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Research Output

Article

Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study

Berkhout, D. J. C., van Keulen, B. J., Niemarkt, H. J., Bessem, J. R., de Boode, W. P., Cossey, V., Hoogenes, N., Hulzebos, C. V., Klaver, E., Andriessen, P., van Kaam, A. H., Kramer, B. W., van Lingen, R. A., Schouten, A., van Goudoever, J. B., Vijlbrief, D. C., van Weissenbruch, M. M., Wicaksono, A. N., Covington, J. A., Benninga, M. A. & 2 others, de Boer, N. K. H. & de Meij, T. G. J., 1 Jan 2019, In : Clinical Infectious Diseases. 68, 1, p. 70-77 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipopolysaccharide-Induced Chorioamnionitis Causes Acute Inflammatory Changes in the Ovine Central Nervous System

Strackx, E., Sparnaaij, M. A. R., Vlassaks, E., Jellema, R., Kuypers, E., Vles, J. S. H., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 1, p. 77-84

Research output: Contribution to journalArticleAcademicpeer-review

Lipopolysaccharide-Induced Chorioamnionitis Is Confined to One Amniotic Compartment in Twin Pregnant Sheep

Gantert, M., Jellema, R. K., Heineman, H., Gantert, J., Collins, J. J. P., Seehase, M., Lambermont, V. A. C., Keck, A., Garnier, Y., Zimmermann, L. J. I., Kadyrov, M., Gavilanes, A. W. D. & Kramer, B. W., 2012, In : Neonatology. 102, 2, p. 81-88

Research output: Contribution to journalArticleAcademicpeer-review

Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep

Schmidt, A. F., Kemp, M. W., Rittenschober-Bohm, J., Kannan, P. S., Usuda, H., Saito, M., Furfaro, L., Watanabe, S., Stock, S., Kramer, B. W., Newnham, J. P., Kallapur, S. G. & Jobe, A. H., 1 Jan 2018, In : American Journal of Obstetrics and Gynecology. 218, 1, p. 132.e1-132.e9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

LPS-induced chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung

Collins, J. J. P., Kuypers, E., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Cleutjens, J. P., Frints, S. G. M., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Nov 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 303, 9, p. L778-L787

Research output: Contribution to journalArticleAcademicpeer-review

Maternofetal pharmacokinetics and fetal lung responses in chronically catheterized sheep receiving constant, low-dose infusions of betamethasone phosphate

Kemp, M. W., Saito, M., Usuda, H., Molloy, T. J., Miura, Y., Sato, S., Watanabe, S., Clarke, M., Fossler, M., Scmidt, A., Kallapur, S. G., Kramer, B. W., Newnham, J. P. & Jobe, A. H., Dec 2016, In : American Journal of Obstetrics and Gynecology. 215, 6, p. 775.e1-775.e12

Research output: Contribution to journalArticleAcademicpeer-review

Maturational Changes in Automated EEG Spectral Power Analysis in Preterm Infants

Niemarkt, H. J., Jennekens, W., Pasman, J. W., Katgert, T., van Pul, C., Gavtlanes, A. W. D., Kramer, B. W., Zimmermann, L. J., Oetomo, S. B. & Andriessen, P., Nov 2011, In : Pediatric Research. 70, 5, p. 529-534

Research output: Contribution to journalArticleAcademicpeer-review

Mesenchymal stem/stromal cells—a key mediator for regeneration after perinatal morbidity?

Mueller, M., Wolfs, T., Schoeberlein, A., Gavilanes, A. D. W., Surbek, D. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mesenchymal Stem Cells Induce T-Cell Tolerance and Protect the Preterm Brain after Global Hypoxia-Ischemia

Jellema, R. K., Wolfs, T. G. A. M., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., Kuypers, E., Hopman, A. H. N., Dudink, J., Steinbusch, H. W., Andriessen, P., Germeraad, W. T. V., Vanderlocht, J. & Kramer, B. W., 26 Aug 2013, In : PLOS ONE. 8, 8, e73031.

