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Research Output

2015

Preconditioning by Oxygen-Glucose Deprivation Preserves Cell Proliferation and Reduces Cytotoxicity in Primary Astrocyte Cultures

Nikiforou, M., Vlassaks, E., Strackx, E., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. W. D., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 1, p. 61-67

Research output: Contribution to journalArticleAcademicpeer-review

Prevalence of systemic air-embolism after prolonged cardiopulmonary resuscitation in newborns: A pilot study

Halbertsma, F. J. J., Mohns, T., Bok, L. A., Niemarkt, H. J. & Kramer, B. W., Aug 2015, In : Resuscitation. 93, p. 96-101

Research output: Contribution to journalArticleAcademicpeer-review

Prophylactic Interleukin-2 Treatment Prevents Fetal Gut Inflammation and Injury in an Ovine Model of Chorioamnionitis

Nikiforou, M., Vanderlocht, J., Chougnet, C. A., Jellema, R. K., Ophelders, D. R. M. G., Joosten, M., Kloosterboer, N., Senden-Gijsbers, B. L. M. G., Germeraad, W. T. V., Kramer, B. W. & Wolfs, T. G. A. M., Sep 2015, In : Inflammatory Bowel Diseases. 21, 9, p. 2026-2038

Research output: Contribution to journalArticleAcademicpeer-review

Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model

Cetinkaya, M., Cansev, M., Cekmez, F., Tayman, C., Canpolat, F. E., Kafa, I. M., Yaylagul, E. O., Kramer, B. W. & Sarici, S. U., 4 May 2015, In : PLOS ONE. 10, 5, e0126028.

Research output: Contribution to journalArticleAcademicpeer-review

Responses of the spleen to intraamniotic lipopolysaccharide exposure in fetal sheep

Kuypers, E., Willems, M. G. M., Jellema, R. K., Kemp, M. W., Newnham, J. P., Delhaas, T., Kallapur, S. G., Jobe, A. H., Wolfs, T. G. A. M. & Kramer, B. W., Jan 2015, In : Pediatric Research. 77, 1, p. 29-35

Research output: Contribution to journalArticleAcademicpeer-review

Using trend templates in a neonatal seizure algorithm improves detection of short seizures in a foetal ovine model

Zwanenburg, A., Andriessen, P., Jellema, R. K., Niemarkt, H. J., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Mar 2015, In : Physiological Measurement. 36, 3, p. 369-384

Research output: Contribution to journalArticleAcademicpeer-review

2014

Altered canonical Wingless-It signaling in the ovine fetal lung after exposure to intra-amniotic lipopolysaccharide and antenatal betamethasone

Kuypers, E., Willems, M. G. M., Collins, J. J. P., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Delhaas, T., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Feb 2014, In : Pediatric Research. 75, 2, p. 281-287

Research output: Contribution to journalArticleAcademicpeer-review

Amplification of steroid-mediated SP-B expression by physiological levels of caffeine

Fehrholz, M., Huetten, M., Kramer, B. W., Speer, C. P. & Kunzmann, S., Jan 2014, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 306, 1, p. L101-L109

Research output: Contribution to journalArticleAcademicpeer-review

Breast-Feeding Improves Gut Maturation Compared With Formula Feeding in Preterm Babies

Reisinger, K. W., de Vaan, L., Kramer, B. W., Wolfs, T. G. A. M., van Heurn, E. & Derikx, J. P. M., Dec 2014, In : Journal of Pediatric Gastroenterology and Nutrition. 59, 6, p. 720-724

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation

Wolfs, T. G. A. M., Kramer, B. W., Thuijls, G., Kemp, M. W., Saito, M., Willems, M. G. M., Senthamarai-Kannan, P., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Mar 2014, In : American Journal of Physiology-Gastrointestinal and Liver Physiology. 306, 5, p. G382-G393

Research output: Contribution to journalArticleAcademicpeer-review

Chronic Pain in the Newborn Toward a Definition

van Ganzewinkel, C., Anand, K. J. S., Kramer, B. W. & Andriessen, P., Nov 2014, In : Clinical Journal of Pain. 30, 11, p. 970-977

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of airway responses in sheep of different age in precision-cut lung slices (PCLS)

Lambermont, V. A., Schleputz, M., Dassow, C., Konig, P., Zimmermann, L. J., Uhlig, S., Kramer, B. W. W. & Martin, C., 17 Sep 2014, In : PLOS ONE. 9, 9, 8 p., e97610.

