Research Output

2019

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

Massonnet, P. & Heeren, R. M. A., 1 Nov 2019, In : Journal of Analytical Atomic Spectrometry. 34, 11, p. 2217-2228 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Advanced Mass Spectrometry Imaging: Pharmaceutical distributions and effects from Cartilage to Cancer

Barré, F. P. Y., 2019

Research output: ThesisDoctoral ThesisInternal

Advances in mass spectrometry imaging enabling observation of localised lipid biochemistry within tissues

Bowman, A. P., Heeren, R. M. A. & Ellis, S. R., Nov 2019, In : Trac-Trends in Analytical Chemistry. 120, 10 p., 115197.

Research output: Contribution to journalReview articleAcademicpeer-review

AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism

Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M. & Schroen, B., 1 Mar 2019, In : Molecular Therapy - Nucleic Acids. 14, p. 424-437 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry

Scupakova, K., Terzopoulos, V., Jain, S., Smeets, D. & Heeren, R. M. A., 27 Feb 2019, In : Scientific Reports. 9, 11 p., 2915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Biomedical imaging by high performance mass spectrometry

Spraggins, J. M. & Siegel, T. P., Mar 2019, In : International Journal of Mass Spectrometry. 437, p. 1-2 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Cardiac Troponin T: Only Small Molecules in Recreational Runners After Marathon Completion

Vroemen, W. H. M., Mezger, S. T. P., Masotti, S., Clerico, A., Bekers, O., de Boer, D. & Mingels, A., Mar 2019, In : The Journal of Applied Laboratory Medicine . 3, 5, p. 909-911 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Class-specific depletion of lipid ion signals in tissues upon formalin fixation

Vos, D. R. N., Bowman, A. P., Heeren, R. M. A., Balluff, B. & Ellis, S. R., Dec 2019, In : International Journal of Mass Spectrometry. 446, p. 1-9 9 p., 116212.

Research output: Contribution to journalArticleAcademicpeer-review

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Evers, T. M. J., Hochane, M., Tans, S. J., Heeren, R. M. A., Semrau, S., Nemes, P. & Mashaghi, A., 5 Nov 2019, In : Analytical Chemistry. 91, 21, p. 13314-13323 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic

Huizing, L. R. S., Ellis, S. R., Beulen, B. W. A. M. M., Barre, F. P. Y., Kwant, P. B., Vreeken, R. J. & Heeren, R. M. A., Apr 2019, In : Clinical mass spectrometry. 12, p. 7-15 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

Mulder, I. A., Potocnik, N. O., Broos, L. A. M., Prop, A., Wermer, M. J. H., Heeren, R. M. A. & van den Maagdenberg, A. M. J. M., 31 Jan 2019, In : Scientific Reports. 9, p. 1-10 10 p., 1090.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

Barre, F. P. Y., Paine, M. R. L., Flinders, B., Trevitt, A. J., Kelly, P. D., Ait-Belkacem, R., Garcia, J. P., Creemers, L. B., Stauber, J., Vreeken, R. J., Cillero-Pastor, B., Ellis, S. R. & Heeren, R. M. A., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10840-10848 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Exploring the Boundaries of Multimodal Mass Spectrometry Imaging: From Neuron to Zebrafish

Bruinen, A., 2019

Research output: ThesisDoctoral ThesisInternal

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Barre, F., Rocha, B., Dewez, F., Towers, M., Murray, P., Claude, E., Cillero-Pastor, B., Heeren, R. & Siegel, T. P., Mar 2019, In : International Journal of Mass Spectrometry. 437, p. 38-48 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging Isomers on a Biological Surface: A Review

Claes, B. S. R., Takeo, E., Fukusaki, E., Shimma, S. & Heeren, R. M. A., 2019, In : Mass spectrometry (Tokyo, Japan). 8, 1, p. A0078 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches

Kooijman, P. C., Nagornov, K. O., Kozhinov, A. N., Kilgour, D. P. A., Tsybin, Y. O., Heeren, R. M. A. & Ellis, S. R., 9 Jan 2019, In : Scientific Reports. 9, p. 1-11 11 p., 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification

Balluff, B., Buck, A., Martin-Lorenzo, M., Dewez, F., Langer, R., McDonnell, L. A., Walch, A. & Heeren, R. M. A., Jan 2019, In : Proteomics Clinical Applications. 13, 1, 5 p., 1800137.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on A beta 1-40 peptide early assembly

Lazzaro, S., Ogrinc, N., Lamont, L., Vecchio, G., Pappalardo, G. & Heeren, R. M. A., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 24, p. 6353-6363 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging

Scott, A. J., Chandler, C. E., Ellis, S. R., Heeren, R. M. A. & Ernst, R. K., 27 Dec 2019, In : Scientific Reports. 9, p. 1-12 12 p., 20160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Genangeli, M., Heijens, A. M. M., Rustichelli, A., Schuit, N. D., Di Bonaventura, M. V. M., Cifani, C., Vittori, S., Siegel, T. P. & Heeren, R. M. A., Oct 2019, In : Journal of the American Society for Mass Spectrometry. 30, 10, p. 2041-2050 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics?

