• P. Debyeplein15, DEB15

    6229 HA Maastricht

    Netherlands

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Article
2020

[F-18]-HX4 PET/CT hypoxia in patients with squamous cell carcinoma of the head and neck treated with chemoradiotherapy: Prognostic results from two prospective trials

Sanduleanu, S., Hamming-Vrieze, O., Wesseling, F. W. R., Even, A. J. G., Hoebers, F. J., Hoeben, A., Vogel, W. V., Tesselaar, M. E. T., Parvin, D., Bartelink, H. & Lambin, P., Jul 2020, In : Clinical and Translational Radiation Oncology. 23, p. 9-15 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy

Keek, S., Sanduleanu, S., Wesseling, F., de Roest, R., van den Brekel, M., van der Heijden, M., Vens, C., Giuseppina, C., Licitra, L., Scheckenbach, K., Vergeer, M., Leemans, C. R., Brakenhoff, R. H., Nauta, I., Cavalieri, S., Woodruff, H. C., Poli, T., Leijenaar, R., Hoebers, F. & Lambin, P., 22 May 2020, In : PLOS ONE. 15, 5, 16 p., 0232639.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

Aspatwar, A., Parvathaneni, N. K., Barker, H., Anduran, E., Supuran, C. T., Dubois, L., Lambin, P., Parkkila, S. & Winum, J-Y., 1 Jan 2020, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 35, 1, p. 109-117 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distributed learning on 20 000+ lung cancer patients - The Personal Health Train

Deist, T. M., Dankers, F. J. W. M., Ojha, P., Marshall, M. S., Janssen, T., Faivre-Finn, C., Masciocchi, C., Valentini, V., Wang, J., Chen, J., Zhang, Z., Spezi, E., Button, M., Nuyttens, J. J., Vernhout, R., van Soest, J., Jochems, A., Monshouwer, R., Bussink, J., Price, G. & 2 others, Lambin, P. & Dekker, A., Mar 2020, In : Radiotherapy and Oncology. 144, p. 189-200 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells

Grasso, D., Medeiros, H. C. D., Zampieri, L. X., Bol, V., Danhier, P., van Gisbergen, M. W., Bouzin, C., Brusa, D., Gregoire, V., Smeets, H., Stassen, A. P. M., Dubois, L. J., Lambin, P., Dutreix, M. & Sonveaux, P., 13 Mar 2020, In : Frontiers in Pharmacology. 11, 16 p., 263.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

Anduran, E., Aspatwar, A., Parvathaneni, N-K., Suylen, D., Bua, S., Nocentini, A., Parkkila, S., Supuran, C. T., Dubois, L., Lambin, P. & Winum, J-Y., May 2020, In : Molecules. 25, 10, p. 1-14 14 p., 2347.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification of microRNAs in skeletal muscle associated with lung cancer cachexia

van de Worp, W. R. P. H., Schols, A. M. W. J., Dingemans, A-M. C., Op den Kamp, C. M. H., Degens, J. H. R. J., Kelders, M. C. J. M., Coort, S., Woodruff, H. C., Kratassiouk, G., Harel-Bellan, A., Theys, J., van Helvoort, A. & Langen, R. C. J., Apr 2020, In : Journal of cachexia, sarcopenia and muscle. 11, 2, p. 452-463 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Preoperative CT-based radiomics combined with intraoperative frozen section is predictive of invasive adenocarcinoma in pulmonary nodules: a multicenter study

Wu, G., Woodruff, H. C., Sanduleanu, S., Refaee, T., Jochems, A., Leijenaar, R., Gietema, H., Shen, J., Wang, R., Xiong, J., Bian, J., Wu, J. & Lambin, P., May 2020, In : European Radiology. 30, 5, p. 2680-2691 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling

Houben, T., Bitorina, A., Oligschlaeger, Y., Jeurissen, M. L. J., Rensen, S., Kohler, S. E., Westerterp, M., Luetjohann, D., Theys, J., Romano, A., Plat, J. & Shiri-Sverdlov, R., Aug 2020, In : Journal of Pathology. 251, 4, p. 429-439 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial

Lieverse, R. I. Y., Van Limbergen, E. J., Oberije, C. J. G., Troost, E. G. C., Hadrup, S. R., Dingemans, A-M. C., Hendriks, L. E. L., Eckert, F., Hiley, C., Dooms, C., Lievens, Y., de Jong, M. C., Bussink, J., Geets, X., Valentini, V., Elia, G., Neri, D., Billiet, C., Abdollahi, A., Pasquier, D. & 5 others, Boisselier, P., Yaromina, A., De Ruysscher, D., Dubois, L. J. & Lambin, P., 15 Jun 2020, In : BMC Cancer. 20, 1, 10 p., 557.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
2019

Acute Hypoxia Profile is a Stronger Prognostic Factor than Chronic Hypoxia in Advanced Stage Head and Neck Cancer Patients

van der Heijden, M., de Jong, M. C., Verhagen, C. V. M., de Roest, R. H., Sanduleanu, S., Hoebers, F., Leemans, C. R., Brakenhoff, R. H., Vens, C., Verheij, M. & Van Den Brekel, M. W. M., Apr 2019, In : Cancers. 11, 4, 13 p., 583.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology

Salgado, R., Solit, D. B., Rimm, D. L., Bogaerts, J., Canetta, R., Lively, T., Lyerly, K., Span, P. N., Bateman-House, A., Makady, A., Bergmann, L., Nagai, S., Smith, C., Robson, M., Savage, M., Voest, E., Sweeney, C., Lambin, P., Thomas, M., Harris, L. & 23 others, Lacombe, D., Massard, C., Lyerly, H. K., Yee, L., Rimm, D., Bateman-Houseaj, A., Bergmann, L., Nagaiam, S., Thomasan, M., Cree, I. A., Hopper, S., Robson, M., Ingelman-Sundberg, M., Maignen, F., Besse, B., Swierzewski, R., Kiermaier, A., Lacombex, D., Livelyad, T., Massard, C., Salgadobf, R., Golfinopoulos, V. & IBCD Fac, Jun 2019, In : European Journal of Cancer. 114, p. 128-136 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Ano-rectal wall dose-surface maps localize the dosimetric benefit of hydrogel rectum spacers in prostate cancer radiotherapy

Vanneste, B. G. L., Buettner, F., Pinkawa, M., Lambin, P. & Hoffmann, A. L., Jan 2019, In : Clinical and Translational Radiation Oncology. 14, p. 17-24 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms

Iglesias, V. S., van Hoof, S. J., Vaniqui, A., Schyns, L. E., Lieuwes, N., Yaromina, A., Spiegelberg, L., Groot, A. J., Verhaegen, F., Theys, J., Dubois, L. & Vooijs, M., 2019, In : British Journal of Radiology. 92, 1095, 10 p., 20180476.

Research output: Contribution to journalArticleAcademicpeer-review

A novel data management platform to improve image-guided precision preclinical biological research

Persoon, L., van Hoof, S., van der Kruijssen, F., Granton, P., Rivero, A. S., Beunk, H., Dubois, L., Doosje, J-W. & Verhaegen, F., 2019, In : British Journal of Radiology. 92, 1095, 7 p., 20180455.

Research output: Contribution to journalArticleAcademicpeer-review

A PROTOCOL FOR PERMISSIVE WEIGHT-BEARING DURING ALLIED HEALTH THERAPY IN SURGICALLY TREATED FRACTURES OF THE PELVIS AND LOWER EXTREMITIES

Meys, G., Kalmet, P. H. S., Sanduleanu, S., van Horn, Y. Y., Maas, G. J., Poeze, M., Brink, P. R. G. & Seelen, H. A. M., Apr 2019, In : Journal of Rehabilitation Medicine. 51, 4, p. 290-297 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-Mediated Release from Thermosensitive Liposomes

Derieppe, M., Escoffre, J-M., de Senneville, B. D., van Houtum, Q., Barten-van Rijbroek, A., van der Wurff-Jacobs, K., Dubois, L., Bos, C. & Moonen, C., Mar 2019, In : Contrast Media & Molecular Imaging. 2019, p. 1-13 13 p., 2645928.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Blood steroids are associated with prognosis and fat distribution in endometrial cancer