Research output: Contribution to journalArticleAcademicpeer-review

Effects of intra-amniotic lipopolysaccharide exposure on the fetal lamb lung as gestation advances

Lambermont, V. A., Kuypers, E., Collins, J. J. R., Pillow, J. J., Newnham, J. P., Polglase, G. R., Nitsos, H., Kemp, M. W., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., Apr 2014, In : Pediatric Research. 75, 4, p. 500-506

Research output: Contribution to journalArticleAcademicpeer-review

Effects of less-invasive surfactant administration on oxygenation, pulmonary surfactant distribution, and lung compliance in spontaneously breathing preterm lambs

Niemarkt, H. J., Kuypers, E., Jellema, R., Ophelders, D., Huetten, M., Nikiforou, M., Kribs, A. & Kramer, B. W., Aug 2014, In : Pediatric Research. 76, 2, p. 166-170

Research output: Contribution to journalArticleAcademicpeer-review

Intestinal fatty acid-binding protein: a possible marker for gut maturation

Reisinger, K. W., Elst, M., Derikx, J. P. M., Nikkels, P. G. J., de Vries, B., Adriaanse, M. P. M., Jellema, R. K., Kramer, B. W. W. & Wolfs, T. G. A. M., Sep 2014, In : Pediatric Research. 76, 3, p. 261-268

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung

Schmidt, A. F., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Nov 2014, In : Pediatric Research. 76, 5, p. 441-447

Research output: Contribution to journalArticleAcademicpeer-review

Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep

Payne, M. S., Kemp, M. W., Kallapur, S. G., Kannan, P. S., Saito, M., Miura, Y., Newnham, J. P., Stock, S., Ireland, D. J., Kramer, B. W. & Jobe, A. H., Jun 2014, In : Pediatric Research. 75, 6, p. 716-722

Research output: Contribution to journalArticleAcademicpeer-review

Miniaturization: The Clue to Clinical Application of the Artificial Placenta

Schoberer, M., Arens, J., Erben, A., Ophelders, D., Jellema, R. K., Kramer, B. W., Bruse, J. L., de Brouwer, P., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Mar 2014, In : Artificial Organs. 38, 3, p. 208-214

Research output: Contribution to journalArticleAcademicpeer-review

Polymyxin B Agonist Capture Therapy for Intrauterine Inflammation: Proof-of-Principle in a Fetal Ovine Model

Saito, M., Payne, M. S., Miura, Y., Ireland, D. J., Stock, S., Kallapur, S. G., Kannan, P. S., Newnham, J. P., Kramer, B. W., Jobe, A. H., Keelan, J. A. & Kemp, M. W., May 2014, In : Reproductive Sciences. 21, 5, p. 623-631

Research output: Contribution to journalArticleAcademicpeer-review

Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs

Gisslen, T., Hillman, N. H., Musk, G. C., Kemp, M. W., Kramer, B. W., Senthamaraikannan, P., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Feb 2014, In : Innate Immunity. 20, 2, p. 214-224

Research output: Contribution to journalArticleAcademicpeer-review

Surfactant protein A binds TGF-beta 1 with high affinity and stimulates the TGF-beta pathway

Willems, C. H. M. P., Zimmermann, L. J. I., Kloosterboer, N., Kramer, B. W. & van Iwaarden, J. F., Feb 2014, In : Innate Immunity. 20, 2, p. 192-199

Research output: Contribution to journalArticleAcademicpeer-review

2013

Antenatal glucocorticoids counteract LPS changes in TGF-beta pathway and caveolin-1 in ovine fetal lung

Collins, J. J. P., Kunzmann, S., Kuypers, E., Kemp, M. W., Speer, C. P., Newnham, J. P., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Mar 2013, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 304, 6, p. L438-L444

