1992 …2020
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Research Output 1992 2020

2020

Biperiden Selectively Impairs Verbal Episodic Memory in a Dose- and Time-Dependent Manner in Healthy Subjects

Borghans, L., Sambeth, A. & Blokland, A., 2020, In : Journal of Clinical Psychopharmacology. 40, 1, p. 30-37 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study

Blokland, A., Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T. & Prickaerts, J., May 2019, In : Neurobiology of Aging. 77, p. 37-43 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

False memory formation in cannabis users: a field study

Kloft, L., Otgaar, H., Blokland, A., Garbaciak, A., Monds, L. A. & Ramaekers, J. G., 28 Jun 2019, In : Psychopharmacology. 236, 12, p. 3439-3450 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

No interaction between rivastigmine and citalopram on memory and novelty processing in healthy human volunteers

Heckman, P. R. A., Blokland, A. & Sambeth, A., Feb 2019, In : Journal of Psychopharmacology. 33, 2, p. 210-218 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Of rats, man, and Neuroscience

Blokland, A., 19 Sep 2019, Maastricht University.

Research output: Book/ReportInaugural speechPopular

Phosphodiesterase Type 4 Inhibition in CNS Diseases

Blokland, A., Heckman, P., Vanmierlo, T., Schreiber, R., Paes, D. & Prickaerts, J., Dec 2019, In : Trends in Pharmacological Sciences. 40, 12, p. 971-985 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2018

Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults

Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Smit, S., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., 15 Mar 2018, In : Neuropharmacology. 131, p. 31-38 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial

Heckman, P. R. A., Van Duinen, M. A., Blokland, A., Uz, T., Prickaerts, J. & Sambeth, A., Jan 2018, In : Psychopharmacology. 235, 1, p. 301–308 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intake of tryptophan-enriched whey protein acutely enhances recall of positive loaded words in patients with multiple sclerosis

Lieben, C. K., Blokland, A., Deutz, N. E., Jansen, W., Han, G. & Hupperts, R. M., Feb 2018, In : Clinical Nutrition. 37, 1, p. 321-328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

Heckman, P. R. A., Schweimer, J. V., Sharp, T., Prickaerts, J. & Blokland, A., Mar 2018, In : Brain Structure & Function. 223, 2, p. 739-748 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations

Heckman, P. R. A., Blokland, A., Bollen, E. P. P. & Prickaerts, J., Apr 2018, In : Neuroscience and Biobehavioral Reviews. 87, p. 233-254 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment

Borghans, L. G. J. M., Sambeth, A., Prickaerts, J., Ramaekers, J. G. & Blokland, A., Aug 2018, In : Psychopharmacology. 235, 8, p. 2407-2416 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity

Heckman, P. R. A., Blokland, A., Van Goethem, N. P., Van Hagen, B. T. J. & Prickaerts, J., 17 Sep 2018, In : Behavioural Brain Research. 350, p. 16-22 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A combination of nootropic ingredients (CAF+) is not better than caffeine in improving cognitive functions

Caldenhove, S., Sambeth, A., Sharma, S., G., W. & Blokland, A., 18 Dec 2017, In : Journal of Cognitive Enhancement. 2, 1, p. 106-113

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of biperiden and acute tryptophan depletion and their combination on verbal memory and electroencephalography

Borghans, L., Blokland, A. & Sambeth, A., Mar 2017, In : European Neuropsychopharmacology. 27, p. S65-S66

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Effects of biperiden and acute tryptophan depletion and their combination on verbal word memory and EEG

Borghans, L. G. J. M., Blokland, A. & Sambeth, A., Apr 2017, In : Psychopharmacology. 234, 7, p. 1135-1143

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of riociguat and biperiden on memory

Borghans, L. G. J. M., Sambeth, A., Prickaerts, J. H. H. J., Ramaekers, J. G. & Blokland, A., Oct 2017, p. S645-S645.

