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Article
2019

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Iglesias, V. S., van Hoof, S. J., Vaniqui, A., Schyns, L. E., Lieuwes, N., Yaromina, A., Spiegelberg, L., Groot, A. J., Verhaegen, F., Theys, J., Dubois, L. & Vooijs, M., 2019, In : British Journal of Radiology. 92, 1095, 10 p., 20180476.

Research output: Contribution to journalArticleAcademicpeer-review

HIF-1 alpha and HIF-2 alpha Differently Regulate the Radiation Sensitivity of NSCLC Cells

Roig, E. M., Groot, A. J., Yaromina, A., Hendrickx, T. C., Barbeau, L. M. O., Giuranno, L., Dams, G., Ient, J., Pimentel, V. O., van Gisbergen, M. W., Dubois, L. J. & Vooijs, M. A., Jan 2019, In : Cells. 8, 1, 15 p., 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NOTCH signaling promotes the survival of irradiated basal airway stem cells

Giuranno, L., Wansleeben, C., Iannone, R., Arathoon, L., Hounjet, J., Groot, A. J. & Vooijs, M., Sep 2019, In : American Journal of Physiology-Lung Cellular and Molecular Physiology. 317, 3, p. L414-L423 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to gamma-secretase inhibition

Hounjet, J., Habets, R., Schaaf, M. B., Hendrickx, T. C., Barbeau, L. M. O., Yahyanejad, S., Rouschop, K. M., Groot, A. J. & Vooijs, M., 4 Jul 2019, In : Oncogene. 38, 27, p. 5457-5468 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics

Othman, Z., Fernandes, H., Groot, A. J., Luider, T. M., Alcinesio, A., Pereira, D. D. M., Guttenplan, A. P. M., Yuan, H. & Habibovic, P., Jul 2019, In : Biomaterials. 210, p. 12-24 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Blocking 17 beta-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach

Konings, G. F. J., Cornel, K. M. C., Xanthoulea, S., Delvoux, B., Skowron, M. A., Kooreman, L., Koskimies, P., Krakstad, C., Salvesen, H. B., van Kuijk, K., Schrooders, Y. J. M., Vooijs, M., Groot, A. J., Bongers, M. Y., Kruitwagen, R. F. P. M., Romano, A. & ENITEC, 1 Feb 2018, In : Journal of Pathology. 244, 2, p. 203-214 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Synergistic Effects of NOTCH/gamma-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

Iglesias, V. S., Theys, J., Groot, A. J., Barbeau, L. M. O., Lemmens, A., Yaromina, A., Losen, M., Houben, R., Dubois, L. & Vooijs, M., 7 Nov 2018, In : Frontiers in Oncology. 8, 13 p., 460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., Groot, A. J., Habets, R., Prickaerts, J., Chalmers, A. J., Eekers, D. B. P., Theys, J., Short, S. C., Verhaegen, F. & Vooijs, M., 5 Jul 2016, In : Oncotarget. 7, 27, p. 41251-41264

Research output: Contribution to journalArticleAcademicpeer-review

Restricted Location of PSEN2/gamma-Secretase Determines Substrate Specificity and Generates an Intracellular A beta Pool

Sannerud, R., Esselens, C., Ejsmont, P., Mattera, R., Rochin, L., Tharkeshwar, A. K., De Baets, G., De Wever, V., Habets, R., Baert, V., Vermeire, W., Michiels, C., Groot, A. J., Wouters, R., Dillen, K., Vints, K., Baatsen, P., Munck, S., Derua, R., Waelkens, E. & 10 others, Basi, G. S., Mercken, M., Vooijs, M., Bollen, M., Schymkowitz, J., Rousseau, F., Bonifacino, J. S., Van Niel, G., De Strooper, B. & Annaert, W., 30 Jun 2016, In : Cell. 166, 1, p. 193-208

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
2015

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17

Habets, R. A. J., Groot, A. J., Yahyanejad, S., Tiyanont, K., Blacklow, S. C. & Vooijs, M., 5 Jun 2015, In : Journal of Biological Chemistry. 290, 23, p. 14705-14716

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

Xu, X., Choi, S. H., Hu, T., Tiyanont, K., Habets, R., Groot, A. J., Vooijs, M., Aster, J. C., Chopra, R., Fryer, C. & Blacklow, S. C., 7 Jul 2015, In : Structure. 23, 7, p. 1227-1235

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
2014

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

Groot, A. J., Habets, R., Yahyanejad, S., Hodin, C. M., Reiss, K., Saftig, P., Theys, J. & Vooijs, M., Aug 2014, In : Molecular and Cellular Biology. 34, 15, p. 2822-2832

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
2013

High NOTCH activity induces radiation resistance in non small cell lung cancer

Theys, J., Yahyanejad, S., Habets, R., Span, P., Dubois, L., Paesmans, K., Kattenbeld, B., Cleutjens, J., Groot, A. J., Schuurbiers, O. C. J., Lambin, P., Bussink, J. & Vooijs, M., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 440-445

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2011

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Theys, J., Jutten, B., Habets, R., Paesmans, K., Groot, A. J., Lambin, P., Wouters, B. G., Lammering, G. & Vooijs, M., Jun 2011, In : Radiotherapy and Oncology. 99, 3, p. 392-397

Research output: Contribution to journalArticleAcademicpeer-review

2010

COMMD1 disrupts HIF-1 alpha/beta dimerization and inhibits human tumor cell invasion

van der Sluis, B., Mao, X., Zhai, Y., Groot, A. J., Vermeulen, J. F., van der Wall, E., van Diest, P. J., Hofker, M. H., Wijmenga, C., Klomp, L. W., Cho, K. R., Fearon, E. R., Vooijs, M. & Burstein, E., Jun 2010, In : Journal of Clinical Investigation. 120, 6, p. 2119-2130

Research output: Contribution to journalArticleAcademicpeer-review