Research output: Contribution to journalArticleAcademicpeer-review

Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner

Wolfs, T. G. A. M., Kallapur, S. G., Knox, C. L., Thuijls, G., Nitsos, I., Polglase, G. R., Collins, J. J. P., Kroon, E., Spierings, J., Shroyer, N. F., Newnham, J. P., Jobe, A. H. & Kramer, B. W., May 2013, In : Mucosal Immunology. 6, 3, p. 547-556

Research output: Contribution to journalArticleAcademicpeer-review

Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Jellema, R. K., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., De Munter, S., Vanderlocht, J., Germeraad, W. T. V., Kuypers, E., Collins, J. J. P., Cleutjens, J. P. M., Jennekens, W., Gavilanes, A. W. D., Seehase, M., Vles, H. J., Steinbusch, H., Andriessen, P., Wolfs, T. G. A. M. & Kramer, B. W., 24 Jan 2013, In : Journal of Neuroinflammation. 10, 13.

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis as a Risk Factor for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis

Been, J. V., Lievense, S., Zimmermann, L. J. I., Kramer, B. W. & Wolfs, T. G. A. M., Feb 2013, In : The Journal of Pediatrics. 162, 2, p. 236-242

Research output: Contribution to journalArticleAcademicpeer-review

Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

Engel, M., Nowacki, R. M. E., Reiss, L. K., Uhlig, S., Willems, C. H. M. P., Kloosterboer, N., van Iwaarden, J. F., Sewing, A. C. P., Seehase, M., Lambermont, V. A. C., Collins, J. J. P., Zimmermann, L. J. I., Vos, G. D. & Kramer, B. W., Feb 2013, In : Lung. 191, 1, p. 77-86

Research output: Contribution to journalArticleAcademicpeer-review

Effects of Intra-Amniotic Lipopolysaccharide and Maternal Betamethasone on Brain Inflammation in Fetal Sheep

Kuypers, E., Jellema, R. K., Ophelders, D. R. M. G., Dudink, J., Nikiforou, M., Wolfs, T. G. A. M., Nitsos, I., Pillow, J. J., Polglasem, G. R., Kemp, M. W., Saito, M., Newnham, J. P., Jobe, A. H., Kallapur, S. G. & Kramer, B. W., 17 Dec 2013, In : PLOS ONE. 8, 12, e81644.

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats

Vlassaks, E., Strackx, E., Vles, J. S. H., Nikiforou, M., Martinez-Martinez, P., Kramer, B. W. & Gavilanes, A. W. D., 26 Jan 2013, In : Journal of Neuroinflammation. 10, 14.

Research output: Contribution to journalArticleAcademicpeer-review

Functional impairment of the auditory pathway after perinatal asphyxia and the short-term effect of perinatal propofol anesthesia in lambs

Smit, A. L., Seehase, M., Stokroos, R. J., Jellema, R. K., Felipe, L., Chenault, M. N., Anteunis, L. J. C., Kremer, B. & Kramer, B. W., Jul 2013, In : Pediatric Research. 74, 1, p. 34-38

Research output: Contribution to journalArticleAcademicpeer-review

Heart rate-mediated blood pressure control in preterm fetal sheep under normal and hypoxic-ischemic conditions

Zwanenburg, A., Jellema, R. K., Jennekens, W., Ophelders, D., Vullings, R., van Hunnik, A., van Pul, C., Bennet, L., Delhaas, T., Kramer, B. W. & Andriessen, P., Apr 2013, In : Pediatric Research. 73, 4, p. 420-426

Research output: Contribution to journalArticleAcademicpeer-review

Intraamniotic Lipopolysaccharide Exposure Changes Cell Populations and Structure of the Ovine Fetal Thymus

Kuypers, E., Wolfs, T. G. A. M., Collins, J. J. P., Jellema, R. K., Newnham, J. P., Kemp, M. W., Kallapur, S. G., Jobe, A. H. & Kramer, B. W., Aug 2013, In : Reproductive Sciences. 20, 8, p. 946-956

Research output: Contribution to journalArticleAcademicpeer-review

Mesenchymal Stem Cells Induce T-Cell Tolerance and Protect the Preterm Brain after Global Hypoxia-Ischemia

Jellema, R. K., Wolfs, T. G. A. M., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., Kuypers, E., Hopman, A. H. N., Dudink, J., Steinbusch, H. W., Andriessen, P., Germeraad, W. T. V., Vanderlocht, J. & Kramer, B. W., 26 Aug 2013, In : PLOS ONE. 8, 8, e73031.

