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Research Output 2013 2019

2019

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Iglesias, V. S., van Hoof, S. J., Vaniqui, A., Schyns, L. E., Lieuwes, N., Yaromina, A., Spiegelberg, L., Groot, A. J., Verhaegen, F., Theys, J., Dubois, L. & Vooijs, M., 2019, In : British Journal of Radiology. 92, 1095, 10 p., 20180476.

Research output: Contribution to journalArticleAcademicpeer-review

HIF-1 alpha and HIF-2 alpha Differently Regulate the Radiation Sensitivity of NSCLC Cells

Roig, E. M., Groot, A. J., Yaromina, A., Hendrickx, T. C., Barbeau, L. M. O., Giuranno, L., Dams, G., Ient, J., Pimentel, V. O., van Gisbergen, M. W., Dubois, L. J. & Vooijs, M. A., Jan 2019, In : Cells. 8, 1, 15 p., 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Spiegelberg, L., Houben, R., Niemans, R., de Ruysscher, D., Yaromina, A., Theys, J., Guise, C. P., Smaill, J. B., Patterson, A. V., Lambin, P. & Dubois, L. J., Feb 2019, In : Clinical and Translational Radiation Oncology. 15, p. 62-69 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach

Meaney, C., Powathil, G. G., Yaromina, A., Dubois, L. J., Lambin, P. & Kohandel, M., 2019, In : Mathematical Biosciences and Engineering. 16, 6, p. 6257-6273 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

Kazokaite, J., Niemans, R., Dudutiene, V., Becker, H. M., Leitans, J., Zubriene, A., Baranauskiene, L., Gondi, G., Zeidler, R., Matuliene, J., Tars, K., Yaromina, A., Lambin, P., Dubois, L. & Matulis, D., 2018, In : Oncotarget. 9, 42, p. 26800-26816

Research output: Contribution to journalArticleAcademicpeer-review

Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis

Roig, E. M., Yaromina, A., Houben, R., Groot, A. J., Dubois, L. & Vooijs, M., 11 Jun 2018, In : Frontiers in Oncology. 8, 11 p., 224.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Synergistic Effects of NOTCH/gamma-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

Iglesias, V. S., Theys, J., Groot, A. J., Barbeau, L. M. O., Lemmens, A., Yaromina, A., Losen, M., Houben, R., Dubois, L. & Vooijs, M., 7 Nov 2018, In : Frontiers in Oncology. 8, 13 p., 460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses

Rekers, N. H., Pimentel, V. O., Yaromina, A., Lieuwes, N. G., Biemans, R., Zegers, C. M. L., Germeraad, W. T. V., Van Limbergen, E. J., Neri, D., Dubois, L. J. & Lambin, P., 1 Jan 2018, In : OncoImmunology . 7, 4, 15 p., e1414119.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

A novel concept for tumour targeting with radiation: Inverse dose-painting or targeting the "Low Drug Uptake Volume"

Yaromina, A., Granzier, M., Biemans, R., Lieuwes, N., van Elmpt, W., Shakirin, G., Dubois, L. & Lambin, P., Sep 2017, In : Radiotherapy and Oncology. 124, 3, p. 513-520 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Combining radiotherapy with immunotherapy: the past, the present and the future

Van Limbergen, E. J., De Ruysscher, D. K., Pimentel, V. O., Marcus, D., Berbee, M., Hoeben, A., Rekers, N., Theys, J., Yaromina, A., Dubois, L. J. & Lambin, P., 2017, In : British Journal of Radiology. 90, 1076, 9 p., 20170157.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
53 Downloads (Pure)

Decision support systems for personalized and participative radiation oncology

Lambin, P., Zindler, J., Vanneste, B. G. L., Van De Voorde, L., Eekers, D., Compter, I., Panth, K. M., Peerlings, J., Larue, R. T. H. M., Deist, T. M., Jochems, A., Lustberg, T., van Soest, J., de Jong, E. E. C., Even, A. J. G., Reymen, B., Rekers, N., van Gisbergen, M., Roelofs, E., Carvalho, S. & 19 others, Leijenaar, R. T. H., Zegers, C. M. L., Jacobs, M., van Timmeren, J., Brouwers, P., Lal, J. A., Dubois, L., Yaromina, A., Van Limbergen, E. J., Berbee, M., van Elmpt, W., Oberije, C., Ramaekers, B., Dekker, A., Boersma, L. J., Hoebers, F., Smits, K. M., Berlanga, A. J. & Walsh, S., 15 Jan 2017, In : Advanced Drug Delivery Reviews. 109, p. 131-153 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
File

Ex vivo gamma H2AX radiation sensitivity assay in prostate cancer: Inter-patient and intra-patient heterogeneity

