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Research Output

Article

Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model

Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Jun 2016, In : Pediatric Research. 79, 6, p. 907-915

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

Engel, M., Nowacki, R. M. E., Reiss, L. K., Uhlig, S., Willems, C. H. M. P., Kloosterboer, N., van Iwaarden, J. F., Sewing, A. C. P., Seehase, M., Lambermont, V. A. C., Collins, J. J. P., Zimmermann, L. J. I., Vos, G. D. & Kramer, B. W., Feb 2013, In : Lung. 191, 1, p. 77-86

Research output: Contribution to journalArticleAcademicpeer-review

Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep

Regan, J. K., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Jan 2016, In : Reproductive Sciences. 23, 1, p. 69-80

Research output: Contribution to journalArticleAcademicpeer-review

Detection of Sepsis in Preterm Infants by Fecal Volatile Organic Compounds Analysis: A Proof of Principle Study

Berkhout, D. J. C., Niemarkt, H. J., Buijck, M., Van Weissenbruch, M. M., Brinkman, P., Benninga, M. A., van Kaam, A. H., Kramer, B. W., Andriessen, P., de Boer, N. K. H. & de Meij, T. G. J., Sep 2017, In : Journal of Pediatric Gastroenterology and Nutrition. 65, 3, p. E47-E52 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detrimental Effects of an Inhaled Phosphodiesterase-4 Inhibitor on Lung Inflammation in Ventilated Preterm Lambs Exposed to Chorioamnionitis Are Dose Dependent

Huetten, M. C., Fehrholz, M., Konrad, F. M., Ophelders, D., Kleintjes, C., Ottensmeier, B., Spiller, O. B., Glaser, K., Kramer, B. W. & Kunzmann, S., Dec 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32, 6, p. 396-404 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development of severe bronchopulmonary dysplasia is associated with alterations in fecal volatile organic compounds

Berkhout, D. J. C., Niemarkt, H. J., Benninga, M. A., Budding, A. E., van Kaam, A. H., Kramer, B. W., Pantophlet, C. M., van Weissenbruch, M. M., de Boer, N. K. H. & de Meij, T. G. J., 1 Feb 2018, In : Pediatric Research. 83, 2, p. 412-419 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dissociation of transforming growth factors beta 1 and beta 2 from surfactant protein A (SP-A) by deglycosylation or deoxycholate treatment

Willems, C. H. M. P., Kloosterboer, N., Kunzmann, S., Kramer, B. W., Zimmermann, L. J. I. & van Iwaarden, J. F., 31 Jan 2012, In : Journal of Immunological Methods. 375, 1-2, p. 111-117

Research output: Contribution to journalArticleAcademicpeer-review

Early Detection of Necrotizing Enterocolitis by Fecal Volatile Organic Compounds Analysis

de Meij, T. G. J., van der Schee, M. P. C., Berkhout, D. J. C., van de Velde, M. E., Jansen, A. E., Kramer, B. W., van Weissenbruch, M. M., van Kaam, A. H., Andriessen, P., van Goudoever, J. B., Niemarkt, H. J. & de Boer, N. K. H., Sep 2015, In : Journal of Pediatrics. 167, 3, p. 562-+

Research output: Contribution to journalArticleAcademicpeer-review

Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial

Onland, W., Cools, F., Kroon, A., Rademaker, K., Merkus, M. P., Dijk, P. H., van Straaten, H. L., Pas, A. B. T., Mohns, T., Bruneel, E., van Heijst, A. F., Kramer, B. W., Debeer, A., Zonnenberg, I., Marechal, Y., Blom, H., Plaskie, K., Offringa, M., van Kaam, A. H., Nuytemans, D. H. & 26 others, de Loo, M. V., Kemper, E. M., Vereeck, I., van der Heide-Jalving, M., de Kort, E., Cavartorta, E., Rassart, A., Eerdekens, A., Stuijvenberg, M., Matthijsse, R., de Boode, W., Niemarkt, H., van Hattum, I., Jebbink, L. G., Mulder-de Tollenaer, S. M., Tan, R., Theyskens, C., van Weissenbruch, M., Dierckx, E., Rigo, V., Vrijlandt, E., van der Tweel, I., van Baal, C., de Wildt, S., STOP-BPD Study Grp & Data Safety Monitoring Comm, 29 Jan 2019, In : JAMA-Journal of the American Medical Association. 321, 4, p. 354-363 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Chronic Carbamazepine Treatment on the ECG in Patients with Focal Seizures

