1990 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Biperiden Selectively Impairs Verbal Episodic Memory in a Dose- and Time-Dependent Manner in Healthy Subjects

Borghans, L., Sambeth, A. & Blokland, A., 2020, In : Journal of Clinical Psychopharmacology. 40, 1, p. 30-37 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cannabis increases susceptibility to false memory

Kloft, L., Otgaar, H., Blokland, A., Monds, L. A., Toennes, S. W., Loftus, E. F. & Ramaekers, J. G., 3 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4585-4589 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation

Tan, S. Z. K., Temel, Y., Chan, A. Y., Mok, A. T. C., Perucho, J. A. U., Blokland, A., Aquili, L., Lim, W. L. & Lim, L. W., Sep 2020, In : Brain Structure & Function. 225, 7, p. 1957-1966 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

Blokland, A., Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T. & Prickaerts, J., May 2019, In : Neurobiology of Aging. 77, p. 37-43 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

False memory formation in cannabis users: a field study

Kloft, L., Otgaar, H., Blokland, A., Garbaciak, A., Monds, L. A. & Ramaekers, J. G., 28 Jun 2019, In : Psychopharmacology. 236, 12, p. 3439-3450 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

No interaction between rivastigmine and citalopram on memory and novelty processing in healthy human volunteers

Heckman, P. R. A., Blokland, A. & Sambeth, A., Feb 2019, In : Journal of Psychopharmacology. 33, 2, p. 210-218 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Smit, S., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., 15 Mar 2018, In : Neuropharmacology. 131, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

Heckman, P. R. A., Van Duinen, M. A., Blokland, A., Uz, T., Prickaerts, J. & Sambeth, A., Jan 2018, In : Psychopharmacology. 235, 1, p. 301–308 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intake of tryptophan-enriched whey protein acutely enhances recall of positive loaded words in patients with multiple sclerosis

Lieben, C. K., Blokland, A., Deutz, N. E., Jansen, W., Han, G. & Hupperts, R. M., Feb 2018, In : Clinical Nutrition. 37, 1, p. 321-328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

Heckman, P. R. A., Schweimer, J. V., Sharp, T., Prickaerts, J. & Blokland, A., Mar 2018, In : Brain Structure & Function. 223, 2, p. 739-748 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment

Borghans, L. G. J. M., Sambeth, A., Prickaerts, J., Ramaekers, J. G. & Blokland, A., Aug 2018, In : Psychopharmacology. 235, 8, p. 2407-2416 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity

Heckman, P. R. A., Blokland, A., Van Goethem, N. P., Van Hagen, B. T. J. & Prickaerts, J., 17 Sep 2018, In : Behavioural Brain Research. 350, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A combination of nootropic ingredients (CAF+) is not better than caffeine in improving cognitive functions

Caldenhove, S., Sambeth, A., Sharma, S., G., W. & Blokland, A., 18 Dec 2017, In : Journal of Cognitive Enhancement. 2, 1, p. 106-113

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of biperiden and acute tryptophan depletion and their combination on verbal word memory and EEG

Borghans, L. G. J. M., Blokland, A. & Sambeth, A., Apr 2017, In : Psychopharmacology. 234, 7, p. 1135-1143

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fornix deep brain stimulation induced long-term spatial memory independent of hippocampal neurogenesis

Hescham, S., Temel, Y., Schipper, S., Lagiere, M., Schönfeld, L-M., Blokland, A. & Jahanshahi, A., Mar 2017, In : Brain Structure & Function. 222, 2, p. 1069–1075 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
153 Downloads (Pure)

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease

Prickaerts, J., Heckman, P. R. A. & Blokland, A., 9 Aug 2017, In : Expert Opinion on Investigational Drugs. 26, 9, p. 1033-1048 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Role of acetylcholine and serotonin in novelty processing using an oddball paradigm

Caldenhove, S., Borghans, L., Blokland, A. & Sambeth, A., 28 Jul 2017, In : Behavioural Brain Research. 331, p. 199-204 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Accelerated cognitive decline in a rodent model for temporal lobe epilepsy

Schipper, S., Aalbers, M. W., Rijkers, K., Lagiere, M., Bogaarts, J. G., Blokland, A., Klinkenberg, S., Hoogland, G. & Vles, J. S. H., Dec 2016, In : Epilepsy & Behavior. 65, p. 33-41 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus

Hescham, S., Jahanshahianvar, A., Schweimer, J. V., Mitchell, S. N., Carter, G., Blokland, A., Sharp, T. & Temel, Y., Nov 2016, In : Brain Structure & Function. 221, 8, p. 4281–4286 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
138 Downloads (Pure)

Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

Heckman, P. R. A., van Duinen, M. A., Bollen, E. P. P., Nishi, A., Wennogle, L. P., Blokland, A. & Prickaerts, J., Oct 2016, In : International Journal of Neuropsychopharmacology. 19, 10, 16 p., pyw030.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
193 Downloads (Pure)

Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2016, In : Learning & Memory. 23, 1, p. 29-37 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
187 Downloads (Pure)

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Vanmierlo, T., Creemers, P., Akkerman, S., van Duinen, M., Sambeth, A., De Vry, J., Uz, T., Blokland, A. & Prickaerts, J., 15 Apr 2016, In : Behavioural Brain Research. 303, p. 26-33 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Why an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine

Blokland, A., Sambeth, A., Prickaerts, J. & Riedel, W. J., 30 Sep 2016, In : Frontiers in Neurology. 7, 4 p., 167.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
168 Downloads (Pure)
2015

Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions

Hescham, S., Jahanshahi, A., Meriaux, C., Lim, L. W., Blokland, A. & Temel, Y., 1 Oct 2015, In : Behavioural Brain Research. 292, p. 353-360

Research output: Contribution to journalArticleAcademicpeer-review

Biperiden selectively induces memory impairment in healthy volunteers : no interaction with citalopram

Sambeth, A., Riedel, W. J., Klinkenberg, I., Kähkönen, S. & Blokland, A., 1 Jan 2015, In : Psychopharmacology. 232, 11, p. 1887-1897

Research output: Contribution to journalArticleAcademicpeer-review

Girls' childhood trajectories of disruptive behavior predict adjustment problems in early adolescence

van der Molen, E., Blokland, A. A. J., Hipwell, A. E., Vermeiren, R. R. J. M., Doreleijers, T. A. H. & Loeber, R., Jul 2015, In : Journal of Child Psychology and Psychiatry. 56, 7, p. 766-773

Research output: Contribution to journalArticleAcademicpeer-review

Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors

Bollen, E., Akkerman, S., Puzzo, D., Gulisano, W., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 17 Apr 2015, In : Neuropharmacology. 95, p. 361-366

Research output: Contribution to journalArticleAcademicpeer-review

PDE5 inhibition improves acquisition processes after learning via a central mechanism

Akkerman, S., Blokland, A., van Goethem, N. P., Cremers, P., Shaffer, C. L., Osgood, S. M., Steinbusch, H. W. M. & Prickaerts, J., Oct 2015, In : Neuropharmacology. 97, p. 233-239 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

PDE and cognitive processing : beyond the memory domain

Heckman, P., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, In : Neurobiology of Learning and Memory. 119, p. 108-122 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W. & Ramaekers, J. G., 1 Jan 2015, In : Psychopharmacology. 232, 2, p. 343-353 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The use of EEG parameters as predictors of drug effects on cognition

Blokland, A., Prickaerts, J., van Duinen, M. & Sambeth, A., 15 Jul 2015, In : European Journal of Pharmacology. 759, p. 163-168 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Treatment of cognitive impairment in schizophrenia: potential value of phosphodiesterase inhibitors in prefrontal dysfunction

van Duinen, M., Reneerkens, O. A. H., Lambrecht, L., Sambeth, A., Rutten, B. P. F., van Os, J., Blokland, A. & Prickaerts, J., 1 Jan 2015, In : Current Pharmaceutical Design. 21, 26, p. 3813-3828 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014

Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation

Hestermann, D., Temel, Y., Blokland, A. & Lim, L. W., 14 Oct 2014, In : Behavioural Brain Research. 273, p. 155-165 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ambulant cognitive assessment using a smartphone

Timmers, C., Maeghs, A., Vestjens, M., Bonnemayer, C. C. W., Hamers, H. & Blokland, A., 1 Jan 2014, In : Applied Neuropsychology-Adult. 21, 2, p. 136-142 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

