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Article
2017

Wharton's Jelly Mesenchymal Stem Cells Protect the Immature Brain in Rats and Modulate Cell Fate

Mueller, M., Oppliger, B., Joerger-Messerli, M., Reinhart, U., Barnea, E., Paidas, M., Kramer, B. W., Surbek, D. V. & Schoeberlein, A., 15 Feb 2017, In : Stem Cells and Development. 26, 4, p. 239-248 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Can the preterm lung recover from perinatal stress?

Hütten, M., Wolfs, T. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model

Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Jun 2016, In : Pediatric Research. 79, 6, p. 907-915

Research output: Contribution to journalArticleAcademicpeer-review

Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep

Regan, J. K., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Jan 2016, In : Reproductive Sciences. 23, 1, p. 69-80

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning in rats results in a preserved placental inflammatory phenotype at birth

Sparnaaij, M. A. R., Chedraui, P., Liem, K. H., Escobar, G. S., Espinoza-Caicedo, J., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. D. W., Feb 2016, In : Placenta. 38, p. 84-92

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine

Nikiforou, M., Jacobs, E. M. R., Kemp, M. W., Hornef, M. W., Payne, M. S., Saito, M., Newnham, J. P., Janssen, L. E. W., Jobe, A. H., Kallapur, S. G., Kramer, B. W. & Wolfs, T. G. A. M., 14 Jul 2016, In : Scientific Reports. 6, 29806.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intrauterine Lipopolysaccharide-Induced Chorioamnionitis in a Sheep: Does It Affect the Auditory System?

Smit, A. L., Lambermont, V. A., Stokroos, R. J., Anteunis, L. J. C., Chenault, M., Schaefer, S. M., Schoenmakers, L. W. G., Kremer, B. & Kramer, B. W., Feb 2016, In : Reproductive Sciences. 23, 2, p. 257-263

Research output: Contribution to journalArticleAcademicpeer-review

Maternofetal pharmacokinetics and fetal lung responses in chronically catheterized sheep receiving constant, low-dose infusions of betamethasone phosphate

Kemp, M. W., Saito, M., Usuda, H., Molloy, T. J., Miura, Y., Sato, S., Watanabe, S., Clarke, M., Fossler, M., Scmidt, A., Kallapur, S. G., Kramer, B. W., Newnham, J. P. & Jobe, A. H., Dec 2016, In : American Journal of Obstetrics and Gynecology. 215, 6, p. 775.e1-775.e12

Research output: Contribution to journalArticleAcademicpeer-review

Mesenchymal stem/stromal cells—a key mediator for regeneration after perinatal morbidity?

Mueller, M., Wolfs, T., Schoeberlein, A., Gavilanes, A. D. W., Surbek, D. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A-K., Radtke, S., Peters, V., Janssen, L., Giebel, B. & Kramer, B. W., Jun 2016, In : Stem Cells Translational Medicine. 5, 6, p. 754-763

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Ophelders, D. R. M. G., Gussenhoven, R., Lammens, M., Kusters, B., Kemp, M. W., Newnham, J. P., Payne, M. S., Kallapur, S. G., Jobe, A. H., Zimmermann, L. J., Kramer, B. W. & Wolfs, T. G. A. M., 2 Feb 2016, In : Journal of Neuroinflammation. 13, 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pain coping strategies: Neonatal intensive care unit survivors in adolescence

van Ganzewinkel, C., Been, J. V., Dieleman, J. P., Katgert, T., Boelen-van der Loo, T., van der Pal, S. M., van Dijk, M., Kramer, B. W. & Andriessen, P., Dec 2016, In : Early Human Development. 103, p. 27-32

Research output: Contribution to journalArticleAcademicpeer-review

Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome

Vanterpool, S. F., Been, J. V., Houben, M. L., Nikkels, P. G. J., De Krijger, R. R., Zimmermann, L. J. I., Kramer, B. W., Progulske-Fox, A. & Reyes, L., 5 Jan 2016, In : PLOS ONE. 11, 1, e0146157.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Propofol administration to the fetal-maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest

Seehase, M., Houthuizen, P., Collins, J. J. P., Zimmermann, L. J. & Kramer, B. W., May 2016, In : Pediatric Research. 79, 5, p. 748-753

Research output: Contribution to journalArticleAcademicpeer-review

Risk of adverse pregnancy outcomes in women with periodontal disease and the effectiveness of interventions in decreasing this risk: protocol for systematic overview of systematic reviews