Tangen, I. L., Fasmer, K. E., Konings, G. F., Jochems, A., Delvoux, B., Xanthoulea, S., Stokowy, T., Strand, E., Berg, H. F., Auriola, S., Trovik, J., Hakkinen, M. R., Haldorsen, I. S., Krakstad, C., Romano, A. & ENITEC, Jan 2019, In : Gynecologic Oncology. 152, 1, p. 46-52 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Can radiomics help to predict skeletal muscle response to chemotherapy in stage IV non-small cell lung cancer?

de Jong, E. E. C., Sanders, K. J. C., Deist, T. M., van Elmpt, W., Jochems, A., van Timmeren, J. E., Leijenaar, R. T. H., Degens, J. H. R. J., Schols, A. M. W. J., Dingemans, A. -M. C. & Lambin, P., Oct 2019, In : European Journal of Cancer. 120, p. 107-113 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Challenges and caveats of a multi-center retrospective radiomics study: an example of early treatment response assessment for NSCLC patients using FDG-PET/CT radiomics

van Timmeren, J. E., Carvalho, S., Leijenaar, R. T. H., Troost, E. G. C., van Elmpt, W., de Ruysscher, D., Muratet, J-P., Denis, F., Schimek-Jasch, T. A., Nestle, U., Jochems, A., Woodruff, H. C., Oberije, C. & Lambin, P., 3 Jun 2019, In : PLOS ONE. 14, 6, 17 p., 0217536.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Computed Tomography-based Radiomics for Risk Stratification in Prostate Cancer

Osman, S. O. S., Leijenaar, R. T. H., Cole, A. J., Lyons, C. A., Hounsell, A. R., Prise, K. M., O'Sullivan, J. M., Lambin, P., McGarry, C. K. & Jain, S., 1 Oct 2019, In : International Journal of Radiation Oncology Biology Physics. 105, 2, p. 448-456 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development and validation of a patient decision aid for prostate Cancer therapy: from paternalistic towards participative shared decision making

Ankolekar, A., Vanneste, B. G. L., Bloemen-van Gurp, E., van Roermund, J. G., van Limbergen, E. J., van de Beek, K., Marcelissen, T., Zambon, V., Oelke, M., Dekker, A., Roumen, C., Lambin, P., Berlanga, A. & Fijten, R., 11 Jul 2019, In : BMC Medical Informatics and Decision Making. 19, 11 p., 130.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity

Spiegelberg, L., van Hoof, S. J., Biemans, R., Lieuwes, N. G., Marcus, D., Niemans, R., Theys, J., Yaromina, A., Lambin, P., Verhaegen, F. & Dubois, L. J., Dec 2019, In : Radiotherapy and Oncology. 141, p. 247-255 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exploring the feasibility of a clinical proton beam with an adaptive aperture for pre-clinical research

Almeida, I. P., Vaniqui, A., Schyns, L. E., van der Heyden, B., Cooley, J., Zwart, T., Langenegger, A. & Verhaegen, F., 2019, In : British Journal of Radiology. 92, 1095, 9 p., 20180446.

Research output: Contribution to journalArticleAcademicpeer-review

Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients-An external validation

Rizzo, S., Raimondi, S., de Jong, E. E. C., van Elmpt, W., De Piano, F., Petrella, F., Bagnardi, V., Jochems, A., Bellomi, M., Dingemans, A. M. & Lambin, P., Jan 2019, In : European Journal of Radiology. 110, p. 148-155 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy

van Tienen, F., Zelissen, R., Timmer, E., van Gisbergen, M., Lindsey, P., Quattrocelli, M., Sampaolesi, M., Mulder-den Hartog, E., de Coo, I. & Smeets, H., 21 Dec 2019, In : Stem Cell Research & Therapy. 10, 1, 10 p., 405.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

HIF-1 alpha and HIF-2 alpha Differently Regulate the Radiation Sensitivity of NSCLC Cells