Sathyaprabha, T. N., Koot, L. A. M., Hermans, B. H. M., Adoor, M., Sinha, S., Kramer, B. W., Raju, T. R., Satishchandra, P. & Delhaas, T., 1 Sep 2018, In : Clinical Drug Investigation. 38, 9, p. 845-851 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of Intra-Amniotic Lipopolysaccharide and Maternal Betamethasone on Brain Inflammation in Fetal Sheep

Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Dudink, J., Nikiforou, M., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglasem, G. R., Kemp, M. W., Saito, M., Newnham, J. P., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., 17 Dec 2013, In : PLOS ONE. 8, 12, e81644.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of intra-amniotic lipopolysaccharide exposure on the fetal lamb lung as gestation advances

Lambermont, V. A., Kuypers, E., Collins, J. J. R., Pillow, J. J., Newnham, J. P., Polglase, G. R., Nitsos, H., Kemp, M. W., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Apr 2014, In : Pediatric Research. 75, 4, p. 500-506

Research output: Contribution to journalArticleAcademicpeer-review

Effects of in utero endotoxemia on the ovine fetal brain: a model for schizophrenia?

Gantert, M., Kreczmanski, P., Kuypers, E., Jellema, R., Strackx, E., Bastian, N., Gavilanes, A. W. D., Zimmermann, L. J. I., Garnier, Y., Schmitz, C. & Kramer, B. W., 1 Jun 2012, In : Frontiers in Bioscience, Elite edition. 1, 4, p. 2845-53 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of less-invasive surfactant administration on oxygenation, pulmonary surfactant distribution, and lung compliance in spontaneously breathing preterm lambs

Niemarkt, H. J., Kuypers, E., Jellema, R., Ophelders, D., Huetten, M., Nikiforou, M., Kribs, A. & Kramer, B. W., Aug 2014, In : Pediatric Research. 76, 2, p. 166-170

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Endotracheal intubation skills of pediatricians versus anesthetists in neonates and children

van Sambeeck, S. J., van Kuijk, S. M. J., Kramer, B. W., Vermeulen, P. M. & Vos, G. D., Aug 2019, In : European Journal of Pediatrics. 178, 8, p. 1219-1227 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Mishra, P-S., Vijayalakshmi, K., Nalini, A., Sathyaprabha, T. N., Kramer, B. W., Alladi, P. A. & Raju, T. R., 16 Dec 2017, In : Journal of Neuroinflammation. 14, 18 p., 251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Expression and function of toll-like receptors in human circulating endothelial colony forming cells

Mazzucchelli, I., Lisini, D., Garofoli, F., Dragoni, S., Angelini, M., Pozzi, M., Bonetti, E., Tzialla, C., Kramer, B. W., Spinillo, A., Maccario, R., Rosti, V., Moccia, F., Borghesi, A. & Stronati, M., Nov 2015, In : Immunology Letters. 168, 1, p. 98-104

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning in rats results in a preserved placental inflammatory phenotype at birth

Sparnaaij, M. A. R., Chedraui, P., Liem, K. H., Escobar, G. S., Espinoza-Caicedo, J., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. D. W., Feb 2016, In : Placenta. 38, p. 84-92