Vanterpool, S., Tomsin, K., Reyes, L., Zimmermann, L., Kramer, B. & Been, J., 2016, In : Systematic Reviews. 5, 6 p., 16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep

Nikiforou, M., Kemp, M. W., van Gorp, R., Saito, M., Newnham, J. P., Reynaert, N. L., Janssen, L. E., Jobe, A. H., Kallapur, S. G., Kramer, B. & Wolfs, T., Jan 2016, In : Laboratory Investigation. 96, 1, p. 69-80 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetus

Willems, M. G. M., Ophelders, D. R. M. G., Nikiforou, M., Jellema, R. K., Butz, A., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 1 Jan 2016, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 310, 1, p. L1-L7

Research output: Contribution to journalArticleAcademicpeer-review

The development of lung biochemical monitoring can play a key role in the early prediction of bronchopulmonary dysplasia

Fabiano, A., Gavilanes, A. D. W., Zimmermann, L. J., Kramer, B. W. W., Paolillo, P., Livolti, G., Picone, S., Bressan, K. & Gazzolo, D., May 2016, In : Acta Paediatrica. 105, 5, p. 535–541 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tobacco control policies and perinatal health: a national quasi-experimental study

Peelen, M. J., Sheikh, A., Kok, M., Hajenius, P., Zimmermann, L. J., Kramer, B. W., Hukkelhoven, C. W., Reiss, I. K., Mol, B. W. & Been, J. V., 22 Apr 2016, In : Scientific Reports. 6, 23907.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Boerger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., O'Driscoll, L., Fais, S., Falcon-Perez, J. M., Felderhoff-Mueser, U., Fraile, L., Gho, Y. S., Goergens, A., Gupta, R. C., Hendrix, A., Hermann, D. M. & 36 others, Hill, A. F., Hochberg, F., Horn, P. A., de Kleijn, D., Kordelas, L., Kramer, B. W., Kraemer-Albers, E-M., Laner-Plamberger, S., Laitinen, S., Leonardi, T., Lorenowicz, M. J., Lim, S. K., Lotvall, J., Maguire, C. A., Marcilla, A., Nazarenko, I., Ochiya, T., Patel, T., Pedersen, S., Pocsfalvi, G., Pluchino, S., Quesenberry, P., Reischl, I. G., Rivera, F. J., Sanzenbacher, R., Schallmoser, K., Slaper-Cortenbach, I., Strunk, D., Tonn, T., Vader, P., van Balkom, B. W. M., Wauben, M., El Andaloussi, S., Thery, C., Rohde, E. & Giebel, B., 2015, In : Journal of Extracellular Vesicles . 4, 30087.

Research output: Contribution to journalArticleAcademicpeer-review

Early Detection of Necrotizing Enterocolitis by Fecal Volatile Organic Compounds Analysis

de Meij, T. G. J., van der Schee, M. P. C., Berkhout, D. J. C., van de Velde, M. E., Jansen, A. E., Kramer, B. W., van Weissenbruch, M. M., van Kaam, A. H., Andriessen, P., van Goudoever, J. B., Niemarkt, H. J. & de Boer, N. K. H., Sep 2015, In : Journal of Pediatrics. 167, 3, p. 562-+

Research output: Contribution to journalArticleAcademicpeer-review

Expression and function of toll-like receptors in human circulating endothelial colony forming cells

Mazzucchelli, I., Lisini, D., Garofoli, F., Dragoni, S., Angelini, M., Pozzi, M., Bonetti, E., Tzialla, C., Kramer, B. W., Spinillo, A., Maccario, R., Rosti, V., Moccia, F., Borghesi, A. & Stronati, M., Nov 2015, In : Immunology Letters. 168, 1, p. 98-104

Research output: Contribution to journalArticleAcademicpeer-review

Fluconazole treatment of intrauterine Candida albicans infection in fetal sheep

Maneenil, G., Payne, M. S., Kannan, P. S., Kallapur, S. G., Kramer, B. W., Newnham, J. P., Miura, Y., Jobe, A. H. & Kemp, M. W., Jun 2015, In : Pediatric Research. 77, 6, p. 740-748

Research output: Contribution to journalArticleAcademicpeer-review

Fully automated predictive intelligent control of oxygenation (PRICO) in resuscitation and ventilation of preterm lambs

Hütten, M. C., Goos, T. G., Ophelders, D., Nikiforou, M., Kuypers, E., Willems, M., Niemarkt, H. J., Dankelman, J., Andriessen, P., Mohns, T., Reiss, I. K. M. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 657-63 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genotype alone does not predict the clinical course of SFTPC deficiency in paediatric patients

