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2010

Chorioamnionitis: a multiorgan disease of the fetus?

Gantert, M., Been, J. V., Gavilanes, A. W. D., Garnier, Y., Zimmermann, L. J. I. & Kramer, B. W., Oct 2010, In : Journal of Perinatology. 30, p. S21-S30

Research output: Contribution to journalArticleAcademicpeer-review

Glucocorticoids potentiate IL-6-induced SP-B expression in H441 cells by enhancing the JAK-STAT signaling pathway

Ladenburger, A., Seehase, M., Kramer, B. W., Thomas, W., Wirbelauer, J., Speer, C. P. & Kunzmann, S., Oct 2010, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 299, 4, p. L578-L584

Research output: Contribution to journalArticleAcademicpeer-review

Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury

Gavilanes, A. W. D., Gantert, M., Strackx, E., Zimmermann, L. J., Seeldrayers, S., Vles, J. S. H. & Kramer, B. W., 1 Jan 2010, In : Frontiers in bioscience - scholar edition. 2, p. 432-8 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation in fetal sheep from intra-amniotic injection of Ureaplasma parvum

Collins, J. J. P., Kallapur, S. G., Knox, C. L., Nitsos, I., Polglase, G. R., Pillow, J. J., Kuypers, E., Newnham, J. P., Jobe, A. H. & Kramer, B. W., Dec 2010, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 299, 6, p. L852-L860

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of fetal inflammatory response on exposure to lipopolysaccharide by chorioamnion, lung, or gut in sheep

Kramer, B. W., Kallapur, S. G., Moss, T. J. M., Nitsos, I., Polglase, G. P., Newnham, J. P. & Jobe, A. H., Jan 2010, In : American Journal of Obstetrics and Gynecology. 202, 1, p. 77.e1-77.e9

Research output: Contribution to journalArticleAcademicpeer-review

Potential role for lipopolysaccharide in congenital sensorineural hearing loss

Smit, A. L., Stokroos, R. J., Litjens, S. G. H., Kremer, B. & Kramer, B. W., Apr 2010, In : Journal of Medical Microbiology. 59, 4, p. 377-383

Research output: Contribution to journalArticleAcademicpeer-review

Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep

Kunzmann, S., Glogger, K., Been, J. V., Kallapur, S. G., Nitsos, I., Moss, T. J. M., Speer, C. P., Newnham, J. P., Jobe, A. H. & Kramer, B. W., May 2010, In : American Journal of Obstetrics and Gynecology. 202, 5, p. 476.e1-476.e9

Research output: Contribution to journalArticleAcademicpeer-review

2011

Airway Angiopoietin-2 in Ventilated Very Preterm Infants: Association With Prenatal Factors and Neonatal Outcome

Thomas, W., Seidenspinner, S., Kramer, B. W., Wirbelauer, J., Kawczynska-Leda, N., Szymankiewicz, M. & Speer, C. P., Aug 2011, In : Pediatric Pulmonology. 46, 8, p. 777-784

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal Inflammation Reduces Expression of Caveolin-1 and Influences Multiple Signaling Pathways in Preterm Fetal Lungs

Kunzmann, S., Collins, J. J. P., Yang, Y., Uhlig, S., Kallapur, S. G., Speer, C. P., Jobe, A. H. & Kramer, B. W., Nov 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 5, p. 969-976

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis

Been, J. V., Degraeuwe, P. L., Kramer, B. W. & Zimmermann, L. J. I., Jan 2011, In : Bjog-an International Journal of Obstetrics and Gynaecology. 118, 2, p. 113-122

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis - New Ideas from Experimental Models

Kramer, B. W., 2011, In : Neonatology. 99, 4, p. 320-325

Research output: Contribution to journalArticleAcademicpeer-review

Chronic Fetal Exposure to Ureaplasma parvum Suppresses Innate Immune Responses in Sheep