Research output: Contribution to journalArticleAcademicpeer-review

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A-K., Radtke, S., Peters, V., Janssen, L., Giebel, B. & Kramer, B. W., Jun 2016, In : Stem Cells Translational Medicine. 5, 6, p. 754-763

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Miniaturization: The Clue to Clinical Application of the Artificial Placenta

Schoberer, M., Arens, J., Erben, A., Ophelders, D., Jellema, R. K., Kramer, B. W., Bruse, J. L., de Brouwer, P., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Mar 2014, In : Artificial Organs. 38, 3, p. 208-214

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of fetal inflammatory response on exposure to lipopolysaccharide by chorioamnion, lung, or gut in sheep

Kramer, B. W., Kallapur, S. G., Moss, T. J. M., Nitsos, I., Polglase, G. P., Newnham, J. P. & Jobe, A. H., Jan 2010, In : American Journal of Obstetrics and Gynecology. 202, 1, p. 77.e1-77.e9

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of lipopolysaccharide-induced chorioamnionitis by Ureaplasma parvum in sheep

Snyder, C. C., Wolfe, K. B., Gisslen, T., Knox, C. L., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., May 2013, In : American Journal of Obstetrics and Gynecology. 208, 5, 399.e1.

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of Lipopolysaccharide-Induced Chorioamnionitis in Fetal Sheep by Maternal Betamethasone

Wolfe, K. B., Snyder, C. C., Gisslen, T., Kemp, M. W., Newnham, J. P., Kramer, B. W., Jobe, A. H. & Kallapur, S., Dec 2013, In : Reproductive Sciences. 20, 12, p. 1447-1454

Research output: Contribution to journalArticleAcademicpeer-review

Multi-channel amplitude-integrated EEG characteristics in preterm infants with a normal neurodevelopment at two years of corrected age

Niemarkt, H. J., Jennekens, W., Maartens, I. A., Wassenberg, T., van Aken, M., Katgert, T., Kramer, B. W., Gavilanes, A. W. D., Zimmermann, L. J., Oetomo, S. B. & Andriessen, P., Apr 2012, In : Early Human Development. 88, 4, p. 209-216

Research output: Contribution to journalArticleAcademicpeer-review

Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain

Jellema, R. K., Ophelders, D. R. M. G., Zwanenburg, A., Nikiforou, M., Delhaas, T., Andriessen, P., Mays, R. W., Deans, R., Germeraad, W. T. V., Wolfs, T. G. A. M. & Kramer, B. W., 23 Dec 2015, In : Journal of Neuroinflammation. 12, p. 241

Research output: Contribution to journalArticleAcademicpeer-review

Mutation pattern in 606 Duchenne muscular dystrophy children with a comparison between familial and non-familial forms: a study in an Indian large single-center cohort

Polavarapu, K., Preethish-Kumar, V., Sekar, D., Vengalil, S., Nashi, S., Mahajan, N. P., Thomas, P. T., Sadasivan, A., Warrier, M., Gupta, A., Arunachal, G., Debnath, M., Keerthipriya, M. S., Pradeep-Chandra-Reddy, C., Puttegowda, A., John, A. P., Tavvala, A., Gunasekaran, S., Sathyaprabha, T. N., Chandra, S. R. & 3 others, Kramer, B., Delhaas, T. & Nalini, A., Sep 2019, In : Journal of Neurology. 266, 9, p. 2177-2185 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Myocardial Response in Preterm Fetal Sheep Exposed to Systemic Endotoxinaemia

Seehase, M., Gantert, M., Ladenburger, A., Garnier, Y., Kunzmann, S., Thomas, W., Wirbelauer, J., Speer, C. P. & Kramer, B. W., Sep 2011, In : Pediatric Research. 70, 3, p. 242-246

