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Research Output

2014

Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation

Wolfs, T. G. A. M., Kramer, B. W., Thuijls, G., Kemp, M. W., Saito, M., Willems, M. G. M., Senthamarai-Kannan, P., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Mar 2014, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 306, 5, p. G382-G393

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Chronic Pain in the Newborn Toward a Definition

van Ganzewinkel, C., Anand, K. J. S., Kramer, B. W. & Andriessen, P., Nov 2014, In : Clinical Journal of Pain. 30, 11, p. 970-977

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Comparison of airway responses in sheep of different age in precision-cut lung slices (PCLS)

Lambermont, V. A., Schleputz, M., Dassow, C., Konig, P., Zimmermann, L. J., Uhlig, S., Kramer, B. W. W. & Martin, C., 17 Sep 2014, In : PLOS ONE. 9, 9, 8 p., e97610.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Effects of intra-amniotic lipopolysaccharide exposure on the fetal lamb lung as gestation advances

Lambermont, V. A., Kuypers, E., Collins, J. J. R., Pillow, J. J., Newnham, J. P., Polglase, G. R., Nitsos, H., Kemp, M. W., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Apr 2014, In : Pediatric Research. 75, 4, p. 500-506

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Effects of less-invasive surfactant administration on oxygenation, pulmonary surfactant distribution, and lung compliance in spontaneously breathing preterm lambs

Niemarkt, H. J., Kuypers, E., Jellema, R., Ophelders, D., Huetten, M., Nikiforou, M., Kribs, A. & Kramer, B. W., Aug 2014, In : Pediatric Research. 76, 2, p. 166-170

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Intestinal fatty acid-binding protein: a possible marker for gut maturation

Reisinger, K. W., Elst, M., Derikx, J. P. M., Nikkels, P. G. J., de Vries, B., Adriaanse, M. P. M., Jellema, R. K., Kramer, B. W. W. & Wolfs, T. G. A. M., Sep 2014, In : Pediatric Research. 76, 3, p. 261-268

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung

Schmidt, A. F., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Nov 2014, In : Pediatric Research. 76, 5, p. 441-447

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep

Payne, M. S., Kemp, M. W., Kallapur, S. G., Kannan, P. S., Saito, M., Miura, Y., Newnham, J. P., Stock, S., Ireland, D. J., Kramer, B. W. & Jobe, A. H., Jun 2014, In : Pediatric Research. 75, 6, p. 716-722

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Miniaturization: The Clue to Clinical Application of the Artificial Placenta

Schoberer, M., Arens, J., Erben, A., Ophelders, D., Jellema, R. K., Kramer, B. W., Bruse, J. L., de Brouwer, P., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Mar 2014, In : Artificial Organs. 38, 3, p. 208-214

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Polymyxin B Agonist Capture Therapy for Intrauterine Inflammation: Proof-of-Principle in a Fetal Ovine Model

Saito, M., Payne, M. S., Miura, Y., Ireland, D. J., Stock, S., Kallapur, S. G., Kannan, P. S., Newnham, J. P., Kramer, B. W., Jobe, A. H., Keelan, J. A. & Kemp, M. W., May 2014, In : Reproductive Sciences. 21, 5, p. 623-631

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs

Gisslen, T., Hillman, N. H., Musk, G. C., Kemp, M. W., Kramer, B. W., Senthamaraikannan, P., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Feb 2014, In : Innate Immunity. 20, 2, p. 214-224

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Surfactant protein A binds TGF-beta 1 with high affinity and stimulates the TGF-beta pathway

Willems, C. H. M. P., Zimmermann, L. J. I., Kloosterboer, N., Kramer, B. W. & van Iwaarden, J. F., Feb 2014, In : Innate Immunity. 20, 2, p. 192-199

Research output: Contribution to journalArticleAcademicpeer-review

2013

Antenatal glucocorticoids counteract LPS changes in TGF-beta pathway and caveolin-1 in ovine fetal lung

Collins, J. J. P., Kunzmann, S., Kuypers, E., Kemp, M. W., Speer, C. P., Newnham, J. P., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Mar 2013, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 304, 6, p. L438-L444

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner

Wolfs, T. G. A. M., Kallapur, S. G., Knox, C. L., Thuijls, G., Nitsos, I., Polglase, G. R., Collins, J. J. P., Kroon, E., Spierings, J., Shroyer, N. F., Newnham, J. P., Jobe, A. H. & Kramer, B. W., May 2013, In : Mucosal Immunology. 6, 3, p. 547-556

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., De Munter, S., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., Jennekens, W., Gavilanes, A. W. D., Seehase, M., Vles, H. J., Steinbusch, H., Andriessen, P., Wolfs, T. G. A. M. & Kramer, B. W., 24 Jan 2013, In : Journal of Neuroinflammation. 10, 13.

