INIS
diseases
100%
oxygen
74%
drugs
66%
mice
66%
receptors
59%
rats
59%
oxidases
52%
medicine
47%
arteries
47%
inhibition
46%
patients
44%
humans
39%
proteins
39%
oxidation
39%
pharmacology
37%
genes
36%
nitric oxide
35%
levels
33%
data
32%
ischemia
32%
therapy
32%
inflammation
31%
hypertension
31%
cyclases
30%
endothelins
30%
kidneys
28%
reviews
27%
applications
26%
angiotensin
25%
brain
23%
muscles
22%
control
20%
enzymes
20%
damage
20%
regulations
20%
tissues
20%
comparative evaluations
20%
myocardial infarction
19%
interactions
19%
cardiovascular diseases
18%
in vivo
18%
phenotype
17%
genetics
17%
blood pressure
16%
validation
16%
injuries
16%
renin
16%
antioxidants
15%
cancer
15%
atherosclerosis
14%
peptides
14%
interventions
14%
kinases
14%
tools
13%
guanosine
13%
fibrosis
12%
endothelium
12%
organs
12%
animals
12%
stimulation
11%
risks
11%
relaxation
11%
in vitro
11%
growth factors
11%
matrices
11%
heart failure
10%
symptoms
10%
doses
10%
metabolites
10%
precision
10%
biology
10%
reduction
10%
knock-out reactions
9%
coronaries
9%
bradykinin
8%
lungs
8%
mitochondria
8%
healing
8%
hypothesis
8%
collagen
8%
vessels
8%
rodents
8%
accumulation
8%
growth
8%
production
8%
adults
8%
volume
8%
hypertrophy
7%
plasma
7%
synthesis
7%
administration
7%
death
7%
macrophages
7%
contraction
7%
populations
6%
molecules
6%
apoptosis
6%
enrichment
6%
breakdown
6%
concentration
6%
Keyphrases
Reactive Oxygen Species
59%
NADPH Oxidase 4 (NOX4)
38%
Oxidative Stress
32%
NADPH Oxidase
30%
Endothelin-1 (ET-1)
25%
Hypertension
25%
Network Medicine
24%
Drug Repurposing
21%
Soluble Guanylate Cyclase
20%
NOX1
19%
Pharmacology
19%
Drug Target
19%
Systems Medicine
19%
Network Pharmacology
18%
Nitric Oxide
16%
Myocardial Infarction
16%
Endothelial Nitric Oxide Synthase (eNOS)
16%
Cyclic GMP
16%
Spontaneously Hypertensive Rats
14%
Resistance Arteries
14%
Therapeutic Target
14%
Ischemic Stroke
13%
Diabetic
13%
Frizzled
13%
Blood Pressure
13%
Mechanism-based
12%
Renin-angiotensin System
12%
Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)
12%
Diabetes
11%
Signaling Pathway
11%
Vascular Smooth muscle Cells
11%
Myofibroblast
11%
Reactive Oxygen Species Production
10%
Hydrogen Peroxide
10%
Mesenteric Resistance Arteries
10%
Cardiovascular Disease
10%
Precision Medicine
10%
Antioxidant
10%
Causal Mechanisms
9%
Drug Discovery
9%
Soluble Guanylate Cyclase Stimulator
9%
NOX5
9%
Microglia
9%
Neutral Endopeptidase
9%
Inflammation
8%
Endothelin-converting Enzyme
8%
NADPH Oxidase 2 (NOX2)
8%
Endothelial Function
8%
Unmet Medical Need
8%
Diabetic Nephropathy
8%
NADPH Oxidase 5
8%
Platelets
8%
Bradykinin
8%
Disease Mechanisms
8%
ApoE KO Mice
8%
Disease Phenotype
7%
Clinical Trials
7%
Brain Ischemia
7%
Thromboinflammation
7%
Heart Failure
7%
Clinical Significance
7%
Complex Disease
7%
Losartan
7%
Drug Development
7%
Angiotensin II (Ang II)
7%
GKT137831
7%
NOX Inhibitors
6%
Target Validation
6%
Comorbidity
6%
Disease Module
6%
Knock-in Mouse Model
6%
Pharmacological Inhibitors
6%
Molecular Mechanism
6%
Redox Signaling
6%
Cardiac Hypertrophy
6%
Clinical Translation
6%
Recent Advances
6%
Overexpression
6%
Endophenotype
6%
Blood Flow
6%
Immune Cells
6%
IUPHAR
6%
Indole-3-carbinol
6%
Patients with Cardiovascular Diseases
6%
Multi-target
6%
Clinical Pharmacology
6%
Arterial Remodeling
5%
Mechanism-based Therapy
5%
Molecular Network
5%
Diseasome
5%
Neuroprotection
5%
Cytochrome P450 1A1 (CYP1A1)
5%
Retinal Microvasculature
5%
Cardiac Disease
5%
Atheroprotection
5%
Diabetic Mice
5%
Protein Kinase
5%
Inflammatory Response
5%
Coronary Artery Bypass Grafting
5%
Renoprotection
5%