De-Colle, C., Yaromina, A., Hennenlotter, J., Thames, H., Mueller, A-C., Neumann, T., Stenzl, A., Scharpf, M., Fend, F., Ricardi, U., Baumann, M., Zips, D. & Menegakis, A., Sep 2017, In : Radiotherapy and Oncology. 124, 3, p. 386-394 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypoxia and hypoxia response-associated molecular markers in esophageal cancer: A systematic review

Peerlings, J., Van De Voorde, L., Mitea, C., Larue, R., Yaromina, A., Sandeleanu, S., Spiegelberg, L., Dubois, L., Lambin, P. & Mottaghy, F. M., 1 Nov 2017, In : Methods. 130, p. 51-62 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs

van Kuijk, S. J. A., Parvathaneni, N. K., Niemans, R., van Gisbergen, M. W., Carta, F., Vullo, D., Pastorekova, S., Yaromina, A., Supuran, C. T., Dubois, L. J., Winurn, J-Y. & Lambin, P., 15 Feb 2017, In : European Journal of Medicinal Chemistry. 127, p. 691-702 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Therapeutic options to overcome tumor hypoxia in radiation oncology

Troost, E. G. C., Koi, L., Yaromina, A. & Krause, M., Oct 2017, In : Clinical and Translational Imaging. 5, 5, p. 455-464 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O-2 consumption?

Wack, L. J., Moennich, D., Yaromina, A., Zips, D., Baumann, M. & Thorwarth, D., Jul 2016, In : Medical Physics. 43, 7, p. 4113-4121

Research output: Contribution to journalArticleAcademicpeer-review

IL2 based immunotherapies: towards a personalized and curative antitumor response

Rekers, N. H., Pimentel, V. O., Yaromina, A., Dubois, L. & Lambin, P., Nov 2016, In : Translational Cancer Research. 5, Suppl 6, p. S1292-S1294

Research output: Contribution to journalArticleAcademicpeer-review

Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours

Jentsch, C., Bergmann, R., Bruechner, K., Mosch, B., Yaromina, A., Krause, M., Zips, D., Troost, E. G. C., Loeck, S., Kotzerke, J., Steinbach, J., Thames, H., Baumann, M. & Beuthien-Baumann, B., Dec 2016, In : Radiotherapy and Oncology. 121, 3, p. 447-452

Research output: Contribution to journalArticleAcademicpeer-review

In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity

Panth, K. M., van den Beucken, T., Biemans, R., Lieuwes, N. G., Weber, M., Losen, M., Yaromina, A., Dubois, L. J. & Lambin, P., 29 Feb 2016, In : Scientific Reports. 6, 22198.

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Prognostic Significance of Carbonic Anhydrase IX expression in Cancer Patients: A Meta-Analysis

van Kuijk, S. J. A., Yaromina, A., Houben, R., Niemans, R., Lambin, P. & Dubois, L. J., 29 Mar 2016, In : Frontiers in Oncology. 6, 69.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Synthesis and in Vivo Biological Evaluation of Ga-68-Labeled Carbonic Anhydrase IX Targeting Small Molecules for Positron Emission Tomography

Sneddon, D., Niemans, R., Bauwens, M., Yaromina, A., van Kuijk, S. J. A., Lieuwes, N. G., Biemans, R., Pooters, I., Pellegrini, P. A., Lengkeek, N. A., Greguric, I., Tonissen, K. F., Supuran, C. T., Lambin, P., Dubois, L. & Poulsen, S-A., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6431-6443

Research output: Contribution to journalArticleAcademicpeer-review

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

van Kuijk, S. J. A., Gieling, R. G., Niemans, R., Lieuwes, N. G., Biemans, R., Telfer, B. A., Haenen, G. R. M. M., Yaromina, A., Lambin, P., Dubois, L. J. & Williams, K. J., 11 Aug 2016, In : PLOS ONE. 11, 8, e0161040.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
8 Citations (Scopus)

Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model

Rekers, N. H., Zegers, C. M. L., Yaromina, A., Lieuwes, N. G., Biemans, R., Senden-Gijsbers, B. L. M. G., Losen, M., Van Limbergen, E. J., Germeraad, W. T. V., Neri, D., Dubois, L. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 438-442

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Current preclinical and clinical applications of hypoxia PET imaging using 2-nitroimidazoles

Peeters, S. G. J. A., Zegers, C. M. L., Yaromina, A., Van Elmpt, W., Dubois, L. & Lambin, P., Mar 2015, In : Quarterly Journal of Nuclear Medicine and Molecular Imaging. 59, 1, p. 39-57