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats

Vlassaks, E., Strackx, E., Vles, J. S. H., Nikiforou, M., Martinez-Martinez, P., Kramer, B. W. & Gavilanes, A. W. D., 26 Jan 2013, In : Journal of Neuroinflammation. 10, 14.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal responses to lipopolysaccharide-induced chorioamnionitis alter immune and airway responses in 7-week-old sheep

Lee, A. J. X., Lambermont, V. A. C., Pillow, J. J., Polglase, G. R., Nitsos, I., Newnham, J. P., Beilharz, M. W., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Apr 2011, In : American Journal of Obstetrics and Gynecology. 204, 4, p. 364

Research output: Contribution to journalArticleAcademicpeer-review

Fifty Years of Work on the Artificial Placenta: Milestones in the History of Extracorporeal Support of the Premature Newborn

Schoberer, M., Arens, J., Lohr, A., Seehase, M., Jellema, R. K., Collins, J. J., Kramer, B. W., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Jun 2012, In : Artificial Organs. 36, 6, p. 512-516

Research output: Contribution to journalArticleAcademicpeer-review

Fluconazole treatment of intrauterine Candida albicans infection in fetal sheep

Maneenil, G., Payne, M. S., Kannan, P. S., Kallapur, S. G., Kramer, B. W., Newnham, J. P., Miura, Y., Jobe, A. H. & Kemp, M. W., Jun 2015, In : Pediatric Research. 77, 6, p. 740-748

Research output: Contribution to journalArticleAcademicpeer-review

Foetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: Evidence from a sheep model of pregnancy

Kemp, M. W., Ahmed, S., Beeton, M. L., Payne, M. S., Saito, M., Miura, Y., Usuda, H., Kallapur, S. G., Kramer, B. W., Stock, S. J., Jobe, A. H., Newnham, J. P. & Spiller, O. B., Jan 2017, In : American Journal of Reproductive Immunology. 77, 1, 9 p., 12599.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fully automated predictive intelligent control of oxygenation (PRICO) in resuscitation and ventilation of preterm lambs

Hütten, M. C., Goos, T. G., Ophelders, D., Nikiforou, M., Kuypers, E., Willems, M., Niemarkt, H. J., Dankelman, J., Andriessen, P., Mohns, T., Reiss, I. K. M. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 657-63 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Functional impairment of the auditory pathway after perinatal asphyxia and the short-term effect of perinatal propofol anesthesia in lambs

Smit, A. L., Seehase, M., Stokroos, R. J., Jellema, R. K., Felipe, L., Chenault, M. N., Anteunis, L. J. C., Kremer, B. & Kramer, B. W., Jul 2013, In : Pediatric Research. 74, 1, p. 34-38

Research output: Contribution to journalArticleAcademicpeer-review

Genotype alone does not predict the clinical course of SFTPC deficiency in paediatric patients

Kroener, C., Reu, S., Teusch, V., Schams, A., Grimmelt, A-C., Barker, M., Brand, J., Gappa, M., Kitz, R., Kramer, B. W., Lange, L., Lau, S., Pfannenstiel, C., Proesmans, M., Seidenberg, J., Sismanlar, T., Aslan, A. T., Werner, C., Zielen, S., Zarbock, R. & 3 others, Brasch, F., Lohse, P. & Griese, M., Jul 2015, In : European Respiratory Journal. 46, 1, p. 197-206

Research output: Contribution to journalArticleAcademicpeer-review

Glucocorticoids potentiate IL-6-induced SP-B expression in H441 cells by enhancing the JAK-STAT signaling pathway

Ladenburger, A., Seehase, M., Kramer, B. W., Thomas, W., Wirbelauer, J., Speer, C. P. & Kunzmann, S., Oct 2010, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 299, 4, p. L578-L584

Research output: Contribution to journalArticleAcademicpeer-review

Heart rate-mediated blood pressure control in preterm fetal sheep under normal and hypoxic-ischemic conditions

