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2019

Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

Martinello, K. A., Meehan, C., Avdic-Belltheus, A., Lingam, I., Ragab, S., Hristova, M., Tann, C. J., Peebles, D., Hagberg, H., Wolfs, T. G. A. M., Klein, N., Tachtsidis, I., Golay, X., Kramer, B. W., Fleiss, B., Gressens, P. & Robertson, N. J., 15 Jul 2019, In : Scientific Reports. 9, 17 p., 10184.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Artifacts in pulse transit time measurements using standard patient monitoring equipment

Bennis, F. C., van Pul, C., van den Bogaart, J. J. L., Andriessen, P., Kramer, B. W. & Delhaas, T., 21 Jun 2019, In : PLOS ONE. 14, 6, 10 p., 0218784.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells

Sumitha, R., Manjunatha, V. M., Sabitha, R. K., Alladi, P. A., Nalini, A., Rao, L. T., Sagar, B. K. C., Steinbusch, H. W. M., Kramer, B. W., Sathyaprabha, T. N. & Raju, T. R., Feb 2019, In : Molecular Neurobiology. 56, 2, p. 1014-1034 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detrimental Effects of an Inhaled Phosphodiesterase-4 Inhibitor on Lung Inflammation in Ventilated Preterm Lambs Exposed to Chorioamnionitis Are Dose Dependent

Huetten, M. C., Fehrholz, M., Konrad, F. M., Ophelders, D., Kleintjes, C., Ottensmeier, B., Spiller, O. B., Glaser, K., Kramer, B. W. & Kunzmann, S., Dec 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32, 6, p. 396-404 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial

Onland, W., Cools, F., Kroon, A., Rademaker, K., Merkus, M. P., Dijk, P. H., van Straaten, H. L., Pas, A. B. T., Mohns, T., Bruneel, E., van Heijst, A. F., Kramer, B. W., Debeer, A., Zonnenberg, I., Marechal, Y., Blom, H., Plaskie, K., Offringa, M., van Kaam, A. H., Nuytemans, D. H. & 24 others, de Loo, M. V., Kemper, E. M., Vereeck, I., van der Heide-Jalving, M., de Kort, E., Cavartorta, E., Rassart, A., Eerdekens, A., Stuijvenberg, M., Matthijsse, R., de Boode, W., Niemarkt, H., van Hattum, I., Jebbink, L. G., Mulder-de Tollenaer, S. M., Tan, R., Theyskens, C., van Weissenbruch, M., Dierckx, E., Rigo, V., Vrijlandt, E., van der Tweel, I., van Baal, C. & de Wildt, S., 29 Jan 2019, In : JAMA-Journal of the American Medical Association. 321, 4, p. 354-363 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Endotracheal intubation skills of pediatricians versus anesthetists in neonates and children

van Sambeeck, S. J., van Kuijk, S. M. J., Kramer, B. W., Vermeulen, P. M. & Vos, G. D., Aug 2019, In : European Journal of Pediatrics. 178, 8, p. 1219-1227 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study

Berkhout, D. J. C., van Keulen, B. J., Niemarkt, H. J., Bessem, J. R., de Boode, W. P., Cossey, V., Hoogenes, N., Hulzebos, C. V., Klaver, E., Andriessen, P., van Kaam, A. H., Kramer, B. W., van Lingen, R. A., Schouten, A., van Goudoever, J. B., Vijlbrief, D. C., van Weissenbruch, M. M., Wicaksono, A. N., Covington, J. A., Benninga, M. A. & 2 others, de Boer, N. K. H. & de Meij, T. G. J., 1 Jan 2019, In : Clinical Infectious Diseases. 68, 1, p. 70-77 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Mutation pattern in 606 Duchenne muscular dystrophy children with a comparison between familial and non-familial forms: a study in an Indian large single-center cohort

Polavarapu, K., Preethish-Kumar, V., Sekar, D., Vengalil, S., Nashi, S., Mahajan, N. P., Thomas, P. T., Sadasivan, A., Warrier, M., Gupta, A., Arunachal, G., Debnath, M., Keerthipriya, M. S., Pradeep-Chandra-Reddy, C., Puttegowda, A., John, A. P., Tavvala, A., Gunasekaran, S., Sathyaprabha, T. N., Chandra, S. R. & 3 others, Kramer, B., Delhaas, T. & Nalini, A., Sep 2019, In : Journal of Neurology. 266, 9, p. 2177-2185 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