Research output: Contribution to journalArticleAcademicpeer-review

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

Hütten, M. C., Kuypers, E., Ophelders, D. R., Nikiforou, M., Jellema, R. K., Niemarkt, H. J., Fuchs, C., Tservistas, M., Razetti, R., Bianco, F. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 664-9 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

Niemarkt, H. J., De Meij, T. G., van Ganzewinkel, C., de Boer, N. K. H., Andriessen, P., Hutten, M. C. & Kramer, B. W., 2019, In : Neonatology. 115, 4, p. 423-431 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Necrotizing Enterocolitis: A Clinical Review on Diagnostic Biomarkers and the Role of the Intestinal Microbiota

Niemarkt, H. J., de Meij, T. G. J., van de Velde, M. E., van der Schee, M. P., van Goudoever, J. B., Kramer, B. W., Andriessen, P. & de Boer, N. K. H., Feb 2015, In : Inflammatory Bowel Diseases. 21, 2, p. 436-444

Research output: Contribution to journalArticleAcademicpeer-review

Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

Schlepuetz, M., Rieg, A. D., Seehase, S., Spillner, J., Perez-Bouza, A., Braunschweig, T., Schroeder, T., Bernau, M., Lambermont, V., Schlumbohm, C., Sewald, K., Autschbach, R., Braun, A., Kramer, B. W., Uhlig, S. & Martin, C., 9 Oct 2012, In : PLOS ONE. 7, 10, e47344.

Research output: Contribution to journalArticleAcademicpeer-review

Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice

de Munter, J. P. J. M., Shafarevich, I., Liundup, A., Pavlov, D., Wolters, E. C., Gorlova, A., Veniaminova, E., Umriukhin, A., Kalueff, A., Svistunov, A., Kramer, B. W., Lesch, K-P. & Strekalova, T., May 2020, In : CNS Neuroscience & Therapeutics. 26, 5, p. 504-517 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Ophelders, D. R. M. G., Gussenhoven, R., Lammens, M., Kusters, B., Kemp, M. W., Newnham, J. P., Payne, M. S., Kallapur, S. G., Jobe, A. H., Zimmermann, L. J., Kramer, B. W. & Wolfs, T. G. A. M., 2 Feb 2016, In : Journal of Neuroinflammation. 13, 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

New Pharmacological Approaches in Infants with Hypoxic-Ischemic Encephalopathy

Buonocore, G., Perrone, S., Turrisi, G., Kramer, B. W. & Balduini, W., Jul 2012, In : Current Pharmaceutical Design. 18, 21, p. 3086-3100

Research output: Contribution to journalArticleAcademicpeer-review

New Surfactant with SP-B and C Analogs Gives Survival Benefit after Inactivation in Preterm Lambs

Seehase, M., Collins, J. J. P., Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Ospina, O. L., Perez-Gil, J., Bianco, F., Garzia, R., Razzetti, R. & Kramer, B. W., 16 Oct 2012, In : PLOS ONE. 7, 10, p. e47631

Research output: Contribution to journalArticleAcademicpeer-review

Oral, Nasal and Pharyngeal Exposure to Lipopolysaccharide Causes a Fetal Inflammatory Response in Sheep

Maneenil, G., Kemp, M. W., Kannan, P. S., Kramer, B. W., Saito, M., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., 20 Mar 2015, In : PLOS ONE. 10, 3, e0119281.

Research output: Contribution to journalArticleAcademicpeer-review

Ovine Fetal Thymus Response to Lipopolysaccharide-Induced Chorioamnionitis and Antenatal Corticosteroids

Kuypers, E., Collins, J. J. P., Jellema, R. K., Wolfs, T. G. A. M., Kemp, M. W., Nitsos, I., Pillow, J. J., Polglase, G. R., Newnham, J. P., Germeraad, W. T. V., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., 31 May 2012, In : PLOS ONE. 7, 5, e38257.

