Birke Benedikter

2024

Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells

Tulen, C. B. M., van de Wetering, C., Schiffers, C. H. J., Weltjens, E., Benedikter, B. J., Leermakers, P. A., Boukhaled, J. H., Drittij, M.-J., Schmeck, B. T., Reynaert, N. L., Opperhuizen, A., van Schooten, F.-J. & Remels, A. H. V., 27 Feb 2024, In: Scientific Reports. 14, 1, 4821.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A time window for rescuing dying retinal ganglion cells

You, W., Knoops, K., Boesten, I., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M. & Gorgels, T. G. M. F., 31 Jan 2024, In: Cell Communication and Signaling. 22, 1, 19 p., 88.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Comparison of assays measuring extracellular vesicle-tissue factor in plasma samples: Communication from the ISTH SSC Subcommittee on Vascular Biology

Bonifay, A., Mackman, N., Hisada, Y., Sachetto, A. T. A., Hau, C., Gray, E., Hogwood, J., Aharon, A., Badimon, L., Barile, L., Baudar, J., Beckmann, L., Benedikter, B., Bolis, S., Bouriche, T., Brambilla, M., Burrello, J., Camera, M., Campello, E. & Ettelaie, C. & 31 others, Faille, D., Featherby, S., Franco, C., Guldenpfennig, M., Hansen, J.-B., Judicone, C., Kim, Y., Kristensen, S. R., Laakmann, K., Langer, F., Latysheva, N., Lucien, F., de Menezes, E. M., Mullier, F., Norris, P., Nybo, J., Orbe, J., Osterud, B., Paramo, J. A., Radu, C. M., Roncal, C., Samadi, N., Snir, O., Suades, R., Wahlund, C., Chareyre, C., Abdili, E., Martinod, K., Thaler, J., Dignat-George, F. & Et al., Oct 2024, In: Journal of Thrombosis and Haemostasis. 22, 10, p. 2910-2921 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. ?. G., Mohanty, S., Möller, A., Nieuwland, R. & Ochiya, T. & 38 others, Sahoo, S., Torrecilhas, A. C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E. M., Brucale, M., Burger, D., Carney, R. P., Cocucci, E., Crescitelli, R., Hanser, E., Harris, A. L., Haughey, N. J., Hendrix, A., Ivanov, A. R., Jovanovic-Talisman, T., Kruh-Garcia, N. A., Faustino, V. K. L., Kyburz, D., Lässer, C., Lennon, K. M., Lötvall, J., Maddox, A. L., Martens-Uzunova, E. S., Mizenko, R. R., Newman, L. A., Ridolfi, A., MISEV Consortium, Rouschop, K., Stassen, F., Thery, C., Witwer, K. W., Beaumont, J., Benedikter, B. & Keulers, T., Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, e12404.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration

You, W., Knoops, K., Berendschot, T. T. J. M., Benedikter, B. J., Webers, C. A. B., Reutelingsperger, C. P. M. & Gorgels, T. G. M. F., 17 Apr 2024, In: Cell Death Discovery. 10, 1, 15 p., 180.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2023

Low mitochondrial DNA copy number in buffy coat DNA of primary open-angle glaucoma patients

Vallbona-Garcia, A., Hamers, I. H. J., van Tienen, F. H. J., Ochoteco-Asensio, J., Berendschot, T. T. J. M., de Coo, I. F. M., Benedikter, B. J., Webers, C. A. B., Smeets, H. J. M. & Gorgels, T. G. M. F., Jul 2023, In: Experimental Eye Research. 232, 1, 10 p., 109500.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Mitochondrial DNA D-loop variants correlate with a primary open-angle glaucoma subgroup