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

gamma H2AX assay in ex vivo irradiated tumour specimens: A novel Method to determine tumour radiation sensitivity in patient-derived material

Menegakis, A., von Neubeck, C., Yaromina, A., Thames, H., Hering, S., Hennenlotter, J., Scharpf, M., Noell, S., Krause, M., Zips, D. & Baumann, M., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 473-479

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Is there a causal relationship between genetic changes and radiomics-based image features? An in vivo preclinical experiment with doxycycline inducible GADD34 tumor cells

Panth, K. M., Leijenaar, R. T. H., Carvalho, S., Lieuwes, N. G., Yaromina, A., Dubois, L. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 462-466

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

New ways to image and target tumour hypoxia and its molecular responses

Dubois, L. J., Niemans, R., van Kuijk, S. J. A., Panth, K. M., Parvathaneni, N-K., Peeters, S. G. J. A., Zegers, C. M. L., Rekers, N. H., van Gisbergen, M. W., Biemans, R., Lieuwes, N. G., Spiegelberg, L., Yaromina, A., Winum, J-Y., Vooijs, M. & Lambin, P., Sep 2015, In : Radiotherapy and Oncology. 116, 3, p. 352-357

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Preclinical Assessment of Efficacy of Radiation Dose Painting Based on Intratumoral FDG-PET Uptake

Trani, D., Yaromina, A., Dubois, L., Granzier, M., Peeters, S. G. J. A., Biemans, R., Nalbantov, G., Lieuwes, N., Reniers, B., Troost, E. E. G. C., Verhaegen, F. & Lambin, P., 15 Dec 2015, In : Clinical Cancer Research. 21, 24, p. 5511-5518

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects

Zegers, C. M. L., Rekers, N. H., Quaden, D. H. F., Lieuwes, N. G., Yaromina, A., Germeraad, W. T. V., Wieten, L., Biessen, E. A. L., Boon, L., Neri, D., Troost, E. G. C., Dubois, L. J. & Lambin, P., Mar 2015, In : Clinical Cancer Research. 21, 5, p. 1151-1160

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [F-18]HX4 Hypoxia PET Imaging

Peeters, S. G. J. A., Zegers, C. M. L., Biemans, R., Lieuwes, N. G., van Stiphout, R. G. P. M., Yaromina, A., Sun, J. D., Hart, C. P., Windhorst, A. D., van Elmpt, W., Dubois, L. J. & Lambin, P., 1 Jul 2015, In : Clinical Cancer Research. 21, 13, p. 2984-2992

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

What Level of Accuracy Is Achievable for Preclinical Dose Painting Studies on a Clinical Irradiation Platform?

Trani, D., Reniers, B., Persoon, L., Podesta, M., Nalbantov, G., Leijenaar, R. T. H., Granzier, M., Yaromina, A., Dubois, L., Verhaegen, F. & Lambin, P., May 2015, In : Radiation Research. 183, 5, p. 501-510

Research output: Contribution to journalArticleAcademicpeer-review

2014
11 Citations (Scopus)

BAY 87-2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts

Helbig, L., Koi, L., Bruechner, K., Gurtner, K., Hess-Stumpp, H., Unterschemmann, K., Baumann, M., Zips, D. & Yaromina, A., 19 Sep 2014, In : Radiation Oncology. 9, 207.

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Effect of [F-18]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice

Schuetze, C., Bergmann, R., Bruechner, K., Mosch, B., Yaromina, A., Zips, D., Hessel, F., Krause, M., Thames, H., Kotzerke, J., Steinbach, J., Baumann, M. & Beuthien-Baumann, B., Apr 2014, In : Radiotherapy and Oncology. 111, 1, p. 81-87

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Hypoxia-Inducible Factor Pathway Inhibition Resolves Tumor Hypoxia and Improves Local Tumor Control After Single-Dose Irradiation

Helbig, L., Koi, L., Bruechner, K., Gurtner, K., Hess-Stumpp, H., Unterschemmann, K., Pruschy, M., Baumann, M., Yaromina, A. & Zips, D., 1 Jan 2014, In : International Journal of Radiation Oncology Biology Physics. 88, 1, p. 159-166

Research output: Contribution to journalArticleAcademicpeer-review

2013
37 Citations (Scopus)

Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs

Dubois, L., Peeters, S. G. J. A., van Kuijk, S. J. A., Yaromina, A., Lieuwes, N. G., Saraya, R., Biemans, R., Rami, M., Parvathaneni, N. K., Vullo, D., Vooijs, M., Supuran, C. T., Winum, J-Y. & Lambin, P., Sep 2013, In : Radiotherapy and Oncology. 108, 3, p. 523-528

Research output: Contribution to journalArticleAcademicpeer-review