Carim - The vulnerable plaque: makers and markers – Publications

2024

Capillary rarefaction: a missing link in renal and cardiovascular disease?

Steegh, F. M. E. G., Keijbeck, A. A., de Hoogt, P. A., Rademakers, T., Houben, A. J. H. M., Reesink, K. D., Stehouwer, C. D. A., Daemen, M. J. A. P. & Peutz-Kootstra, C. J., Feb 2024, In: Angiogenesis. 27, 1, p. 23-35 13 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

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Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways

Curaj, A., Vanholder, R., Loscalzo, J., Quach, K., Wu, Z., Jankowski, V. & Jankowski, J., 1 Mar 2024, In: Circulation Research. 134, 5, p. 592-613 22 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization

Singh, A., Kraaijeveld, A. O., Curaj, A., Wichapong, K., Hammerich, L., de Jager, S. C. A., Bot, I., Atamas, S. P., van Berkel, T. J. C., Jukema, J. W., Comerford, I., Mccoll, S. R., Mees, B., Heemskerk, J. W. M., Nicolaes, G. A. F., Hackeng, T., Liehn, E. A., Tacke, F. & Biessen, E. A. L., 13 May 2024, In: Frontiers in Immunology. 15, 15 p., 1327051.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Clonal Expansion in Cardiovascular Pathology

Lin, A., Brittan, M., Baker, A. H., Dimmeler, S., Fisher, E. A., Sluimer, J. C. & Misra, A., 1 Jan 2024, In: JACC: Basic to Translational Science. 9, 1, p. 120-144 25 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics

Medina, I., Wieland, E. B., Temmerman, L., Otten, J. J. T., Bermudez, B., Bot, I., Rademakers, T., Wijnands, E., Schurgers, L., Mees, B., van Berkel, T. J. C., Goossens, P. & Biessen, E. A. L., 1 Jan 2024, (E-pub ahead of print) In: European Journal of Immunology.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

COVID-19 plasma induces subcellular remodelling within the pulmonary microvascular endothelium

Passi, R., Cholewa-Waclaw, J., Wereski, R., Bennett, M., Veizades, S., Berkeley, B., Caporali, A., Li, Z., Rodor, J., Dewerchin, M., Mills, N. L., Beqqali, A., Brittan, M. & Baker, A. H., Mar 2024, In: Vascular Pharmacology. 154, 10 p., 107277.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Designing feedback processes in the workplace-based learning of undergraduate health professions education: a scoping review

Fuentes-Cimma, J., Sluijsmans, D., Riquelme, A., Villagran, I., Isbej, L., Olivares-Labbe, M. T. & Heeneman, S., 23 Apr 2024, In: BMC Medical Education. 24, 1, 25 p., 440.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality

Devaux, Y., Zhang, L., Lumley, A. I., Karaduzovic-Hadziabdic, K., Mooser, V., Rousseau, S., Shoaib, M., Satagopam, V., Adilovic, M., Srivastava, P. K., Emanueli, C., Martelli, F., Greco, S., Badimon, L., Padro, T., Lustrek, M., Scholz, M., Rosolowski, M., Jordan, M. & Brandenburger, T. & 15 others, Benczik, B., Agg, B., Ferdinandy, P., Vehreschild, J. J., Lorenz-Depiereux, B., Dörr, M., Witzke, O., Sanchez, G., Kul, S., Baker, A. H., Fagherazzi, G., Ollert, M., Wereski, R., Mills, N. L. & Firat, H., 1 Dec 2024, In: Nature Communications. 15, 1, 12 p., 4259.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension

Zhang, Q., Yaoita, N., Tabuchi, A., Liu, S., Chen, S.-H., Li, Q., Hegemann, N., Li, C., Rodor, J., Timm, S., Laban, H., Finkel, T., Stevens, T., Alvarez, D. F., Erfinanda, L., de Perrot, M., Kucherenko, M. M., Knosalla, C., Ochs, M. & Dimmeler, S. & 4 others, Korff, T., Verma, S., Baker, A. H. & Kuebler, W. M., 6 Aug 2024, In: Circulation. 150, 6, p. 466-487 22 p.

