• P. Debyelaan 25

    6229 HX Maastricht

    Netherlands

Research Output

Cardiac Troponin T: It’s all in the shape of you

Vroemen, W., 2020

Research output: ThesisDoctoral ThesisInternal

Plasma Kallikrein Contributes to Coagulation in the Absence of Factor XI by Activating Factor IX

Visser, M., van Oerle, R., ten Cate, H., Laux, V., Mackman, N., Heitmeier, S. & Spronk, H. M. H., Jan 2020, In : Arteriosclerosis Thrombosis and Vascular Biology. 40, 1, p. 103-111 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tamsulosin Associated with Interstitial Lung Damage in CYP2D6 Variant Alleles Carriers

Jessurun, N. T., Wijnen, P. A., Bast, A., van Puijenbroek, E. P., Bekers, O. & Drent, M., Apr 2020, In : International journal of molecular sciences. 21, 8, 9 p., 2770.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Cardiac Troponin T: Only Small Molecules in Recreational Runners After Marathon Completion

Vroemen, W. H. M., Mezger, S. T. P., Masotti, S., Clerico, A., Bekers, O., de Boer, D. & Mingels, A., Mar 2019, In : The Journal of Applied Laboratory Medicine . 3, 5, p. 909-911 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Drug-induced interstitial lung disease: role of pharmacogenetics in predicting cytotoxic mechanisms and risks of side effects

Jessurun, N. T., Drent, M., van Puijenbroek, E. P., Bekers, O., Wijnen, P. A. & Bast, A., Sep 2019, In : Current Opinion in Pulmonary Medicine. 25, 5, p. 468-477 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Effects of the PAR-1 Antagonist Vorapaxar on Platelet Activation and Coagulation Biomarkers in Patients with Stable Coronary Artery Disease

Olie, R. H., van der Meijden, P. E. J., Spronk, H. M. H., van Oerle, R., Barvik, S., Bonarjee, V. V. S., Ten Cate, H. & Nilsen, D. W. T., Jul 2019, In : TH open : companion journal to thrombosis and haemostasis. 3, 3, p. e259-e262 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access

Everyday cognitive failure in patients suffering from neurosarcoidosis

Voortman, M., De Vries, J., Hendriks, C. M. R., Elfferich, M. D. P., Wijnen, P. A. H. M. & Drent, M., 2019, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 36, 1, p. 2-10 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Impact of CYP3A5 Genetic Polymorphism on Intrapatient Variability of Tacrolimus Exposure in Chinese Kidney Transplant Recipients

Cheung, C. Y., Chan, K. M., Wong, Y. T., Chak, W. L., Bekers, O. & van Hooff, J. P., 2019, In : Transplantation Proceedings. 51, 6, p. 1754-1757 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay

Damen, S. A. J., Vroemen, W. H. M., Brouwer, M. A., Mezger, S. T. P., Suryapranata, H., van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., de Boer, D., Cramer, G. E. & Mingels, A. M. A., 16 Jul 2019, In : Journal of the American Heart Association. 8, 14, 26 p., 012602.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

New membranes based on polyethersulfone - SlipSkin (TM) polymer blends with low fouling and high blood compatibility

ter Beek, O., Pavlenko, D., Suck, M., Helfrich, S., Bolhuis-Versteeg, L., Snisarenko, D., Causserand, C., Bacchin, P., Aimar, P., van Oerle, R., Wetzels, R., Verhezen, P., Henskens, Y. & Stamatialis, D., 15 Oct 2019, In : Separation and Purification Technology. 225, p. 60-73 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes

Posthuma, J. J., Posma, J. J. N., Schep, G., Bender, M. M. H., van Oerle, R., van der Wal, A. C., Ten Cate, H. & Spronk, H. M. H., Apr 2019, In : Journal of Vascular Surgery. 69, 4, p. 1243-1250 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Sarcoidosis and Work Participation: The Need to Develop a Disease-Specific Core Set for Assessment of Work Ability

Hendriks, C. M. R., Saketkoo, L. A., Elfferich, M. D. P., De Vries, J., Wijnen, P. A. H. M. & Drent, M., Aug 2019, In : Lung. 197, 4, p. 407-413 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease

Kremers, B. M. M., Birocchi, S., van Oerle, R., Zeerleder, S., Spronk, H. M. H., Mees, B. M. E., Luken, B. M., ten Cate, H. & ten Cate-Hoek, A. J., 2 Apr 2019, In : Frontiers in cardiovascular medicine. 6, p. 1-11 11 p., 33.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Self-reported Gastrointestinal Side Effects of Antifibrotic Drugs in Dutch Idiopathic Pulmonary Fibrosis patients