Niemarkt, H. J., De Meij, T. G., van Ganzewinkel, C., de Boer, N. K. H., Andriessen, P., Hutten, M. C. & Kramer, B. W., 2019, In : Neonatology. 115, 4, p. 423-431 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

Barkhuizen, M., Vles, J. S. H., van Mechelen, R., Vermeer, M., Kramer, B. W., Chedraui, P., Bergs, P., van Kranen-Mastenbroek, V. H. J. M. & Gavilanes, A. W. D., Sep 2019, In : Diagnostics. 9, 3, 8 p., 123.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

van Gorp, C., de Lange, I. H., Spiller, O. B., Dewez, F., Pastor, B. C., Heeren, R. M. A., Kessels, L., Kloosterboer, N., van Gemert, W. G., Beeton, M. L., Stock, S. J., Jobe, A. H., Payne, M. S., Kemp, M. W., Zimmermann, L. J., Kramer, B. W., Plat, J. & Wolfs, T. G. A. M., May 2019, In : Nutrients. 11, 5, p. 1-21 21 p., 968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Risk Factors for Late-Onset Sepsis in Preterm Infants: A Multicenter Case-Control Study

el Hassani, S. E. M., Berkhout, D. J. C., Niemarkt, H. J., Mann, S., de Boode, W. P., Cossey, V., Hulzebos, C. V., van Kaam, A. H., Kramer, B. W., van Lingen, R. A., van Goudoever, J. B., Vijlbrief, D. C., van Weissenbruch, M. M., Benninga, M. A., de Boer, N. K. H. & de Meij, T. G. J., 2019, In : Neonatology. 116, 1, p. 42-51 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Standardized human bone marrow-derived stem cells infusion improves survival and recovery in a rat model of spinal cord injury

de Munter, J. P., Beugels, J., Munter, S., Jansen, L., Cillero-Pastor, B., Moskvin, O., Brook, G., Pavlov, D., Strekalova, T., Kramer, B. W. & Wolters, E. C., 15 Jul 2019, In : Journal of the Neurological Sciences. 402, p. 16-29 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy

Barkhuizen, M., van Mechelen, R., Vermeer, M., Chedraui, P., Paes, D., van den Hove, D. L. A., Vaes, B., Mays, R. W., Steinbusch, H. W. M., Robertson, N. J., Kramer, B. W. & Gavilanes, A. W. D., 19 Apr 2019, In : Behavioural Brain Research. 362, p. 77-81 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Antenatal Corticosteroid Exposure Disrupts Myelination in the Auditory Nerve of Preterm Sheep

Rittenschober-Bohm, J., Rodger, J., Jobe, A. H., Kallapur, S. G., Doherty, D. A., Kramer, B. W., Payne, M. S., Archer, M., Rittenschober, C., Newnham, J. P., Miura, Y., Berger, A., Matthews, S. G. & Kemp, M. W., 1 Jan 2018, In : Neonatology. 114, 1, p. 62-68 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus

Gussenhoven, R., Westerlaken, R. J. J., Ophelders, D. R. M. G., Jobe, A. H., Kemp, M. W., Kallapur, S. G., Zimmermann, L. J., Sangild, P. T., Pankratova, S., Gressens, P., Kramer, B. W., Fleiss, B. & Wolfs, T. G. A. M., 19 Apr 2018, In : Journal of Neuroinflammation. 15, 13 p., 113.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Development of severe bronchopulmonary dysplasia is associated with alterations in fecal volatile organic compounds

Berkhout, D. J. C., Niemarkt, H. J., Benninga, M. A., Budding, A. E., van Kaam, A. H., Kramer, B. W., Pantophlet, C. M., van Weissenbruch, M. M., de Boer, N. K. H. & de Meij, T. G. J., 1 Feb 2018, In : Pediatric Research. 83, 2, p. 412-419 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Chronic Carbamazepine Treatment on the ECG in Patients with Focal Seizures

Sathyaprabha, T. N., Koot, L. A. M., Hermans, B. H. M., Adoor, M., Sinha, S., Kramer, B. W., Raju, T. R., Satishchandra, P. & Delhaas, T., 1 Sep 2018, In : Clinical Drug Investigation. 38, 9, p. 845-851 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep

Schmidt, A. F., Kemp, M. W., Rittenschober-Bohm, J., Kannan, P. S., Usuda, H., Saito, M., Furfaro, L., Watanabe, S., Stock, S., Kramer, B. W., Newnham, J. P., Kallapur, S. G. & Jobe, A. H., 1 Jan 2018, In : American Journal of Obstetrics and Gynecology. 218, 1, p. 132.e1-132.e9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pediatric Early Warning System Scores: Lessons to be Learned

van Sambeeck, S. J., Fuijkschot, J., Kramer, B. W. & Vos, G. D., 1 Mar 2018, In : Journal of Pediatric Intensive Care. 7, 1, p. 27-32 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis

Barkhuizen, M., Rodrigues, F. B., Anderson, D. G., Winkens, B., Wild, E. J., Kramer, B. W. & Gavilanes, A. W. D., Oct 2018, In : Parkinsonism & Related Disorders. 55, p. 55-60 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs

Duc Ninh Nguyen, Thymann, T., Goericke-Pesch, S. K., Ren, S., Wei, W., Skovgaard, K., Damborg, P., Brunse, A., van Gorp, C., Kramer, B. W., Wolfs, T. G. & Sangild, P. T., Nov 2018, In : American Journal of Pathology. 188, 11, p. 2629-2643 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

ST waveform analysis for monitoring hypoxic distress in fetal sheep after prolonged umbilical cord occlusion

Andriessen, P., Zwanenburg, A., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., 16 Apr 2018, In : PLOS ONE. 13, 4, 14 p., e0195978.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb

Barkhuizen, M., van Dijck, F. J. P., Jellema, R. K., Gussenhoven, R., Engelbertink, I., van Mechele, R., Cleutjens, J. P. M., Seehase, M., Steinbusch, H. W. M., Zimmerman, L. J., Gavilanes, A. W. D. & Kramer, B. W., 1 Jun 2018, In : Pediatric Research. 83, 6, p. 1190-1199 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin A Supplementation by Endotracheal Application of a Nano-encapsulated Preparation Is Feasible in Ventilated Preterm Lambs

Wahl, H. B., Hutten, M. C., Monz, D., Tutdibi, E., Ophelders, D., Nikiforou, M., Tschernig, T., Gortner, L., Nohr, D., Biesalski, H. K. & Kramer, B. W., 1 Dec 2018, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 31, 6, p. 323-330 8 p., 323-330.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Antenatal dexamethasone vs. betamethasone dosing for lung maturation in fetal sheep

Schmidt, A. F., Kemp, M. W., Kannan, P. S., Kramer, B. W., Newnham, J. R., Kallapur, S. G. & Jobe, A. H., Mar 2017, In : Pediatric Research. 81, 3, p. 496-503 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line

Shruthi, S., Sumitha, R., Varghese, A. M., Ashok, S., Sagar, B. K. C., Sathyaprabha, T. N., Nalini, A., Kramer, B. W., Raju, T. R., Vijayalakshmi, K. & Alladi, P. A., 2017, In : Neurodegenerative Diseases. 17, 1, p. 44-58 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bronchopulmonary Dysplasia and Ureaplasma: What Do We Know So Far?

De La Haye, N., Hütten, M. C., Kunzmann, S. & Kramer, B. W., 27 Feb 2017, In : Neonatal Medicine. 24, 1, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Classic Galactosemia: Study on the Late Prenatal Development of GALT Specific Activity in a Sheep Model

Coelho, A. I., Bierau, J., Lindhout, M., Achten, J., Kramer, B. W. & Rubio-Gozalbo, M. E., Sep 2017, In : The Anatomical Record: advances in integrative anatomy and evolutionary biology. 300, 9, p. 1570-1575 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detection of Sepsis in Preterm Infants by Fecal Volatile Organic Compounds Analysis: A Proof of Principle Study

Berkhout, D. J. C., Niemarkt, H. J., Buijck, M., Van Weissenbruch, M. M., Brinkman, P., Benninga, M. A., van Kaam, A. H., Kramer, B. W., Andriessen, P., de Boer, N. K. H. & de Meij, T. G. J., Sep 2017, In : Journal of Pediatric Gastroenterology and Nutrition. 65, 3, p. E47-E52 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Mishra, P-S., Vijayalakshmi, K., Nalini, A., Sathyaprabha, T. N., Kramer, B. W., Alladi, P. A. & Raju, T. R., 16 Dec 2017, In : Journal of Neuroinflammation. 14, 18 p., 251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Foetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: Evidence from a sheep model of pregnancy

