If you made any changes in Pure these will be visible here soon.

Research Output

2016

Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model

Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Jun 2016, In : Pediatric Research. 79, 6, p. 907-915

Research output: Contribution to journalArticleAcademicpeer-review

Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep

Regan, J. K., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Jan 2016, In : Reproductive Sciences. 23, 1, p. 69-80

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning in rats results in a preserved placental inflammatory phenotype at birth

Sparnaaij, M. A. R., Chedraui, P., Liem, K. H., Escobar, G. S., Espinoza-Caicedo, J., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. D. W., Feb 2016, In : Placenta. 38, p. 84-92

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine

Nikiforou, M., Jacobs, E. M. R., Kemp, M. W., Hornef, M. W., Payne, M. S., Saito, M., Newnham, J. P., Janssen, L. E. W., Jobe, A. H., Kallapur, S. G., Kramer, B. W. & Wolfs, T. G. A. M., 14 Jul 2016, In : Scientific Reports. 6, 29806.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intrauterine Lipopolysaccharide-Induced Chorioamnionitis in a Sheep: Does It Affect the Auditory System?

Smit, A. L., Lambermont, V. A., Stokroos, R. J., Anteunis, L. J. C., Chenault, M., Schaefer, S. M., Schoenmakers, L. W. G., Kremer, B. & Kramer, B. W., Feb 2016, In : Reproductive Sciences. 23, 2, p. 257-263

Research output: Contribution to journalArticleAcademicpeer-review

Maternofetal pharmacokinetics and fetal lung responses in chronically catheterized sheep receiving constant, low-dose infusions of betamethasone phosphate

Kemp, M. W., Saito, M., Usuda, H., Molloy, T. J., Miura, Y., Sato, S., Watanabe, S., Clarke, M., Fossler, M., Scmidt, A., Kallapur, S. G., Kramer, B. W., Newnham, J. P. & Jobe, A. H., Dec 2016, In : American Journal of Obstetrics and Gynecology. 215, 6, p. 775.e1-775.e12

Research output: Contribution to journalArticleAcademicpeer-review

Mesenchymal stem/stromal cells—a key mediator for regeneration after perinatal morbidity?

Mueller, M., Wolfs, T., Schoeberlein, A., Gavilanes, A. D. W., Surbek, D. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A-K., Radtke, S., Peters, V., Janssen, L., Giebel, B. & Kramer, B. W., Jun 2016, In : Stem Cells Translational Medicine. 5, 6, p. 754-763

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Ophelders, D. R. M. G., Gussenhoven, R., Lammens, M., Kusters, B., Kemp, M. W., Newnham, J. P., Payne, M. S., Kallapur, S. G., Jobe, A. H., Zimmermann, L. J., Kramer, B. W. & Wolfs, T. G. A. M., 2 Feb 2016, In : Journal of Neuroinflammation. 13, 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pain coping strategies: Neonatal intensive care unit survivors in adolescence

van Ganzewinkel, C., Been, J. V., Dieleman, J. P., Katgert, T., Boelen-van der Loo, T., van der Pal, S. M., van Dijk, M., Kramer, B. W. & Andriessen, P., Dec 2016, In : Early Human Development. 103, p. 27-32

Research output: Contribution to journalArticleAcademicpeer-review

Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome

Vanterpool, S. F., Been, J. V., Houben, M. L., Nikkels, P. G. J., De Krijger, R. R., Zimmermann, L. J. I., Kramer, B. W., Progulske-Fox, A. & Reyes, L., 5 Jan 2016, In : PLOS ONE. 11, 1, e0146157.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Propofol administration to the fetal-maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest

Seehase, M., Houthuizen, P., Collins, J. J. P., Zimmermann, L. J. & Kramer, B. W., May 2016, In : Pediatric Research. 79, 5, p. 748-753

Research output: Contribution to journalArticleAcademicpeer-review

Risk of adverse pregnancy outcomes in women with periodontal disease and the effectiveness of interventions in decreasing this risk: protocol for systematic overview of systematic reviews

Vanterpool, S., Tomsin, K., Reyes, L., Zimmermann, L., Kramer, B. & Been, J., 2016, In : Systematic Reviews. 5, 6 p., 16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep

Nikiforou, M., Kemp, M. W., van Gorp, R., Saito, M., Newnham, J. P., Reynaert, N. L., Janssen, L. E., Jobe, A. H., Kallapur, S. G., Kramer, B. & Wolfs, T., Jan 2016, In : Laboratory Investigation. 96, 1, p. 69-80 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetus

Willems, M. G. M., Ophelders, D. R. M. G., Nikiforou, M., Jellema, R. K., Butz, A., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 1 Jan 2016, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 310, 1, p. L1-L7

Research output: Contribution to journalArticleAcademicpeer-review

The development of lung biochemical monitoring can play a key role in the early prediction of bronchopulmonary dysplasia

Fabiano, A., Gavilanes, A. D. W., Zimmermann, L. J., Kramer, B. W. W., Paolillo, P., Livolti, G., Picone, S., Bressan, K. & Gazzolo, D., May 2016, In : Acta Paediatrica. 105, 5, p. 535–541 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tobacco control policies and perinatal health: a national quasi-experimental study

Peelen, M. J., Sheikh, A., Kok, M., Hajenius, P., Zimmermann, L. J., Kramer, B. W., Hukkelhoven, C. W., Reiss, I. K., Mol, B. W. & Been, J. V., 22 Apr 2016, In : Scientific Reports. 6, 23907.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

25 years of research on global asphyxia in the immature rat brain

Barkhuizen, M., van den Hove, D. L. A., Vles, J. S. H., Steinbusch, H. W. M., Kramer, B. W. & Gavilanes, A. W. D., Apr 2017, In : Neuroscience and Biobehavioral Reviews. 75, p. 166-182 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Antenatal dexamethasone vs. betamethasone dosing for lung maturation in fetal sheep

Schmidt, A. F., Kemp, M. W., Kannan, P. S., Kramer, B. W., Newnham, J. R., Kallapur, S. G. & Jobe, A. H., Mar 2017, In : Pediatric Research. 81, 3, p. 496-503 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line

Shruthi, S., Sumitha, R., Varghese, A. M., Ashok, S., Sagar, B. K. C., Sathyaprabha, T. N., Nalini, A., Kramer, B. W., Raju, T. R., Vijayalakshmi, K. & Alladi, P. A., 2017, In : Neurodegenerative Diseases. 17, 1, p. 44-58 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bronchopulmonary Dysplasia and Ureaplasma: What Do We Know So Far?

De La Haye, N., Hütten, M. C., Kunzmann, S. & Kramer, B. W., 27 Feb 2017, In : Neonatal Medicine. 24, 1, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Classic Galactosemia: Study on the Late Prenatal Development of GALT Specific Activity in a Sheep Model

Coelho, A. I., Bierau, J., Lindhout, M., Achten, J., Kramer, B. W. & Rubio-Gozalbo, M. E., Sep 2017, In : The Anatomical Record: advances in integrative anatomy and evolutionary biology. 300, 9, p. 1570-1575 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detection of Sepsis in Preterm Infants by Fecal Volatile Organic Compounds Analysis: A Proof of Principle Study

Berkhout, D. J. C., Niemarkt, H. J., Buijck, M., Van Weissenbruch, M. M., Brinkman, P., Benninga, M. A., van Kaam, A. H., Kramer, B. W., Andriessen, P., de Boer, N. K. H. & de Meij, T. G. J., Sep 2017, In : Journal of Pediatric Gastroenterology and Nutrition. 65, 3, p. E47-E52 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Mishra, P-S., Vijayalakshmi, K., Nalini, A., Sathyaprabha, T. N., Kramer, B. W., Alladi, P. A. & Raju, T. R., 16 Dec 2017, In : Journal of Neuroinflammation. 14, 18 p., 251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Foetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: Evidence from a sheep model of pregnancy

Kemp, M. W., Ahmed, S., Beeton, M. L., Payne, M. S., Saito, M., Miura, Y., Usuda, H., Kallapur, S. G., Kramer, B. W., Stock, S. J., Jobe, A. H., Newnham, J. P. & Spiller, O. B., Jan 2017, In : American Journal of Reproductive Immunology. 77, 1, 9 p., 12599.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In Vivo Evaluation of the Acute Pulmonary Response to Poractant Alfa and Bovactant Treatments in Lung-Lavaged Adult Rabbits and in Preterm Lambs with Respiratory Distress Syndrome