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Chorioamnionitis as a Risk Factor for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis

Been, J. V., Lievense, S., Zimmermann, L. J. I., Kramer, B. W. & Wolfs, T. G. A. M., Feb 2013, In : The Journal of Pediatrics. 162, 2, p. 236-242

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

Engel, M., Nowacki, R. M. E., Reiss, L. K., Uhlig, S., Willems, C. H. M. P., Kloosterboer, N., van Iwaarden, J. F., Sewing, A. C. P., Seehase, M., Lambermont, V. A. C., Collins, J. J. P., Zimmermann, L. J. I., Vos, G. D. & Kramer, B. W., Feb 2013, In : Lung. 191, 1, p. 77-86

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Effects of Intra-Amniotic Lipopolysaccharide and Maternal Betamethasone on Brain Inflammation in Fetal Sheep

Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Dudink, J., Nikiforou, M., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglasem, G. R., Kemp, M. W., Saito, M., Newnham, J. P., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., 17 Dec 2013, In : PLOS ONE. 8, 12, e81644.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats

Vlassaks, E., Strackx, E., Vles, J. S. H., Nikiforou, M., Martinez-Martinez, P., Kramer, B. W. & Gavilanes, A. W. D., 26 Jan 2013, In : Journal of Neuroinflammation. 10, 14.

Research output: Contribution to journalArticleAcademicpeer-review

Functional impairment of the auditory pathway after perinatal asphyxia and the short-term effect of perinatal propofol anesthesia in lambs

Smit, A. L., Seehase, M., Stokroos, R. J., Jellema, R. K., Felipe, L., Chenault, M. N., Anteunis, L. J. C., Kremer, B. & Kramer, B. W., Jul 2013, In : Pediatric Research. 74, 1, p. 34-38

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Heart rate-mediated blood pressure control in preterm fetal sheep under normal and hypoxic-ischemic conditions

Zwanenburg, A., Jellema, R. K., Jennekens, W., Ophelders, D., Vullings, R., van Hunnik, A., van Pul, C., Bennet, L., Delhaas, T., Kramer, B. W. & Andriessen, P., Apr 2013, In : Pediatric Research. 73, 4, p. 420-426

Research output: Contribution to journalArticleAcademicpeer-review

Intraamniotic Lipopolysaccharide Exposure Changes Cell Populations and Structure of the Ovine Fetal Thymus

Kuypers, E., Wolfs, T. G. A. M., Collins, J. J. P., Jellema, R. K., Newnham, J. P., Kemp, M. W., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Aug 2013, In : Reproductive Sciences. 20, 8, p. 946-956

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Mesenchymal Stem Cells Induce T-Cell Tolerance and Protect the Preterm Brain after Global Hypoxia-Ischemia

Jellema, R. K., Wolfs, T. G. A. M., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., Kuypers, E., Hopman, A. H. N., Dudink, J., Steinbusch, H. W., Andriessen, P., Germeraad, W. T. V., Vanderlocht, J. & Kramer, B. W., 26 Aug 2013, In : PLOS ONE. 8, 8, e73031.

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Modulation of lipopolysaccharide-induced chorioamnionitis by Ureaplasma parvum in sheep

Snyder, C. C., Wolfe, K. B., Gisslen, T., Knox, C. L., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., May 2013, In : American Journal of Obstetrics and Gynecology. 208, 5, 399.e1.

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Modulation of Lipopolysaccharide-Induced Chorioamnionitis in Fetal Sheep by Maternal Betamethasone

Wolfe, K. B., Snyder, C. C., Gisslen, T., Kemp, M. W., Newnham, J. P., Kramer, B. W., Jobe, A. H. & Kallapur, S., Dec 2013, In : Reproductive Sciences. 20, 12, p. 1447-1454

Research output: Contribution to journalArticleAcademicpeer-review

Repeated Intrauterine Exposures to Inflammatory Stimuli Attenuated Transforming Growth Factor-beta Signaling in the Ovine Fetal Lung

Collins, J. J. P., Kallapur, S. G., Knox, C. L., Kemp, M. W., Kuypers, E., Zimmermann, L. J. I., Newnham, J. P., Jobe, A. H. & Kramer, B. W., 2013, In : Neonatology. 104, 1, p. 49-55

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Selective Exposure of the Fetal Lung and Skin/Amnion (but Not Gastro-Intestinal Tract) to LPS Elicits Acute Systemic Inflammation in Fetal Sheep

