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Research Output

2017

Antenatal dexamethasone vs. betamethasone dosing for lung maturation in fetal sheep

Schmidt, A. F., Kemp, M. W., Kannan, P. S., Kramer, B. W., Newnham, J. R., Kallapur, S. G. & Jobe, A. H., Mar 2017, In : Pediatric Research. 81, 3, p. 496-503 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line

Shruthi, S., Sumitha, R., Varghese, A. M., Ashok, S., Sagar, B. K. C., Sathyaprabha, T. N., Nalini, A., Kramer, B. W., Raju, T. R., Vijayalakshmi, K. & Alladi, P. A., 2017, In : Neurodegenerative Diseases. 17, 1, p. 44-58 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bronchopulmonary Dysplasia and Ureaplasma: What Do We Know So Far?

De La Haye, N., Hütten, M. C., Kunzmann, S. & Kramer, B. W., 27 Feb 2017, In : Neonatal Medicine. 24, 1, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Classic Galactosemia: Study on the Late Prenatal Development of GALT Specific Activity in a Sheep Model

Coelho, A. I., Bierau, J., Lindhout, M., Achten, J., Kramer, B. W. & Rubio-Gozalbo, M. E., Sep 2017, In : The Anatomical Record: advances in integrative anatomy and evolutionary biology. 300, 9, p. 1570-1575 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Detection of Sepsis in Preterm Infants by Fecal Volatile Organic Compounds Analysis: A Proof of Principle Study

Berkhout, D. J. C., Niemarkt, H. J., Buijck, M., Van Weissenbruch, M. M., Brinkman, P., Benninga, M. A., van Kaam, A. H., Kramer, B. W., Andriessen, P., de Boer, N. K. H. & de Meij, T. G. J., Sep 2017, In : Journal of Pediatric Gastroenterology and Nutrition. 65, 3, p. E47-E52 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Mishra, P-S., Vijayalakshmi, K., Nalini, A., Sathyaprabha, T. N., Kramer, B. W., Alladi, P. A. & Raju, T. R., 16 Dec 2017, In : Journal of Neuroinflammation. 14, 18 p., 251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Foetal Ureaplasma parvum bacteraemia as a function of gestation-dependent complement insufficiency: Evidence from a sheep model of pregnancy

Kemp, M. W., Ahmed, S., Beeton, M. L., Payne, M. S., Saito, M., Miura, Y., Usuda, H., Kallapur, S. G., Kramer, B. W., Stock, S. J., Jobe, A. H., Newnham, J. P. & Spiller, O. B., Jan 2017, In : American Journal of Reproductive Immunology. 77, 1, 9 p., 12599.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

In Vivo Evaluation of the Acute Pulmonary Response to Poractant Alfa and Bovactant Treatments in Lung-Lavaged Adult Rabbits and in Preterm Lambs with Respiratory Distress Syndrome

Ricci, F., Salomone, F., Kuypers, E., Ophelders, D., Nikiforou, M., Willems, M., Krieger, T., Murgia, X., Huetten, M., Kramer, B. W. & Bianco, F., 31 Aug 2017, In : Frontiers in pediatrics. 5, 10 p., 186.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight

van Ganzewinkel, C. J. L. M., Been, J. V., Verbeek, I., van der Loo, T. B., van der Pal, S. M., Kramer, B. W. & Andriessen, P., Jul 2017, In : Early Human Development. 110, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pentoxifylline modulates LPS-induced hyperinflammation in monocytes of preterm infants in vitro

Schuller, S. S., Wisgrill, L., Herndl, E., Spittler, A., Forster-Waldl, E., Sadeghi, K., Kramer, B. W. & Berger, A., Aug 2017, In : Pediatric Research. 82, 2, p. 215-225 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Probiotic Supplementation in Preterm Infants Does Not Affect the Risk of Bronchopulmonary Dysplasia: A Meta-Analysis of Randomized Controlled Trials