Vallbona-Garcia, A., Lindsey, P. J., Kamps, R., Stassen, A. P. M., Nguyen, N., van Tienen, F. H. J., Hamers, I. H. J., Hardij, R., van Gisbergen, M. W., Benedikter, B. J., de Coo, I. F. M., Webers, C. A. B., Gorgels, T. G. M. F. & Smeets, H. J. M., 1 Jan 2023, In: Frontiers in Ophthalmology. 3, 1309836.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Klabunde, B., Wesener, A., Bertrams, W., Beinborn, I., Paczia, N., Surmann, K., Blankenburg, S., Wilhelm, J., Serrania, J., Knoops, K., Elsayed, E. M., Laakmann, K., Jung, A. L., Kirschbaum, A., Hammerschmidt, S., Alshaar, B., Gisch, N., Abu Mraheil, M., Becker, A. & Völker, U. & 3 others, Vollmeister, E., Benedikter, B. J. & Schmeck, B., 2 Oct 2023, In: Nature Communications. 14, 1, 16 p., 5818.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner

Klabunde, B., Wesener, A., Bertrams, W., Ringshandl, S., Halder, L. D., Vollmeister, E., Schmeck, B. & Benedikter, B. J., 17 Aug 2023, In: Cell Communication and Signaling. 21, 1, 10 p., 208.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release

You, W., Zhou, T., Knoops, K., Berendschot, T. T. J. M., van Zandvoort, M. A. M. J., Germeraad, W. T. V., Benedikter, B., Webers, C. A. B., Reutelingsperger, C. P. M. & Gorgels, T. G. M. F., 8 Jul 2023, In: Scientific Reports. 13, 1, 16 p., 11045.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2021

Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samples

Roessler, F. K., Benedikter, B. J., Schmeck, B. & Bar, N., 13 May 2021, In: Scientific Reports. 11, 1, 13 p., 10258.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The clinical role of host and bacterial-derived extracellular vesicles in pneumonia

Jung, A. L., Schmeck, B., Wiegand, M., Bedenbender, K. & Benedikter, B. J., 1 Sept 2021, In: Advanced Drug Delivery Reviews. 176, 15 p., 113811.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

2020

How to Count Our Microbes? The Effect of Different Quantitative Microbiome Profiling Approaches

Galazzo, G., van Best, N., Benedikter, B. J., Janssen, K., Bervoets, L., Driessen, C., Oomen, M., Lucchesi, M., van Eijck, P. H., Becker, H. E. F., Hornef, M. W., Savelkoul, P. H., Stassen, F. R. M., Wolffs, P. F. & Penders, J., 7 Aug 2020, In: Frontiers in Cellular and Infection Microbiology. 10, 10 p., 403.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium

Gomez, I., Ward, B., Souilhol, C., Recarti, C., Ariaans, M., Johnston, J., Burnett, A., Mahmoud, M., Le Anh Luong, West, L., Long, M., Parry, S., Woods, R., Hulston, C., Benedikter, B., Niespolo, C., Bazaz, R., Francis, S., Kiss-Toth, E. & van Zandvoort, M. & 4 others, Schober, A., Hellewell, P., Evans, P. C. & Ridger, V., 10 Jan 2020, In: Nature Communications. 11, 1, 18 p., 214.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells

Huebner, K., Karwelat, D., Pietsch, E., Beinborn, I., Winterberg, S., Bedenbender, K., Benedikter, B. J., Schmeck, B. & Vollmeister, E., Mar 2020, In: Cellular Signalling. 67, 10 p., 109498.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Vaping, vapor, vesicles! Electronic cigarettes provoke vascular extracellular vesicle release in healthy volunteers

Benedikter, B. J. & Koenen, R. R., May 2020, In: Atherosclerosis. 301, p. 79-81 3 p.

Research output: Contribution to journal › Editorial › Academic › peer-review

Open Access

2019

Cell Type- and Exposure-Specific Modulation of CD63/CD81-Positive and Tissue Factor-Positive Extracellular Vesicle Release in response to Respiratory Toxicants

Stassen, F. R. M., van Eijck, P. H., Savelkoul, P. H. M., Wouters, E. F. M., Rohde, G. G. U., Briede, J. J., Reynaert, N. L., de Kok, T. M. & Benedikter, B. J., 14 Aug 2019, In: Oxidative Medicine and Cellular Longevity. 2019, 9 p., 5204218.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Personalized medicine for patients with COPD: where are we?