Kroener, C., Reu, S., Teusch, V., Schams, A., Grimmelt, A-C., Barker, M., Brand, J., Gappa, M., Kitz, R., Kramer, B. W., Lange, L., Lau, S., Pfannenstiel, C., Proesmans, M., Seidenberg, J., Sismanlar, T., Aslan, A. T., Werner, C., Zielen, S., Zarbock, R. & 3 others, Brasch, F., Lohse, P. & Griese, M., Jul 2015, In : European Respiratory Journal. 46, 1, p. 197-206

Research output: Contribution to journalArticleAcademicpeer-review

Intra-Amniotic LPS Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain

Strackx, E., Jellema, R. K., Rieke, R., Gussenhoven, R., Vles, J. S. H., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : BioMed Research International. 276029.

Research output: Contribution to journalArticleAcademicpeer-review

Lipopolysaccharide-Induced Chorioamnionitis Causes Acute Inflammatory Changes in the Ovine Central Nervous System

Strackx, E., Sparnaaij, M. A. R., Vlassaks, E., Jellema, R., Kuypers, E., Vles, J. S. H., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 1, p. 77-84

Research output: Contribution to journalArticleAcademicpeer-review

Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain

Jellema, R. K., Ophelders, D. R. M. G., Zwanenburg, A., Nikiforou, M., Delhaas, T., Andriessen, P., Mays, R. W., Deans, R., Germeraad, W. T. V., Wolfs, T. G. A. M. & Kramer, B. W., 23 Dec 2015, In : Journal of Neuroinflammation. 12, p. 241

Research output: Contribution to journalArticleAcademicpeer-review

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

Hütten, M. C., Kuypers, E., Ophelders, D. R., Nikiforou, M., Jellema, R. K., Niemarkt, H. J., Fuchs, C., Tservistas, M., Razetti, R., Bianco, F. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 664-9 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Necrotizing Enterocolitis: A Clinical Review on Diagnostic Biomarkers and the Role of the Intestinal Microbiota

Niemarkt, H. J., de Meij, T. G. J., van de Velde, M. E., van der Schee, M. P., van Goudoever, J. B., Kramer, B. W., Andriessen, P. & de Boer, N. K. H., Feb 2015, In : Inflammatory Bowel Diseases. 21, 2, p. 436-444

Research output: Contribution to journalArticleAcademicpeer-review

Oral, Nasal and Pharyngeal Exposure to Lipopolysaccharide Causes a Fetal Inflammatory Response in Sheep

Maneenil, G., Kemp, M. W., Kannan, P. S., Kramer, B. W., Saito, M., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., 20 Mar 2015, In : PLOS ONE. 10, 3, e0119281.

Research output: Contribution to journalArticleAcademicpeer-review

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia

Chedraui, P., Andrade, M. E., Salazar-Pousada, D., Escobar, G. S., Hidalgo, L., Ramirez, C., Spaanderman, M. E. A., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : Gynecological Endocrinology. 31, 7, p. 569-572

Research output: Contribution to journalArticleAcademicpeer-review

Preconditioning by Oxygen-Glucose Deprivation Preserves Cell Proliferation and Reduces Cytotoxicity in Primary Astrocyte Cultures

Nikiforou, M., Vlassaks, E., Strackx, E., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. W. D., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 1, p. 61-67

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of systemic air-embolism after prolonged cardiopulmonary resuscitation in newborns: A pilot study

Halbertsma, F. J. J., Mohns, T., Bok, L. A., Niemarkt, H. J. & Kramer, B. W., Aug 2015, In : Resuscitation. 93, p. 96-101

Research output: Contribution to journalArticleAcademicpeer-review

Prophylactic Interleukin-2 Treatment Prevents Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis

Nikiforou, M., Vanderlocht, J., Chougnet, C. A., Jellema, R. K., Ophelders, D. R. M. G., Joosten, M., Kloosterboer, N., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Kramer, B. W. & Wolfs, T. G. A. M., Sep 2015, In : Inflammatory Bowel Diseases. 21, 9, p. 2026-2038

Research output: Contribution to journalArticleAcademicpeer-review

Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model

Cetinkaya, M., Cansev, M., Cekmez, F., Tayman, C., Canpolat, F. E., Kafa, I. M., Yaylagul, E. O., Kramer, B. W. & Sarici, S. U., 4 May 2015, In : PLOS ONE. 10, 5, e0126028.