Zwanenburg, A., Jellema, R. K., Jennekens, W., Ophelders, D., Vullings, R., van Hunnik, A., van Pul, C., Bennet, L., Delhaas, T., Kramer, B. W. & Andriessen, P., Apr 2013, In : Pediatric Research. 73, 4, p. 420-426

Research output: Contribution to journalArticleAcademicpeer-review

Histological villous maturation in placentas of complicated pregnancies

Vangrieken, P., Vanterpool, S. F., van Schooten, F. J., Al-Nasiry, S., Andriessen, P., Degreef, E., Alfer, J., Kramer, B. W. & von Rango, U., Aug 2020, In : Histology and Histopathology. 35, 8, p. 849-862 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

IFN-gamma and TNF-alpha Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Laug, R., Fehrholz, M., Schuetze, N., Kramer, B. W., Krump-Konvalinkova, V., Speer, C. P. & Kunzmann, S., 20 Sep 2012, In : PLOS ONE. 7, 9, e45430.

Research output: Contribution to journalArticleAcademicpeer-review

IL-1 alpha Mediated Chorioamnionitis Induces Depletion of FoxP3+Cells and Ileal Inflammation in the Ovine Fetal Gut

Wolfs, T. G. A. M., Kallapur, S. G., Polglase, G. R., Pillow, J. J., Nitsos, I., Newnham, J. P., Chougnet, C. A., Kroon, E., Spierings, J., Willems, C. H. M. P., Jobe, A. H. & Kramer, B. W., 29 Mar 2011, In : PLOS ONE. 6, 3, p. 9

Research output: Contribution to journalArticleAcademicpeer-review

Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury

Gavilanes, A. W. D., Gantert, M., Strackx, E., Zimmermann, L. J., Seeldrayers, S., Vles, J. S. H. & Kramer, B. W., 1 Jan 2010, In : Frontiers in bioscience - scholar edition. 2, p. 432-8 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis

Kaemmerer, E., Schneider, U., Klaus, C., Plum, P., Reinartz, A., Adolf, M., Renner, M., Wolfs, T. G. A. M., Kramer, B. W., Wagner, N., Mollenhauer, J. & Gassler, N., Mar 2012, In : Histopathology. 60, 4, p. 561-569

Research output: Contribution to journalArticleAcademicpeer-review

Increased Number of Cerebellar Granule Cells and Astrocytes in the Internal Granule Layer in Sheep Following Prenatal Intra-amniotic Injection of Lipopolysaccharide

Strackx, E., Gantert, M., Moers, V., van Kooten, I. A. J., Rieke, R., Hurter, H., Lemmens, M. A. M., Steinbusch, H. W. M., Zimmermann, L. J. I., Vles, J. S. H., Garnier, Y., Gavilanes, A. W. D. & Kramer, B. W., Mar 2012, In : Cerebellum. 11, 1, p. 132-144

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis

Wolfs, T. G. A. M., Jellema, R. K., Turrisi, G., Becucci, E., Buonocore, G. & Kramer, B. W., Apr 2012, In : Journal of Maternal-Fetal & Neonatal Medicine. 25, p. 8-11

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation in fetal sheep from intra-amniotic injection of Ureaplasma parvum

Collins, J. J. P., Kallapur, S. G., Knox, C. L., Nitsos, I., Polglase, G. R., Pillow, J. J., Kuypers, E., Newnham, J. P., Jobe, A. H. & Kramer, B. W., Dec 2010, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 299, 6, p. L852-L860

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation of the Fetal Ovine Skin Following in utero Exposure to Ureaplasma parvum

Kemp, M. W., Saito, M., Kallapur, S. G., Jobe, A. H., Keelan, J. A., Li, S., Kramer, B., Zhang, L., Knox, C. L., Yaegashi, N. & Newnham, J. P., Nov 2011, In : Reproductive Sciences. 18, 11, p. 1128-1137

