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2020

(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation

Milenkovic, D., Declerck, K., Guttman, Y., Kerem, Z., Claude, S., Weseler, A. R., Bast, A., Schroeter, H., Morand, C. & Vanden Berghe, W., Mar 2020, In : Biochemical Pharmacology. 173, 16 p., 113699.

Research output: Contribution to journalArticleAcademicpeer-review

2018

Dietary Advanced Glycation Endproducts Induce an Inflammatory Response in Human Macrophages in Vitro

van der Lugt, T., Weseler, A. R., Gebbink, W. A., Vrolijk, M. F., Opperhuizen, A. & Bast, A., 1 Dec 2018, In : Nutrients. 10, 12, 10 p., 1868.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro

Verissimo, G., Bast, A. & Weseler, A. R., 1 Aug 2018, In : Chemico-Biological Interactions. 291, p. 237-244 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia

Decroix, L., Tonoli, C., Lespagnol, E., Balestra, C., Descat, A., Drittij-Reijnders, M. J., Blackwell, J. R., Stahl, W., Jones, A. M., Weseler, A. R., Bast, A., Meeusen, R. & Heyman, E., 1 Jul 2018, In : Journal of Applied Physiology. 125, 1, p. 8-18 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The direct and sustained consequences of severe placental hypoxia on vascular contractility

Vangrieken, P., Al-Nasiry, S., Janssen, G. M. J., Weseler, A. R., Spaanderman, M. E., Bast, A. & Schiffers, P. M. H., 24 Aug 2018, In : PLOS ONE. 13, 8, 15 p., e0202648.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial

Decroix, L., Tonoli, C., Soares, D. D., Descat, A., Drittij-Reijnders, M-J., Weseler, A. R., Bast, A., Stahl, W., Heyman, E. & Meeusen, R., 10 Aug 2017, In : Journal of the International Society of Sports Nutrition. 14, 11 p., 28.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Paraquat disrupts the anti-inflammatory action of cortisol in human macrophages in vitro: therapeutic implications for paraquat intoxications

Verssimo, G., Bast, A. & Weseler, A. R., 1 Mar 2017, In : Toxicology Research. 6, 2, p. 232-241 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Time in Redox Adaptation Processes: From Evolution to Hormesis

Sthijns, M. M. J. P. E., Weseler, A. R., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : International journal of molecular sciences. 17, 10, 1649.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

Heyninck, K., Sabbe, L., Chirumamilla, C. S., Szic, K. S. V., Veken, P. V., Lemmens, K. J. A., Lahtela-Kakkonen, M., Naulaerts, S., de Beeck, K. O., Laukens, K., Van Camp, G., Weseler, A. R., Bast, A., Haenen, G. R. M. M., Haegeman, G. & Berghe, W. V., 1 Jun 2016, In : Biochemical Pharmacology. 109, p. 48-61

Research output: Contribution to journalArticleAcademicpeer-review

2014

Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State

Milenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szarc Vel Szic, K., Heyninck, K., Laukens, K., Bizet, M., Defrance, M., Dedeurwaerder, S., Calonne, E., Fuks, F., Haegeman, G., Haenen, G. R., Bast, A. & Weseler, A. R., 24 Apr 2014, In : PLOS ONE. 9, 4, 13 p., e95527.

Research output: Contribution to journalArticleAcademicpeer-review

Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup

Hazewindus, M., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : PLOS ONE. 9, 12, e114387.

Research output: Contribution to journalArticleAcademicpeer-review

The cocoa flavanol (-)-epicatechin protects the cortisol response.

Ruijters, E. J., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : Pharmacological Research. 79, p. 28-33 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Über den Genen: Epigenetik - Teil 2

Weseler, A. R., 1 Jan 2014, In : Apotheken-Magazin: Fachmagazin fuer pharmazeutische Fortbildung. 5, p. 6-13

Research output: Contribution to journalArticleAcademic

2013

The flavanol (-)-epicatechin and its metabolites protect against oxidative stress in primary endothelial cells via a direct antioxidant effect.

Ruijters, E. J. B., Weseler, A. R., Kicken, C., Haenen, G. R. M. M. & Bast, A., 5 Sep 2013, In : European Journal of Pharmacology. 715, 1-3, p. 147-153 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2012

Pleiotropic-acting nutrients require integrative investigational approaches: the example of flavonoids.

Weseler, A. R. & Bast, A., 12 Sep 2012, In : Journal of Agricultural and Food Chemistry. 60, 36, p. 8941-8946 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and alpha-tocopherol

Hazewindus, M., Haenen, G. R. M. M., Weseler, A. R. & Bast, A., 15 May 2012, In : Food Chemistry. 132, 2, p. 954-958 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2011

Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health - a randomized controlled clinical pilot study

Weseler, A. R., Ruijters, E. J. B., Reesink, K. D., Haenen, G. R. M. M. & Bast, A., 8 Dec 2011, In : PLOS ONE. 6, 12, 12 p., 28460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2010

Erythritol is a sweet antioxidant

den Hartog, G. J., Boots, A. W., Adam Perrot, A., Brouns, F. J. P. H., Verkooijen, I. W., Weseler, A. R., Haenen, G. R. & Bast, A., 1 Jan 2010, In : Nutrition. 26, 4, p. 449-458

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine.

Geraets, L., Haegens, A., Weseler, A. R., Brauers, K., Vernooy, J. H., Wouters, E. F., Bast, A. & Hageman, G. J., 10 Mar 2010, In : European Journal of Pharmacology. 629, 1-3, p. 132-139 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oxidative stress and antioxidants in interstitial lung disease.

Bast, A., Weseler, A. R., Haenen, G. R. M. M. & den Hartog, G. J. M., 1 Jan 2010, In : Current Opinion in Pulmonary Medicine. 16, 5, p. 516-520

Research output: Contribution to journalArticleAcademicpeer-review

Oxidative stress and vascular function: implications for pharmacologic treatments.

Weseler, A. R. & Bast, A., Jun 2010, In : Current Hypertension Reports. 12, 3, p. 154-161 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009

Poly (ADP-ribose) Polymerase-1-Inhibiting Flavonoids Attenuate Cytokine Release in Blood from Male Patients with Chronic Obstructive Pulmonary Disease or Type 2 Diabetes

Weseler, A. R., Geraets, L., Moonen, H. J., Manders, R. J., van Loon, L. J., Pennings, H. J., Wouters, E. F., Bast, A. & Hageman, G. J., 1 Jan 2009, In : Journal of Nutrition. 139, 5, p. 952-957

Research output: Contribution to journalArticleAcademicpeer-review