Research output: Contribution to journalArticleAcademicpeer-review

Responses of the spleen to intraamniotic lipopolysaccharide exposure in fetal sheep

Kuypers, E., Willems, M. G. M., Jellema, R. K., Kemp, M. W., Newnham, J. P., Delhaas, T., Kallapur, S. G., Jobe, A. H., Wolfs, T. G. A. M. & Kramer, B. W., Jan 2015, In : Pediatric Research. 77, 1, p. 29-35

Research output: Contribution to journalArticleAcademicpeer-review

Using trend templates in a neonatal seizure algorithm improves detection of short seizures in a foetal ovine model

Zwanenburg, A., Andriessen, P., Jellema, R. K., Niemarkt, H. J., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Mar 2015, In : Physiological Measurement. 36, 3, p. 369-384

Research output: Contribution to journalArticleAcademicpeer-review

2014

Altered canonical Wingless-It signaling in the ovine fetal lung after exposure to intra-amniotic lipopolysaccharide and antenatal betamethasone

Kuypers, E., Willems, M. G. M., Collins, J. J. P., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Delhaas, T., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Feb 2014, In : Pediatric Research. 75, 2, p. 281-287

Research output: Contribution to journalArticleAcademicpeer-review

Amplification of steroid-mediated SP-B expression by physiological levels of caffeine

Fehrholz, M., Huetten, M., Kramer, B. W., Speer, C. P. & Kunzmann, S., Jan 2014, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 306, 1, p. L101-L109

Research output: Contribution to journalArticleAcademicpeer-review

Breast-Feeding Improves Gut Maturation Compared With Formula Feeding in Preterm Babies

Reisinger, K. W., de Vaan, L., Kramer, B. W., Wolfs, T. G. A. M., van Heurn, E. & Derikx, J. P. M., Dec 2014, In : Journal of Pediatric Gastroenterology and Nutrition. 59, 6, p. 720-724

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation

Wolfs, T. G. A. M., Kramer, B. W., Thuijls, G., Kemp, M. W., Saito, M., Willems, M. G. M., Senthamarai-Kannan, P., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Mar 2014, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 306, 5, p. G382-G393

Research output: Contribution to journalArticleAcademicpeer-review

Chronic Pain in the Newborn Toward a Definition

van Ganzewinkel, C., Anand, K. J. S., Kramer, B. W. & Andriessen, P., Nov 2014, In : Clinical Journal of Pain. 30, 11, p. 970-977

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of airway responses in sheep of different age in precision-cut lung slices (PCLS)

Lambermont, V. A., Schleputz, M., Dassow, C., Konig, P., Zimmermann, L. J., Uhlig, S., Kramer, B. W. W. & Martin, C., 17 Sep 2014, In : PLOS ONE. 9, 9, 8 p., e97610.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of intra-amniotic lipopolysaccharide exposure on the fetal lamb lung as gestation advances

Lambermont, V. A., Kuypers, E., Collins, J. J. R., Pillow, J. J., Newnham, J. P., Polglase, G. R., Nitsos, H., Kemp, M. W., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Apr 2014, In : Pediatric Research. 75, 4, p. 500-506

Research output: Contribution to journalArticleAcademicpeer-review

Effects of less-invasive surfactant administration on oxygenation, pulmonary surfactant distribution, and lung compliance in spontaneously breathing preterm lambs

Niemarkt, H. J., Kuypers, E., Jellema, R., Ophelders, D., Huetten, M., Nikiforou, M., Kribs, A. & Kramer, B. W., Aug 2014, In : Pediatric Research. 76, 2, p. 166-170

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal fatty acid-binding protein: a possible marker for gut maturation

Reisinger, K. W., Elst, M., Derikx, J. P. M., Nikkels, P. G. J., de Vries, B., Adriaanse, M. P. M., Jellema, R. K., Kramer, B. W. W. & Wolfs, T. G. A. M., Sep 2014, In : Pediatric Research. 76, 3, p. 261-268

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung

Schmidt, A. F., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Nov 2014, In : Pediatric Research. 76, 5, p. 441-447

Research output: Contribution to journalArticleAcademicpeer-review

Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep

Payne, M. S., Kemp, M. W., Kallapur, S. G., Kannan, P. S., Saito, M., Miura, Y., Newnham, J. P., Stock, S., Ireland, D. J., Kramer, B. W. & Jobe, A. H., Jun 2014, In : Pediatric Research. 75, 6, p. 716-722

Research output: Contribution to journalArticleAcademicpeer-review