of early hypoxia on patient survival.

Seigneuric, R., Starmans, M. H. W., Fung, G., Krishnapuram, B., Nuyten, D. S. A., van Erk, A. A., Magagnin, M. G., Rouschop, K. M. A., Krishnan, S., Rao, R. B., Evelo, C. T. A., Beqq, A. C., Wouters, B. G. & Lambin, P., 1 Jan 2007, In : Radiotherapy and Oncology. 83, 3, p. 374-382

Research output: Contribution to journalArticleAcademicpeer-review

2006
24 Citations (Scopus)

Effects of radiotherapy and chemotherapy on angiogenesis and leukocyte infiltration in rectal cancer

Baeten, C. I., Castermans, K. E. R., Lammering, G., Hillen, F., Wouters, B. G., Hillen, H. F., Griffioen, A. W. & Baeten, C. G., 1 Jan 2006, In : International Journal of Radiation Oncology Biology Physics. 66, 4, p. 1219-1227

Research output: Contribution to journalArticleAcademicpeer-review

2004
76 Citations (Scopus)

Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients.

Lutgens, L. C. H. W., Deutz, N., Granzier-Peeters, M., Beets-Tan, R. G. H., de Ruysscher, D. K. M., Gueulette, J., Cleutjens, J. P. M., Berger, M. P. F., Wouters, B. G., von Meyenfeldt, M. F. & Lambin, P., 1 Jan 2004, In : International Journal of Radiation Oncology Biology Physics. 60, 1, p. 275-85

Research output: Contribution to journalArticleAcademicpeer-review

2003
86 Citations (Scopus)

Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage

Lutgens, L. C. H. W., Deutz, N. E. P., Gueulette, J., Cleutjens, J. P. M., Berger, M. P. F., Wouters, B. G., von Meyenfeldt, M. F. & Lambin, P., 1 Jan 2003, In : International Journal of Radiation Oncology Biology Physics. 57, 4, p. 1067-1074 7 p.

Research output: Contribution to journalArticleAcademicpeer-review