Kallapur, S. G., Kramer, B. W., Knox, C. L., Berry, C. A., Collins, J. J. P., Kemp, M. W., Nitsos, I., Polglase, G. R., Robinson, J., Hillman, N. H., Newnham, J. P., Chougnet, C. A. & Jobe, A. H., 1 Sep 2011, In : Journal of Immunology. 187, 5, p. 2688-2695

Research output: Contribution to journalArticleAcademicpeer-review

Fetal responses to lipopolysaccharide-induced chorioamnionitis alter immune and airway responses in 7-week-old sheep

Lee, A. J. X., Lambermont, V. A. C., Pillow, J. J., Polglase, G. R., Nitsos, I., Newnham, J. P., Beilharz, M. W., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Apr 2011, In : American Journal of Obstetrics and Gynecology. 204, 4, p. 364

Research output: Contribution to journalArticleAcademicpeer-review

IL-1 alpha Mediated Chorioamnionitis Induces Depletion of FoxP3+Cells and Ileal Inflammation in the Ovine Fetal Gut

Wolfs, T. G. A. M., Kallapur, S. G., Polglase, G. R., Pillow, J. J., Nitsos, I., Newnham, J. P., Chougnet, C. A., Kroon, E., Spierings, J., Willems, C. H. M. P., Jobe, A. H. & Kramer, B. W., 29 Mar 2011, In : PLOS ONE. 6, 3, p. 9

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation of the Fetal Ovine Skin Following in utero Exposure to Ureaplasma parvum

Kemp, M. W., Saito, M., Kallapur, S. G., Jobe, A. H., Keelan, J. A., Li, S., Kramer, B., Zhang, L., Knox, C. L., Yaegashi, N. & Newnham, J. P., Nov 2011, In : Reproductive Sciences. 18, 11, p. 1128-1137

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-1 in Lipopolysaccharide Induced Chorioamnionitis in the Fetal Sheep

Berry, C. A., Nitsos, I., Hillman, N. H., Pillow, J. J., Polglase, G. R., Kramer, B. W., Kemp, M. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Nov 2011, In : Reproductive Sciences. 18, 11, p. 1092-1102

Research output: Contribution to journalArticleAcademicpeer-review

Maturational Changes in Automated EEG Spectral Power Analysis in Preterm Infants

Niemarkt, H. J., Jennekens, W., Pasman, J. W., Katgert, T., van Pul, C., Gavtlanes, A. W. D., Kramer, B. W., Zimmermann, L. J., Oetomo, S. B. & Andriessen, P., Nov 2011, In : Pediatric Research. 70, 5, p. 529-534

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Response in Preterm Fetal Sheep Exposed to Systemic Endotoxinaemia

Seehase, M., Gantert, M., Ladenburger, A., Garnier, Y., Kunzmann, S., Thomas, W., Wirbelauer, J., Speer, C. P. & Kramer, B. W., Sep 2011, In : Pediatric Research. 70, 3, p. 242-246

Research output: Contribution to journalArticleAcademicpeer-review

Precocious Maturation of the Fetal Ovine Skin Following In Utero Exposure to LPS

Cox, T., Kallapur, S. G., Keelan, J. A., Saito, M., Jobe, A. H., Kramer, B., Nitsos, I., Li, S., Zhang, L., Yang, H. & Kemp, M. W., Mar 2011, In : Reproductive Sciences. 18, 3, p. 237A-237A

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary and systemic inflammatory responses to intra-amniotic IL-1 alpha in fetal sheep

Kallapur, S. G., Kramer, B. W., Nitsos, I., Pillow, J. J., Collins, J. J. P., Polglase, G. R., Newnham, J. P. & Jobe, A. H., Sep 2011, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 301, 3, p. L285-L295

