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Research Output

Article

Necrotizing Enterocolitis, Gut Microbiota, and Brain Development: Role of the Brain-Gut Axis

Niemarkt, H. J., De Meij, T. G., van Ganzewinkel, C., de Boer, N. K. H., Andriessen, P., Hutten, M. C. & Kramer, B. W., 2019, In : Neonatology. 115, 4, p. 423-431 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Necrotizing Enterocolitis: A Clinical Review on Diagnostic Biomarkers and the Role of the Intestinal Microbiota

Niemarkt, H. J., de Meij, T. G. J., van de Velde, M. E., van der Schee, M. P., van Goudoever, J. B., Kramer, B. W., Andriessen, P. & de Boer, N. K. H., Feb 2015, In : Inflammatory Bowel Diseases. 21, 2, p. 436-444

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

Schlepuetz, M., Rieg, A. D., Seehase, S., Spillner, J., Perez-Bouza, A., Braunschweig, T., Schroeder, T., Bernau, M., Lambermont, V., Schlumbohm, C., Sewald, K., Autschbach, R., Braun, A., Kramer, B. W., Uhlig, S. & Martin, C., 9 Oct 2012, In : PLOS ONE. 7, 10, e47344.

Research output: Contribution to journalArticleAcademicpeer-review

Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice

de Munter, J. P. J. M., Shafarevich, I., Liundup, A., Pavlov, D., Wolters, E. C., Gorlova, A., Veniaminova, E., Umriukhin, A., Kalueff, A., Svistunov, A., Kramer, B. W., Lesch, K-P. & Strekalova, T., May 2020, In : CNS Neuroscience & Therapeutics. 26, 5, p. 504-517 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Ophelders, D. R. M. G., Gussenhoven, R., Lammens, M., Kusters, B., Kemp, M. W., Newnham, J. P., Payne, M. S., Kallapur, S. G., Jobe, A. H., Zimmermann, L. J., Kramer, B. W. & Wolfs, T. G. A. M., 2 Feb 2016, In : Journal of Neuroinflammation. 13, 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

New Pharmacological Approaches in Infants with Hypoxic-Ischemic Encephalopathy

Buonocore, G., Perrone, S., Turrisi, G., Kramer, B. W. & Balduini, W., Jul 2012, In : Current Pharmaceutical Design. 18, 21, p. 3086-3100

Research output: Contribution to journalArticleAcademicpeer-review

New Surfactant with SP-B and C Analogs Gives Survival Benefit after Inactivation in Preterm Lambs

Seehase, M., Collins, J. J. P., Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Ospina, O. L., Perez-Gil, J., Bianco, F., Garzia, R., Razzetti, R. & Kramer, B. W., 16 Oct 2012, In : PLOS ONE. 7, 10, p. e47631

Research output: Contribution to journalArticleAcademicpeer-review

Oral, Nasal and Pharyngeal Exposure to Lipopolysaccharide Causes a Fetal Inflammatory Response in Sheep

Maneenil, G., Kemp, M. W., Kannan, P. S., Kramer, B. W., Saito, M., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., 20 Mar 2015, In : PLOS ONE. 10, 3, e0119281.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Ovine Fetal Thymus Response to Lipopolysaccharide-Induced Chorioamnionitis and Antenatal Corticosteroids

Kuypers, E., Collins, J. J. P., Jellema, R. K., Wolfs, T. G. A. M., Kemp, M. W., Nitsos, I., Pillow, J. J., Polglase, G. R., Newnham, J. P., Germeraad, W. T. V., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., 31 May 2012, In : PLOS ONE. 7, 5, e38257.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Pain coping strategies: Neonatal intensive care unit survivors in adolescence

van Ganzewinkel, C., Been, J. V., Dieleman, J. P., Katgert, T., Boelen-van der Loo, T., van der Pal, S. M., van Dijk, M., Kramer, B. W. & Andriessen, P., Dec 2016, In : Early Human Development. 103, p. 27-32

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight

van Ganzewinkel, C. J. L. M., Been, J. V., Verbeek, I., van der Loo, T. B., van der Pal, S. M., Kramer, B. W. & Andriessen, P., Jul 2017, In : Early Human Development. 110, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pediatric Early Warning System Scores: Lessons to be Learned

van Sambeeck, S. J., Fuijkschot, J., Kramer, B. W. & Vos, G. D., 1 Mar 2018, In : Journal of Pediatric Intensive Care. 7, 1, p. 27-32 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pentoxifylline modulates LPS-induced hyperinflammation in monocytes of preterm infants in vitro

