Maastricht MultiModal Molecular Imaging Institute

Research output

Research output per year 2014 2016 2019 2020 2021 2022 2023

• 323 Article
• 31 Review article
• 20 Doctoral Thesis
• 9 Editorial
• 20 More
  • 4 Chapter
  • 4 Comment/Letter to the editor
  • 3 Inaugural speech
  • 3 Conference Abstract/Poster in journal
  • 2 Conference article in proceeding
  • 1 Report
  • 1 Conference article in journal
  • 1 Erratum / corrigendum / retractions
  • 1 Web publication/site

Research output per year

Research output per year

Search results

• 2023

  A Multimodal SIMS/MALDI Mass Spectrometry Imaging Source with Secondary Electron Imaging Capabilities for Use with timsTOF Instruments

  Krijnen, K., Keelor, J. D., Bohm, S., Ellis, S. R., Koster, C., Hohndorf, J., Heeren, R. M. A. & Anthony, I. G. M., 5 Apr 2023, In: Journal of the American Society for Mass Spectrometry. 34, 4, p. 720-727 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Clinical application of mass spectrometry imaging for analysis of bone and cartilage: towards improved molecular understanding of impaired skeletal healing

  Nauta, S. P., 2023, Maastricht: Maastricht University. 317 p.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  66 Downloads (Pure)

• Extracellular histone release by renal cells after warm and cold ischemic kidney injury: Studies in an ex-vivo porcine kidney perfusion model

  van Smaalen, T. C., Beurskens, D. M. H., Kox, J. J. H. F. M., Polonia, R., Vos, R., Duimel, H., van de Wetering, W. J., Lopez-Iglesias, C., Reutelingsperger, C. P., van Heurn, L. W. E., Peutz-Kootstra, C. J. & Nicolaes, G. A. F., 20 Jan 2023, In: PLOS ONE. 18, 1, 18 p., e0279944.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• High-Resolution Ion Mobility Spectrometry Mass Spectrometry for Isomeric Separation of Prostanoids after Girard's reagent T Derivatization

  Lamont, L., Hadavi, D., Bowman, A. P., Flinders, B., Cooper-Shepherd, D., Palmer, M., Jordens, J., Mengerink, Y., Honing, M., Langridge, J., Siegel, T. P., Vreeken, R. J. & Heeren, R. M. A., 15 Mar 2023, In: Rapid Communications in Mass Spectrometry. 37, 5, 10 p., e9439.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Ionic mononuclear [Fe] and heterodinuclear [Fe,Ru] bis (diphenylphosphino)alkane complexes: Synthesis, spectroscopy, DFT structures, cytotoxicity, and biomolecular interactions

  Odachowski, M., Neven, R., Perversi, G., Romano, D., Slabber, C. A., Hadiji, M., Honing, M., Munro, O. Q., Zhao, Y. D. & Blom, B., 1 May 2023, In: Journal of Inorganic Biochemistry. 242, 20 p., 112156.

  Research output: Contribution to journal › Article › Academic › peer-review

• MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined

  Claes, B. S. R., Krestensen, K. K., Yagnik, G., Grgic, A., Kuik, C., Lim, M. J., Rothschild, K. J., Vandenbosch, M. & Heeren, R. M. A., 13 Jan 2023, In: Analytical Chemistry. 95, 4, p. 2329–2338 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Polymer film-based microwell array platform for long-term culture and research of human bronchial organoids

  Baptista, D., Birgani, Z. T., Widowski, H., Passanha, F., Stylianidis, V., Knoops, K., Gubbins, E., Iriondo, C., Skarp, K. P., Rottier, R. J., Wolfs, T. G., van Blitterswijk, C., LaPointe, V., Habibovic, P., Reynaert, N. L., Giselbrecht, S. & Truckenmuller, R., 1 Apr 2023, In: Materials today. Bio. 19, 14 p., 100603.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• PSC-derived intestinal organoids with apical-out orientation as a tool to study nutrient uptake, drug absorption and metabolism

  Kakni, P., Lopez-Iglesias, C., Truckenmuller, R., Habibovic, P. & Giselbrecht, S., 18 Jan 2023, In: Frontiers in Molecular Biosciences. 10, 13 p., 1102209.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Sample preparation for lipid analysis of intra-articular adipose tissue by using matrix-assisted laser desorption/ionization imaging