A neuroanatomical analysis of the effects of a memory impairing dose of scopolamine in the rat brain using cytochrome c oxidase as principle marker

Hescham, S., Temel, Y., Casaca-Carreira, J., Arslantas, K., Yakkioui, Y., Blokland, A. & Jahanshahi, A., Sep 2014, In : Journal of Chemical Neuroanatomy. 59-60, p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling

Bollen, E., Puzzo, D., Rutten, K., Privitera, L., De Vry, J., Vanmierlo, T., Kenis, G., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 12 May 2014, In : Neuropsychopharmacology. 39, p. 2497-2505

Research output: Contribution to journalArticleAcademicpeer-review

Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse

van Donkelaar, E. L., Vaessen, K. R. D., Pawluski, J. L., Sierksma, A. S., Blokland, A., Canete, R. & Steinbusch, H. W. M., 13 Oct 2014, In : PLOS ONE. 9, 10, 10 p., e106960.

Research output: Contribution to journalArticleAcademicpeer-review

Mind the gap: Delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2014, In : Neurobiology of Learning and Memory. 109, p. 139-143

Research output: Contribution to journalArticleAcademicpeer-review

PDE5 inhibition improves object memory in standard housed rats but not in rats housed in an enriched environment : implications for memory models?

Akkerman, S., Prickaerts, J., Bruder, A. K., Wolfs, K. H. M., De Vry, J., Vanmierlo, T. & Blokland, A., 1 Jan 2014, In : PLOS ONE. 9, 11, e111692.

Research output: Contribution to journalArticleAcademicpeer-review

Purinergic signaling and hippocampal long-term potentiation

Duster, R., Prickaerts, J. & Blokland, A., 1 Jan 2014, In : Current Neuropharmacology. 12, 1, p. 37-43

Research output: Contribution to journalArticleAcademicpeer-review

Translational issues with the development of cognition enhancing drugs

Blokland, A., van Goethem, N., Heckman, P., Schreiber, R. & Prickaerts, J., 1 Jan 2014, In : Frontiers in Neurology. 5, 190.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Unhindered spatial processing during route memorization is required to maximize both spatial and verbal route knowledge

van Doorn, R. R. A. & Blokland, A., 1 Jan 2014, In : Applied Cognitive Psychology. 28, 1, p. 22-29 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Cholinergic gating of hippocampal auditory evoked potentials in freely moving rats

Klinkenberg, I., Sambeth, A. & Blokland, A., Aug 2013, In : European Neuropsychopharmacology. 23, 8, p. 988-997 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cholinergic modulation of auditory processing, sensory gating and novelty detection in human participants

Klinkenberg, I., Blokland, A., Riedel, W. J. & Sambeth, A., Feb 2013, In : Psychopharmacology. 225, 4, p. 903-921 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: The role of stimulation parameters

Hescham, S., Lim, L. W., Jahanshahi, A., Steinbusch, H. W. M., Prickaerts, J., Blokland, A. & Temel, Y., 1 Jan 2013, In : Brain stimulation. 6, 1, p. 72-77 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

Reneerkens, O. A. H., Rutten, K., Bollen, E., Hage, T., Blokland, A., Steinbusch, H. W. M. & Prickaerts, J., 1 Jan 2013, In : Behavioural Brain Research. 236, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Korte termijn geheugen en werkgeheugen: Zinnig of onzinnig

Aben, B., Stapert, S. & Blokland, A., 2013, In : Tijdschrift voor neuropsychologie. 8, 2, p. 70-78 8 p.

Research output: Contribution to journalArticleProfessional

No effect of acute tryptophan depletion on phosphodiesterase inhibition-related improvements of short-term object memory in male Wistar rats

van Donkelaar, E. L., Prickaerts, J., Akkerman, S., Rutten, K., Steinbusch, H. & Blokland, A., Aug 2013, In : Acta Psychiatrica Scandinavica. 128, 2, p. 107-113 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats

Reneerkens, O. A. H., Sambeth, A., Blokland, A. & Prickaerts, J., 1 Aug 2013, In : Behavioural Brain Research. 250, p. 251-256 6 p.

Research output: Contribution to journalArticleAcademicpeer-review