Proesmans, V. L. J., Drent, M., Elfferich, M. D. P., Wijnen, P. A. H. M., Jessurun, N. T. & Bast, A., Oct 2019, In : Lung. 197, 5, p. 551-558 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice

Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H. & Spronk, H. M. H., 7 Mar 2019, In : Scientific Reports. 9, 9 p., 3909.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study

Gulpen, A. J. W., ten Cate, H., Henskens, Y. M. C., van Oerle, R., Wetzels, R., Schalla, S., Crijns, H. J. & ten Cate-Hoek, A. J., 6 Jun 2019, In : PLOS ONE. 14, 6, 14 p., 0217302.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Trends in mass spectrometry imaging for cardiovascular diseases

Mezger, S. T. P., Mingels, A. M. A., Bekers, O., Cillero-Pastor, B. & Heeren, R. M. A., Jul 2019, In : Analytical and Bioanalytical Chemistry. 411, 17, p. 3709-3720 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis

Wijnen, P., Drent, M., Bekers, O., Verschakelen, J. & Bast, A., 1 Mar 2019, In : International journal of molecular sciences. 20, 5, 10 p., 1160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study

Panova-Noeva, M., Schulz, A., Spronk, H. M., Beicht, A., Laubert-Reh, D., van Oerle, R., Arnold, N., Prochaska, J. H., Blettner, M., Beutel, M., Pfeiffer, N., Munzel, T., Lackner, K. J., ten Cate, H. & Wild, P. S., 1 May 2018, In : Thrombosis and Haemostasis. 118, 5, p. 873-882 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Hofmann, I., Geer, M. J., Vogtle, T., Crispin, A., Campagna, D. R., Barr, A., Calicchio, M. L., Heising, S., van Geffen, J. P., Kuijpers, M. J. E., Heemskerk, J. W. M., Eble, J. A., Schmitz-Abe, K., Obeng, E. A., Douglas, M., Freson, K., Pondarre, C., Favier, R., Jarvis, G. E., Markianos, K. & 5 others, Turro, E., Ouwehand, W. H., Mazharian, A., Fleming, M. D. & Senis, Y. A., 27 Sep 2018, In : Blood. 132, 13, p. 1399-1412 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study

Hendriks, C., Drent, M., De Kleijn, W., Elfferich, M., Wijnen, P. & De Vries, J., 1 May 2018, In : Respiratory Medicine. 138, p. S24-S30 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Exploration of the platelet proteome in patients with early-stage cancer

Sabrkhany, S., Kuijpers, M. J. E., Knol, J. C., Damink, S. W. M. O., Dingemans, A-M. C., Verheul, H. M., Piersma, S. R., Pham, T. V., Griffioen, A. W., Egbrink, M. G. A. O. & Jimenez, C. R., 15 Apr 2018, In : Journal of Proteomics. 177, p. 65-74 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy

Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M. & van der Meijden, P. E. J., 31 Aug 2018, In : Haematologica-the Hematology Journal. 103, 9, p. 1557-1567 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis

de Brouwer, B., Drent, M., van den Ouweland, J. M. W., Wijnen, P. A., van Moorsel, C. H. M., Bekers, O., Grutters, J. C., White, E. S. & Janssen, R., 20 Mar 2018, In : Respiratory Research. 19, 4 p., 45.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access

Pharmacogenetic variants and vitamin K deficiency: a risk factor or trigger for fibrosing interstitial pneumonias?

Drent, M., Wijnen, P. & Bast, A., 1 May 2018, In : Current Opinion in Pulmonary Medicine. 24, 3, p. 287-295 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice

Vries, M. J., van der Meijden, P. E., Kuiper, G. J., Nelemans, P. J., Wetzels, R. J., van Oerle, R. G., Lance, M. D., ten Cate, H. & Henskens, Y. M., Oct 2018, In : Research and practice in thrombosis and haemostasis. 2, 4, p. 767-777 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

Geer, M. J., van Geffen, J. P., Gopalasingam, P., Vogtle, T., Smith, C. W., Heising, S., Kuijpers, M. J. E., Tullemans, B. M. E., Jarvis, G. E., Eble, J. A., Jeeves, M., Overduin, M., Heemskerk, J. W. M., Mazharian, A. & Senis, Y. A., 27 Sep 2018, In : Blood. 132, 13, p. 1413-1425 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Platelets in cancer: a big role for small cells

Sabrkhany, A. S., 2017

Research output: ThesisDoctoral ThesisInternal

Prevalence of interstitial and other lung diseases on Aruba

Deenstra, D., Wolvetang, N., Kock, S., Wills, S., Cobben, N., Wijnen, P. & Drent, M., 2017, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 34, 3, p. 217-225 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function