  Haartmans, M. J. J., Claes, B. S. R., Emanuel, K. S., Tuijthof, G. J. M., Heeren, R. M. A., Emans, P. J. & Cillero-Pastor, B., 1 Feb 2023, In: Analytical Biochemistry. 662, 5 p., 115018.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Strategies for molecular structure elucidation in static and dynamic systems

  Hadavi, D., 2023, Maastricht: Maastricht University. 185 p.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  110 Downloads (Pure)

• Time-Resolved Imaging of High Mass Proteins and Metastable Fragments Using Matrix-Assisted Laser Desorption/Ionization, Axial Time-of-Flight Mass Spectrometry, and TPX3CAM

  Mathew, A., Keelor, J. D., Eijkel, G. B., Anthony, I. G. M., Long, J., Prangsma, J., Heeren, R. M. A. & Ellis, S. R., 2023, In: Analytical Chemistry. 95, 2, p. 1470-1479 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Tumor ratio of unsaturated to saturated sulfatide species is associated with disease-free survival in intrahepatic cholangiocarcinoma

  Huizing, L., Chen, L., Roeth, A. A., Heij, L. R., Flinders, B., Bouwense, S. A. W., Balluff, B., Neumann, U. P., Heeren, R. M. A., Damink, S. W. M. O., Vreeken, R. J. & Schaap, F. G., 1 Jan 2023, (E-pub ahead of print) In: Cellular oncology. 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  An optimized MALDI MSI protocol for spatial detection of tryptic peptides in fresh frozen prostate tissue

  Høiem, T. S., Andersen, M. K., Martin-Lorenzo, M., Longuespée, R., Claes, B. S. R., Nordborg, A., Dewez, F., Balluff, B., Giampà, M., Sharma, A., Hagen, L., Heeren, R. M. A., Bathen, T. F., Giskeødegård, G. F., Krossa, S. & Tessem, M-B., May 2022, In: Proteomics. 22, 10, 13 p., 2100223.

  Research output: Contribution to journal › Article › Academic › peer-review
  3 Citations (Web of Science)

• An overview of image registration for aligning mass spectrometry imaging with clinically relevant imaging modalities

  Balluff, B., Heeren, R. M. A. & Race, A. M., 1 Jan 2022, In: Journal of Mass Spectrometry and Advances in the Clinical Lab. 23, p. 26-38 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Web of Science)

• Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects: a strong link with NEC pathology

  van Gorp, C., de Lange, I. H., Hütten, M. C., López-Iglesias, C., Massy, K. R., Kessels, L., Kramer, B., van de Wetering, W., Spiller, B., Birchenough, G. M., van Gemert, W. G., Zimmermann, L. J. & Wolfs, T. G., 28 Dec 2022, (E-pub ahead of print) In: Tissue Barriers. p. 2158016 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Aspirational metrics: A guide for working towards citational justice

  Carlier, A., Nguyen, H., Hollanders, H., Basaraba, N., Wyatt, S. & Anyango, S., 16 May 2022

  Research output: Non-textual / digital / web - outputs › Web publication/site › Academic

• Automated 3D Sampling and Imaging of Uneven Sample Surfaces with LA-REIMS

  Nauta, S. P., Huysmans, P., Tuijthof, G. J. M., Eijkel, G. B., Poeze, M., Siegel, T. P. & Heeren, R. M. A., 5 Jan 2022, In: Journal of the American Society for Mass Spectrometry. 33, 1, p. 111-122 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Web of Science)

• Cell-controlled dynamic surfaces for skeletal stem cell growth and differentiation

  Anderson, H. J., Sahoo, J. K., Wells, J., van Nuffel, S., Dhowre, H. S., Oreffo, R. O. C., Zelzer, M., Ulijn, R. V. & Dalby, M. J., 17 May 2022, In: Scientific Reports. 12, 1, 13 p., 8165.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Web of Science)

• Characterization of microchannel plate detector response for the detection of native multiply charged high mass single ions in orthogonal-time-of-flight mass spectrometry using a Timepix detector