Kemp, M. W., Kannan, P. S., Saito, M., Newnham, J. P., Cox, T., Jobe, A. H., Kramer, B. W. & Kallapur, S. G., 17 May 2013, In : PLOS ONE. 8, 5, e63355.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia

Jellema, R. K., Passos, V. L., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Zwanenburg, A., De Munter, S., Nikiforou, M., Collins, J. J. P., Kuypers, E., Bos, G. M. J., Steinbusch, H. W., Vanderlocht, J., Andriessen, P., Germeraad, W. T. V. & Kramer, B. W., Dec 2013, In : Experimental Neurology. 250, p. 293-303

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

The effects of fetal and perinatal asphyxia on neuronal cytokine levels and ceramide metabolism in adulthood

Vlassaks, E., Gavilanes, A. W. D., Vles, J. S. H., Deville, S., Kramer, B. W., Strackx, E. & Martinez-Martinez, P., 15 Feb 2013, In : Journal of Neuroimmunology. 255, 1-2, p. 97-101

Research output: Contribution to journalArticleAcademicpeer-review

Thrown off balance: the effect of antenatal inflammation on the developing lung and immune system

Kunzmann, S., Collins, J. J. P., Kuypers, E. & Kramer, B. W., Jun 2013, In : American Journal of Obstetrics and Gynecology. 208, 6, p. 429-437

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Ureaplasma and BPD

Kallapur, S. G., Kramer, B. W. & Jobe, A. H., Apr 2013, In : Seminars in Perinatology. 37, 2, p. 94-101

Research output: Contribution to journalArticleAcademicpeer-review

Ureaplasma parvum Serovar 3 Multiple Banded Antigen Size Variation after Chronic Intra-Amniotic Infection/Colonization

Robinson, J. W., Dando, S. J., Nitsos, I., Newnham, J., Polglase, G. R., Kallapur, S. G., Pillow, J. J., Kramer, B. W., Jobe, A. H., Payton, D. & Knox, C. L., 26 Apr 2013, In : PLOS ONE. 8, 4, e62746.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
2012

Bacterial reprogramming of PBMCs impairs monocyte phagocytosis and modulates adaptive T cell responses

Andre, M. C., Gille, C., Glemser, P., Woiterski, J., Hsu, H-Y., Spring, B., Keppeler, H., Kramer, B. W., Handgretinger, R., Poets, C. F., Lauber, K. & Orlikowsky, T. W., Jun 2012, In : Journal of Leukocyte Biology. 91, 6, p. 977-989

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Dissociation of transforming growth factors beta 1 and beta 2 from surfactant protein A (SP-A) by deglycosylation or deoxycholate treatment

Willems, C. H. M. P., Kloosterboer, N., Kunzmann, S., Kramer, B. W., Zimmermann, L. J. I. & van Iwaarden, J. F., 31 Jan 2012, In : Journal of Immunological Methods. 375, 1-2, p. 111-117

Research output: Contribution to journalArticleAcademicpeer-review

Effects of in utero endotoxemia on the ovine fetal brain: a model for schizophrenia?

Gantert, M., Kreczmanski, P., Kuypers, E., Jellema, R., Strackx, E., Bastian, N., Gavilanes, A. W. D., Zimmermann, L. J. I., Garnier, Y., Schmitz, C. & Kramer, B. W., 1 Jun 2012, In : Frontiers in Bioscience, Elite edition. 1, 4, p. 2845-53 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fifty Years of Work on the Artificial Placenta: Milestones in the History of Extracorporeal Support of the Premature Newborn

Schoberer, M., Arens, J., Lohr, A., Seehase, M., Jellema, R. K., Collins, J. J., Kramer, B. W., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Jun 2012, In : Artificial Organs. 36, 6, p. 512-516

Research output: Contribution to journalArticleAcademicpeer-review

IFN-gamma and TNF-alpha Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Laug, R., Fehrholz, M., Schuetze, N., Kramer, B. W., Krump-Konvalinkova, V., Speer, C. P. & Kunzmann, S., 20 Sep 2012, In : PLOS ONE. 7, 9, e45430.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis

Kaemmerer, E., Schneider, U., Klaus, C., Plum, P., Reinartz, A., Adolf, M., Renner, M., Wolfs, T. G. A. M., Kramer, B. W., Wagner, N., Mollenhauer, J. & Gassler, N., Mar 2012, In : Histopathology. 60, 4, p. 561-569

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Increased Number of Cerebellar Granule Cells and Astrocytes in the Internal Granule Layer in Sheep Following Prenatal Intra-amniotic Injection of Lipopolysaccharide