Villamor-Martinez, E., Pierro, M., Cavallaro, G., Mosca, F., Kramer, B. & Villamor, E., Nov 2017, In : Nutrients. 9, 11, 19 p., 1197.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide

Willems, M. G. M., Kemp, M. W., Fast, L. A., Wagemaker, N. M. M., Janssen, L. E. W., Newnham, J. P., Payne, M. S., Spiller, O. B., Kallapur, S. G., Jobe, A. H., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 30 Jun 2017, In : PLOS ONE. 12, 6, 16 p., 0180114.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stem cells and Bronchopulmonary Dysplasia - The five questions: Which cells, when, in which dose, to which patients via which route?

Mueller, M. & Kramer, B. W., Sep 2017, In : Paediatric Respiratory Reviews. 24, p. 54-59 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications

Niemarkt, H. J., Hutten, M. C. & Kramer, B. W., 2017, In : Neonatology. 111, 4, p. 408-414 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systemic pro-inflammatory cytokine status following therapeutic hypothermia in a piglet hypoxia-ischemia model

Rocha-Ferreira, E., Kelen, D., Faulkner, S., Broad, K. D., Chandrasekaran, M., Kerenyi, A., Kato, T., Bainbridge, A., Golay, X., Sullivan, M., Kramer, B. W. & Robertson, N. J., 3 Mar 2017, In : Journal of Neuroinflammation. 14, 13 p., 44.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tabaksontmoediging en perinatale gezondheid*

Peelen, M. J., Sheikh, A., Kok, M., Hajenius, P., Zimmermann, L., Kramer, B., Hukkelhoven, C. W. P. M., Reiss, I. K. M., Mol, B. W. J. & Been, J., 2017, In : Nederlands Tijdschrift voor Geneeskunde. p. 1-6 6 p., 161:D563.

Research output: Contribution to journalArticleAcademicpeer-review

The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development

Gussenhoven, R., Ophelders, D. R. M. G., Kemp, M. W., Payne, M. S., Spiller, O. B., Beeton, M. L., Stock, S. J., Cillero-Pastor, B., Barre, F. P. Y., Heeren, R. M. A., Kessels, L., Stevens, B., Rutten, B. P., Kallapur, S. G., Jobe, A. H., Kramer, B. W. & Wolfs, T. G. A. M., 2017, In : Developmental Neuroscience. 39, 6, p. 472-486 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Wharton's Jelly Mesenchymal Stem Cells Protect the Immature Brain in Rats and Modulate Cell Fate

Mueller, M., Oppliger, B., Joerger-Messerli, M., Reinhart, U., Barnea, E., Paidas, M., Kramer, B. W., Surbek, D. V. & Schoeberlein, A., 15 Feb 2017, In : Stem Cells and Development. 26, 4, p. 239-248 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Can the preterm lung recover from perinatal stress?

Hütten, M., Wolfs, T. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 15.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Comparison of ECG-based physiological markers for hypoxia in a preterm ovine model

Zwanenburg, A., Hermans, B. J. M., Andriessen, P., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Vullings, R., Wolfs, T. G. A. M., Kramer, B. W. & Delhaas, T., Jun 2016, In : Pediatric Research. 79, 6, p. 907-915

Research output: Contribution to journalArticleAcademicpeer-review

Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep

Regan, J. K., Kannan, P. S., Kemp, M. W., Kramer, B. W., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., Jan 2016, In : Reproductive Sciences. 23, 1, p. 69-80

Research output: Contribution to journalArticleAcademicpeer-review

Fetal asphyctic preconditioning in rats results in a preserved placental inflammatory phenotype at birth

Sparnaaij, M. A. R., Chedraui, P., Liem, K. H., Escobar, G. S., Espinoza-Caicedo, J., Kramer, B. W., Vles, J. S. H. & Gavilanes, A. D. W., Feb 2016, In : Placenta. 38, p. 84-92

Research output: Contribution to journalArticleAcademicpeer-review

Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine

Nikiforou, M., Jacobs, E. M. R., Kemp, M. W., Hornef, M. W., Payne, M. S., Saito, M., Newnham, J. P., Janssen, L. E. W., Jobe, A. H., Kallapur, S. G., Kramer, B. W. & Wolfs, T. G. A. M., 14 Jul 2016, In : Scientific Reports. 6, 29806.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intrauterine Lipopolysaccharide-Induced Chorioamnionitis in a Sheep: Does It Affect the Auditory System?