  Mathew, A., Eijkel, G. B., Anthony, I. G. M., Ellis, S. R. & Heeren, R. M. A., 1 Apr 2022, In: Journal of Mass Spectrometry. 57, 4, 9 p., e4820.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Web of Science)

• Cholecalciferol as Bioactive Plasticizer of High Molecular Weight Poly(D,L-Lactic Acid) Scaffolds for Bone Regeneration

  Calore, A., Hadavi, D., Honing, M., Albillos-Sanchez, A., Mota, C., Bernaerts, K., Harings, J. & Moroni, L., 1 Jul 2022, In: Tissue Engineering. 28, 7, p. 335-350 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  1 Citation (Web of Science)

• Combined Quantitative (Phospho)proteomics and Mass Spectrometry Imaging Reveal Temporal and Spatial Protein Changes in Human Intestinal Ischemia-Reperfusion

  Kip, A. M., Valverde, J. M., Altelaar, M., Heeren, R. M. A., Hundscheid, I. H. R., Dejong, C. H. C., Damink, S. W. M. O., Balluff, B. & Lenaerts, K., 7 Jan 2022, In: Journal of Proteome Research. 21, 1, p. 49-66 18 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  8 Citations (Web of Science)

• Controlling tosylation versus chlorination during end group modification of PCL

  Beeren, I. A. O., Dijkstra, P. J., Massonnet, P., Camarero-Espinosa, S., Baker, M. B. & Moroni, L., 5 Nov 2022, In: European Polymer Journal. 180, 5 p., 111576.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Web of Science)

• Cre/Lox-Assisted Tracking Of Cardiac Intercellular Communication

  Ottaviani, L., Pinto, V. S., Knoops, K., Wouters, K., Martins, P. A. D. & Abreu, R., 1 Apr 2022, In: Tissue Engineering. 28, p. S339-S340 2 p.

  Research output: Contribution to journal › Conference Abstract/Poster in journal › Academic

• Cryo-electron tomography on FIB-lamellae for the structural characterization of bacterial secretion systems

  Berger, C., 2022, Maastricht: Maastricht University. 161 p.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  152 Downloads (Pure)

• Cyclic Peptide Protomer Detection in the Gas Phase: Impact on CCS Measurement and Fragmentation Patterns

  McCann, A., Kune, C., Massonnet, P., Far, J., Ongena, M., Eppe, G., Quinton, L. & De Pauw, E., 4 May 2022, In: Journal of the American Society for Mass Spectrometry. 33, 5, p. 851-858 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Web of Science)

• Deciphering the role of mycobacterial secreted proteins through structural biology

  Gijsbers Alejandre, A., 2022, Maastricht: ProefschriftMaken. 193 p.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  223 Downloads (Pure)

• Desymmetrization via Activated Esters Enables Rapid Synthesis of Multifunctional Benzene-1,3,5-tricarboxamides and Creation of Supramolecular Hydrogelators

  Hafeez, S., Ooi, H. W., Suylen, D., Duimel, H., Hackeng, T. M., van Blitterswijk, C. & Baker, M. B., 9 Mar 2022, In: Journal of the American Chemical Society. 144, 9, p. 4057-4070 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Web of Science)

• Evaluation of Fast and Sensitive Proteome Profiling of FF and FFPE Kidney Patient Tissues

  Dapic, I., Uwugiaren, N., Kers, J., Mohammed, Y., Goodlett, D. R. & Corthals, G., 1 Feb 2022, In: Molecules. 27, 3, 13 p., 1137.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  3 Citations (Web of Science)

• Evaluation of the Anti-Inflammatory and Chondroprotective Effect of Celecoxib on Cartilage Ex Vivo and in a Rat Osteoarthritis Model

  Haartmans, M. J. J., Timur, U. T., Emanuel, K. S., Caron, M. M. J., Jeuken, R. M., Welting, T. J. M., van Osch, G. J. V. M., Heeren, R. M. A., Cillero-Pastor, B. & Emans, P. J., 7 Aug 2022, In: Cartilage. 13, 3, 12 p., 19476035221115541.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Evaluation of the Sensitivity of Metabolic Profiling by Rapid Evaporative Ionization Mass Spectrometry: Toward More Radical Oral Cavity Cancer Resections