Franssen, F. M. E., Alter, P., Bar, N., Benedikter, B. J., Iurato, S., Maier, D., Maxheim, M., Roessler, F. K., Spruit, M. A., Vogelmeier, C. F., Wouters, E. F. M., Schmeck, B. & SysMed-COPD consortium, 2019, In: International journal of chronic obstructive pulmonary disease. 14, p. 1465-1484 20 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles

Benedikter, B. J., Bouwman, F. G., Heinzmann, A. C. A., Vajen, T., Mariman, E. C., Wouters, E. F. M., Savelkoul, P. H. M., Koenen, R. R., Rohde, G. G. U., van Oerle, R., Spronk, H. M. & Stassen, F. R. M., 1 Jan 2019, In: Journal of Extracellular Vesicles. 8, 1, 16 p., 1585163.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2018

Extracellular vesicles as mediators of the response to respiratory exposures

Benedikter, B. J., 2018, Maastricht: Maastricht University. 277 p.

Research output: Thesis › Doctoral Thesis › Internal

Open Access

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Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Benedikter, B. J., Wouters, E. F. M., Savelkoul, P. H. M., Rohde, G. G. U. & Stassen, F. R. M., 1 Jan 2018, In: Journal of Toxicology and Environmental Health-Part B-Critical Reviews. 21, 3, p. 142-160 19 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Redox-dependent thiol modifications: implications for the release of extracellular vesicles

Benedikter, B. J., Weseler, A. R., Wouters, E. F. M., Savelkoul, P. H. M., Rohde, G. G. U. & Stassen, F. R. M., Jul 2018, In: Cellular and Molecular Life Sciences. 75, 13, p. 2321-2337 17 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

2017

Bead-based flow-cytometry for semi-quantitative analysis of complex membrane vesicle populations released by bacteria and host cells

Volgers, C., Benedikter, B. J., Grauls, G. E., Savelkoul, P. H. M. & Stassen, F. R. M., 2017, In: Microbiological Research. 200, p. 25-32 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants

Benedikter, B. J., Volgers, C., van Eijck, P. H., Wouters, E. F. M., Savelkoul, P. H. M., Reynaert, N. L., Haenen, G. R. M. M., Rohde, G. G. U., Weseler, A. R. & Stassen, F. R. M., Jul 2017, In: Free Radical Biology and Medicine. 108, p. 334-344 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Effects of N-acetyl-L-cysteine on the membrane vesicle release and growth of respiratory pathogens

Volgers, C., Benedikter, B. J., Grauls, G. E., Hellebrand, P. H. M., Savelkoul, P. H. M. & Stassen, F. R. M., May 2017, In: Fems Microbiology Letters. 364, 9, 8 p., 087.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Immunomodulatory role for membrane vesicles released by THP-1 macrophages and respiratory pathogens during macrophage infection

Volgers, C., Benedikter, B. J., Grauls, G. E., Savelkoul, P. H. M. & Stassen, F. R. M., 13 Nov 2017, In: BMC Microbiology. 17, 1, 14 p., 216.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype

Vajen, T., Benedikter, B. J., Heinzmann, A. C. A., Vasina, E. M., Henskens, Y., Parsons, M., Maguire, P. B., Stassen, F. R., Heemskerk, J. W. M., Schurgers, L. J. & Koenen, R. R., 16 May 2017, In: Journal of Extracellular Vesicles. 6, 1, 14 p., 1322454.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies

Benedikter, B. J., Bouwman, F. G., Vajen, T., Heinzmann, A. C. A., Grauls, G., Mariman, E. C., Wouters, E. F. M., Savelkoul, P. H., Lopez-Iglesias, C., Koenen, R. R., Rohde, G. G. U. & Stassen, F. R. M., 10 Nov 2017, In: Scientific Reports. 7, 1, 13 p., 15297.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2015

Cigarette smoke extract induces the release of extracellular vesicles by airway epithelial cells via cellular carbonyl stress

Benedikter, B. J., Volgers, C., Haenen, G. R. M. M., Savelkoul, P. H. M., Wouters, E. F. M., Rohde, G. G. U., Weseler, A. R. & Stassen, F. R. M., 1 Sept 2015, In: European Respiratory Journal. 46, suppl 59, 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Birke Benedikter

Research output

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