Research output: Contribution to journal › Article › Academic › peer-review

Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease

Hall, I. F., Kishta, F., Xu, Y., Baker, A. H. & Kovacic, J. C., 22 Feb 2024, In: Cardiovascular Research. 120, 3, p. 223-236 14 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Extracellular vesicles from differentiated stem cells contain novel proangiogenic miRNAs and induce angiogenic responses at low doses

Kesidou, D., Bennett, M., Monteiro, J. P., McCracken, I. R., Klimi, E., Rodor, J., Condie, A., Cowan, S., Caporali, A., Wit, J. B. M., Mountford, J. C., Brittan, M., Beqqali, A. & Baker, A. H., 3 Jan 2024, In: Molecular Therapy. 32, 1, p. 185-203 19 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

From v-atpase to protein palmitoylation: Novel targets against lipid-induced cardiomyopathy

Schianchi, F., 2024, Maastricht.

Research output: Thesis › Doctoral Thesis › Internal

Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability

Jin, H., Zhang, C., Nagenborg, J., Juhasz, P., Ruder, A. V., Sikkink, C. J. J. M., Mees, B. M. E., Waring, O., Sluimer, J. C., Neumann, D., Goossens, P., Donners, M. M. P. C., Mardinoglu, A. & Biessen, E. A. L., 8 Jul 2024, In: Cardiovascular Diabetology. 23, 1, 240.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis

Wang, S., Han, Y., Liu, R., Hou, M., Neumann, D., Zhang, J., Wang, F., Li, Y., Zhao, X., Schianchi, F., Dai, C., Liu, L., Nabben, M., Glatz, J. F. C., Wu, X., Lu, X., Li, X. & Luiken, J. J. F. P., 1 Mar 2024, In: Circulation Research. 134, 5, p. 505-525 21 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

How to use polarity thinking™ to manage tensions between accountability and learner agency when using a multipurpose portfolio?

van der Gulden, R., Thoonen, B. P. A., Heeneman, S., Muris, J. W. M., Sagasser, M. H., Timmerman, A. A. & Scherpbier-de Haan, N. D., 2024, In: Education for Primary Care. 35, 3-4, p. 71-80 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype

Rademakers, T., Manca, M., Jin, H., Orban, T., Perisic, L. M., Frissen, H. J. M., Rühle, F., Hautvast, P., van Rijssel, J., van Kuijk, K., Mees, B. M. E., Peutz-Kootstra, C. J., Heeneman, S., Daemen, M. J. A. P., Pasterkamp, G., Stoll, M., van Zandvoort, M. A. M. J., Hedin, U., Dequiedt, F. & van Buul, J. D. & 2 others, Sluimer, J. C. & Biessen, E. A. L., Aug 2024, In: Angiogenesis. 27, 3, p. 461-474 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients

Lu, C., Donners, M. M. P. C., de Baaij, J. B. J., Jin, H., Otten, J. J. T., Manca, M., van Zonneveld, A. J., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Mees, B., Sluimer, J. C., Cavill, R., Karel, J. M. H., Goossens, P. & Biessen, E. A. L., 12 Feb 2024, In: Frontiers in Immunology. 15, 13 p., 1286382.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis

Döring, Y., van der Vorst, E. P. C., Yan, Y., Neideck, C., Blanchet, X., Jansen, Y., Kemmerich, M., Bayasgalan, S., Peters, L. J. F., Hristov, M., Bidzhekov, K., Yin, C., Zhang, X., Leberzammer, J., Li, Y., Park, I., Kral, M., Nitz, K., Parma, L. & Gencer, S. & 10 others, Habenicht, A. J. R., Faussner, A., Teupser, D., Monaco, C., Holdt, L., Megens, R. T. A., Atzler, D., Santovito, D., von Hundelshausen, P. & Weber, C., Feb 2024, In: Nature cardiovascular research. 3, 2, p. 221-242 22 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health