  Vaysse, P-M., Demers, I., van den Hout, M. F. C. M., van de Worp, W., Anthony, I. G. M., Baijens, L. W. J., Tan, B. I., Lacko, M., Vaassen, L. A. A., van Mierlo, A., Langen, R. C. J., Speel, E-J. M., Heeren, R. M. A., Porta Siegel, T. & Kremer, B., 17 May 2022, In: Analytical Chemistry. 94, 19, p. 6939-6947 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Fast Mass Microscopy: Mass Spectrometry Imaging of a Gigapixel Image in 34 Minutes

  Körber, A., Keelor, J. D., Claes, B. S. R., Heeren, R. M. A. & Anthony, I. G. M., 25 Oct 2022, In: Analytical Chemistry. 94, 42, p. 14652-14658 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Web of Science)

• Fat causes necrosis and inflammation in parenchymal cells in human steatotic liver

  Wisse, E., Braet, F., Shami, G. J., Zapotoczny, B., Vreuls, C., Verhaegh, P., Frederik, P., Peters, P. J., Damink, S. O. & Koek, G., Jan 2022, In: Histochemistry and Cell Biology. 157, 1, p. 27-38 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  2 Citations (Web of Science)

• First Line Research Data Management for Life Sciences: a Case Study

  Van Schayck, J. P. & Coonen, M., 22 Jul 2022, In: International Journal of Digital Curation. 16, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Harmonization of Rapid Evaporative Ionization Mass Spectrometry Workflows across Four Sites and Testing Using Reference Material and Local Food-Grade Meats

  Kaufmann, M., Vaysse, P-M., Savage, A., Amgheib, A., Marton, A., Manoli, E., Fichtinger, G., Pringle, S. D., Rudan, J. F., Heeren, R. M. A., Takáts, Z., Balog, J. & Porta Siegel, T., 17 Nov 2022, In: Metabolites. 12, 11, 13 p., 1130.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• High resolution mass spectrometry imaging for pharmaceutical and clinical applications

  Huizing, L. R. S., 2022, Maastricht: Ridderprint. 183 p.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  82 Downloads (Pure)

• Innovations in ambient mass spectrometry imaging: from ionization to detection

  Kooijman, P., 2022, Maastricht University.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  63 Downloads (Pure)

• Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context

  Goossens, P., Lu, C., Cao, J., Gijbels, M. J., Karel, J. M. H., Wijnands, E., Claes, B. S. R., Fazzi, G. E., Hendriks, T. F. E., Wouters, K., Smirnov, E., van Zandvoort, M. J. M., Balluff, B., Cuypers, E., Donners, M. M. P. C., Heeren, R. M. A. & Biessen, E. A. L., 2 Aug 2022, In: Cell Metabolism. 34, 8, p. 1214-1225.e6 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  4 Citations (Web of Science)

• Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells

  Ottaviani, L., Juni, R. P., de Abreu, R. C., Sansonetti, M., Sampaio-Pinto, V., Halkein, J., Hegenbarth, J. C., Ring, N., Knoops, K., Kocken, J. M. M., Jesus, C. D., Ernault, A. C., El Azzouzi, H., Rühle, F., Olieslagers, S., Fernandes, H., Ferreira, L., Braga, L., Stoll, M., Nascimento, D. S., & 2 othersde Windt, L. J. & da Costa Martins, P. A., 1 Jun 2022, In: Molecular Therapy. 30, 6, p. 2257-2273 17 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  2 Citations (Web of Science)

• In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed

  Bonanini, F., Kurek, D., Previdi, S., Nicolas, A., Hendriks, D., de Ruiter, S., Meyer, M., Cabrer, M. C., Dinkelberg, R., Garcia, S. B., Kramer, B., Olivier, T., Hu, H. L., Lopez-Iglesias, C., Schavemaker, F., Walinga, E., Dutta, D., Queiroz, K., Domansky, K., Ronden, B., & 6 othersJoore, J., Lanz, H. L., Peters, P. J., Trietsch, S. J., Clevers, H. & Vulto, P., Nov 2022, In: Angiogenesis. 25, 4, p. 455-470 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  7 Citations (Web of Science)

• Ion mobility spectrometry-tandem mass spectrometry strategies for the on-line monitoring of a continuous microflow reaction