Smit, A. L., Lambermont, V. A., Stokroos, R. J., Anteunis, L. J. C., Chenault, M., Schaefer, S. M., Schoenmakers, L. W. G., Kremer, B. & Kramer, B. W., Feb 2016, In : Reproductive Sciences. 23, 2, p. 257-263

Research output: Contribution to journalArticleAcademicpeer-review

Maternofetal pharmacokinetics and fetal lung responses in chronically catheterized sheep receiving constant, low-dose infusions of betamethasone phosphate

Kemp, M. W., Saito, M., Usuda, H., Molloy, T. J., Miura, Y., Sato, S., Watanabe, S., Clarke, M., Fossler, M., Scmidt, A., Kallapur, S. G., Kramer, B. W., Newnham, J. P. & Jobe, A. H., Dec 2016, In : American Journal of Obstetrics and Gynecology. 215, 6, p. 775.e1-775.e12

Research output: Contribution to journalArticleAcademicpeer-review

Mesenchymal stem/stromal cells—a key mediator for regeneration after perinatal morbidity?

Mueller, M., Wolfs, T., Schoeberlein, A., Gavilanes, A. D. W., Surbek, D. & Kramer, B., 2016, In : Molecular and Cellular Pediatrics. 3, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

Ophelders, D. R. M. G., Wolfs, T. G. A. M., Jellema, R. K., Zwanenburg, A., Andriessen, P., Delhaas, T., Ludwig, A-K., Radtke, S., Peters, V., Janssen, L., Giebel, B. & Kramer, B. W., Jun 2016, In : Stem Cells Translational Medicine. 5, 6, p. 754-763

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Ophelders, D. R. M. G., Gussenhoven, R., Lammens, M., Kusters, B., Kemp, M. W., Newnham, J. P., Payne, M. S., Kallapur, S. G., Jobe, A. H., Zimmermann, L. J., Kramer, B. W. & Wolfs, T. G. A. M., 2 Feb 2016, In : Journal of Neuroinflammation. 13, 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pain coping strategies: Neonatal intensive care unit survivors in adolescence

van Ganzewinkel, C., Been, J. V., Dieleman, J. P., Katgert, T., Boelen-van der Loo, T., van der Pal, S. M., van Dijk, M., Kramer, B. W. & Andriessen, P., Dec 2016, In : Early Human Development. 103, p. 27-32

Research output: Contribution to journalArticleAcademicpeer-review

Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome

Vanterpool, S. F., Been, J. V., Houben, M. L., Nikkels, P. G. J., De Krijger, R. R., Zimmermann, L. J. I., Kramer, B. W., Progulske-Fox, A. & Reyes, L., 5 Jan 2016, In : PLOS ONE. 11, 1, e0146157.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Propofol administration to the fetal-maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest

Seehase, M., Houthuizen, P., Collins, J. J. P., Zimmermann, L. J. & Kramer, B. W., May 2016, In : Pediatric Research. 79, 5, p. 748-753

Research output: Contribution to journalArticleAcademicpeer-review

Risk of adverse pregnancy outcomes in women with periodontal disease and the effectiveness of interventions in decreasing this risk: protocol for systematic overview of systematic reviews

Vanterpool, S., Tomsin, K., Reyes, L., Zimmermann, L., Kramer, B. & Been, J., 2016, In : Systematic Reviews. 5, 6 p., 16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Selective IL-1α exposure to the fetal gut, lung, and chorioamnion/skin causes intestinal inflammatory and developmental changes in fetal sheep

