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Blanche Schroen

Dr.

20062019
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Research Output 2006 2019

2019

AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M. & Schroen, B., 1 Mar 2019, In : Molecular Therapy - Nucleic Acids. 14, p. 424-437 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure

Verjans, R., Derks, W. J. A., Korn, K., Soennichsen, B., van Leeuwen, R. E. W., Schroen, B., van Bilsen, M. & Heymans, S., 15 Apr 2019, In : Scientific Reports. 9, 15 p., 6055.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Assessing fatty acid oxidation flux in rodent cardiomyocyte models

Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B. & Nabben, M., 24 Jan 2018, In : Scientific Reports. 8, 6 p., 1505.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Long non-coding RNAs in the failing heart and vasculature

Hermans-Beijnsberger, S., van Bilsen, M. & Schroen, B., Sep 2018, In : Non-coding RNA research. 3, 3, p. 118-130 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

MicroRNA-155 Amplifies Nitric Oxide/cGMP Signaling and Impairs Vascular Angiotensin II Reactivity in Septic Shock

Vasques-Novoa, F., Laundos, T. L., Cerqueira, R. J., Quina-Rodrigues, C., Soares-dos-Reis, R., Baganha, F., Ribeiro, S., Mendonca, L., Goncalves, F., Reguenga, C., Verhesen, W., Carneiro, F., Paiva, J. A., Schroen, B., Castro-Chaves, P., Pinto-do-O, P., Nascimento, D. S., Heymans, S., Leite-Moreira, A. F. & Roncon-Albuquerque, R., 1 Sep 2018, In : Critical Care Medicine. 46, 9, p. E945-E954 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure

Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A. & Schroen, B., 1 Feb 2018, In : Hypertension. 71, 2, p. 280-288 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle

Rech, M., Aizpurua, A. B., van Empel, V., van Bilsen, M. & Schroen, B., 1 May 2018, In : Cardiovascular Research. 114, 6, p. 782-793 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population

Suthahar, N., Meijers, W. C., Ho, J. E., Gansevoort, R. T., Voors, A. A., van der Meer, P., Bakker, S. J. L., Heymans, S., van Empel, V., Schroen, B., van der Harst, P., van Veldhuisen, D. J. & de Boer, R. A., 1 Aug 2018, In : European journal of heart failure. 20, 8, p. 1205-1214 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Targeted HFpEF therapy based on matchmaking of human and animal models

Aizpurua, A. B., Schroen, B., van Bilsen, M. & van Empel, V., Dec 2018, In : American Journal of Physiology-heart and Circulatory Physiology. 315, 6, p. H1670-H1683 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

What fills the heart

Schroen, B., 9 Nov 2018

Research output: Book/ReportInaugural speechPopular

2017

Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling

van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B. & van Bilsen, M., 22 Nov 2017, In : Scientific Reports. 7, 9 p., 16042.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Steinbusch, M. M. F., Caron, M. M. J., Surtel, D. A. M., Friedrich, F., Lausch, E., Pruijn, G. J. M., Verhesen, W., Schroen, B. L. M., van Rhijn, L. W., Zabel, B. & Welting, T. J. M., 25 Jul 2017, In : Scientific Reports. 7, 15 p., 6440.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

Heggermont, W. A., Papageorgiou, A-P., Quaegebeur, A., Deckx, S., Carai, P., Verhesen, W., Eelen, G., Schoors, S., van Leeuwen, R., Alekseev, S., Elzenaar, I., Vinckier, S., Pokreisz, P., Walravens, A-S., Gijsbers, R., Van Den Haute, C., Nickel, A., Schroen, B., van Bilsen, M., Janssens, S. & 4 others, Maack, C., Pinto, Y., Carmeliet, P. & Heymans, S., 22 Aug 2017, In : Circulation. 136, 8, p. 747-761 33 p.