Research output: Contribution to journalArticleAcademicpeer-review

Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial

Onland, W., Offringa, M., Cools, F., De Jaegere, A. P., Rademaker, K., Blom, H., Cavatorta, E., Debeer, A., Dijk, P. H., van Heijst, A. F., Kramer, B. W., Kroon, A. A., Mohns, T., van Straaten, H. L. M., te Pas, A. B., Theyskens, C., van Weissenbruch, M. M. & van Kaam, A. H., 9 Nov 2011, In : Bmc Pediatrics. 11, 1, p. 102

Research output: Contribution to journalArticleAcademicpeer-review

2012

Bacterial reprogramming of PBMCs impairs monocyte phagocytosis and modulates adaptive T cell responses

Andre, M. C., Gille, C., Glemser, P., Woiterski, J., Hsu, H-Y., Spring, B., Keppeler, H., Kramer, B. W., Handgretinger, R., Poets, C. F., Lauber, K. & Orlikowsky, T. W., Jun 2012, In : Journal of Leukocyte Biology. 91, 6, p. 977-989

Research output: Contribution to journalArticleAcademicpeer-review

Dissociation of transforming growth factors beta 1 and beta 2 from surfactant protein A (SP-A) by deglycosylation or deoxycholate treatment

Willems, C. H. M. P., Kloosterboer, N., Kunzmann, S., Kramer, B. W., Zimmermann, L. J. I. & van Iwaarden, J. F., 31 Jan 2012, In : Journal of Immunological Methods. 375, 1-2, p. 111-117

Research output: Contribution to journalArticleAcademicpeer-review

Effects of in utero endotoxemia on the ovine fetal brain: a model for schizophrenia?

Gantert, M., Kreczmanski, P., Kuypers, E., Jellema, R., Strackx, E., Bastian, N., Gavilanes, A. W. D., Zimmermann, L. J. I., Garnier, Y., Schmitz, C. & Kramer, B. W., 1 Jun 2012, In : Frontiers in Bioscience, Elite edition. 1, 4, p. 2845-53 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fifty Years of Work on the Artificial Placenta: Milestones in the History of Extracorporeal Support of the Premature Newborn

Schoberer, M., Arens, J., Lohr, A., Seehase, M., Jellema, R. K., Collins, J. J., Kramer, B. W., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Jun 2012, In : Artificial Organs. 36, 6, p. 512-516

Research output: Contribution to journalArticleAcademicpeer-review

IFN-gamma and TNF-alpha Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Laug, R., Fehrholz, M., Schuetze, N., Kramer, B. W., Krump-Konvalinkova, V., Speer, C. P. & Kunzmann, S., 20 Sep 2012, In : PLOS ONE. 7, 9, e45430.

Research output: Contribution to journalArticleAcademicpeer-review

Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis

Kaemmerer, E., Schneider, U., Klaus, C., Plum, P., Reinartz, A., Adolf, M., Renner, M., Wolfs, T. G. A. M., Kramer, B. W., Wagner, N., Mollenhauer, J. & Gassler, N., Mar 2012, In : Histopathology. 60, 4, p. 561-569

Research output: Contribution to journalArticleAcademicpeer-review

Increased Number of Cerebellar Granule Cells and Astrocytes in the Internal Granule Layer in Sheep Following Prenatal Intra-amniotic Injection of Lipopolysaccharide

Strackx, E., Gantert, M., Moers, V., van Kooten, I. A. J., Rieke, R., Hurter, H., Lemmens, M. A. M., Steinbusch, H. W. M., Zimmermann, L. J. I., Vles, J. S. H., Garnier, Y., Gavilanes, A. W. D. & Kramer, B. W., Mar 2012, In : Cerebellum. 11, 1, p. 132-144

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis

Wolfs, T. G. A. M., Jellema, R. K., Turrisi, G., Becucci, E., Buonocore, G. & Kramer, B. W., Apr 2012, In : Journal of Maternal-Fetal & Neonatal Medicine. 25, p. 8-11

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs

Kuypers, E., Collins, J. J. P., Kramer, B. W., Ofman, G., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Gavilanes, A. W. D., Nowacki, R., Ikegami, M., Jobe, A. H. & Kallapur, S. G., Feb 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 302, 4, p. L380-L389