  Hadavi, D., Han, P. L. & Honing, M., Jun 2022, In: Journal of Flow Chemistry. 12, 2, p. 175-184 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer

  Young, R. S. E., Bowman, A. P., Tousignant, K. D., Poad, B. L. J., Gunter, J. H., Philp, L. K., Nelson, C. C., Ellis, S. R., Heeren, R. M. A., Sadowski, M. C. & Blanksby, S. J., Jun 2022, In: Journal of Lipid Research. 63, 6, 16 p., 100223.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Web of Science)

• Lipid Analysis of Fracture Hematoma With MALDI-MSI: Specific Lipids are Associated to Bone Fracture Healing Over Time

  Groven, R. V. M., Nauta, S. P., Gruisen, J., Claes, B. S. R., Greven, J., van Griensven, M., Poeze, M., Heeren, R. M. A., Porta Siegel, T., Cillero-Pastor, B. & Blokhuis, T. J., 3 Mar 2022, In: Frontiers in Chemistry. 9, 15 p., 780626.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Web of Science)

• Lipid A Structural Determination from a Single Colony

  Yang, H., Smith, R. D., Chandler, C. E., Johnson, J. K., Jackson, S. N., Woods, A. S., Scott, A. J., Goodlett, D. R. & Ernst, R. K., 31 May 2022, In: Analytical Chemistry. 94, 21, p. 7460-7465 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review
  1 Citation (Web of Science)

• Local metabolism in preclinical disease models studied with mass spectrometry imaging

  Cao, J-H., 2022, Maastricht: Maastricht University.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  124 Downloads (Pure)

• Mass spectrometry imaging identifies altered hepatic lipid signatures during experimental Leishmania donovani infection

  Tans, R., Dey, S., Dey, N. S., Cao, J-H., Paul, P. S., Calder, G., O'Toole, P., Kaye, P. M. & Heeren, R. M. A., 28 Jul 2022, In: Frontiers in Immunology. 13, 14 p., 862104.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  1 Citation (Web of Science)

• Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients

  Buck, A., Prade, V. M., Kunzke, T., Feuchtinger, A., Kroll, D., Feith, M., Dislich, B., Balluff, B., Langer, R. & Walch, A., Feb 2022, In: Journal of Pathology. 256, 2, p. 202-213 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  5 Citations (Web of Science)

• Molecular imaging of humain hair with MeV-SIMS: A case study of cocaine detection and distribution in the hair of a cocaine user

  Jeromel, L., Ogrinc, N., Siketić, Z., Vavpetič, P., Rupnik, Z., Bučar, K., Jenčič, B., Kelemen, M., Vencelj, M., Vogel-Mikuš, K., Kovač, J., Heeren, R. M. A., Flinders, B., Cuypers, E., Barba, Ž. & Pelicon, P., 2022, In: PLOS ONE. 17, 3, 11 p., 0263338.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Molecular signatures of myocardial infarction: a multidisciplinary analytical approach

  Mezger, S. T. P., 2022, Maastricht: Maastricht University.

  Research output: Thesis › Doctoral Thesis › Internal

  Open Access

  File
  137 Downloads (Pure)

• Multimodal molecular imaging in drug discovery and development

  Vermeulen, I., Isin, E. M., Barton, P., Cillero-Pastor, B. & Heeren, R. M. A., Aug 2022, In: Drug Discovery Today. 27, 8, p. 2086-2099 14 p.

  Research output: Contribution to journal › (Systematic) Review article › peer-review

  Open Access
  2 Citations (Web of Science)

• Mycobacteria-host interactions in human bronchiolar airway organoids

  Iakobachvili, N., Leon-Icaza, S. A., Knoops, K., Sachs, N., Mazeres, S., Simeone, R., Peixoto, A., Bernard, C., Murris-Espin, M., Mazieres, J., Cam, K., Chalut, C., Guilhot, C., Lopez-Iglesias, C., Ravelli, R. B. G., Neyrolles, O., Meunier, E., Lugo-Villarino, G., Clevers, H., Cougoule, C., & 1 othersPeters, P. J., Mar 2022, In: Molecular Microbiology. 117, 3, p. 682-692 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
  16 Citations (Web of Science)