Research output: Contribution to journalArticleAcademicpeer-review

MiRNA Deregulation in Cardiac Aging and Associated Disorders

Verjans, R., van Bilsen, M. & Schroen, B., 2017, International Review of Cell and Molecular Biology: MiRNAs in Aging and Cancer. Galluzzi, L. & Vitale, I. (eds.). Elsevier Science, Vol. 334. p. 207-263 57 p. (International Review of Cell and Molecular Biology, Vol. 334).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

Micheletti, R., Plaisance, I., Abraham, B. J., Sarre, A., Ting, C-C., Alexanian, M., Maric, D., Maison, D., Nemir, M., Young, R. A., Schroen, B., Gonzalez, A., Ounzain, S. & Pedrazzini, T., 21 Jun 2017, In : Science Translational Medicine. 9, 395, 17 p., eaai9118.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function

McDermott-Roe, C., Leleu, M., Rowe, G. C., Palygin, O., Bukowy, J. D., Kuo, J., Rech, M., Hermans-Beijnsberger, S., Schaefer, S., Adami, E., Creemers, E. E., Heinig, M., Schroen, B., Arany, Z., Petretto, E. & Geurts, A. M., 3 Feb 2017, In : PLOS ONE. 12, 2, 20 p., 0170458.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016
2 Citations (Scopus)

Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity

Gast, M., Schroen, B., Voigt, A., Haas, J., Kuehl, U., Lassner, D., Skurk, C., Escher, F., Wang, X., Kratzer, A., Michalik, K., Papageorgiou, A., Peters, T., Loebel, M., Wilk, S., Althof, N., Prasanth, K. V., Katus, H., Meder, B., Nakagawa, S. & 6 others, Scheibenbogen, C., Schultheiss, H-P., Landmesser, U., Dimmeler, S., Heymans, S. & Poller, W., Apr 2016, In : Journal of Molecular Cell Biology. 8, 2, p. 178-181

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice

Peters, T., Beijnsberger, S., Beqqali, A., Bitsch, N., Nakagawa, S., Prasanth, K. V., de Windt, L. J., van Oort, R. J., Heymans, S. & Schroen, B., 26 Feb 2016, In : PLOS ONE. 11, 2, e0150236.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection

Van Aelst, L. N. L., Summer, G., Li, S., Gupta, S. K., Heggermont, W., De Vusser, K., Carai, P., Naesens, M., Van Cleemput, J., Van de Werf, F., Vanhaecke, J., Thum, T., Waer, M., Papageorgiou, A. -P., Schroen, B. & Heymans, S., Jan 2016, In : American Journal of Transplantation. 16, 1, p. 99-110 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
20 Citations (Scopus)

CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis

Ounzain, S., Micheletti, R., Arnan, C., Plaisance, I., Cecchi, D., Schroen, B., Reverter, F., Alexanian, M., Gonzales, C., Ng, S. Y., Bussotti, G., Pezzuto, I., Notredame, C., Heymans, S., Guigo, R., Johnson, R. & Pedrazzini, T., Dec 2015, In : Journal of Molecular and Cellular Cardiology. 89, p. 98-112

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs

Ounzain, S., Micheletti, R., Beckmann, T., Schroen, B., Alexanian, M., Pezzuto, I., Crippa, S., Nemir, M., Sarre, A., Johnson, R., Dauvillier, J., Burdet, F., Ibberson, M., Guigo, R., Xenarios, I., Heymans, S. & Pedrazzini, T., 7 Feb 2015, In : European Heart Journal. 36, 6, p. 353-+

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Long noncoding RNAs in cardiac development and ageing

Devaux, Y., Zangrando, J., Schroen, B., Creemers, E. E., Pedrazzini, T., Chang, C-P., Dorn, G. W. . II., Thum, T. & Heymans, S., Jul 2015, In : Nature Reviews Cardiology. 12, 7, p. 415-425

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis

Corsten, M., Heggermont, W., Papageorgiou, A-P., Deckx, S., Tijsma, A., Verhesen, W., van Leeuwen, R., Carai, P., Thibaut, H-J., Custers, K., Summer, G., Hazebroek, M., Verheyen, F., Neyts, J., Schroen, B. & Heymans, S., 7 Nov 2015, In : European Heart Journal. 36, 42, p. 2909-U56

Research output: Contribution to journalArticleAcademicpeer-review

2014
30 Citations (Scopus)

microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-beta(1) up-regulation

Beaumont, J., Lopez, B., Hermida, N., Schroen, B., Jose, G. S., Heymans, S., Valencia, F., Jose Gomez-Doblas, J., De Teresa, E., Diez, J. & Gonzalez, A., Apr 2014, In : Clinical Science. 126, 7-8, p. 497-506

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Missing links in cardiology: long non-coding RNAs enter the arena