Research output: Contribution to conferencePosterAcademic

109 Downloads (Pure)

Fornix deep brain stimulation induced long-term spatial memory independent of hippocampal neurogenesis

Hescham, S., Temel, Y., Schipper, S., Lagiere, M., Schönfeld, L-M., Blokland, A. & Jahanshahi, A., Mar 2017, In : Brain Structure & Function. 222, 2, p. 1069–1075 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File

From Age-Related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential Role for Phosphodiesterases

Heckman, P. R. A., Blokland, A. & Prickaerts, J., 2017, Phosphodiesterases: CNS Functions and Diseases. Zhang, H-T., Xu, Y. & O'Donnell, J. M. (eds.). Springer, p. 135-168 34 p. (Advances in Neurobiology, Vol. 17).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

From age-related cognitive decline to Alzheimer’s disease: a translational overview of the potential role for phosphodiesterases

Heckman, P., Blokland, A. & Prickaerts, J., 2017, Phosphodiesterases: CNS Functions and Diseases. . Zhang, H-T., Xu, Y. & O'Donnell, J. M. (eds.). Berlin: Springer Verlag, p. 217-221 4 p. (Advances in Neurobiology, Vol. 17).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease

Prickaerts, J., Heckman, P. R. A. & Blokland, A., 9 Aug 2017, In : Expert Opinion on Investigational Drugs. 26, 9, p. 1033-1048 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System

Todorova, V. & Blokland, A., 2017, In : Current Neuropharmacology. 15, 1, p. 166-173 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Role of acetylcholine and serotonin in novelty processing using an oddball paradigm

Caldenhove, S., Borghans, L., Blokland, A. & Sambeth, A., 28 Jul 2017, In : Behavioural Brain Research. 331, p. 199-204 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The PDE4-inhibitor roflumilast improves memory: findings from a translational perspective

Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T., Blokland, A. & Prickaerts, J., Oct 2017, In : European Neuropsychopharmacology. 27, Suppl 4, p. S1024-S1025

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

2016
1 Citation (Scopus)

Accelerated cognitive decline in a rodent model for temporal lobe epilepsy

Schipper, S., Aalbers, M. W., Rijkers, K., Lagiere, M., Bogaarts, J. G., Blokland, A., Klinkenberg, S., Hoogland, G. & Vles, J. S. H., Dec 2016, In : Epilepsy & Behavior. 65, p. 33-41 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

83 Downloads (Pure)

Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus

Hescham, S., Jahanshahianvar, A., Schweimer, J. V., Mitchell, S. N., Carter, G., Blokland, A., Sharp, T. & Temel, Y., Nov 2016, In : Brain Structure & Function. 221, 8, p. 4281–4286 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
143 Downloads (Pure)

Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications

Heckman, P. R. A., van Duinen, M. A., Bollen, E. P. P., Nishi, A., Wennogle, L. P., Blokland, A. & Prickaerts, J., Oct 2016, In : International Journal of Neuropsychopharmacology. 19, 10, 16 p., pyw030.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2 Citations (Scopus)
138 Downloads (Pure)

Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2016, In : Learning & Memory. 23, 1, p. 29-37 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
6 Citations (Scopus)

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Vanmierlo, T., Creemers, P., Akkerman, S., van Duinen, M., Sambeth, A., De Vry, J., Uz, T., Blokland, A. & Prickaerts, J., 15 Apr 2016, In : Behavioural Brain Research. 303, p. 26-33 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

117 Downloads (Pure)

Why an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine

Blokland, A., Sambeth, A., Prickaerts, J. & Riedel, W. J., 30 Sep 2016, In : Frontiers in Neurology. 7, 4 p., 167.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2015
3 Citations (Scopus)

Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions

Hescham, S., Jahanshahi, A., Meriaux, C., Lim, L. W., Blokland, A. & Temel, Y., 1 Oct 2015, In : Behavioural Brain Research. 292, p. 353-360

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Biperiden selectively induces memory impairment in healthy volunteers : no interaction with citalopram

Sambeth, A., Riedel, W. J., Klinkenberg, I., Kähkönen, S. & Blokland, A., 1 Jan 2015, In : Psychopharmacology. 232, 11, p. 1887-1897

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Declarative memory

Riedel, W. J. & Blokland, A., 2015, Handbook of Experimental Pharmacology. Vol. 228. p. 215-36 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Episodic memory and the medial temporal lobe: towards a unifying framework of recognition and recall

