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Adriaan de Bruïne

Dr.

19932016

Research output per year

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Research Output

The emerging role of GATA transcription factors in development and disease

Lentjes - Beer, M., Niessen, H. E. C., Akiyama, Y., De Bruine, A. P., Melotte, V. & Van Engeland, M., 8 Mar 2016, In : Expert Reviews in Molecular Medicine. 18, e3.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
2014

CHFR Promoter Methylation Indicates Poor Prognosis in Stage II Microsatellite Stable Colorectal Cancer

Cleven, A. H. G., Derks, S., Draht, M. X. G., Smits, K. M., Melotte, V., Van Neste, L., Tournier, B., Jooste, V., Chapusot, C., Weijenberg, M. P., Herman, J. G., de Bruine, A. P. & van Engeland, M., 15 Jun 2014, In : Clinical Cancer Research. 20, 12, p. 3261-3271

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine

Derks, S., Cleven, A. H. G., Melotte, V., Smits, K. M., Brandes, J. C., Azad, N., van Criekinge, W., de Bruine, A. P., Herman, J. G. & van Engeland, M., Mar 2014, In : Cancer and Metastasis Reviews. 33, 1, p. 161-171

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Promoter CpG island methylation of RET predicts poor prognosis in stage II colorectal cancer patients

Draht, M. X. G., Smits, K. M., Tournier, B., Jooste, V., Chapusot, C., Carvalho, B., Cleven, A. H. G., Derks, S., Wouters, K. A. D., Belt, E. J. T., Stockmann, H. B. A. C., Bril, H., Weijenberg, M. P., van den Brandt, P. A., de Bruïne, A. P., Herman, J. G., Meijer, G. A., Piard, F., Melotte, V. & van Engeland, M., 1 Jan 2014, In : Molecular oncology. 8, 3, p. 679-688

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2013

A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis

Simons, C., Hughes, L. A. E., Smits, K. M., Khalid-de Bakker, C. A., de Bruine, A. P., Carvalho, B., Meijer, G. A., Schouten, L. J., van den Brandt, P. A., Weijenberg, M. P. & van Engeland, M., Aug 2013, In : Annals of Oncology. 24, 8, p. 2048-2056

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC

Gilsing, A. M. J., Fransen, F., de Kok, T. M., Goldbohm, A. R., Schouten, L. J., de Bruine, A. P., van Engeland, M., van den Brandt, P. A., de Goeij, A. F. P. M. & Weijenberg, M. P., Dec 2013, In : Carcinogenesis. 34, 12, p. 2757-2766

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2012

Chromosome 5q Loss in Colorectal Flat Adenomas

Voorham, Q. J. M., Carvalho, B., Spiertz, A. J., van Grieken, N. C. T., Mongera, S., Rondagh, E. J. A., van de Wiel, M. A., Jordanova, E. S., Ylstra, B., Kliment, M., Grabsch, H., Rembacken, B. J., Arai, T., de Bruine, A. P., Sanduleanu, S., Quirke, P., Mulder, C. J. J., van Engeland, M. & Meijer, G. A., 1 Sep 2012, In : Clinical Cancer Research. 18, 17, p. 4560-4569

Research output: Contribution to journalArticleAcademicpeer-review

Nonpolypoid colorectal neoplasms: Gender differences in prevalence and malignant potential

Rondagh, E. J. A., Masclee, A. A. M., van der Valk, M. E., Winkens, B., de Bruine, A. P., Kaltenbach, T., Soetikno, R. M. & Sanduleanu, S., 1 Jan 2012, In : Scandinavian Journal of Gastroenterology. 47, 1, p. 80-88 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)
2011

Accuracy of Gadofosveset-enhanced MRI for Nodal Staging and Restaging in Rectal Cancer

Lambregts, D. M., Beets, G. L., Maas, M., Kessels, A. G. H., Bakers, F. C., Cappendijk, V. C., Engelen, S. M., Lahaye, M. J., de Bruine, A. P., Lammering, G., Leiner, T., Verwoerd, J. L., Wildberger, J. E. & Beets Tan, R. G., Mar 2011, In : Annals of Surgery. 253, 3, p. 539-545 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

A new model to study intestinal ischemia-reperfusion damage in man.

