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Research Output

Article

Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

Martinello, K. A., Meehan, C., Avdic-Belltheus, A., Lingam, I., Ragab, S., Hristova, M., Tann, C. J., Peebles, D., Hagberg, H., Wolfs, T. G. A. M., Klein, N., Tachtsidis, I., Golay, X., Kramer, B. W., Fleiss, B., Gressens, P. & Robertson, N. J., 15 Jul 2019, In : Scientific Reports. 9, 17 p., 10184.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Airway Angiopoietin-2 in Ventilated Very Preterm Infants: Association With Prenatal Factors and Neonatal Outcome

Thomas, W., Seidenspinner, S., Kramer, B. W., Wirbelauer, J., Kawczynska-Leda, N., Szymankiewicz, M. & Speer, C. P., Aug 2011, In : Pediatric Pulmonology. 46, 8, p. 777-784

Research output: Contribution to journalArticleAcademicpeer-review

Altered canonical Wingless-It signaling in the ovine fetal lung after exposure to intra-amniotic lipopolysaccharide and antenatal betamethasone

Kuypers, E., Willems, M. G. M., Collins, J. J. P., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Delhaas, T., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Feb 2014, In : Pediatric Research. 75, 2, p. 281-287

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Amplification of steroid-mediated SP-B expression by physiological levels of caffeine

Fehrholz, M., Huetten, M., Kramer, B. W., Speer, C. P. & Kunzmann, S., Jan 2014, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 306, 1, p. L101-L109

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Antenatal Corticosteroid Exposure Disrupts Myelination in the Auditory Nerve of Preterm Sheep

Rittenschober-Bohm, J., Rodger, J., Jobe, A. H., Kallapur, S. G., Doherty, D. A., Kramer, B. W., Payne, M. S., Archer, M., Rittenschober, C., Newnham, J. P., Miura, Y., Berger, A., Matthews, S. G. & Kemp, M. W., 1 Jan 2018, In : Neonatology. 114, 1, p. 62-68 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal dexamethasone vs. betamethasone dosing for lung maturation in fetal sheep

Schmidt, A. F., Kemp, M. W., Kannan, P. S., Kramer, B. W., Newnham, J. R., Kallapur, S. G. & Jobe, A. H., Mar 2017, In : Pediatric Research. 81, 3, p. 496-503 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal glucocorticoids counteract LPS changes in TGF-beta pathway and caveolin-1 in ovine fetal lung

Collins, J. J. P., Kunzmann, S., Kuypers, E., Kemp, M. W., Speer, C. P., Newnham, J. P., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Mar 2013, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 304, 6, p. L438-L444

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Antenatal Inflammation Reduces Expression of Caveolin-1 and Influences Multiple Signaling Pathways in Preterm Fetal Lungs

Kunzmann, S., Collins, J. J. P., Yang, Y., Uhlig, S., Kallapur, S. G., Speer, C. P., Jobe, A. H. & Kramer, B. W., Nov 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 5, p. 969-976

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis

Been, J. V., Degraeuwe, P. L., Kramer, B. W. & Zimmermann, L. J. I., Jan 2011, In : Bjog-an International Journal of Obstetrics and Gynaecology. 118, 2, p. 113-122

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner

Wolfs, T. G. A. M., Kallapur, S. G., Knox, C. L., Thuijls, G., Nitsos, I., Polglase, G. R., Collins, J. J. P., Kroon, E., Spierings, J., Shroyer, N. F., Newnham, J. P., Jobe, A. H. & Kramer, B. W., May 2013, In : Mucosal Immunology. 6, 3, p. 547-556

Research output: Contribution to journalArticleAcademicpeer-review

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Boerger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., O'Driscoll, L., Fais, S., Falcon-Perez, J. M., Felderhoff-Mueser, U., Fraile, L., Gho, Y. S., Goergens, A., Gupta, R. C., Hendrix, A., Hermann, D. M. & 36 others, Hill, A. F., Hochberg, F., Horn, P. A., de Kleijn, D., Kordelas, L., Kramer, B. W., Kraemer-Albers, E-M., Laner-Plamberger, S., Laitinen, S., Leonardi, T., Lorenowicz, M. J., Lim, S. K., Lotvall, J., Maguire, C. A., Marcilla, A., Nazarenko, I., Ochiya, T., Patel, T., Pedersen, S., Pocsfalvi, G., Pluchino, S., Quesenberry, P., Reischl, I. G., Rivera, F. J., Sanzenbacher, R., Schallmoser, K., Slaper-Cortenbach, I., Strunk, D., Tonn, T., Vader, P., van Balkom, B. W. M., Wauben, M., El Andaloussi, S., Thery, C., Rohde, E. & Giebel, B., 2015, In : Journal of Extracellular Vesicles . 4, 30087.