Leung, F., Eberlin, L. S., Schwamborn, K., Heeren, R. M. A., Winograd, N. & Cooks, R. G., Apr 2019, In : Clinical Chemistry. 65, 4, p. 510-513 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Mass Spectrometry Imaging:Enabling Comprehensive Local Analysis of Molecular Biomarkers in Tissue for Personalized Medicine

Porta, T., Olde Damink, S. & Heeren, R., 2019, Handbook of Biomarkers and Precision Medicine. Chapman and Hall/CRC, p. 439-445 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay

Damen, S. A. J., Vroemen, W. H. M., Brouwer, M. A., Mezger, S. T. P., Suryapranata, H., van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., de Boer, D., Cramer, G. E. & Mingels, A. M. A., 16 Jul 2019, In : Journal of the American Heart Association. 8, 14, 26 p., 012602.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Precise co-registration of mass spectrometry imaging, histology, and laser microdissection-based omics

Dewez, F., Martin-Lorenzo, M., Herfs, M., Baiwir, D., Mazzucchelli, G., De Pauw, E., Heeren, R. M. A. & Balluff, B., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 22, p. 5647-5653 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Prognostic factors in the progression of intervertebral disc degeneration: Which patient should be targeted with regenerative therapies?

Rustenburg, C. M. E., Faraj, S. S. A., Ket, J. C. F., Emanuel, K. S. & Smit, T. H., Sep 2019, In : JOR spine. 2, 3, 17 p., e1063.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

van Gorp, C., de Lange, I. H., Spiller, O. B., Dewez, F., Pastor, B. C., Heeren, R. M. A., Kessels, L., Kloosterboer, N., van Gemert, W. G., Beeton, M. L., Stock, S. J., Jobe, A. H., Payne, M. S., Kemp, M. W., Zimmermann, L. J., Kramer, B. W., Plat, J. & Wolfs, T. G. A. M., May 2019, In : Nutrients. 11, 5, p. 1-21 21 p., 968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging

van Smaalen, T. C., Ellis, S. R., Mascini, N. E., Siegel, T. P., Cillero-Pastor, B., Hillen, L. M., van Heurn, L. W. E., Peutz-Kootstra, C. J. & Heeren, R. M. A., 5 Mar 2019, In : Analytical Chemistry. 91, 5, p. 3575-3581 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Recent technological developments in MALDI-MSI based hair analysis

Flinders, B., Bassindale, T. & Heeren, R., 2019, Emerging Technologies for the Analysis of Forensic Traces. Springer, Cham, p. 133-149 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics

Siegel, T. P., Ekroos, K. & Ellis, S. R., 13 May 2019, In : Angewandte Chemie-International Edition. 58, 20, p. 6492-6501 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Standardized human bone marrow-derived stem cells infusion improves survival and recovery in a rat model of spinal cord injury

de Munter, J. P., Beugels, J., Munter, S., Jansen, L., Cillero-Pastor, B., Moskvin, O., Brook, G., Pavlov, D., Strekalova, T., Kramer, B. W. & Wolters, E. C., 15 Jul 2019, In : Journal of the Neurological Sciences. 402, p. 16-29 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Stigmatic imaging of secondary ions in MeV-SIMS spectrometry by linear Time-of-Flight mass spectrometer and the TimePix detector

Jencic, B., Sepec, L., Vavpetic, P., Kelemen, M., Rupnik, Z., Vencelj, M., Vogel-Mikus, K., Potocnik, N. O., Ellis, S. R., Heeren, R. & Pelicon, P., 1 Aug 2019, In : Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms. 452, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Strategies for managing multi-patient 3D mass spectrometry imaging data

Vos, D. R. N., Jansen, R. L., Lucas, M., Paine, M. R. L., de Boer, O. J., Meijer, S. L., Savci-Heijink, C. D., Marquering, H. A., de Bruin, D. M., Heeren, R. M. A., Ellis, S. R. & Balluff, B., 20 Feb 2019, In : Journal of Proteomics. 193, p. 184-191 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Synthesis and Catalytic Application of Knolker-Type Iron Complexes with a Novel Asymmetric Cyclopentadienone Ligand Design

van Slagmaat, C. A. M. R., Chou, K. C., Morick, L., Hadavi, D., Blom, B. & De Wildeman, S. M. A., Oct 2019, In : Catalysts. 9, 10, 24 p., 790.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The biomechanical effect of single-level laminectomy and posterior instrumentation on spinal stability in degenerative lumbar scoliosis: a human cadaveric study

Rustenburg, C. M. E., Faraj, S. S. A., Holewijn, R. M., Kingma, I., van Royen, B. J., Stadhouder, A. & Emanuel, K. S., 1 May 2019, In : Neurosurgical Focus. 46, 5, p. E15 8 p., 15.