Research output: Contribution to journalArticleAcademicpeer-review

Pain coping strategies: Neonatal intensive care unit survivors in adolescence

van Ganzewinkel, C., Been, J. V., Dieleman, J. P., Katgert, T., Boelen-van der Loo, T., van der Pal, S. M., van Dijk, M., Kramer, B. W. & Andriessen, P., Dec 2016, In : Early Human Development. 103, p. 27-32

Research output: Contribution to journalArticleAcademicpeer-review

Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight

van Ganzewinkel, C. J. L. M., Been, J. V., Verbeek, I., van der Loo, T. B., van der Pal, S. M., Kramer, B. W. & Andriessen, P., Jul 2017, In : Early Human Development. 110, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pediatric Early Warning System Scores: Lessons to be Learned

van Sambeeck, S. J., Fuijkschot, J., Kramer, B. W. & Vos, G. D., 1 Mar 2018, In : Journal of Pediatric Intensive Care. 7, 1, p. 27-32 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pentoxifylline modulates LPS-induced hyperinflammation in monocytes of preterm infants in vitro

Schuller, S. S., Wisgrill, L., Herndl, E., Spittler, A., Forster-Waldl, E., Sadeghi, K., Kramer, B. W. & Berger, A., Aug 2017, In : Pediatric Research. 82, 2, p. 215-225 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis

Barkhuizen, M., Rodrigues, F. B., Anderson, D. G., Winkens, B., REGISTRY Investigators European, Wild, E. J., Kramer, B. W. & Gavilanes, A. W. D., Oct 2018, In : Parkinsonism & Related Disorders. 55, p. 55-60 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia

Chedraui, P., Andrade, M. E., Salazar-Pousada, D., Escobar, G. S., Hidalgo, L., Ramirez, C., Spaanderman, M. E. A., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : Gynecological Endocrinology. 31, 7, p. 569-572

Research output: Contribution to journalArticleAcademicpeer-review

Polymyxin B Agonist Capture Therapy for Intrauterine Inflammation: Proof-of-Principle in a Fetal Ovine Model

Saito, M., Payne, M. S., Miura, Y., Ireland, D. J., Stock, S., Kallapur, S. G., Kannan, P. S., Newnham, J. P., Kramer, B. W., Jobe, A. H., Keelan, J. A. & Kemp, M. W., May 2014, In : Reproductive Sciences. 21, 5, p. 623-631

Research output: Contribution to journalArticleAcademicpeer-review

Poractant alfa (Curosurf (R)) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo

Willems, C. H. M. P., Urlichs, F., Seidenspinner, S., Kunzmann, S., Speer, C. P. & Kramer, B. W., 9 Mar 2012, In : Respiratory Research. 13, p. 17

Research output: Contribution to journalArticleAcademicpeer-review

Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome

Vanterpool, S. F., Been, J. V., Houben, M. L., Nikkels, P. G. J., De Krijger, R. R., Zimmermann, L. J. I., Kramer, B. W., Progulske-Fox, A. & Reyes, L., 5 Jan 2016, In : PLOS ONE. 11, 1, e0146157.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Potential role for lipopolysaccharide in congenital sensorineural hearing loss

Smit, A. L., Stokroos, R. J., Litjens, S. G. H., Kremer, B. & Kramer, B. W., Apr 2010, In : Journal of Medical Microbiology. 59, 4, p. 377-383

Research output: Contribution to journalArticleAcademicpeer-review

Precocious Maturation of the Fetal Ovine Skin Following In Utero Exposure to LPS

Cox, T., Kallapur, S. G., Keelan, J. A., Saito, M., Jobe, A. H., Kramer, B., Nitsos, I., Li, S., Zhang, L., Yang, H. & Kemp, M. W., Mar 2011, In : Reproductive Sciences. 18, 3, p. 237A-237A

Research output: Contribution to journalArticleAcademicpeer-review

Preconditioning by Oxygen-Glucose Deprivation Preserves Cell Proliferation and Reduces Cytotoxicity in Primary Astrocyte Cultures