Research output: Contribution to journalArticleAcademicpeer-review

Artifacts in pulse transit time measurements using standard patient monitoring equipment

Bennis, F. C., van Pul, C., van den Bogaart, J. J. L., Andriessen, P., Kramer, B. W. & Delhaas, T., 21 Jun 2019, In : PLOS ONE. 14, 6, 10 p., 0218784.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Bacterial reprogramming of PBMCs impairs monocyte phagocytosis and modulates adaptive T cell responses

Andre, M. C., Gille, C., Glemser, P., Woiterski, J., Hsu, H-Y., Spring, B., Keppeler, H., Kramer, B. W., Handgretinger, R., Poets, C. F., Lauber, K. & Orlikowsky, T. W., Jun 2012, In : Journal of Leukocyte Biology. 91, 6, p. 977-989

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line

Shruthi, S., Sumitha, R., Varghese, A. M., Ashok, S., Sagar, B. K. C., Sathyaprabha, T. N., Nalini, A., Kramer, B. W., Raju, T. R., Vijayalakshmi, K. & Alladi, P. A., 2017, In : Neurodegenerative Diseases. 17, 1, p. 44-58 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Breast-Feeding Improves Gut Maturation Compared With Formula Feeding in Preterm Babies

Reisinger, K. W., de Vaan, L., Kramer, B. W., Wolfs, T. G. A. M., van Heurn, E. & Derikx, J. P. M., Dec 2014, In : Journal of Pediatric Gastroenterology and Nutrition. 59, 6, p. 720-724

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Bronchopulmonary Dysplasia and Ureaplasma: What Do We Know So Far?

De La Haye, N., Hütten, M. C., Kunzmann, S. & Kramer, B. W., 27 Feb 2017, In : Neonatal Medicine. 24, 1, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Can the preterm lung recover from perinatal stress?

Hütten, M., Wolfs, T. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., De Munter, S., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., Jennekens, W., Gavilanes, A. W. D., Seehase, M., Vles, H. J., Steinbusch, H., Andriessen, P., Wolfs, T. G. A. M. & Kramer, B. W., 24 Jan 2013, In : Journal of Neuroinflammation. 10, 13.

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells

Sumitha, R., Manjunatha, V. M., Sabitha, R. K., Alladi, P. A., Nalini, A., Rao, L. T., Sagar, B. K. C., Steinbusch, H. W. M., Kramer, B. W., Sathyaprabha, T. N. & Raju, T. R., Feb 2019, In : Molecular Neurobiology. 56, 2, p. 1014-1034 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus

Gussenhoven, R., Westerlaken, R. J. J., Ophelders, D. R. M. G., Jobe, A. H., Kemp, M. W., Kallapur, S. G., Zimmermann, L. J., Sangild, P. T., Pankratova, S., Gressens, P., Kramer, B. W., Fleiss, B. & Wolfs, T. G. A. M., 19 Apr 2018, In : Journal of Neuroinflammation. 15, 13 p., 113.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Chorioamnionitis: a multiorgan disease of the fetus?

Gantert, M., Been, J. V., Gavilanes, A. W. D., Garnier, Y., Zimmermann, L. J. I. & Kramer, B. W., Oct 2010, In : Journal of Perinatology. 30, p. S21-S30

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis as a Risk Factor for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis

Been, J. V., Lievense, S., Zimmermann, L. J. I., Kramer, B. W. & Wolfs, T. G. A. M., Feb 2013, In : The Journal of Pediatrics. 162, 2, p. 236-242

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation

Wolfs, T. G. A. M., Kramer, B. W., Thuijls, G., Kemp, M. W., Saito, M., Willems, M. G. M., Senthamarai-Kannan, P., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Mar 2014, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 306, 5, p. G382-G393

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Chorioamnionitis - New Ideas from Experimental Models

Kramer, B. W., 2011, In : Neonatology. 99, 4, p. 320-325

Research output: Contribution to journalArticleAcademicpeer-review

Chronic Fetal Exposure to Ureaplasma parvum Suppresses Innate Immune Responses in Sheep

Kallapur, S. G., Kramer, B. W., Knox, C. L., Berry, C. A., Collins, J. J. P., Kemp, M. W., Nitsos, I., Polglase, G. R., Robinson, J., Hillman, N. H., Newnham, J. P., Chougnet, C. A. & Jobe, A. H., 1 Sep 2011, In : Journal of Immunology. 187, 5, p. 2688-2695