Kuiper, G. J. A. J. M., Houben, R., Wetzels, R. J. H., Verhezen, P. W. M., van Oerle, R., ten Cate, H., Henskens, Y. M. C. & Lance, M. D., 2017, In : Platelets. 28, 7, p. 668-675 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Biomarkers for Prediction of Central Venous Catheter Related-Thrombosis in Patients With Hematological Malignancies

Boersma, R. S., Hamulyak, K., van Oerle, R., Tuinenburg, A., Ten Cate - Hoek, A. & Schouten, H. C., Nov 2016, In : Clinical and Applied Thrombosis-Hemostasis. 22, 8, p. 779-784

Research output: Contribution to journalArticleAcademicpeer-review

Early platelet recovery following cardiac surgery with cardiopulmonary bypass

van Poucke, S., Stevens, K., Wetzels, R., Kicken, C., Verhezen, P., Theunissen, M., Kuiper, G-J., van Oerle, R., Henskens, Y. & Lance, M., 2016, In : Platelets. 27, 8, p. 751-757 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events

Loeffen, R. A., van Oerle, R., Leers, M. P. G., Kragten, J. A., Crijns, H., Spronk, H. M. H. & ten Cate, H., 15 Jul 2016, In : PLOS ONE. 11, 7, 16 p., e0158355.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased coagulation and fibrinolytic potential of solvent-detergent plasma: a comparative study between Omniplasma and fresh frozen plasma

van Beers, J. J. B. C., van Egmond, L. T., Wetzels, R. J. H., Verhezen, P. W. M., Beckers, E. A. M., van Oerle, R., Spronk, H. M. H., Straat, R. J. M. H. E. & Henskens, Y. M. C., Jul 2016, In : Vox Sanguinis. 111, 1, p. 33-42

Research output: Contribution to journalArticleAcademicpeer-review

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes

Gerdes, N., Seijkens, T., Lievens, D., Kuijpers, M. J. E., Winkels, H., Projahn, D., Hartwig, H., Beckers, L., Megens, R. T. A., Boon, L., Noelle, R. J., Soehnlein, O., Heemskerk, J. W. M., Weber, C. & Lutgens, E., Mar 2016, In : Arteriosclerosis Thrombosis and Vascular Biology. 36, 3, p. 482-490

Research output: Contribution to journalArticleAcademicpeer-review

Sunitinib uptake inhibits platelet function in cancer patients

Sabrkhany, S., Griffioen, A. W., Pineda, S., Sanders, L., Mattheij, N., van Geffen, A., Aarts, M. J., Heemskerk, J. W. M., Oude Egbrink, M. & Kuijpers, M. J. E., Oct 2016, In : European Journal of Cancer. 66, p. 47-54 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage

Mattheij, N. J. A., Braun, A., van Kruchten, R., Castoldi, E., Pircher, J., Baaten, C. C. F. M. J., Wuelling, M., Kuijpers, M. J. E., Koehler, R., Poole, A. W., Schreiber, R., Vortkamp, A., Collins, P. W., Nieswandt, B., Kunzelmann, K., Cosemans, J. M. E. M. & Heemskerk, J. W. M., Feb 2016, In : Faseb Journal. 30, 2, p. 727-737

Research output: Contribution to journalArticleAcademicpeer-review

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling and swelling

Mattheij, N., Braun, A., van Kruchten, R., Castoldi, E., PIRCHER, J., Baaten, C., WÜLLING, M., Kuijpers, M., KÖHLER, R., POOLE, A. W., Schreiber, R., VORTKAMP, A., COLLINS, P. W., Nieswandt, B., KUNZELMANN, K., Cosemans, J. & Heemskerk, J., 2016, In : Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde. 41, p. 207-208

Research output: Contribution to journalArticleAcademicpeer-review

Uitdagingen bij het screenen en diagnosticeren van milde bloedingsziekten

Moenen, F. C., Vries, M. C., Henskens, Y., ten Cate, H., Wetzels, R. J., Verhezen, P. W., van Oerle, R. & Beckers, E., 2016, In : Nederlands Tijdschrift voor Hematologie. 13, 5, p. 182-189

Research output: Contribution to journalArticleAcademicpeer-review

Validation of a modified thromboelastometry approach to detect changes in fibrinolytic activity

Kuiper, G-J., Kleinegris, M-C., van Oerle, R., Spronk, H., Lance, M., ten Cate, H. & Henskens, Y., 14 Jan 2016, In : Thrombosis Journal. 14, 13 p., 1.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Acute eosinophilic pneumonia associated with glyphosate-surfactant exposure

de Raadt, W. M., Wijnen, P. A., Bast, A., Bekers, O. & Drent, M., 2015, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 32, 2, p. 172-175

Research output: Contribution to journalArticleAcademicpeer-review