Research output: Contribution to journalArticleAcademicpeer-review

Lipopolysaccharide-Induced Chorioamnionitis Is Confined to One Amniotic Compartment in Twin Pregnant Sheep

Gantert, M., Jellema, R. K., Heineman, H., Gantert, J., Collins, J. J. P., Seehase, M., Lambermont, V. A. C., Keck, A., Garnier, Y., Zimmermann, L. J. I., Kadyrov, M., Gavilanes, A. W. D. & Kramer, B. W., 2012, In : Neonatology. 102, 2, p. 81-88

Research output: Contribution to journalArticleAcademicpeer-review

LPS-induced chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung

Collins, J. J. P., Kuypers, E., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Cleutjens, J. P., Frints, S. G. M., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Nov 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 303, 9, p. L778-L787

Research output: Contribution to journalArticleAcademicpeer-review

Multi-channel amplitude-integrated EEG characteristics in preterm infants with a normal neurodevelopment at two years of corrected age

Niemarkt, H. J., Jennekens, W., Maartens, I. A., Wassenberg, T., van Aken, M., Katgert, T., Kramer, B. W., Gavilanes, A. W. D., Zimmermann, L. J., Oetomo, S. B. & Andriessen, P., Apr 2012, In : Early Human Development. 88, 4, p. 209-216

Research output: Contribution to journalArticleAcademicpeer-review

Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

Schlepuetz, M., Rieg, A. D., Seehase, S., Spillner, J., Perez-Bouza, A., Braunschweig, T., Schroeder, T., Bernau, M., Lambermont, V., Schlumbohm, C., Sewald, K., Autschbach, R., Braun, A., Kramer, B. W., Uhlig, S. & Martin, C., 9 Oct 2012, In : PLOS ONE. 7, 10, e47344.

Research output: Contribution to journalArticleAcademicpeer-review

New Pharmacological Approaches in Infants with Hypoxic-Ischemic Encephalopathy

Buonocore, G., Perrone, S., Turrisi, G., Kramer, B. W. & Balduini, W., Jul 2012, In : Current Pharmaceutical Design. 18, 21, p. 3086-3100

Research output: Contribution to journalArticleAcademicpeer-review

New Surfactant with SP-B and C Analogs Gives Survival Benefit after Inactivation in Preterm Lambs

Seehase, M., Collins, J. J. P., Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Ospina, O. L., Perez-Gil, J., Bianco, F., Garzia, R., Razzetti, R. & Kramer, B. W., 16 Oct 2012, In : PLOS ONE. 7, 10, p. e47631

Research output: Contribution to journalArticleAcademicpeer-review

Ovine Fetal Thymus Response to Lipopolysaccharide-Induced Chorioamnionitis and Antenatal Corticosteroids

Kuypers, E., Collins, J. J. P., Jellema, R. K., Wolfs, T. G. A. M., Kemp, M. W., Nitsos, I., Pillow, J. J., Polglase, G. R., Newnham, J. P., Germeraad, W. T. V., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., 31 May 2012, In : PLOS ONE. 7, 5, e38257.

Research output: Contribution to journalArticleAcademicpeer-review

Poractant alfa (Curosurf (R)) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo

Willems, C. H. M. P., Urlichs, F., Seidenspinner, S., Kunzmann, S., Speer, C. P. & Kramer, B. W., 9 Mar 2012, In : Respiratory Research. 13, p. 17

Research output: Contribution to journalArticleAcademicpeer-review

Regenerative Therapies in Neonatology: Clinical Perspectives

Gortner, L., Felderhoff-Mueser, U., Monz, D., Bieback, K., Klueter, H., Jellema, R., Kramer, B. W., Keller, B. M., Reiss, I. K., Horn, P. A. & Giebel, B., Jul 2012, In : Klinische Padiatrie. 224, 4, p. 233-240