Research output: Contribution to journalArticleAcademicpeer-review

Chronic Pain in the Newborn Toward a Definition

van Ganzewinkel, C., Anand, K. J. S., Kramer, B. W. & Andriessen, P., Nov 2014, In : Clinical Journal of Pain. 30, 11, p. 970-977

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Classic Galactosemia: Study on the Late Prenatal Development of GALT Specific Activity in a Sheep Model

Coelho, A. I., Bierau, J., Lindhout, M., Achten, J., Kramer, B. W. & Rubio-Gozalbo, M. E., Sep 2017, In : The Anatomical Record: advances in integrative anatomy and evolutionary biology. 300, 9, p. 1570-1575 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of airway responses in sheep of different age in precision-cut lung slices (PCLS)

Lambermont, V. A., Schleputz, M., Dassow, C., Konig, P., Zimmermann, L. J., Uhlig, S., Kramer, B. W. W. & Martin, C., 17 Sep 2014, In : PLOS ONE. 9, 9, 8 p., e97610.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model

Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Jun 2016, In : Pediatric Research. 79, 6, p. 907-915

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

Engel, M., Nowacki, R. M. E., Reiss, L. K., Uhlig, S., Willems, C. H. M. P., Kloosterboer, N., van Iwaarden, J. F., Sewing, A. C. P., Seehase, M., Lambermont, V. A. C., Collins, J. J. P., Zimmermann, L. J. I., Vos, G. D. & Kramer, B. W., Feb 2013, In : Lung. 191, 1, p. 77-86

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep

Regan, J. K., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Jan 2016, In : Reproductive Sciences. 23, 1, p. 69-80

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Detection of Sepsis in Preterm Infants by Fecal Volatile Organic Compounds Analysis: A Proof of Principle Study

Berkhout, D. J. C., Niemarkt, H. J., Buijck, M., Van Weissenbruch, M. M., Brinkman, P., Benninga, M. A., van Kaam, A. H., Kramer, B. W., Andriessen, P., de Boer, N. K. H. & de Meij, T. G. J., Sep 2017, In : Journal of Pediatric Gastroenterology and Nutrition. 65, 3, p. E47-E52 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detrimental Effects of an Inhaled Phosphodiesterase-4 Inhibitor on Lung Inflammation in Ventilated Preterm Lambs Exposed to Chorioamnionitis Are Dose Dependent

Huetten, M. C., Fehrholz, M., Konrad, F. M., Ophelders, D., Kleintjes, C., Ottensmeier, B., Spiller, O. B., Glaser, K., Kramer, B. W. & Kunzmann, S., Dec 2019, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32, 6, p. 396-404 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development of severe bronchopulmonary dysplasia is associated with alterations in fecal volatile organic compounds

Berkhout, D. J. C., Niemarkt, H. J., Benninga, M. A., Budding, A. E., van Kaam, A. H., Kramer, B. W., Pantophlet, C. M., van Weissenbruch, M. M., de Boer, N. K. H. & de Meij, T. G. J., 1 Feb 2018, In : Pediatric Research. 83, 2, p. 412-419 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Dissociation of transforming growth factors beta 1 and beta 2 from surfactant protein A (SP-A) by deglycosylation or deoxycholate treatment

Willems, C. H. M. P., Kloosterboer, N., Kunzmann, S., Kramer, B. W., Zimmermann, L. J. I. & van Iwaarden, J. F., 31 Jan 2012, In : Journal of Immunological Methods. 375, 1-2, p. 111-117

Research output: Contribution to journalArticleAcademicpeer-review

Early Detection of Necrotizing Enterocolitis by Fecal Volatile Organic Compounds Analysis

de Meij, T. G. J., van der Schee, M. P. C., Berkhout, D. J. C., van de Velde, M. E., Jansen, A. E., Kramer, B. W., van Weissenbruch, M. M., van Kaam, A. H., Andriessen, P., van Goudoever, J. B., Niemarkt, H. J. & de Boer, N. K. H., Sep 2015, In : Journal of Pediatrics. 167, 3, p. 562-+