Nikiforou, M., Kemp, M. W., van Gorp, R., Saito, M., Newnham, J. P., Reynaert, N. L., Janssen, L. E., Jobe, A. H., Kallapur, S. G., Kramer, B. & Wolfs, T., Jan 2016, In : Laboratory Investigation. 96, 1, p. 69-80 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetus

Willems, M. G. M., Ophelders, D. R. M. G., Nikiforou, M., Jellema, R. K., Butz, A., Delhaas, T., Kramer, B. W. & Wolfs, T. G. A. M., 1 Jan 2016, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 310, 1, p. L1-L7

Research output: Contribution to journalArticleAcademicpeer-review

The development of lung biochemical monitoring can play a key role in the early prediction of bronchopulmonary dysplasia

Fabiano, A., Gavilanes, A. D. W., Zimmermann, L. J., Kramer, B. W. W., Paolillo, P., Livolti, G., Picone, S., Bressan, K. & Gazzolo, D., May 2016, In : Acta Paediatrica. 105, 5, p. 535–541 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tobacco control policies and perinatal health: a national quasi-experimental study

Peelen, M. J., Sheikh, A., Kok, M., Hajenius, P., Zimmermann, L. J., Kramer, B. W., Hukkelhoven, C. W., Reiss, I. K., Mol, B. W. & Been, J. V., 22 Apr 2016, In : Scientific Reports. 6, 23907.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Boerger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., O'Driscoll, L., Fais, S., Falcon-Perez, J. M., Felderhoff-Mueser, U., Fraile, L., Gho, Y. S., Goergens, A., Gupta, R. C., Hendrix, A., Hermann, D. M. & 36 others, Hill, A. F., Hochberg, F., Horn, P. A., de Kleijn, D., Kordelas, L., Kramer, B. W., Kraemer-Albers, E-M., Laner-Plamberger, S., Laitinen, S., Leonardi, T., Lorenowicz, M. J., Lim, S. K., Lotvall, J., Maguire, C. A., Marcilla, A., Nazarenko, I., Ochiya, T., Patel, T., Pedersen, S., Pocsfalvi, G., Pluchino, S., Quesenberry, P., Reischl, I. G., Rivera, F. J., Sanzenbacher, R., Schallmoser, K., Slaper-Cortenbach, I., Strunk, D., Tonn, T., Vader, P., van Balkom, B. W. M., Wauben, M., El Andaloussi, S., Thery, C., Rohde, E. & Giebel, B., 2015, In : Journal of Extracellular Vesicles . 4, 30087.

Research output: Contribution to journalArticleAcademicpeer-review

Early Detection of Necrotizing Enterocolitis by Fecal Volatile Organic Compounds Analysis

de Meij, T. G. J., van der Schee, M. P. C., Berkhout, D. J. C., van de Velde, M. E., Jansen, A. E., Kramer, B. W., van Weissenbruch, M. M., van Kaam, A. H., Andriessen, P., van Goudoever, J. B., Niemarkt, H. J. & de Boer, N. K. H., Sep 2015, In : Journal of Pediatrics. 167, 3, p. 562-+

Research output: Contribution to journalArticleAcademicpeer-review

Expression and function of toll-like receptors in human circulating endothelial colony forming cells

Mazzucchelli, I., Lisini, D., Garofoli, F., Dragoni, S., Angelini, M., Pozzi, M., Bonetti, E., Tzialla, C., Kramer, B. W., Spinillo, A., Maccario, R., Rosti, V., Moccia, F., Borghesi, A. & Stronati, M., Nov 2015, In : Immunology Letters. 168, 1, p. 98-104

Research output: Contribution to journalArticleAcademicpeer-review

Fluconazole treatment of intrauterine Candida albicans infection in fetal sheep

Maneenil, G., Payne, M. S., Kannan, P. S., Kallapur, S. G., Kramer, B. W., Newnham, J. P., Miura, Y., Jobe, A. H. & Kemp, M. W., Jun 2015, In : Pediatric Research. 77, 6, p. 740-748