Harlacher, E., Schulte, C., Vondenhoff, S., Schmitt-Kopplin, P., Diederich, P., Hemmers, C., Moellmann, J., Wollenhaupt, J., Veltrop, R., Biessen, E., Lehrke, M., Peters, B., Schlieper, G., Kuppe, C., Floege, J., Jankowski, V., Marx, N., Jankowski, J. & Noels, H., 6 Mar 2024, In: Frontiers in Cardiovascular Medicine. 11, 11 p., 1346475.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Inflammatory cells and blood-brain barrier leakage in cerebral small vessel diseases

Kerkhofs, D. J. H., 2024, Maastricht: Maastricht University. 180 p.

Research output: Thesis › Doctoral Thesis › Internal

Open Access

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Inhibition of endothelial to mesenchymal transition in a large animal preclinical arterio-venous fistula model leads to improved remodeling and reduced stenosis

Xu, Y., Korayem, A., Cruz-Solbes, A. S., Chandel, N., Sakata, T., Mazurek, R., Mavropoulos, S. A., Kariya, T., Aikawa, T., Yamada, K. P., D'Escamard, V., V'Gangula, B., Baker, A. H., Ma, L., Björkegren, J. L. M., Fuster, V., Boehm, M., Fish, K. M., Tadros, R. & Ishikawa, K. & 1 others, Kovacic, J. C., 26 Jul 2024, (E-pub ahead of print) In: Cardiovascular Research.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

Christ, A., Maas, S. L., Jin, H., Lu, C., Legein, B., Wijnands, E., Temmerman, L., Otten, J., Isaacs, A., Zenke, M., Stoll, M., Biessen, E. A. L. & van der Vorst, E. P. C., 5 Jan 2024, In: Free Radical Biology and Medicine. 210, p. 406-415 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Integration of Urinary Peptidome and Fecal Microbiome to Explore Patient Clustering in Chronic Kidney Disease

Mavrogeorgis, E., Valkenburg, S., Siwy, J., Latosinska, A., Glorieux, G., Mischak, H. & Jankowski, J., 1 Apr 2024, In: Proteomes. 12, 2, 15 p., 11.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

In vitro and in vivo evaluation of biohybrid tissue-engineered vascular grafts with transformative ¹H/¹⁹F MRI traceable scaffolds

Rama, E., Mohapatra, S. R., Sugimura, Y., Suzuki, T., Siebert, S., Barmin, R., Hermann, J., Baier, J., Rix, A., Lemainque, T., Koletnik, S., Elshafei, A. S., Pallares, R. M., Dadfar, S. M., Tolba, R. H., Schulz, V., Jankowski, J., Apel, C., Akhyari, P. & Jockenhoevel, S. & 1 others, Kiessling, F., 1 Dec 2024, In: Biomaterials. 311, 16 p., 122669.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation

Reutelingsperger, C. P. M., Gijbels, M. J., Spronk, H., Van Oerle, R., Schrijver, R., Ekhart, P., de Kimpe, S. & Nicolaes, G. A. F., Feb 2024, In: International Journal of Molecular Sciences. 25, 3, 12 p., 1376.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Macrophage heterogeneity in atherosclerosis: A matter of context

Wieland, E. B., Kempen, L. J., Donners, M. M., Biessen, E. A. & Goossens, P., Jan 2024, In: European journal of immunology. 54, 1, 9 p., 2350464.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Metabolic and Shear Stress Regulate Endothelial Epas1 in Atherosclerosis

Sluimer, J. C., 26 Sept 2024, In: Circulation Research. 135, 8, p. 838-840 3 p.

Research output: Contribution to journal › Editorial › Academic › peer-review

Microrna-26b plays a major regulatory role in cardiometabolic diseases

Peters, L. J. F., 2024, Maastricht: Maastricht University.