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial

Onland, W., Cools, F., Kroon, A., Rademaker, K., Merkus, M. P., Dijk, P. H., van Straaten, H. L., Pas, A. B. T., Mohns, T., Bruneel, E., van Heijst, A. F., Kramer, B. W., Debeer, A., Zonnenberg, I., Marechal, Y., Blom, H., Plaskie, K., Offringa, M., van Kaam, A. H., Nuytemans, D. H. & 24 others, de Loo, M. V., Kemper, E. M., Vereeck, I., van der Heide-Jalving, M., de Kort, E., Cavartorta, E., Rassart, A., Eerdekens, A., Stuijvenberg, M., Matthijsse, R., de Boode, W., Niemarkt, H., van Hattum, I., Jebbink, L. G., Mulder-de Tollenaer, S. M., Tan, R., Theyskens, C., van Weissenbruch, M., Dierckx, E., Rigo, V., Vrijlandt, E., van der Tweel, I., van Baal, C. & de Wildt, S., 29 Jan 2019, In : JAMA-Journal of the American Medical Association. 321, 4, p. 354-363 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Chronic Carbamazepine Treatment on the ECG in Patients with Focal Seizures

Sathyaprabha, T. N., Koot, L. A. M., Hermans, B. H. M., Adoor, M., Sinha, S., Kramer, B. W., Raju, T. R., Satishchandra, P. & Delhaas, T., 1 Sep 2018, In : Clinical Drug Investigation. 38, 9, p. 845-851 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of Intra-Amniotic Lipopolysaccharide and Maternal Betamethasone on Brain Inflammation in Fetal Sheep

Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Dudink, J., Nikiforou, M., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglasem, G. R., Kemp, M. W., Saito, M., Newnham, J. P., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., 17 Dec 2013, In : PLOS ONE. 8, 12, e81644.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of intra-amniotic lipopolysaccharide exposure on the fetal lamb lung as gestation advances

Lambermont, V. A., Kuypers, E., Collins, J. J. R., Pillow, J. J., Newnham, J. P., Polglase, G. R., Nitsos, H., Kemp, M. W., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Apr 2014, In : Pediatric Research. 75, 4, p. 500-506

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Effects of in utero endotoxemia on the ovine fetal brain: a model for schizophrenia?

Gantert, M., Kreczmanski, P., Kuypers, E., Jellema, R., Strackx, E., Bastian, N., Gavilanes, A. W. D., Zimmermann, L. J. I., Garnier, Y., Schmitz, C. & Kramer, B. W., 1 Jun 2012, In : Frontiers in Bioscience, Elite edition. 1, 4, p. 2845-53 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of less-invasive surfactant administration on oxygenation, pulmonary surfactant distribution, and lung compliance in spontaneously breathing preterm lambs

Niemarkt, H. J., Kuypers, E., Jellema, R., Ophelders, D., Huetten, M., Nikiforou, M., Kribs, A. & Kramer, B. W., Aug 2014, In : Pediatric Research. 76, 2, p. 166-170

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
Open Access

Endotracheal intubation skills of pediatricians versus anesthetists in neonates and children

van Sambeeck, S. J., van Kuijk, S. M. J., Kramer, B. W., Vermeulen, P. M. & Vos, G. D., Aug 2019, In : European Journal of Pediatrics. 178, 8, p. 1219-1227 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Mishra, P-S., Vijayalakshmi, K., Nalini, A., Sathyaprabha, T. N., Kramer, B. W., Alladi, P. A. & Raju, T. R., 16 Dec 2017, In : Journal of Neuroinflammation. 14, 18 p., 251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Expression and function of toll-like receptors in human circulating endothelial colony forming cells

Mazzucchelli, I., Lisini, D., Garofoli, F., Dragoni, S., Angelini, M., Pozzi, M., Bonetti, E., Tzialla, C., Kramer, B. W., Spinillo, A., Maccario, R., Rosti, V., Moccia, F., Borghesi, A. & Stronati, M., Nov 2015, In : Immunology Letters. 168, 1, p. 98-104

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning in rats results in a preserved placental inflammatory phenotype at birth

Sparnaaij, M. A. R., Chedraui, P., Liem, K. H., Escobar, G. S., Espinoza-Caicedo, J., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. D. W., Feb 2016, In : Placenta. 38, p. 84-92

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats

Vlassaks, E., Strackx, E., Vles, J. S. H., Nikiforou, M., Martinez-Martinez, P., Kramer, B. W. & Gavilanes, A. W. D., 26 Jan 2013, In : Journal of Neuroinflammation. 10, 14.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal responses to lipopolysaccharide-induced chorioamnionitis alter immune and airway responses in 7-week-old sheep

Lee, A. J. X., Lambermont, V. A. C., Pillow, J. J., Polglase, G. R., Nitsos, I., Newnham, J. P., Beilharz, M. W., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Apr 2011, In : American Journal of Obstetrics and Gynecology. 204, 4, p. 364

Research output: Contribution to journalArticleAcademicpeer-review