Derikx, J. P., Matthijsen, R. A., de Bruine, A. P., van Dam, R. M., Buurman, W. A. & Dejong, C. H., Apr 2011, In : Journal of Surgical Research. 166, 2, p. 222-226 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Body Size, Physical Activity and Risk of Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP)

Hughes, L. A. E., Simons, C. C. J. M., van den Brandt, P. A., Goldbohm, R. A. S., de Goeij, A. F. P. M., de Bruine, A. P., van Engeland, M. & Weijenberg, M. P., 5 Apr 2011, In : PLOS ONE. 6, 4, e18571.

Research output: Contribution to journalArticleAcademicpeer-review

Endoscopic red flags for the detection of high-risk serrated polyps: an observational study

Rondagh, E. J. A., Masclee, A. A. M., Bouwens, M. W. E., Winkens, B., Riedl, R. G., de Bruine, A. P., de Ridder, R., Kaltenbach, T., Soetikno, R. M. & Sanduleanu, S., 1 Jan 2011, In : Endoscopy. 43, 12, p. 1052-1058

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Loss of SerpinA5 protein expression is associated with advanced-stage serous ovarian tumors

Bijsmans, I. T. G. W., Smits, K. M., de Graeff, P., Wisman, G. B. A., van der Zee, A. G. J., Slangen, B. F., de Bruine, A. P., van Engeland, M., Sieben, N. L. & Van de Vijver, K. K., Mar 2011, In : Modern Pathology. 24, 3, p. 463-470

Research output: Contribution to journalArticleAcademicpeer-review

Test performance of immunologic fecal occult blood testing and sigmoidoscopy compared with primary colonoscopy screening for colorectal advanced adenomas

Khalid-de Bakker, C. A., Jonkers, D. M. A. E., Sanduleanu, S., de Bruine, A. P., Meijer, G. A., Janssen, J. B., van Engeland, M., Stockbrügger, R. W. & Masclee, A. A. M., Oct 2011, In : Cancer prevention research. 4, 10, p. 1563-1571 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
2010

Absence of tumor invasion into pelvic structures in locally recurrent rectal cancer: prediction with preoperative MR imaging

Dresen, R. C., Kusters, M., Daniels Gooszen, A. W., Cappendijk, V. C., Nieuwenhuijzen, G. A., Kessels, A. G. H., de Bruine, A. P., Beets, G. L., Rutten, H. J. & Beets Tan, R. G. H., Jul 2010, In : Radiology. 256, 1, p. 143-150 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Butyrate enemas improve intestinal anastomotic strength in a rat model

Bloemen, J. G., Schreinemacher, M. H. F., de Bruine, A. P., Buurman, W. A., Bouvy, N. D. & Dejong, C. H. C., Jul 2010, In : Diseases of the Colon & Rectum. 53, 7, p. 1069-1075 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Childhood and adolescent energy restriction and subsequent colorectal cancer risk: results from the Netherlands Cohort Study

Hughes, L. A. E., van den Brandt, P. A., Goldbohm, R. A. S., de Goeij, A. F. P. M., de Bruine, A. P., van Engeland, M. & Weijenberg, M. P., Oct 2010, In : International Journal of Epidemiology. 39, 5, p. 1333-1344

Research output: Contribution to journalArticleAcademicpeer-review

Human intestinal ischemia-reperfusion-induced inflammation characterized: experiences from a new translational model.

Grootjans, J., Lenaerts, K., Derikx, J. P., Matthijsen, R. A., de Bruine, A. P., van Bijnen, A. A., van Dam, R. M., Dejong, C. H. C. & Buurman, W. A., May 2010, In : American Journal of Pathology. 176, 5, p. 2283-2291 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

In vivo diagnosis and classification of colorectal neoplasia by chromoendoscopy-guided confocal laser endomicroscopy.