Research output: Thesis › Doctoral Thesis › External prepared

Open Access

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Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study

Mouzakis, F. L., Hima, F., Kashefi, A., Greven, J., Rink, L., van der Vorst, E. P. C., Jankowski, J., Mottaghy, K. & Spillner, J., 1 Aug 2024, In: Biomedicines. 12, 8, 12 p., 1883.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Myeloid PHD2 Conditional Knockout Improves Intraplaque Angiogenesis and Vascular Remodeling in a Murine Model of Venous Bypass Grafting

Sluiter, T. J., Tillie, R. J. H. A., de Jong, A., de Bruijn, J. B. G., Peters, H. A. B., van de Leijgraaf, R., Halawani, R., Westmaas, M., Starink, L. I. W., Quax, P. H. A., Sluimer, J. C. & de Vries, M. R., 6 Feb 2024, In: Journal of the American Heart Association. 13, 3, p. 033109 e033109.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Non-coding RNAs to treat vascular smooth muscle cell dysfunction

Brown, S. D., Klimi, E., Bakker, W. A. M., Beqqali, A. & Baker, A. H., 1 May 2024, (E-pub ahead of print) In: British Journal of Pharmacology. 35 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Peritoneal Dialysis Aggravates and Accelerates Atherosclerosis in Uremic ApoE-/- Mice

Kane, J., Vos, W. G., Bosmans, L. A., van Os, B. W., den Toom, M., Hoeksema-Hackmann, S., Moen-de Wit, D., Gijbels, M. J., Beckers, L., Grefhorst, A., Levels, J. H. M., Jakulj, L., Vervloet, M. G., Lutgens, E. & Eringa, E. C., 16 Jul 2024, In: Journal of the American Heart Association. 13, 14, p. e034066 15 p., e034066.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Plaque stabilizing and destabilizing effects in atherosclerosis: the role of microvessels, macrophage metabolism and fibroblasts

Tillie, R., 2024, Maastricht: Maastricht University. 361 p.

Research output: Thesis › Doctoral Thesis › Internal

Open Access

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Post-translational modifications in kidney diseases and associated cardiovascular risk

Noels, H., Jankowski, V., Schunk, S. J., Vanholder, R., Kalim, S. & Jankowski, J., Aug 2024, In: Nature Reviews Nephrology. 20, 8, p. 495-512 18 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation

Cao, J., Martin-Lorenzo, M., van Kuijk, K., Wieland, E., Gijbels, M. J., Claes, B. S. R., Heredero, A., Aldamiz-Echevarria, G., Heeren, R. M. A., Goossens, P., Sluimer, J., Balluff, B. & Alvarez-Llamas, G., Mar 2024, In: Arteriosclerosis Thrombosis and Vascular Biology. 44, 3, p. 741-754 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Specific Compounds Derived from Traditional Chinese Medicine Ameliorate Lipid-Induced Contractile Dysfunction in Cardiomyocytes

Wang, F., Neumann, D., Kapsokalyvas, D., Hoes, M. F., Schianchi, F., Glatz, J. F. C., Nabben, M. & Luiken, J. J. F. P., 25 Jul 2024, In: International Journal of Molecular Sciences. 25, 15, 20 p., 8131.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Tackling the complexity of CKD-associated cardiovascular disease: from small molecules to proteins

Saar-Kovrov, V., 2024, Maastricht: Maastricht University. 220 p.

Research output: Thesis › Doctoral Thesis › Internal

Open Access

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Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

Harber, K. J., Neele, A. E., van Roomen, C. P., Gijbels, M. J., Beckers, L., Toom, M. D., Schomakers, B. V., Heister, D. A., Willemsen, L., Griffith, G. R., de Goede, K. E., van Dierendonck, X. A., Reiche, M. E., Poli, A., L-H Mogensen, F., Michelucci, A., Verberk, S. G., de Vries, H., van Weeghel, M. & Van den Bossche, J. & 1 others, de Winther, M. P., 22 Jan 2024, In: Redox Biology. 70, 14 p., 103054.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis

Adam, S., Maas, S. L., Huchzermeier, R., Rakateli, L., Abschlag, K., Hohl, M., Liao, L., Bartneck, M., Teunissen, M., Wouters, K., Santovito, D., Jankowski, J., Biessen, E. A. L. & van der Vorst, E. P. C., 1 Sept 2024, In: EBioMedicine. 107, 16 p., 105293.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The dual effects of miR-222 in cardiac hypertrophy: bridging pathological and physiological paradigms

Kesidou, D., Beqqali, A. & Baker, A. H., 1 Feb 2024, In: Cardiovascular Research. 120, 3, p. 217-219 3 p.