Research output: Contribution to journalArticleAcademicpeer-review

Sex Differences in Lung Gas Volumes After Lipopolysaccharide-Induced Chorioamnionitis in Fetal Sheep

Lambermont, V. A. C., Been, J. V., Kunzmann, S., Vanterpool, S. F., Newnham, J. P., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Aug 2012, In : Gender Medicine. 9, 4, p. 278-286

Research output: Contribution to journalArticleAcademicpeer-review

Surfactant Protein A Influences Reepithelialization in an Alveolocapillary Model System

Willems, C. H. M. P., Zimmermann, L. J. I., Langen, R. M. R., van den Bosch, M. J. A., Kloosterboer, N., Kramer, B. W. & van Iwaarden, J. F., Dec 2012, In : Lung. 190, 6, p. 661-669

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic Effect of Caffeine and Glucocorticoids on Expression of Surfactant Protein B (SP-B) mRNA

Fehrholz, M., Bersani, I., Kramer, B. W., Speer, C. P. & Kunzmann, S., 14 Dec 2012, In : PLOS ONE. 7, 12, e51575.

Research output: Contribution to journalArticleAcademicpeer-review

White matter injury following fetal inflammatory response syndrome induced by chorioamnionitis and fetal sepsis: Lessons from experimental ovine models

Kuypers, E., Ophelders, D., Jellema, R. K., Kunzmann, S., Gavilanes, A. W. & Kramer, B. W., Dec 2012, In : Early Human Development. 88, 12, p. 931-936

Research output: Contribution to journalArticleAcademicpeer-review

2013

Antenatal glucocorticoids counteract LPS changes in TGF-beta pathway and caveolin-1 in ovine fetal lung

Collins, J. J. P., Kunzmann, S., Kuypers, E., Kemp, M. W., Speer, C. P., Newnham, J. P., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Mar 2013, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 304, 6, p. L438-L444

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner

Wolfs, T. G. A. M., Kallapur, S. G., Knox, C. L., Thuijls, G., Nitsos, I., Polglase, G. R., Collins, J. J. P., Kroon, E., Spierings, J., Shroyer, N. F., Newnham, J. P., Jobe, A. H. & Kramer, B. W., May 2013, In : Mucosal Immunology. 6, 3, p. 547-556

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., De Munter, S., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., Jennekens, W., Gavilanes, A. W. D., Seehase, M., Vles, H. J., Steinbusch, H., Andriessen, P., Wolfs, T. G. A. M. & Kramer, B. W., 24 Jan 2013, In : Journal of Neuroinflammation. 10, 13.

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis as a Risk Factor for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis

Been, J. V., Lievense, S., Zimmermann, L. J. I., Kramer, B. W. & Wolfs, T. G. A. M., Feb 2013, In : The Journal of Pediatrics. 162, 2, p. 236-242

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

Engel, M., Nowacki, R. M. E., Reiss, L. K., Uhlig, S., Willems, C. H. M. P., Kloosterboer, N., van Iwaarden, J. F., Sewing, A. C. P., Seehase, M., Lambermont, V. A. C., Collins, J. J. P., Zimmermann, L. J. I., Vos, G. D. & Kramer, B. W., Feb 2013, In : Lung. 191, 1, p. 77-86

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Intra-Amniotic Lipopolysaccharide and Maternal Betamethasone on Brain Inflammation in Fetal Sheep

Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Dudink, J., Nikiforou, M., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglasem, G. R., Kemp, M. W., Saito, M., Newnham, J. P., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., 17 Dec 2013, In : PLOS ONE. 8, 12, e81644.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats

Vlassaks, E., Strackx, E., Vles, J. S. H., Nikiforou, M., Martinez-Martinez, P., Kramer, B. W. & Gavilanes, A. W. D., 26 Jan 2013, In : Journal of Neuroinflammation. 10, 14.

Research output: Contribution to journalArticleAcademicpeer-review