Roig, E. M., Groot, A. J., Yaromina, A., Hendrickx, T. C., Barbeau, L. M. O., Giuranno, L., Dams, G., Ient, J., Pimentel, V. O., van Gisbergen, M. W., Dubois, L. J. & Vooijs, M. A., Jan 2019, In : Cells. 8, 1, 15 p., 45.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Spiegelberg, L., Houben, R., Niemans, R., de Ruysscher, D., Yaromina, A., Theys, J., Guise, C. P., Smaill, J. B., Patterson, A. V., Lambin, P. & Dubois, L. J., Feb 2019, In : Clinical and Translational Radiation Oncology. 15, p. 62-69 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impact of SBRT fractionation in hypoxia dose painting - Accounting for heterogeneous and dynamic tumor oxygenation

Lindblom, E. K., Ureba, A., Dasu, A., Wersall, P., Even, A. J. G., van Elmpt, W., Lambin, P. & Toma-Dasu, I., May 2019, In : Medical Physics. 46, 5, p. 2512-2521 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Improving decision making in larynx cancer by developing a decision aid: A mixed methods approach

Petersen, J. F., Berlanga, A., Stuiver, M. M., Hamming-Vrieze, O., Hoebers, F., Lambin, P. & van den Brekel, M. W. M., Dec 2019, In : Laryngoscope. 129, 12, p. 2733-2739 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial

Eekers, D. B. P., Roelofs, E., Cubillos-Mesias, M., Niel, C., Smeenk, R. J., Hoeben, A., Minken, A. W. H., Granzier, M., Janssens, G. O., Kaanders, J. H. A. M., Lambin, P. & Troost, E. G. C., 2019, In : Acta Oncologica. 58, 1, p. 57-65 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Longitudinal radiomics of cone-beam CT images from non-small cell lung cancer patients: Evaluation of the added prognostic value for overall survival and locoregional recurrence

van Timmeren, J. E., van Elmpt, W., Leijenaar, R. T. H., Reymen, B., Monshouwer, R., Bussink, J., Paelinck, L., Bogaert, E., De Wagter, C., Elhaseen, E., Lievens, Y., Hansen, O., Brink, C. & Lambin, P., Jul 2019, In : Radiotherapy and Oncology. 136, p. 78-85 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

On the determination of planning target margins due to motion for mice lung tumours using a four-dimensional MOBY phantom

Vaniqui, A., van der Heyden, B., Almeida, I. P., Schyns, L. E., van Hoof, S. J. & Verhaegen, F., 2019, In : British Journal of Radiology. 92, 1095, 9 p., 20180445.

Research output: Contribution to journalArticleAcademicpeer-review

Performing clinical F-18-FDG-PET/MRI of the mediastinum optimising a dedicated, patient-friendly protocol

Peerlings, J., Paulis, L., Mitea, C., Bakers, F., Berbee, M., Wierts, R., Voo, S., Wildberger, J., Hoffmann, A., Lambin, P. & Mottaghy, F., Aug 2019, In : Nuclear Medicine Communications. 40, 8, p. 815-826 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach

Meaney, C., Powathil, G. G., Yaromina, A., Dubois, L. J., Lambin, P. & Kohandel, M., 2019, In : Mathematical Biosciences and Engineering. 16, 6, p. 6257-6273 17 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Stability of radiomics features in apparent diffusion coefficient maps from a multi-centre test-retest trial

Peerlings, J., Woodruff, H. C., Winfield, J. M., Ibrahim, A., Van Beers, B. E., Heerschap, A., Jackson, A., Wildberger, J. E., Mottaghy, F. M., DeSouza, N. M. & Lambin, P., 18 Mar 2019, In : Scientific Reports. 9, p. 1-10 10 p., 4800.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The VAMPIRE challenge: A multi-institutional validation study of CT ventilation imaging

Kipritidis, J., Tahir, B. A., Cazoulat, G., Hofman, M. S., Siva, S., Callahan, J., Hardcastle, N., Yamamoto, T., Christensen, G. E., Reinhardt, J. M., Kadoya, N., Patton, T. J., Gerard, S. E., Duarte, I., Archibald-Heeren, B., Byrne, M., Sims, R., Ramsay, S., Booth, J. T., Eslick, E. & 8 others, Hegi-Johnson, F., Woodruff, H. C., Ireland, R. H., Wild, J. M., Cai, J., Bayouth, J. E., Brock, K. & Keall, P. J., Mar 2019, In : Medical Physics. 46, 3, p. 1198-1217 20 p.

Research output: Contribution to journalArticleAcademicpeer-review