Ricci, F., Salomone, F., Kuypers, E., Ophelders, D., Nikiforou, M., Willems, M., Krieger, T., Murgia, X., Huetten, M., Kramer, B. W. & Bianco, F., 31 Aug 2017, In : Frontiers in pediatrics. 5, 10 p., 186.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight

van Ganzewinkel, C. J. L. M., Been, J. V., Verbeek, I., van der Loo, T. B., van der Pal, S. M., Kramer, B. W. & Andriessen, P., Jul 2017, In : Early Human Development. 110, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pentoxifylline modulates LPS-induced hyperinflammation in monocytes of preterm infants in vitro

Schuller, S. S., Wisgrill, L., Herndl, E., Spittler, A., Forster-Waldl, E., Sadeghi, K., Kramer, B. W. & Berger, A., Aug 2017, In : Pediatric Research. 82, 2, p. 215-225 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

Villamor-Martinez, E., Pierro, M., Cavallaro, G., Mosca, F., Kramer, B. & Villamor, E., Nov 2017, In : Nutrients. 9, 11, 19 p., 1197.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide

Willems, M. G. M., Kemp, M. W., Fast, L. A., Wagemaker, N. M. M., Janssen, L. E. W., Newnham, J. P., Payne, M. S., Spiller, O. B., Kallapur, S. G., Jobe, A. H., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 30 Jun 2017, In : PLOS ONE. 12, 6, 16 p., 0180114.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stem cells and Bronchopulmonary Dysplasia - The five questions: Which cells, when, in which dose, to which patients via which route?

Mueller, M. & Kramer, B. W., Sep 2017, In : Paediatric Respiratory Reviews. 24, p. 54-59 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications

Niemarkt, H. J., Hutten, M. C. & Kramer, B. W., 2017, In : Neonatology. 111, 4, p. 408-414 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model

Rocha-Ferreira, E., Kelen, D., Faulkner, S., Broad, K. D., Chandrasekaran, M., Kerenyi, A., Kato, T., Bainbridge, A., Golay, X., Sullivan, M., Kramer, B. W. & Robertson, N. J., 3 Mar 2017, In : Journal of Neuroinflammation. 14, 13 p., 44.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tabaksontmoediging en perinatale gezondheid*

Peelen, M. J., Sheikh, A., Kok, M., Hajenius, P., Zimmermann, L., Kramer, B., Hukkelhoven, C. W. P. M., Reiss, I. K. M., Mol, B. W. J. & Been, J., 2017, In : Nederlands Tijdschrift voor Geneeskunde. p. 1-6 6 p., 161:D563.

Research output: Contribution to journalArticleAcademicpeer-review

The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development

Gussenhoven, R., Ophelders, D. R. M. G., Kemp, M. W., Payne, M. S., Spiller, O. B., Beeton, M. L., Stock, S. J., Cillero-Pastor, B., Barre, F. P. Y., Heeren, R. M. A., Kessels, L., Stevens, B., Rutten, B. P., Kallapur, S. G., Jobe, A. H., Kramer, B. W. & Wolfs, T. G. A. M., 2017, In : Developmental Neuroscience. 39, 6, p. 472-486 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Wharton's Jelly Mesenchymal Stem Cells Protect the Immature Brain in Rats and Modulate Cell Fate

Mueller, M., Oppliger, B., Joerger-Messerli, M., Reinhart, U., Barnea, E., Paidas, M., Kramer, B. W., Surbek, D. V. & Schoeberlein, A., 15 Feb 2017, In : Stem Cells and Development. 26, 4, p. 239-248 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Antenatal Corticosteroid Exposure Disrupts Myelination in the Auditory Nerve of Preterm Sheep

Rittenschober-Bohm, J., Rodger, J., Jobe, A. H., Kallapur, S. G., Doherty, D. A., Kramer, B. W., Payne, M. S., Archer, M., Rittenschober, C., Newnham, J. P., Miura, Y., Berger, A., Matthews, S. G. & Kemp, M. W., 1 Jan 2018, In : Neonatology. 114, 1, p. 62-68 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus

Gussenhoven, R., Westerlaken, R. J. J., Ophelders, D. R. M. G., Jobe, A. H., Kemp, M. W., Kallapur, S. G., Zimmermann, L. J., Sangild, P. T., Pankratova, S., Gressens, P., Kramer, B. W., Fleiss, B. & Wolfs, T. G. A. M., 19 Apr 2018, In : Journal of Neuroinflammation. 15, 13 p., 113.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Development of severe bronchopulmonary dysplasia is associated with alterations in fecal volatile organic compounds

Berkhout, D. J. C., Niemarkt, H. J., Benninga, M. A., Budding, A. E., van Kaam, A. H., Kramer, B. W., Pantophlet, C. M., van Weissenbruch, M. M., de Boer, N. K. H. & de Meij, T. G. J., 1 Feb 2018, In : Pediatric Research. 83, 2, p. 412-419 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Donor Human Milk Protects against Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis

Villamor-Martinez, E., Pierro, M., Cavallaro, G., Mosca, F., Kramer, B. W. & Villamor, E., 20 Feb 2018, In : Nutrients. 10, 2, 16 p., 238.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Effects of Chronic Carbamazepine Treatment on the ECG in Patients with Focal Seizures

Sathyaprabha, T. N., Koot, L. A. M., Hermans, B. H. M., Adoor, M., Sinha, S., Kramer, B. W., Raju, T. R., Satishchandra, P. & Delhaas, T., 1 Sep 2018, In : Clinical Drug Investigation. 38, 9, p. 845-851 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future

Schueller, S. S., Kramer, B. W., Villamor, E., Spittler, A., Berger, A. & Levy, O., 19 Jul 2018, In : Frontiers in pediatrics. 6, 17 p., 199.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep

Schmidt, A. F., Kemp, M. W., Rittenschober-Bohm, J., Kannan, P. S., Usuda, H., Saito, M., Furfaro, L., Watanabe, S., Stock, S., Kramer, B. W., Newnham, J. P., Kallapur, S. G. & Jobe, A. H., 1 Jan 2018, In : American Journal of Obstetrics and Gynecology. 218, 1, p. 132.e1-132.e9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pediatric Early Warning System Scores: Lessons to be Learned

van Sambeeck, S. J., Fuijkschot, J., Kramer, B. W. & Vos, G. D., 1 Mar 2018, In : Journal of Pediatric Intensive Care. 7, 1, p. 27-32 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis

Barkhuizen, M., Rodrigues, F. B., Anderson, D. G., Winkens, B., REGISTRY Investigators European, Wild, E. J., Kramer, B. W. & Gavilanes, A. W. D., Oct 2018, In : Parkinsonism & Related Disorders. 55, p. 55-60 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs

Duc Ninh Nguyen, Thymann, T., Goericke-Pesch, S. K., Ren, S., Wei, W., Skovgaard, K., Damborg, P., Brunse, A., van Gorp, C., Kramer, B. W., Wolfs, T. G. & Sangild, P. T., Nov 2018, In : American Journal of Pathology. 188, 11, p. 2629-2643 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Risk Factors for Necrotizing Enterocolitis: A Prospective Multicenter Case-Control Study

Berkhout, D. J. C., Klaassen, P., Niemarkt, H. J., de Boode, W. P., Cossey, V., van Goudoever, J. B., Hulzebos, C. V., Andriessen, P., van Kaam, A. H., Kramer, B. W., van Lingen, R. A., Vijlbrief, D. C., van Weissenbruch, M. M., Benninga, M., de Boer, N. K. H. & de Meij, T. G. J., 1 Jan 2018, In : Neonatology. 114, 3, p. 277-284 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

ST waveform analysis for monitoring hypoxic distress in fetal sheep after prolonged umbilical cord occlusion

Andriessen, P., Zwanenburg, A., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., 16 Apr 2018, In : PLOS ONE. 13, 4, 14 p., e0195978.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb

Barkhuizen, M., van Dijck, F. J. P., Jellema, R. K., Gussenhoven, R., Engelbertink, I., van Mechele, R., Cleutjens, J. P. M., Seehase, M., Steinbusch, H. W. M., Zimmerman, L. J., Gavilanes, A. W. D. & Kramer, B. W., 1 Jun 2018, In : Pediatric Research. 83, 6, p. 1190-1199 10 p.

Research output: Contribution to journalArticleAcademicpeer-review