Research output: Contribution to journalArticleAcademicpeer-review

Fully automated predictive intelligent control of oxygenation (PRICO) in resuscitation and ventilation of preterm lambs

Hütten, M. C., Goos, T. G., Ophelders, D., Nikiforou, M., Kuypers, E., Willems, M., Niemarkt, H. J., Dankelman, J., Andriessen, P., Mohns, T., Reiss, I. K. M. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 657-63 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Genotype alone does not predict the clinical course of SFTPC deficiency in paediatric patients

Kroener, C., Reu, S., Teusch, V., Schams, A., Grimmelt, A-C., Barker, M., Brand, J., Gappa, M., Kitz, R., Kramer, B. W., Lange, L., Lau, S., Pfannenstiel, C., Proesmans, M., Seidenberg, J., Sismanlar, T., Aslan, A. T., Werner, C., Zielen, S., Zarbock, R. & 3 others, Brasch, F., Lohse, P. & Griese, M., Jul 2015, In : European Respiratory Journal. 46, 1, p. 197-206

Research output: Contribution to journalArticleAcademicpeer-review

Intra-Amniotic LPS Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain

Strackx, E., Jellema, R. K., Rieke, R., Gussenhoven, R., Vles, J. S. H., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : BioMed Research International. 276029.

Research output: Contribution to journalArticleAcademicpeer-review

Lipopolysaccharide-Induced Chorioamnionitis Causes Acute Inflammatory Changes in the Ovine Central Nervous System

Strackx, E., Sparnaaij, M. A. R., Vlassaks, E., Jellema, R., Kuypers, E., Vles, J. S. H., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : Cns & Neurological Disorders-Drug Targets. 14, 1, p. 77-84

Research output: Contribution to journalArticleAcademicpeer-review

Multipotent adult progenitor cells for hypoxic-ischemic injury in the preterm brain

Jellema, R. K., Ophelders, D. R. M. G., Zwanenburg, A., Nikiforou, M., Delhaas, T., Andriessen, P., Mays, R. W., Deans, R., Germeraad, W. T. V., Wolfs, T. G. A. M. & Kramer, B. W., 23 Dec 2015, In : Journal of Neuroinflammation. 12, p. 241

Research output: Contribution to journalArticleAcademicpeer-review

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

Hütten, M. C., Kuypers, E., Ophelders, D. R., Nikiforou, M., Jellema, R. K., Niemarkt, H. J., Fuchs, C., Tservistas, M., Razetti, R., Bianco, F. & Kramer, B. W., Dec 2015, In : Pediatric Research. 78, 6, p. 664-9 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Necrotizing Enterocolitis: A Clinical Review on Diagnostic Biomarkers and the Role of the Intestinal Microbiota

Niemarkt, H. J., de Meij, T. G. J., van de Velde, M. E., van der Schee, M. P., van Goudoever, J. B., Kramer, B. W., Andriessen, P. & de Boer, N. K. H., Feb 2015, In : Inflammatory Bowel Diseases. 21, 2, p. 436-444

Research output: Contribution to journalArticleAcademicpeer-review

Oral, Nasal and Pharyngeal Exposure to Lipopolysaccharide Causes a Fetal Inflammatory Response in Sheep

Maneenil, G., Kemp, M. W., Kannan, P. S., Kramer, B. W., Saito, M., Newnham, J. P., Jobe, A. H. & Kallapur, S. G., 20 Mar 2015, In : PLOS ONE. 10, 3, e0119281.

Research output: Contribution to journalArticleAcademicpeer-review

Polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) in the placenta of pregnancies complicated with preeclampsia

Chedraui, P., Andrade, M. E., Salazar-Pousada, D., Escobar, G. S., Hidalgo, L., Ramirez, C., Spaanderman, M. E. A., Kramer, B. W. & Gavilanes, A. W. D., 2015, In : Gynecological Endocrinology. 31, 7, p. 569-572

Research output: Contribution to journalArticleAcademicpeer-review