Schuller, S. S., Wisgrill, L., Herndl, E., Spittler, A., Forster-Waldl, E., Sadeghi, K., Kramer, B. W. & Berger, A., Aug 2017, In : Pediatric Research. 82, 2, p. 215-225 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis

Barkhuizen, M., Rodrigues, F. B., Anderson, D. G., Winkens, B., REGISTRY Investigators European, Wild, E. J., Kramer, B. W. & Gavilanes, A. W. D., Oct 2018, In : Parkinsonism & Related Disorders. 55, p. 55-60 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia

Chedraui, P., Andrade, M. E., Salazar-Pousada, D., Escobar, G. S., Hidalgo, L., Ramirez, C., Spaanderman, M. E. A., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : Gynecological Endocrinology. 31, 7, p. 569-572

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Polymyxin B Agonist Capture Therapy for Intrauterine Inflammation: Proof-of-Principle in a Fetal Ovine Model

Saito, M., Payne, M. S., Miura, Y., Ireland, D. J., Stock, S., Kallapur, S. G., Kannan, P. S., Newnham, J. P., Kramer, B. W., Jobe, A. H., Keelan, J. A. & Kemp, M. W., May 2014, In : Reproductive Sciences. 21, 5, p. 623-631

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Poractant alfa (Curosurf (R)) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo

Willems, C. H. M. P., Urlichs, F., Seidenspinner, S., Kunzmann, S., Speer, C. P. & Kramer, B. W., 9 Mar 2012, In : Respiratory Research. 13, p. 17

Research output: Contribution to journalArticleAcademicpeer-review

Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome

Vanterpool, S. F., Been, J. V., Houben, M. L., Nikkels, P. G. J., De Krijger, R. R., Zimmermann, L. J. I., Kramer, B. W., Progulske-Fox, A. & Reyes, L., 5 Jan 2016, In : PLOS ONE. 11, 1, e0146157.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Potential role for lipopolysaccharide in congenital sensorineural hearing loss

Smit, A. L., Stokroos, R. J., Litjens, S. G. H., Kremer, B. & Kramer, B. W., Apr 2010, In : Journal of Medical Microbiology. 59, 4, p. 377-383

Research output: Contribution to journalArticleAcademicpeer-review

Precocious Maturation of the Fetal Ovine Skin Following In Utero Exposure to LPS

Cox, T., Kallapur, S. G., Keelan, J. A., Saito, M., Jobe, A. H., Kramer, B., Nitsos, I., Li, S., Zhang, L., Yang, H. & Kemp, M. W., Mar 2011, In : Reproductive Sciences. 18, 3, p. 237A-237A

Research output: Contribution to journalArticleAcademicpeer-review

Preconditioning by Oxygen-Glucose Deprivation Preserves Cell Proliferation and Reduces Cytotoxicity in Primary Astrocyte Cultures

Nikiforou, M., Vlassaks, E., Strackx, E., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. W. D., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 1, p. 61-67

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Prenatal Intra-Amniotic Endotoxin Induces Fetal Gut and Lung Immune Responses and Postnatal Systemic Inflammation in Preterm Pigs

Duc Ninh Nguyen, Thymann, T., Goericke-Pesch, S. K., Ren, S., Wei, W., Skovgaard, K., Damborg, P., Brunse, A., van Gorp, C., Kramer, B. W., Wolfs, T. G. & Sangild, P. T., Nov 2018, In : American Journal of Pathology. 188, 11, p. 2629-2643 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats

Barkhuizen, M., Vles, J. S. H., van Mechelen, R., Vermeer, M., Kramer, B. W., Chedraui, P., Bergs, P., van Kranen-Mastenbroek, V. H. J. M. & Gavilanes, A. W. D., Sep 2019, In : Diagnostics. 9, 3, 8 p., 123.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prevalence of systemic air-embolism after prolonged cardiopulmonary resuscitation in newborns: A pilot study

Halbertsma, F. J. J., Mohns, T., Bok, L. A., Niemarkt, H. J. & Kramer, B. W., Aug 2015, In : Resuscitation. 93, p. 96-101

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Prophylactic Interleukin-2 Treatment Prevents Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis

Nikiforou, M., Vanderlocht, J., Chougnet, C. A., Jellema, R. K., Ophelders, D. R. M. G., Joosten, M., Kloosterboer, N., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Kramer, B. W. & Wolfs, T. G. A. M., Sep 2015, In : Inflammatory Bowel Diseases. 21, 9, p. 2026-2038