Berkers, R., van Goethem, N., Rutten, K., Blokland, A. & Prickaerts, J., 2015, Episodic Memory: Formation, Clinical Disorders and Role of Aging. . Edison, K. (ed.). New York: Nova Science Publishers, p. 85-134 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2 Citations (Scopus)

Girls' childhood trajectories of disruptive behavior predict adjustment problems in early adolescence

van der Molen, E., Blokland, A. A. J., Hipwell, A. E., Vermeiren, R. R. J. M., Doreleijers, T. A. H. & Loeber, R., Jul 2015, In : Journal of Child Psychology and Psychiatry. 56, 7, p. 766-773

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors

Bollen, E., Akkerman, S., Puzzo, D., Gulisano, W., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 17 Apr 2015, In : Neuropharmacology. 95, p. 361-366

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

PDE5 inhibition improves acquisition processes after learning via a central mechanism

Akkerman, S., Blokland, A., van Goethem, N. P., Cremers, P., Shaffer, C. L., Osgood, S. M., Steinbusch, H. W. M. & Prickaerts, J., Oct 2015, In : Neuropharmacology. 97, p. 233-239 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

PDE and cognitive processing : beyond the memory domain

Heckman, P., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, In : Neurobiology of Learning and Memory. 119, p. 108-122 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Phosphodiesterase 2A inhibition and impulsivity

Heckman, P. R. A., Van Duinen, M., Blokland, A., Ramaekers, J. & Prickaerts, J., Mar 2015, p. S31-S31.

Research output: Contribution to conferenceAbstractAcademic

4 Citations (Scopus)

Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., Prickaerts, J., Toennes, S. W. & Ramaekers, J. G., 1 Jan 2015, In : Psychopharmacology. 232, 2, p. 343-353 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The use of EEG parameters as predictors of drug effects on cognition

Blokland, A., Prickaerts, J., van Duinen, M. & Sambeth, A., 15 Jul 2015, In : European Journal of Pharmacology. 759, p. 163-168 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Treatment of cognitive impairment in schizophrenia: potential value of phosphodiesterase inhibitors in prefrontal dysfunction

van Duinen, M., Reneerkens, O. A. H., Lambrecht, L., Sambeth, A., Rutten, B. P. F., van Os, J., Blokland, A. & Prickaerts, J., 1 Jan 2015, In : Current Pharmaceutical Design. 21, 26, p. 3813-3828 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

2014
7 Citations (Scopus)

Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation

Hestermann, D., Temel, Y., Blokland, A. & Lim, L. W., 14 Oct 2014, In : Behavioural Brain Research. 273, p. 155-165 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Ambulant cognitive assessment using a smartphone

Timmers, C., Maeghs, A., Vestjens, M., Bonnemayer, C. C. W., Hamers, H. & Blokland, A., 1 Jan 2014, In : Applied Neuropsychology-Adult. 21, 2, p. 136-142 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

A neuroanatomical analysis of the effects of a memory impairing dose of scopolamine in the rat brain using cytochrome c oxidase as principle marker

Hescham, S., Temel, Y., Casaca-Carreira, J., Arslantas, K., Yakkioui, Y., Blokland, A. & Jahanshahi, A., Sep 2014, In : Journal of Chemical Neuroanatomy. 59-60, p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling

Bollen, E., Puzzo, D., Rutten, K., Privitera, L., De Vry, J., Vanmierlo, T., Kenis, G., Palmeri, A., D'Hooge, R., Balschun, D., Steinbusch, H. W. M., Blokland, A. & Prickaerts, J., 12 May 2014, In : Neuropsychopharmacology. 39, p. 2497-2505

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse

van Donkelaar, E. L., Vaessen, K. R. D., Pawluski, J. L., Sierksma, A. S., Blokland, A., Canete, R. & Steinbusch, H. W. M., 13 Oct 2014, In : PLOS ONE. 9, 10, 10 p., e106960.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Mind the gap: Delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors

Akkerman, S., Blokland, A. & Prickaerts, J., 1 Jan 2014, In : Neurobiology of Learning and Memory. 109, p. 139-143

Research output: Contribution to journalArticleAcademicpeer-review