Strackx, E., Gantert, M., Moers, V., van Kooten, I. A. J., Rieke, R., Hurter, H., Lemmens, M. A. M., Steinbusch, H. W. M., Zimmermann, L. J. I., Vles, J. S. H., Garnier, Y., Gavilanes, A. W. D. & Kramer, B. W., Mar 2012, In : Cerebellum. 11, 1, p. 132-144

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis

Wolfs, T. G. A. M., Jellema, R. K., Turrisi, G., Becucci, E., Buonocore, G. & Kramer, B. W., Apr 2012, In : Journal of Maternal-Fetal & Neonatal Medicine. 25, p. 8-11

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs

Kuypers, E., Collins, J. J. P., Kramer, B. W., Ofman, G., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Gavilanes, A. W. D., Nowacki, R., Ikegami, M., Jobe, A. H. & Kallapur, S. G., Feb 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 302, 4, p. L380-L389

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Lipopolysaccharide-Induced Chorioamnionitis Is Confined to One Amniotic Compartment in Twin Pregnant Sheep

Gantert, M., Jellema, R. K., Heineman, H., Gantert, J., Collins, J. J. P., Seehase, M., Lambermont, V. A. C., Keck, A., Garnier, Y., Zimmermann, L. J. I., Kadyrov, M., Gavilanes, A. W. D. & Kramer, B. W., 2012, In : Neonatology. 102, 2, p. 81-88

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

LPS-induced chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung

Collins, J. J. P., Kuypers, E., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Cleutjens, J. P., Frints, S. G. M., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Nov 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 303, 9, p. L778-L787

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Multi-channel amplitude-integrated EEG characteristics in preterm infants with a normal neurodevelopment at two years of corrected age

Niemarkt, H. J., Jennekens, W., Maartens, I. A., Wassenberg, T., van Aken, M., Katgert, T., Kramer, B. W., Gavilanes, A. W. D., Zimmermann, L. J., Oetomo, S. B. & Andriessen, P., Apr 2012, In : Early Human Development. 88, 4, p. 209-216

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

Schlepuetz, M., Rieg, A. D., Seehase, S., Spillner, J., Perez-Bouza, A., Braunschweig, T., Schroeder, T., Bernau, M., Lambermont, V., Schlumbohm, C., Sewald, K., Autschbach, R., Braun, A., Kramer, B. W., Uhlig, S. & Martin, C., 9 Oct 2012, In : PLOS ONE. 7, 10, e47344.

Research output: Contribution to journalArticleAcademicpeer-review

New Pharmacological Approaches in Infants with Hypoxic-Ischemic Encephalopathy

Buonocore, G., Perrone, S., Turrisi, G., Kramer, B. W. & Balduini, W., Jul 2012, In : Current Pharmaceutical Design. 18, 21, p. 3086-3100

Research output: Contribution to journalArticleAcademicpeer-review

New Surfactant with SP-B and C Analogs Gives Survival Benefit after Inactivation in Preterm Lambs

Seehase, M., Collins, J. J. P., Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Ospina, O. L., Perez-Gil, J., Bianco, F., Garzia, R., Razzetti, R. & Kramer, B. W., 16 Oct 2012, In : PLOS ONE. 7, 10, p. e47631

Research output: Contribution to journalArticleAcademicpeer-review

Ovine Fetal Thymus Response to Lipopolysaccharide-Induced Chorioamnionitis and Antenatal Corticosteroids

Kuypers, E., Collins, J. J. P., Jellema, R. K., Wolfs, T. G. A. M., Kemp, M. W., Nitsos, I., Pillow, J. J., Polglase, G. R., Newnham, J. P., Germeraad, W. T. V., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., 31 May 2012, In : PLOS ONE. 7, 5, e38257.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Poractant alfa (Curosurf (R)) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo

Willems, C. H. M. P., Urlichs, F., Seidenspinner, S., Kunzmann, S., Speer, C. P. & Kramer, B. W., 9 Mar 2012, In : Respiratory Research. 13, p. 17

Research output: Contribution to journalArticleAcademicpeer-review

Regenerative Therapies in Neonatology: Clinical Perspectives

Gortner, L., Felderhoff-Mueser, U., Monz, D., Bieback, K., Klueter, H., Jellema, R., Kramer, B. W., Keller, B. M., Reiss, I. K., Horn, P. A. & Giebel, B., Jul 2012, In : Klinische Padiatrie. 224, 4, p. 233-240

Research output: Contribution to journalArticleAcademicpeer-review