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Propofol administration to the fetal-maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest

Seehase, M., Houthuizen, P., Collins, J. J. P., Zimmermann, L. J. & Kramer, B. W., May 2016, In : Pediatric Research. 79, 5, p. 748-753

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

van Gorp, C., de Lange, I. H., Spiller, O. B., Dewez, F., Pastor, B. C., Heeren, R. M. A., Kessels, L., Kloosterboer, N., van Gemert, W. G., Beeton, M. L., Stock, S. J., Jobe, A. H., Payne, M. S., Kemp, M. W., Zimmermann, L. J., Kramer, B. W., Plat, J. & Wolfs, T. G. A. M., May 2019, In : Nutrients. 11, 5, p. 1-21 21 p., 968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model

Cetinkaya, M., Cansev, M., Cekmez, F., Tayman, C., Canpolat, F. E., Kafa, I. M., Yaylagul, E. O., Kramer, B. W. & Sarici, S. U., 4 May 2015, In : PLOS ONE. 10, 5, e0126028.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Pulmonary and systemic inflammatory responses to intra-amniotic IL-1 alpha in fetal sheep

Kallapur, S. G., Kramer, B. W., Nitsos, I., Pillow, J. J., Collins, J. J. P., Polglase, G. R., Newnham, J. P. & Jobe, A. H., Sep 2011, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 301, 3, p. L285-L295

Research output: Contribution to journalArticleAcademicpeer-review

Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide

Willems, M. G. M., Kemp, M. W., Fast, L. A., Wagemaker, N. M. M., Janssen, L. E. W., Newnham, J. P., Payne, M. S., Spiller, O. B., Kallapur, S. G., Jobe, A. H., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 30 Jun 2017, In : PLOS ONE. 12, 6, 16 p., 0180114.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Regenerative Therapies in Neonatology: Clinical Perspectives

Gortner, L., Felderhoff-Mueser, U., Monz, D., Bieback, K., Klueter, H., Jellema, R., Kramer, B. W., Keller, B. M., Reiss, I. K., Horn, P. A. & Giebel, B., Jul 2012, In : Klinische Padiatrie. 224, 4, p. 233-240

Research output: Contribution to journalArticleAcademicpeer-review

Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs

Gisslen, T., Hillman, N. H., Musk, G. C., Kemp, M. W., Kramer, B. W., Senthamaraikannan, P., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Feb 2014, In : Innate Immunity. 20, 2, p. 214-224

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Repeated Intrauterine Exposures to Inflammatory Stimuli Attenuated Transforming Growth Factor-beta Signaling in the Ovine Fetal Lung

Collins, J. J. P., Kallapur, S. G., Knox, C. L., Kemp, M. W., Kuypers, E., Zimmermann, L. J. I., Newnham, J. P., Jobe, A. H. & Kramer, B. W., 2013, In : Neonatology. 104, 1, p. 49-55

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Responses of the spleen to intraamniotic lipopolysaccharide exposure in fetal sheep

Kuypers, E., Willems, M. G. M., Jellema, R. K., Kemp, M. W., Newnham, J. P., Delhaas, T., Kallapur, S. G., Jobe, A. H., Wolfs, T. G. A. M. & Kramer, B. W., Jan 2015, In : Pediatric Research. 77, 1, p. 29-35

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Risk Factors for Late-Onset Sepsis in Preterm Infants: A Multicenter Case-Control Study

el Hassani, S. E. M., Berkhout, D. J. C., Niemarkt, H. J., Mann, S., de Boode, W. P., Cossey, V., Hulzebos, C. V., van Kaam, A. H., Kramer, B. W., van Lingen, R. A., van Goudoever, J. B., Vijlbrief, D. C., van Weissenbruch, M. M., Benninga, M. A., de Boer, N. K. H. & de Meij, T. G. J., 2019, In : Neonatology. 116, 1, p. 42-51 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Risk of adverse pregnancy outcomes in women with periodontal disease and the effectiveness of interventions in decreasing this risk: protocol for systematic overview of systematic reviews

Vanterpool, S., Tomsin, K., Reyes, L., Zimmermann, L., Kramer, B. & Been, J., 2016, In : Systematic Reviews. 5, 6 p., 16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Selective Exposure of the Fetal Lung and Skin/Amnion (but Not Gastro-Intestinal Tract) to LPS Elicits Acute Systemic Inflammation in Fetal Sheep