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-1 in Lipopolysaccharide Induced Chorioamnionitis in the Fetal Sheep

Berry, C. A., Nitsos, I., Hillman, N. H., Pillow, J. J., Polglase, G. R., Kramer, B. W., Kemp, M. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Nov 2011, In : Reproductive Sciences. 18, 11, p. 1092-1102

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal fatty acid-binding protein: a possible marker for gut maturation

Reisinger, K. W., Elst, M., Derikx, J. P. M., Nikkels, P. G. J., de Vries, B., Adriaanse, M. P. M., Jellema, R. K., Kramer, B. W. W. & Wolfs, T. G. A. M., Sep 2014, In : Pediatric Research. 76, 3, p. 261-268

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine

Nikiforou, M., Jacobs, E. M. R., Kemp, M. W., Hornef, M. W., Payne, M. S., Saito, M., Newnham, J. P., Janssen, L. E. W., Jobe, A. H., Kallapur, S. G., Kramer, B. W. & Wolfs, T. G. A. M., 14 Jul 2016, In : Scientific Reports. 6, 29806.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intraamniotic Lipopolysaccharide Exposure Changes Cell Populations and Structure of the Ovine Fetal Thymus

Kuypers, E., Wolfs, T. G. A. M., Collins, J. J. P., Jellema, R. K., Newnham, J. P., Kemp, M. W., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Aug 2013, In : Reproductive Sciences. 20, 8, p. 946-956

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs

Kuypers, E., Collins, J. J. P., Kramer, B. W., Ofman, G., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Gavilanes, A. W. D., Nowacki, R., Ikegami, M., Jobe, A. H. & Kallapur, S. G., Feb 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 302, 4, p. L380-L389

Research output: Contribution to journalArticleAcademicpeer-review

Intra-Amniotic LPS Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain

Strackx, E., Jellema, R. K., Rieke, R., Gussenhoven, R., Vles, J. S. H., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : BioMed Research International. 276029.

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung

Schmidt, A. F., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Nov 2014, In : Pediatric Research. 76, 5, p. 441-447

Research output: Contribution to journalArticleAcademicpeer-review

Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep

Payne, M. S., Kemp, M. W., Kallapur, S. G., Kannan, P. S., Saito, M., Miura, Y., Newnham, J. P., Stock, S., Ireland, D. J., Kramer, B. W. & Jobe, A. H., Jun 2014, In : Pediatric Research. 75, 6, p. 716-722

Research output: Contribution to journalArticleAcademicpeer-review

Intrauterine Lipopolysaccharide-Induced Chorioamnionitis in a Sheep: Does It Affect the Auditory System?

Smit, A. L., Lambermont, V. A., Stokroos, R. J., Anteunis, L. J. C., Chenault, M., Schaefer, S. M., Schoenmakers, L. W. G., Kremer, B. & Kramer, B. W., Feb 2016, In : Reproductive Sciences. 23, 2, p. 257-263

Research output: Contribution to journalArticleAcademicpeer-review

Introduction of less invasive surfactant administration (LISA), impact on diagnostic and therapeutic procedures in early life: a historical cohort study

Bugter, I. A. L., Janssen, L. C. E., Dieleman, J., Kramer, B. W., Andriessen, P. & Niemarkt, H. J., 3 Sep 2020, In : Bmc Pediatrics. 20, 1, 9 p., 421.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In Vivo Evaluation of the Acute Pulmonary Response to Poractant Alfa and Bovactant Treatments in Lung-Lavaged Adult Rabbits and in Preterm Lambs with Respiratory Distress Syndrome

Ricci, F., Salomone, F., Kuypers, E., Ophelders, D., Nikiforou, M., Willems, M., Krieger, T., Murgia, X., Huetten, M., Kramer, B. W. & Bianco, F., 31 Aug 2017, In : Frontiers in pediatrics. 5, 10 p., 186.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access