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of lipopolysaccharide-induced chorioamnionitis by Ureaplasma parvum in sheep

Snyder, C. C., Wolfe, K. B., Gisslen, T., Knox, C. L., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., May 2013, In : American Journal of Obstetrics and Gynecology. 208, 5, 399.e1.

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of Lipopolysaccharide-Induced Chorioamnionitis in Fetal Sheep by Maternal Betamethasone

Wolfe, K. B., Snyder, C. C., Gisslen, T., Kemp, M. W., Newnham, J. P., Kramer, B. W., Jobe, A. H. & Kallapur, S., Dec 2013, In : Reproductive Sciences. 20, 12, p. 1447-1454

Research output: Contribution to journalArticleAcademicpeer-review

Repeated Intrauterine Exposures to Inflammatory Stimuli Attenuated Transforming Growth Factor-beta Signaling in the Ovine Fetal Lung

Collins, J. J. P., Kallapur, S. G., Knox, C. L., Kemp, M. W., Kuypers, E., Zimmermann, L. J. I., Newnham, J. P., Jobe, A. H. & Kramer, B. W., 2013, In : Neonatology. 104, 1, p. 49-55

Research output: Contribution to journalArticleAcademicpeer-review

Selective Exposure of the Fetal Lung and Skin/Amnion (but Not Gastro-Intestinal Tract) to LPS Elicits Acute Systemic Inflammation in Fetal Sheep

Kemp, M. W., Kannan, P. S., Saito, M., Newnham, J. P., Cox, T., Jobe, A. H., Kramer, B. W. & Kallapur, S. G., 17 May 2013, In : PLOS ONE. 8, 5, e63355.

Research output: Contribution to journalArticleAcademicpeer-review

Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia

Jellema, R. K., Passos, V. L., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Zwanenburg, A., De Munter, S., Nikiforou, M., Collins, J. J. P., Kuypers, E., Bos, G. M. J., Steinbusch, H. W., Vanderlocht, J., Andriessen, P., Germeraad, W. T. V. & Kramer, B. W., Dec 2013, In : Experimental Neurology. 250, p. 293-303

Research output: Contribution to journalArticleAcademicpeer-review

The effects of fetal and perinatal asphyxia on neuronal cytokine levels and ceramide metabolism in adulthood

Vlassaks, E., Gavilanes, A. W. D., Vles, J. S. H., Deville, S., Kramer, B. W., Strackx, E. & Martinez-Martinez, P., 15 Feb 2013, In : Journal of Neuroimmunology. 255, 1-2, p. 97-101

Research output: Contribution to journalArticleAcademicpeer-review

Thrown off balance: the effect of antenatal inflammation on the developing lung and immune system

Kunzmann, S., Collins, J. J. P., Kuypers, E. & Kramer, B. W., Jun 2013, In : American Journal of Obstetrics and Gynecology. 208, 6, p. 429-437

Research output: Contribution to journalArticleAcademicpeer-review

Ureaplasma and BPD

Kallapur, S. G., Kramer, B. W. & Jobe, A. H., Apr 2013, In : Seminars in Perinatology. 37, 2, p. 94-101

Research output: Contribution to journalArticleAcademicpeer-review

Ureaplasma parvum Serovar 3 Multiple Banded Antigen Size Variation after Chronic Intra-Amniotic Infection/Colonization

Robinson, J. W., Dando, S. J., Nitsos, I., Newnham, J., Polglase, G. R., Kallapur, S. G., Pillow, J. J., Kramer, B. W., Jobe, A. H., Payton, D. & Knox, C. L., 26 Apr 2013, In : PLOS ONE. 8, 4, e62746.