Sanduleanu, S., Driessen, A., Gomez Garcia, E., Hameeteman, W., de Bruine, A. & Masclee, A., 1 Jan 2010, In : Clinical gastroenterology and hepatology. 8, 4, p. 371-378

Research output: Contribution to journalArticleAcademicpeer-review

83 Citations (Scopus)

Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut

Wolfs, T. G., Derikx, J. P., Hodin, C. M., Vanderlocht, J., Driessen, A., de Bruine, A. P., Bevins, C. L., Lasitschka, F., Gassler, N., van Gemert, W. G. & Buurman, W. A., 1 Jan 2010, In : Inflammatory Bowel Diseases. 16, 1, p. 68-75 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma

van Vlodrop, I. J. H., Baldewijns, M. M. L., Smits, K. M., Schouten, L. J., van Neste, L., Van Criekinge, W., van Poppel, H., Lerut, E., Schuebel, K. E., Ahuja, N., Herman, J. G., de Bruine, A. P. & van Engeland, M., Feb 2010, In : American Journal of Pathology. 176, 2, p. 575-584

Research output: Contribution to journalArticleAcademicpeer-review

The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications

Melotte, V., Qu, X., Ongenaert, M., Van Criekinge, W., de Bruine, A. P., Baldwin, H. S. & van Engeland, M., Nov 2010, In : Faseb Journal. 24, 11, p. 4153-4166

Research output: Contribution to journalArticleAcademicpeer-review

Urine-based detection of intestinal tight junction loss.

Thuijls, G., Derikx, J. P., de Haan, J. J., Grootjans, J., de Bruine, A., Masclee, A. A., Heineman, E. & Buurman, W. A., 1 Jan 2010, In : Journal of Clinical Gastroenterology. 44, 1, p. e14-19

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

VHL and HIF signalling in renal cell carcinogenesis

Baldewijns, M. M., van Vlodrop, I. J. H., Vermeulen, P. B., Soetekouw, P. M. M. B., van Engeland, M. & de Bruine, A. P., Jun 2010, In : Journal of Pathology. 221, 2, p. 125-138

Research output: Contribution to journalArticleAcademicpeer-review

2009

GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer

Hellebrekers, D. M., Lentjes, M. H., van den Bosch, S. M., Melotte, V., Wouters, K. A., Daenen, K. L., Smits, K. M., Akiyama, Y., Yuasa, Y., Sanduleanu, S., Khalid - de Bakker, C. A., Jonkers, D., Weijenberg, M. P., Louwagie, J., van Criekinge, W., Carvalho, B., Meijer, G. A., Baylin, S. B., Herman, J. G., de Bruine, A. P. & 1 others, van Engeland, M., 1 Jan 2009, In : Clinical Cancer Research. 15, 12, p. 3990-7

Research output: Contribution to journalArticleAcademicpeer-review

103 Citations (Scopus)
62 Citations (Scopus)

Inflammatory cloacogenic polyp: diagnostic features by confocal endomicroscopy.

Sanduleanu, S., Driessen, A., Hameeteman, W., van Gemert, W., de Bruine, A. & Masclee, A., 1 Jan 2009, In : Gastrointestinal Endoscopy. 69, 3, p. 595-598

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part I. Are we able to predict tumor confined to the rectal wall?

Dresen, R. C., Beets, G. L., Rutten, H. J., Engelen, S. M., Lahaye, M. J., Vliegen, R. F., de Bruine, A. P., Kessels, A. G., Lammering, G. & Beets Tan, R. G. H., 1 Jan 2009, In : Radiology. 252, 1, p. 71-80

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part II. What are the criteria to predict involved lymph nodes?

Lahaye, M. J., Beets, G. L., Engelen, S. M., Kessels, A. G., de Bruine, A. P., Kwee, H. W., van Engelshoven, J. M., van de Velde, C. J. & Beets Tan, R. G., 1 Jan 2009, In : Radiology. 252, 1, p. 81-91

Research output: Contribution to journalArticleAcademicpeer-review

57 Citations (Scopus)

Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer

Glockner, S. C., Dhir, M., Yi, J. M., McGarvey, K. E., van Neste, L., Louwagie, J., Chan, T. A., Kleeberger, W., de Bruine, A. P., Smits, K. M., Khalid - de Bakker, C. A., Jonkers, D. M., Stockbrugger, R. W., Meijer, G. A., Oort, F. A., Iacobuzio Donahue, C., Bierau, K., Herman, J. G., Baylin, S. B., van Engeland, M. & 2 others, Schuebel, K. E. & Ahuja, N., 1 Jan 2009, In : Cancer Research. 69, 11, p. 4691-9