Kemp, M. W., Kannan, P. S., Saito, M., Newnham, J. P., Cox, T., Jobe, A. H., Kramer, B. W. & Kallapur, S. G., 17 May 2013, In : PLOS ONE. 8, 5, e63355.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep

Nikiforou, M., Kemp, M. W., van Gorp, R., Saito, M., Newnham, J. P., Reynaert, N. L., Janssen, L. E., Jobe, A. H., Kallapur, S. G., Kramer, B. & Wolfs, T., Jan 2016, In : Laboratory Investigation. 96, 1, p. 69-80 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Sex Differences in Lung Gas Volumes After Lipopolysaccharide-Induced Chorioamnionitis in Fetal Sheep

Lambermont, V. A. C., Been, J. V., Kunzmann, S., Vanterpool, S. F., Newnham, J. P., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Aug 2012, In : Gender Medicine. 9, 4, p. 278-286

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Standardized human bone marrow-derived stem cells infusion improves survival and recovery in a rat model of spinal cord injury

de Munter, J. P., Beugels, J., Munter, S., Jansen, L., Cillero-Pastor, B., Moskvin, O., Brook, G., Pavlov, D., Strekalova, T., Kramer, B. W. & Wolters, E. C., 15 Jul 2019, In : Journal of the Neurological Sciences. 402, p. 16-29 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

ST waveform analysis for monitoring hypoxic distress in fetal sheep after prolonged umbilical cord occlusion

Andriessen, P., Zwanenburg, A., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., 16 Apr 2018, In : PLOS ONE. 13, 4, 14 p., e0195978.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications

Niemarkt, H. J., Hutten, M. C. & Kramer, B. W., 2017, In : Neonatology. 111, 4, p. 408-414 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Surfactant protein A binds TGF-beta 1 with high affinity and stimulates the TGF-beta pathway

Willems, C. H. M. P., Zimmermann, L. J. I., Kloosterboer, N., Kramer, B. W. & van Iwaarden, J. F., Feb 2014, In : Innate Immunity. 20, 2, p. 192-199

Research output: Contribution to journalArticleAcademicpeer-review

Surfactant Protein A Influences Reepithelialization in an Alveolocapillary Model System

Willems, C. H. M. P., Zimmermann, L. J. I., Langen, R. M. R., van den Bosch, M. J. A., Kloosterboer, N., Kramer, B. W. & van Iwaarden, J. F., Dec 2012, In : Lung. 190, 6, p. 661-669

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic Effect of Caffeine and Glucocorticoids on Expression of Surfactant Protein B (SP-B) mRNA

Fehrholz, M., Bersani, I., Kramer, B. W., Speer, C. P. & Kunzmann, S., 14 Dec 2012, In : PLOS ONE. 7, 12, e51575.

Research output: Contribution to journalArticleAcademicpeer-review

Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia

Jellema, R. K., Passos, V. L., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Zwanenburg, A., De Munter, S., Nikiforou, M., Collins, J. J. P., Kuypers, E., Bos, G. M. J., Steinbusch, H. W., Vanderlocht, J., Andriessen, P., Germeraad, W. T. V. & Kramer, B. W., Dec 2013, In : Experimental Neurology. 250, p. 293-303

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial

Onland, W., Offringa, M., Cools, F., De Jaegere, A. P., Rademaker, K., Blom, H., Cavatorta, E., Debeer, A., Dijk, P. H., van Heijst, A. F., Kramer, B. W., Kroon, A. A., Mohns, T., van Straaten, H. L. M., te Pas, A. B., Theyskens, C., van Weissenbruch, M. M. & van Kaam, A. H., 9 Nov 2011, In : Bmc Pediatrics. 11, 1, p. 102

Research output: Contribution to journalArticleAcademicpeer-review

Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetus

Willems, M. G. M., Ophelders, D. R. M. G., Nikiforou, M., Jellema, R. K., Butz, A., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 1 Jan 2016, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 310, 1, p. L1-L7

Research output: Contribution to journalArticleAcademicpeer-review

Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy

Barkhuizen, M., van Mechelen, R., Vermeer, M., Chedraui, P., Paes, D., van den Hove, D. L. A., Vaes, B., Mays, R. W., Steinbusch, H. W. M., Robertson, N. J., Kramer, B. W. & Gavilanes, A. W. D., 19 Apr 2019, In : Behavioural Brain Research. 362, p. 77-81 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access