Nikiforou, M., Vlassaks, E., Strackx, E., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. W. D., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 1, p. 61-67

Research output: Contribution to journalArticleAcademicpeer-review

Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs

Duc Ninh Nguyen, Thymann, T., Goericke-Pesch, S. K., Ren, S., Wei, W., Skovgaard, K., Damborg, P., Brunse, A., van Gorp, C., Kramer, B. W., Wolfs, T. G. & Sangild, P. T., Nov 2018, In : American Journal of Pathology. 188, 11, p. 2629-2643 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

Barkhuizen, M., Vles, J. S. H., van Mechelen, R., Vermeer, M., Kramer, B. W., Chedraui, P., Bergs, P., van Kranen-Mastenbroek, V. H. J. M. & Gavilanes, A. W. D., Sep 2019, In : Diagnostics. 9, 3, 8 p., 123.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevalence of systemic air-embolism after prolonged cardiopulmonary resuscitation in newborns: A pilot study

Halbertsma, F. J. J., Mohns, T., Bok, L. A., Niemarkt, H. J. & Kramer, B. W., Aug 2015, In : Resuscitation. 93, p. 96-101

Research output: Contribution to journalArticleAcademicpeer-review

Prophylactic Interleukin-2 Treatment Prevents Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis

Nikiforou, M., Vanderlocht, J., Chougnet, C. A., Jellema, R. K., Ophelders, D. R. M. G., Joosten, M., Kloosterboer, N., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Kramer, B. W. & Wolfs, T. G. A. M., Sep 2015, In : Inflammatory Bowel Diseases. 21, 9, p. 2026-2038

Research output: Contribution to journalArticleAcademicpeer-review

Propofol administration to the fetal-maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest

Seehase, M., Houthuizen, P., Collins, J. J. P., Zimmermann, L. J. & Kramer, B. W., May 2016, In : Pediatric Research. 79, 5, p. 748-753

Research output: Contribution to journalArticleAcademicpeer-review

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

van Gorp, C., de Lange, I. H., Spiller, O. B., Dewez, F., Pastor, B. C., Heeren, R. M. A., Kessels, L., Kloosterboer, N., van Gemert, W. G., Beeton, M. L., Stock, S. J., Jobe, A. H., Payne, M. S., Kemp, M. W., Zimmermann, L. J., Kramer, B. W., Plat, J. & Wolfs, T. G. A. M., May 2019, In : Nutrients. 11, 5, p. 1-21 21 p., 968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model

Cetinkaya, M., Cansev, M., Cekmez, F., Tayman, C., Canpolat, F. E., Kafa, I. M., Yaylagul, E. O., Kramer, B. W. & Sarici, S. U., 4 May 2015, In : PLOS ONE. 10, 5, e0126028.

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary and systemic inflammatory responses to intra-amniotic IL-1 alpha in fetal sheep

Kallapur, S. G., Kramer, B. W., Nitsos, I., Pillow, J. J., Collins, J. J. P., Polglase, G. R., Newnham, J. P. & Jobe, A. H., Sep 2011, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 301, 3, p. L285-L295

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide

Willems, M. G. M., Kemp, M. W., Fast, L. A., Wagemaker, N. M. M., Janssen, L. E. W., Newnham, J. P., Payne, M. S., Spiller, O. B., Kallapur, S. G., Jobe, A. H., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 30 Jun 2017, In : PLOS ONE. 12, 6, 16 p., 0180114.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Regenerative Therapies in Neonatology: Clinical Perspectives

Gortner, L., Felderhoff-Mueser, U., Monz, D., Bieback, K., Klueter, H., Jellema, R., Kramer, B. W., Keller, B. M., Reiss, I. K., Horn, P. A. & Giebel, B., Jul 2012, In : Klinische Padiatrie. 224, 4, p. 233-240

Research output: Contribution to journalArticleAcademicpeer-review