Research output: Contribution to journalArticleAcademicpeer-review

138 Citations (Scopus)

N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer

Melotte, V., Lentjes, M. H., van den Bosch, S. M., Hellebrekers, D. M., de Hoon, J. P. J., Wouters, K. A., Daenen, K. L., Partouns Hendriks, I. E., Stessels, F., Louwagie, J., Smits, K. M., Weijenberg, M. P., Sanduleanu, S., Khalid - de Bakker, C. A., Oort, F. A., Meijer, G. A., Jonkers, D. M., Herman, J. G., de Bruine, A. P. & van Engeland, M., 1 Jan 2009, In : Journal of the National Cancer Institute. 101, 13, p. 916-27

Research output: Contribution to journalArticleAcademicpeer-review

105 Citations (Scopus)
2008

Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction

Vliegen, R. F., Beets, G. L., Lammering, G., Dresen, R. C., Rutten, H. J., Kessels, A. G., Oei, T. K., de Bruine, A. P., van Engelshoven, J. M. & Beets Tan, R. G., 1 Jan 2008, In : Radiology. 246, 2, p. 454-62

Research output: Contribution to journalArticleAcademicpeer-review

108 Citations (Scopus)

Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation.

Derikx, J. P., Matthijsen, R. A., de Bruine, A. P., van Bijnen, A. A., Heineman, E., van Dam, R. M., Dejong, C. H. & Buurman, W. A., 1 Jan 2008, In : PLOS ONE. 3, 10, e3428.

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)

USPIO-enhanced MR imaging for nodal staging in patients with primary rectal cancer: predictive criteria

Lahaye, M. J., Engelen, S. M., Kessels, A. G., de Bruine, A. P., von Meyenfeldt, M. F., van Engelshoven, J. M., van de Velde, C. J., Beets, G. L. & Beets Tan, R. G., 1 Jan 2008, In : Radiology. 246, 3, p. 804-11

Research output: Contribution to journalArticleAcademicpeer-review

110 Citations (Scopus)
2007

Associations between O6MGMT and MLH1 promoter methylation and APC and KRAS gene mutations in colorectal cancer: indications for distinct pathways and sequence of events ambridge, Massachusetts

de Vogel, S. C., Weijenberg, M. P., Herman, J. G., Wouters, K. A., de Goeij, A. F. P., van den Brandt, P. A., de Bruine, A. & van Engeland, M., 1 Jan 2007, Advances in colon cancer research. Cambridge, Massachusetts

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer

de Vogel, S. C., Bongaerts, B. W., Wouters, K. A., de Goeij, A. F., de Bruine, A. P., Goldbohm, R. A., van den Brandt, P. A., van Engeland, M. & Weijenberg, M. P., 1 Jan 2007, Advances in colon cancer research. Cambridge, Massachusetts

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Can tailor-made treatment of primary rectal carcinoma based on USPIO MRI decrease the number of incomplete resections?

Engelen, S. M. E., Lahaye, M. J., Beets-Tan, R. G. H., de Bruine, A. P., Post, P. J. M., Debets, J. M. H., Verkooijen, H. C. M., van de Velde, C. J. H. & Beets, G. L., 1 Jan 2007, In : Nederlands Tijdschrift voor Heelkunde. 16, 3, p. 379-380

Research output: Contribution to journalArticleAcademicpeer-review

GATA4 and GATA5 as tumor suppressors and biomarkers in colorectal cancer

Hellebrekers, D. M. E. I., Lentjes, M., van den Bosch, S., Daenen, K., Akiyama, Y., Yuasa, Y., Sanduleanu, S., Khalid, C., Weijenberg, M. P., Louwagie, J., van Criekinge, W., Meijer, G., Herman, J., de Bruine, A. P. & van Engeland, M. I., 1 Jan 2007, Advances in colon cancer research.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

N-Myc Downstream regulated gene 4 (NDRG4) promoter methylation is a sensitive and specific biomarker for colorectal cancer ambridge, Massachusetts

Melotte, V., Lentjes, M., van den Bosch, S., Hellebrekers, D. M. E. I., Wouters, K., Menting, D., Daenen, K., Sanduleanu, S., Khalid, C., Weijenberg, M. P., Oort, F., Meijer, G. J., Herman, J., de Bruine, A. & van Engeland, M., 1 Jan 2007, Advances in colon cancer research.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

2006

Dialectiek in de academische pathologie: RIP?

de Bruine, A. P., 23 Jun 2006, Maastricht: Maastricht University. 25 p.