Kemp, M. W., Ahmed, S., Beeton, M. L., Payne, M. S., Saito, M., Miura, Y., Usuda, H., Kallapur, S. G., Kramer, B. W., Stock, S. J., Jobe, A. H., Newnham, J. P. & Spiller, O. B., Jan 2017, In : American Journal of Reproductive Immunology. 77, 1, 9 p., 12599.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In Vivo Evaluation of the Acute Pulmonary Response to Poractant Alfa and Bovactant Treatments in Lung-Lavaged Adult Rabbits and in Preterm Lambs with Respiratory Distress Syndrome

Ricci, F., Salomone, F., Kuypers, E., Ophelders, D., Nikiforou, M., Willems, M., Krieger, T., Murgia, X., Huetten, M., Kramer, B. W. & Bianco, F., 31 Aug 2017, In : Frontiers in pediatrics. 5, 10 p., 186.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight

van Ganzewinkel, C. J. L. M., Been, J. V., Verbeek, I., van der Loo, T. B., van der Pal, S. M., Kramer, B. W. & Andriessen, P., Jul 2017, In : Early Human Development. 110, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pentoxifylline modulates LPS-induced hyperinflammation in monocytes of preterm infants in vitro

Schuller, S. S., Wisgrill, L., Herndl, E., Spittler, A., Forster-Waldl, E., Sadeghi, K., Kramer, B. W. & Berger, A., Aug 2017, In : Pediatric Research. 82, 2, p. 215-225 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide

Willems, M. G. M., Kemp, M. W., Fast, L. A., Wagemaker, N. M. M., Janssen, L. E. W., Newnham, J. P., Payne, M. S., Spiller, O. B., Kallapur, S. G., Jobe, A. H., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 30 Jun 2017, In : PLOS ONE. 12, 6, 16 p., 0180114.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications

Niemarkt, H. J., Hutten, M. C. & Kramer, B. W., 2017, In : Neonatology. 111, 4, p. 408-414 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model

Rocha-Ferreira, E., Kelen, D., Faulkner, S., Broad, K. D., Chandrasekaran, M., Kerenyi, A., Kato, T., Bainbridge, A., Golay, X., Sullivan, M., Kramer, B. W. & Robertson, N. J., 3 Mar 2017, In : Journal of Neuroinflammation. 14, 13 p., 44.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tabaksontmoediging en perinatale gezondheid*

Peelen, M. J., Sheikh, A., Kok, M., Hajenius, P., Zimmermann, L., Kramer, B., Hukkelhoven, C. W. P. M., Reiss, I. K. M., Mol, B. W. J. & Been, J., 2017, In : Nederlands Tijdschrift voor Geneeskunde. p. 1-6 6 p., 161:D563.

Research output: Contribution to journalArticleAcademicpeer-review

The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development

Gussenhoven, R., Ophelders, D. R. M. G., Kemp, M. W., Payne, M. S., Spiller, O. B., Beeton, M. L., Stock, S. J., Cillero-Pastor, B., Barre, F. P. Y., Heeren, R. M. A., Kessels, L., Stevens, B., Rutten, B. P., Kallapur, S. G., Jobe, A. H., Kramer, B. W. & Wolfs, T. G. A. M., 2017, In : Developmental Neuroscience. 39, 6, p. 472-486 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Wharton's Jelly Mesenchymal Stem Cells Protect the Immature Brain in Rats and Modulate Cell Fate

Mueller, M., Oppliger, B., Joerger-Messerli, M., Reinhart, U., Barnea, E., Paidas, M., Kramer, B. W., Surbek, D. V. & Schoeberlein, A., 15 Feb 2017, In : Stem Cells and Development. 26, 4, p. 239-248 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Can the preterm lung recover from perinatal stress?

Hütten, M., Wolfs, T. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model

Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Jun 2016, In : Pediatric Research. 79, 6, p. 907-915

Research output: Contribution to journalArticleAcademicpeer-review

Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep

Regan, J. K., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Jan 2016, In : Reproductive Sciences. 23, 1, p. 69-80

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Fetal asphyctic preconditioning in rats results in a preserved placental inflammatory phenotype at birth

Sparnaaij, M. A. R., Chedraui, P., Liem, K. H., Escobar, G. S., Espinoza-Caicedo, J., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. D. W., Feb 2016, In : Placenta. 38, p. 84-92

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine

Nikiforou, M., Jacobs, E. M. R., Kemp, M. W., Hornef, M. W., Payne, M. S., Saito, M., Newnham, J. P., Janssen, L. E. W., Jobe, A. H., Kallapur, S. G., Kramer, B. W. & Wolfs, T. G. A. M., 14 Jul 2016, In : Scientific Reports. 6, 29806.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access