Research output: Contribution to journalArticleAcademicpeer-review

2012

Bacterial reprogramming of PBMCs impairs monocyte phagocytosis and modulates adaptive T cell responses

Andre, M. C., Gille, C., Glemser, P., Woiterski, J., Hsu, H-Y., Spring, B., Keppeler, H., Kramer, B. W., Handgretinger, R., Poets, C. F., Lauber, K. & Orlikowsky, T. W., Jun 2012, In : Journal of Leukocyte Biology. 91, 6, p. 977-989

Research output: Contribution to journalArticleAcademicpeer-review

Dissociation of transforming growth factors beta 1 and beta 2 from surfactant protein A (SP-A) by deglycosylation or deoxycholate treatment

Willems, C. H. M. P., Kloosterboer, N., Kunzmann, S., Kramer, B. W., Zimmermann, L. J. I. & van Iwaarden, J. F., 31 Jan 2012, In : Journal of Immunological Methods. 375, 1-2, p. 111-117

Research output: Contribution to journalArticleAcademicpeer-review

Effects of in utero endotoxemia on the ovine fetal brain: a model for schizophrenia?

Gantert, M., Kreczmanski, P., Kuypers, E., Jellema, R., Strackx, E., Bastian, N., Gavilanes, A. W. D., Zimmermann, L. J. I., Garnier, Y., Schmitz, C. & Kramer, B. W., 1 Jun 2012, In : Frontiers in Bioscience, Elite edition. 1, 4, p. 2845-53 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fifty Years of Work on the Artificial Placenta: Milestones in the History of Extracorporeal Support of the Premature Newborn

Schoberer, M., Arens, J., Lohr, A., Seehase, M., Jellema, R. K., Collins, J. J., Kramer, B. W., Schmitz-Rode, T., Steinseifer, U. & Orlikowsky, T., Jun 2012, In : Artificial Organs. 36, 6, p. 512-516

Research output: Contribution to journalArticleAcademicpeer-review

IFN-gamma and TNF-alpha Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Laug, R., Fehrholz, M., Schuetze, N., Kramer, B. W., Krump-Konvalinkova, V., Speer, C. P. & Kunzmann, S., 20 Sep 2012, In : PLOS ONE. 7, 9, e45430.

Research output: Contribution to journalArticleAcademicpeer-review

Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis

Kaemmerer, E., Schneider, U., Klaus, C., Plum, P., Reinartz, A., Adolf, M., Renner, M., Wolfs, T. G. A. M., Kramer, B. W., Wagner, N., Mollenhauer, J. & Gassler, N., Mar 2012, In : Histopathology. 60, 4, p. 561-569

Research output: Contribution to journalArticleAcademicpeer-review

Increased Number of Cerebellar Granule Cells and Astrocytes in the Internal Granule Layer in Sheep Following Prenatal Intra-amniotic Injection of Lipopolysaccharide

Strackx, E., Gantert, M., Moers, V., van Kooten, I. A. J., Rieke, R., Hurter, H., Lemmens, M. A. M., Steinbusch, H. W. M., Zimmermann, L. J. I., Vles, J. S. H., Garnier, Y., Gavilanes, A. W. D. & Kramer, B. W., Mar 2012, In : Cerebellum. 11, 1, p. 132-144

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis

Wolfs, T. G. A. M., Jellema, R. K., Turrisi, G., Becucci, E., Buonocore, G. & Kramer, B. W., Apr 2012, In : Journal of Maternal-Fetal & Neonatal Medicine. 25, p. 8-11

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs

Kuypers, E., Collins, J. J. P., Kramer, B. W., Ofman, G., Nitsos, I., Pillow, J. J., Polglase, G. R., Kemp, M. W., Newnham, J. P., Gavilanes, A. W. D., Nowacki, R., Ikegami, M., Jobe, A. H. & Kallapur, S. G., Feb 2012, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 302, 4, p. L380-L389

Research output: Contribution to journalArticleAcademicpeer-review