Research output: Contribution to journalArticleAcademicpeer-review

The Crystalline Sponge Method in Water

de Poel, W., Tinnemans, P., Duchateau, A. L. L., Honing, M., Rutjes, F. P. J. T., Vlieg, E. & de Gelder, R., 22 Nov 2019, In : Chemistry: a European journal. 25, 65, p. 14999-15003 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

The importance of clinical tissue imaging

Spraggins, J. M., Schwamborn, K., Heeren, R. M. A. & Eberlin, L. S., Apr 2019, In : Clinical mass spectrometry. 12, p. 47-49 3 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis

Paine, M. R. L., Liu, J., Huang, D., Ellis, S. R., Trede, D., Kobarg, J. H., Heeren, R. M. A., Fernandez, F. M. & MacDonald, T. J., 18 Feb 2019, In : Scientific Reports. 9, p. 1-10 10 p., 2205.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Trends in mass spectrometry imaging for cardiovascular diseases

Mezger, S. T. P., Mingels, A. M. A., Bekers, O., Cillero-Pastor, B. & Heeren, R. M. A., Jul 2019, In : Analytical and Bioanalytical Chemistry. 411, 17, p. 3709-3720 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Adduct-ion formation in trapped ion mobility spectrometry as a potential tool for studying molecular structures and conformations

Zietek, B. M., Mengerink, Y., Jordens, J., Somsen, G. W., Kool, J. & Honing, M., Jun 2018, In : International Journal for Ion Mobility Spectrometry. 21, 1-2, p. 19-32 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Automated, parallel mass spectrometry imaging and structural identification of lipids

Ellis, S. R., Paine, M. R. L., Eijkel, G. B., Pauling, J. K., Husen, P., Jervelund, M. W., Hermansson, M., Ejsing, C. S. & Heeren, R. M. A., Jul 2018, In : Nature Methods. 15, 7, p. 515–518 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Flinders, B., Huizing, L. R. S., van Heerden, M., Cuyckens, F., Neumann, U. P., van der Laan, L. J. W., Damink, S. W. M. O., Heeren, R. M. A., Schaap, F. G. & Vreeken, R. J., 16 Oct 2018, In : Analytical Chemistry. 90, 20, p. 11835-11846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Digestion-Free Analysis of Peptides from 30-year-old Formalin-Fixed, Paraffin-Embedded Tissue by Mass Spectrometry Imaging

Paine, M. R. L., Ellis, S. R., Maloney, D., Heeren, R. M. A. & Verhaert, P. D. E. M., 7 Aug 2018, In : Analytical Chemistry. 90, 15, p. 9272-9280 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Door de Moleculen het Systeem niet meer zien: Elektronen, Structuren en Activiteit

Honing, M., 27 Sep 2018, Maastricht: Maastricht University.

Research output: Book/ReportInaugural speechPopular

Open Access
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Evaluation of Thin-Layer Chromatography-Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Imaging for Visualization of Crude Oil Interactions

Zahraei, A., Arisz, P. W. F., van Bawl, A. P. & Heeren, R. M. A., Jul 2018, In : Energy & Fuels. 32, 7, p. 7347-7357 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification and High-Resolution Imaging of alpha-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry

Bruinen, A. L., Fisher, G. L., Balez, R., van der Sar, A. M., Ooi, L. & Heeren, R. M. A., Aug 2018, In : Journal of the American Society for Mass Spectrometry. 29, 8, p. 1571-1581 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept

Liigand, P., Liigand, J., Cuyckens, F., Vreeken, R. J. & Kruve, A., 22 Nov 2018, In : Analytica Chimica Acta. 1032, p. 68-74 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Lipid surface modifications increase mesoporous silica nanoparticle labeling properties in mesenchymal stem cells

Rosenbrand, R., Barata, D., Sutthavas, P., Mohren, R., Cillero-Pastor, B., Habibovic, P. & van Rijt, S., 2018, In : International Journal of Nanomedicine. 13, p. 7711-7725 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access