Research output: Book/ReportInaugural speechPopular

Open Access
File
147 Downloads (Pure)

Het insulinoom van het pancreas

Engelen, S. M. E., Freijzer, P. L., Greve, J. W. M., Soeters, P. B., de Bruine, A. P. & Dejong, C. H. C., 1 Jan 2006, In : Nederlands Tijdschrift voor Heelkunde. 15, 3

Research output: Contribution to journalArticleAcademicpeer-review

Promoter methylation precedes chromosomal alterations in colorectal cancer development

Derks, S., Postma, C., Moerkerk, P. T. M., van den Bosch, S. M., Carvalho, B., Hermsen, M. A., Giaretti, W., Herman, J. G., Weijenberg, M. P., de Bruine, A. P., Meijer, G. A. L. & van Engeland, M., 1 Jan 2006, In : Cellular oncology. 28, 5-6, p. 247-257

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)
2005

Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in the Netherlands Cohort Study

Brink, M., Weijenberg, M. P., de Goeij, A. F. P. M., Roemen, G. M. J. M., Lentjes, M. H. F. M., de Bruine, A. P., van Engeland, M., Goldbohm, R. A. & van den Brandt, P. A., 1 Jan 2005, In : International Journal of Cancer. 114, 5, p. 824-830

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14 Citations (Scopus)
162 Downloads (Pure)

Meat and Fish Consumption, APCGene Mutations and hMLH1 Expression in Colon and Rectal Cancer: a Prospective Cohort Study (The Netherlands)

Luchtenborg, M., Weijenberg, M. P., de Goeij, A. F., Wark, P. A., Brink, M., Roemen, G. M. J. M., Lentjes, M. H. F. M., de Bruine, A. P., Goldbohm, R. A., van 't Veer, P. & van den Brandt, P. A., 1 Jan 2005, In : Cancer Causes & Control. 16, 9, p. 1041-1054

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study

Brink, M., Weijenberg, M. P., de Goeij, A. F., Roemen, G. M. J. M., Lentjes, M. H. F. M., de Bruine, A. P., Goldbohm, R. A. & van den Brandt, P. A., 1 Jan 2005, In : British Journal of Cancer. 92, 7, p. 1310-1320

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
35 Citations (Scopus)
184 Downloads (Pure)

Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.

Luchtenborg, M., Weijenberg, M. P., Wark, P. A., Saritas, A. M., Roemen, G. M. J. M., van Muijen, G. N. P., de Bruine, A. P., van den Brandt, P. A. & de Goeij, A. F., 1 Jan 2005, In : BMC Cancer. 5, 1, p. 160

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
41 Citations (Scopus)
160 Downloads (Pure)
2004

APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study

Luchtenborg, M., Weijenberg, M. P., Roemen, G. M. J. M., de Bruine, A. P., van den Brandt, P. A., Lentjes, M. H. F. M., Brink, M., van Engeland, M., Goldbohm, R. A. & de Goeij, A. F. P. M., 1 Jan 2004, In : Carcinogenesis. 25, 7, p. 1219-26

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
53 Citations (Scopus)
169 Downloads (Pure)

Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study

Brink, M., Weijenberg, M. P., de Goeij, A. F. P. M., Schouten, L. J., Koedijk, F. D., Roemen, G. M. J. M., Lentjes, M. H. F. M., de Bruine, A. P., Goldbohm, R. A. & van den Brandt, P. A., 1 Jan 2004, In : Carcinogenesis. 25, 9, p. 1619-1628

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
20 Citations (Scopus)
162 Downloads (Pure)