Research output: Contribution to journal › Editorial › Academic › peer-review

Open Access

The PRIDE database resources in 2023

Bhargava, S. & Jankowski, J., Jan 2024, In: Nephrology Dialysis Transplantation. 39, 1, p. 4-6 3 p., gfad176.

Research output: Contribution to journal › Editorial › Academic › peer-review

Open Access

Unlocking Deprescribing Potential in Nursing Homes: Insights from a Focus Group Study with Healthcare Professionals

Visser, A. G. R., Poddighe de-Bruijn, J. B. G., Spaetgens, B., Winkens, B., Janknegt, R. & Schols, J. M. G. A., Mar 2024, In: Drugs & Aging. 41, 3, p. 261-270 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Urinary peptide analysis to predict the response to blood pressure medication

Jaimes Campos, M. A., Mavrogeorgis, E., Latosinska, A., Eder, S., Buchwinkler, L., Mischak, H., Siwy, J., Rossing, P., Mayer, G. & Jankowski, J., 1 May 2024, In: Nephrology Dialysis Transplantation. 39, 5, p. 873-883 11 p., gfad223.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

You Get What You Reward: A Qualitative Study Exploring Medical Student Engagement in 2 Different Assessment Systems

Jauregui, J., McClintock, A. H., Schrepel, C., Fainstad, T., Bierer, S. B. & Heeneman, S., 6 Sept 2024, (E-pub ahead of print) In: Academic Medicine. 10.1097/ACM.0000000000005848.

Research output: Contribution to journal › Article › Academic › peer-review

2023

A breath of fresh air in cardiovascular research

Sluimer, J., 17 May 2023, Maastricht University.

Research output: Book/Report › Inaugural speech › Professional

Open Access

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ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?

Maas, S. L., Donners, M. M. P. C. & van der Vorst, E. P. C., 1 Apr 2023, In: International Journal of Molecular Sciences. 24, 8, 23 p., 7309.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Adipocytes control hematopoiesis and inflammation through CD40 signaling

Reiche, M. E., Poels, K., Bosmans, L. A., Vos, W. G., Van Tiel, C. M., Gijbels, M. J. J., Aarts, S. A. B. M., Den Toom, M., Beckers, L., Weber, C., Atzler, D., Rensen, P. C. N., Kooijman, S. & Lutgens, E., 1 Jul 2023, In: Haematologica-the Hematology Journal. 108, 7, p. 1873-1885 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Alleviating burnout in medical school: increasing a sense of belonging and collegiality in the clinical workplace

Puranitee, P., 2023, Maastricht: Maastricht University. 194 p.

Research output: Thesis › Doctoral Thesis › External prepared

Open Access

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Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice

Kerkhofs, D., Helgers, R., Hermes, D., Steinbusch, H. P. J., Van Essen, H., Leenders, P., Prickaerts, J., Staals, J., Biessen, E. A., Van Oostenbrugge, R. J. & Foulquier, S., 1 Jul 2023, In: Journal of Hypertension. 41, 7, p. 1159-1167 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Blood endotoxin levels as biomarker of non-alcoholic fatty liver disease: a systematic review and meta-analysis

Soppert, J., Brandt, E. F., Heussen, N. M., Barzakova, E., Blank, L. M., Kuepfer, L., Hornef, M. W., Trebicka, J., Jankowski, J., Berres, M.-L. & Noels, H., Oct 2023, In: Clinical gastroenterology and hepatology. 21, 11, p. 2746-2758 13 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Carim - The vulnerable plaque: makers and markers

Research output

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