Peters, T. & Schroen, B., Jun 2014, In : Pflugers Archiv-European Journal of Physiology. 466, 6, p. 1177-1187

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

The microRNA-15 family inhibits the TGF beta-pathway in the heart

Tijsen, A. J., van der Made, I., van den Hoogenhof, M. M., Wijnen, W. J., van Deel, E. D., de Groot, N. E., Alekseev, S., Fluiter, K., Schroen, B., Goumans, M-J., van der Velden, J., Duncker, D. J., Pinto, Y. M. & Creemers, E. E., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 61-71

Research output: Contribution to journalArticleAcademicpeer-review

2013
71 Citations (Scopus)

Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

Heymans, S., Corsten, M. F., Verhesen, W., Carai, P., van Leeuwen, R. E., Custers, K., Peters, T., Hazebroek, M., Stoger, L., Wijnands, E., Janssen, B. J., Creemers, E. E., Pinto, Y. M., Grimm, D., Schurmann, N., Vigorito, E., Thum, T., Stassen, F. R., Yin, X., Mayr, M. & 9 others, De Windt, L. J., Lutgens, E., Wouters, K., de Winther, M. P., Zacchigna, S., Giacca, M., van Bilsen, M., Papageorgiou, A. P. & Schroen, B. L., 24 Sep 2013, In : Circulation. 128, 13, p. 1420-1432

Research output: Contribution to journalArticleAcademicpeer-review

2012
73 Citations (Scopus)

Hematopoietic miR155 Deficiency Enhances Atherosclerosis and Decreases Plaque Stability in Hyperlipidemic Mice

Donners, M. M. P. C., Wolfs, I. M. J., Stoger, L. J., van der Vorst, E. P. C., Pottgens, C. C. H., Heymans, S., Schroen, B., Gijbels, M. J. J. & de Winther, M. P. J., 25 Apr 2012, In : PLOS ONE. 7, 4, e35877.

Research output: Contribution to journalArticleAcademicpeer-review

Inflammation in viral myocarditis: friend or foe?

Corsten, M. F., Schroen, B. & Heymans, S., Jul 2012, In : Trends in Molecular Medicine. 18, 7, p. 426-437

Research output: Contribution to journalArticleAcademicpeer-review

Small but smart-microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing

Schroen, B. & Heymans, S., 15 Mar 2012, In : Cardiovascular Research. 93, 4, p. 605-613

Research output: Contribution to journalArticleAcademicpeer-review

106 Citations (Scopus)

Use of Circulating MicroRNAs to Diagnose Acute Myocardial Infarction

Devaux, Y., Vausort, M., Goretti, E., Nazarov, P. V., Azuaje, F., Gilson, G., Corsten, M. F., Schroen, B., Lair, M-L., Heymans, S. & Wagner, D. R., Mar 2012, In : Clinical Chemistry. 58, 3, p. 559-567

Research output: Contribution to journalArticleAcademicpeer-review

2011

Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy

van Almen, G. C., Swinnen, M., Carai, P., Verhesen, W., Cleutjens, J. P. M., D'hooge, J., Verheyen, F. K., Pinto, Y. M., Schroen, B., Carmeliet, P. & Heymans, S., Sep 2011, In : Journal of Molecular and Cellular Cardiology. 51, 3, p. 318-328

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure

van Almen, G. C., Verhesen, W., van Leeuwen, R. E. W., van de Vrie, M., Eurlings, C., Schellings, M. W. M., Swinnen, M., Cleutjens, J. P. M., van Zandvoort, M. A. M. J., Heymans, S. & Schroen, B., Oct 2011, In : Aging Cell. 10, 5, p. 769-779

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA Involvement in Immune Activation During Heart Failure

van de Vrie, M., Heymans, S. & Schroen, B., Apr 2011, In : Cardiovascular Drugs and Therapy. 25, 2, p. 161-170

Research output: Contribution to journalArticleAcademicpeer-review

2006
23 Citations (Scopus)

Biologically relevant effects of mRNA amplification on gene expression profiles

van Haaften, R. I. M., Schroen, B. L., Janssen, B. J., van Erk, A. A., Debets, J. J., Smeets, H. J., Smits, J. F., van den Wijngaard, A., Pinto, Y. M. & Evelo, C. T., 1 Jan 2006, In : BMC Bioinformatics. 7, p. 200

Research output: Contribution to journalArticleAcademicpeer-review